Dent, Arlene E, Chelimo, Kiprotich, Sumba, Peter O, Spring, Michele D, Crabb, Brendan S, Moormann, Ann M, ...
Abstract Background Naturally acquired immunity to blood-stage Plasmodium falciparum infection develops with age and after repeated infections. In order to identify immune surrogates that can inform...
Dent, Arlene E, Chelimo, Kiprotich, Sumba, Peter O, Spring, Michele D, Crabb, Brendan S, Moormann, Ann M, ...
BACKGROUND: Naturally acquired immunity to blood-stage Plasmodium falciparum infection develops with age and after repeated infections. In order to identify immune surrogates that can inform vaccine...
Baum, Jake, Papenfuss, Anthony T., Mair, Gunnar R., Janse, Chris J., Vlachou, Dina, Waters, Andrew P., ...
Techniques for targeted genetic disruption in Plasmodium, the causative agent of malaria, are currently intractable for those genes that are essential for blood stage development. The ability to use...
Lundie, Rachel J., Davey, Gayle M., Nie, Catherine Q., Hansen, Diana S., Lau, Lei Shong, ...
Although CD8+ T cells do not contribute to protection against the blood stage of Plasmodium infection, there is mounting evidence that they are principal mediators of murine experimental cerebral...
Drew, Damien R., Chesson, Joanne M., Beeson, James G., Crabb, Brendan S.
Merozoite surface protein 8 (MSP8) has shown promise as a vaccine candidate in the Plasmodium yoelii rodent malaria model and has a proposed role in merozoite invasion of erythrocytes. However, the...
The Importance of Human FcγRI in Mediating Protection to Malaria (2007)
Richard S. McIntosh, Jianguo Shi, Richard M. Jennings, Jonathan C. Chappel, Tim Smith, ...
The success of passive immunization suggests that antibody-based therapies will be effective at controlling malaria. We describe the development of fully human antibodies specific for Plasmodium...
Importance of human FcyRI in mediating protection to malaria (2007)
McIntosh, Richard S., Shi, Jianguo, Jennings, Richard M., Chappel, Jonathan C., Smith, Tim, ...
The success of passive immunization suggests that antibody-based therapies will be effective at controlling malaria. We describe the development of fully human antibodies specific for Plasmodium...
McCoubrie, Joanne E., Miller, Susanne K., Sargeant, Tobias, Good, Robert T., Hodder, Anthony N., Speed, Terence P., ...
Serine repeat antigens (SERAs) are a family of secreted "cysteine-like" proteases of Plasmodium parasites. Several SERAs possess an atypical active-site serine residue in place of the...
The importance of human FcyRI in mediating protection to malaria (2007)
McIntosh, Richard S., Shi, Jianguo, Jennings, Richard M., Chappel, Jonathan C., Smith, Tim, ...
The success of passive immunization suggests that antibody-based therapies will be effective at controlling malaria. We describe the development of fully human antibodies specific for Plasmodium...
McCoubrie, Joanne E., Miller, Susanne K., Sargeant, Tobias, Good, Robert T., Hodder, Anthony N., Speed, Terence P., ...
Serine repeat antigens (SERAs) are a family of secreted “cysteine-like” proteases of Plasmodium parasites. Several SERAs possess an atypical active-site serine residue in place of the...
Wilson, Nicholas S., Behrens, Georg M. N., Lundie, Rachel J., Smith, Christopher M., Waithman, Jason, Young, Louise, ...
The mechanisms responsible for the immunosuppression associated with sepsis or some chronic blood infections remain poorly understood. Here we show that infection with a malaria parasite (Plasmodium...
Promising Functional Readouts of Immunity in a Blood-Stage Malaria Vaccine Trial (2005)
Brendan S. Crabb, James G. Beeson
The authors discuss results from an early trial of a vaccine based on Plasmodium MSP-3 protein reported by Pierre Druilhe and colleagues.
Bourgon, Richard, Delorenzi, Mauro, Sargeant, Tobias, Hodder, Anthony N., Crabb, Brendan S., Speed, Terence P.
Plasmodium falciparum is the parasite responsible for the most acute form of malaria in humans. Recently, the serine repeat antigen (SERA) in P. falciparum has attracted attention as a potential...
Bourgon, Richard, Delorenzi, Mauro, Sargeant, Tobias, Hodder, Anthony N., Crabb, Brendan S., Speed, Terence P.
Plasmodium falciparum is the parasite responsible for the most acute form of malaria in humans. Recently, the serine repeat antigen (SERA) in P. falciparum has attracted attention as a potential...
Bourgon, Richard, Delorenzi, Mauro, Sargeant, Tobias, Hodder, Anthony N., Crabb, Brendan S., Speed, Terence P.
Plasmodium falciparum is the parasite responsible for the most acute form of malaria in humans. Recently, the serine repeat antigen (SERA) in P. falciparum has attracted attention as a potential...
Plasmodium falciparum virulence determinants unveiled (2002)
Crabb, Brendan S, Cowman, Alan F
Abstract The human malaria parasite Plasmodium falciparum, one of the world's most devastating pathogens, has an astonishing array of sequences and genes that play key roles in pathogenesis and...
ODonnell, Rebecca A., Preiser, Peter R., Williamson, Donald H., Moore, Peter W., Cowman, Alan F., Crabb, Brendan S.
Transfection of the human malaria parasite Plasmodium falciparum is currently performed with circularised plasmids that are maintained episomally in parasites under drug selection but which are...
Reed, Michael B., Caruana, Sonia R., Batchelor, Adrian H., Thompson, Jennifer K., Crabb, Brendan S., Cowman, Alan F.
Erythrocyte invasion by Plasmodium requires molecules present both on the merozoite surface and within the specialized organelles of the apical complex. The Plasmodium erythrocyte binding protein...
O’Donnell, Rebecca A., Preiser, Peter R., Williamson, Donald H., Moore, Peter W., Cowman, Alan F., Crabb, Brendan S.
Transfection of the human malaria parasite Plasmodium falciparum is currently performed with circularised plasmids that are maintained episomally in parasites under drug selection but which are...
Hinton, Tracey M., Li, Feng, Crabb, Brendan S.
Equine rhinitis A virus (ERAV) has recently been classified as an aphthovirus, a genus otherwise comprised of the different serotypes of Foot-and-mouth disease virus (FMDV). FMDV initiates...
Warner, Simone, Hartley, Carol A., Stevenson, Rachel A., Ficorilli, Nino, Varrasso, Annalisa, Studdert, Michael J., ...
Equine rhinitis A virus (ERAV) is a respiratory pathogen of horses and is classified as an Aphthovirus, the only non-Foot-and-mouth disease virus (FMDV) member of this genus. In FMDV, virion protein...
O’Donnell, Rebecca A., Freitas-Junior, Lúcio H., Preiser, Peter R., Williamson, Donald H., Duraisingh, Manoj, McElwain, Terry F., ...
Bacterial plasmids introduced into the human malaria parasite Plasmodium falciparum replicate well but are poorly segregated during mitosis. In this paper, we screened a random P.falciparum genomic...
Baldi, Deborah L., Good, Robert, Duraisingh, Manoj T., Crabb, Brendan S., Cowman, Alan F.
The low-molecular-mass rhoptry complex of Plasmodium falciparum consists of three proteins, rhoptry-associated protein 1 (RAP1), RAP2, and RAP3. The genes encoding RAP1 and RAP2 are known; however,...
RAP1 controls rhoptry targeting of RAP2 in the malaria parasite Plasmodium falciparum
Baldi, Deborah L., Andrews, Katherine T., Waller, Ross F., Roos, David S., Howard, Randall F., Crabb, Brendan S., ...
Rhoptry associated protein 1 (RAP1) and 2 (RAP2), together with a poorly described third protein RAP3, form the low molecular weight complex within the rhoptries of Plasmodium falciparum. These...
Plasmodium falciparum virulence determinants unveiled
Crabb, Brendan S, Cowman, Alan F
The human malaria parasite Plasmodium falciparum, has many sequences and genes that play key roles in pathogenesis and immune evasion. We must understand the functions of these elements if the...
Corran, Patrick H., O'Donnell, Rebecca A., Todd, Jim, Uthaipibull, Chairat, Holder, Anthony A., Crabb, Brendan S., ...
In a cross-sectional survey of 187 Gambian children and adults, we have analyzed prevalence, fine specificity, and 19-kilodalton merozoite surface protein 1 (MSP-119)-specific erythrocyte invasion...
Tivendale, Kelly A., Allen, Joanne L., Ginns, Carol A., Crabb, Brendan S., Browning, Glenn F.
Avian pathogenic Escherichia coli (APEC) is an economically important respiratory pathogen of chickens worldwide. Factors previously associated with the virulence of APEC include adhesins,...
Several Recombinant Capsid Proteins of Equine Rhinitis A Virus Show Potential as Diagnostic Antigens
Li, Fan, Stevenson, Rachel A., Crabb, Brendan S., Studdert, Michael J., Hartley, Carol A.
Equine rhinitis A virus (ERAV) is a significant pathogen of horses and is also closely related to Foot-and-mouth disease virus (FMDV). Despite these facts, knowledge of the prevalence and importance...
Trafficking of STEVOR to the Maurer's clefts in Plasmodium falciparum-infected erythrocytes
Przyborski, Jude M, Miller, Susanne K, Pfahler, Judith M, Henrich, Philipp P, Rohrbach, Petra, Crabb, Brendan S, ...
The human malarial parasite Plasmodium falciparum exports proteins to destinations within its host erythrocyte, including cytosol, surface and membranous profiles of parasite origin termed Maurer's...
Promising Functional Readouts of Immunity in a Blood-Stage Malaria Vaccine Trial
Crabb, Brendan S, Beeson, James G
The authors discuss results from an early trial of a vaccine based on Plasmodium MSP-3 protein reported by Pierre Druilhe and colleagues.
Drew, Damien R., Sanders, Paul R., Crabb, Brendan S.
To date, the following seven glycosylphosphatidylinositol (GPI)-anchored merozoite antigens have been described in Plasmodium falciparum: merozoite-associated surface protein 1 (MSP-1), MSP-2, MSP-4,...
Sanders, Paul R., Kats, Lev M., Drew, Damien R., O'Donnell, Rebecca A., O'Neill, Matthew, Maier, Alexander G., ...
Targeted gene disruption has proved to be a powerful approach for studying the function of important ligands involved in erythrocyte invasion by the extracellular merozoite form of the human malaria...
Reed, Michael B., Caruana, Sonia R., Batchelor, Adrian H., Thompson, Jennifer K., Crabb, Brendan S., Cowman, Alan F.
Erythrocyte invasion by Plasmodium requires molecules present both on the merozoite surface and within the specialized organelles of the apical complex. The Plasmodium erythrocyte binding protein...
O’Donnell, Rebecca A., Preiser, Peter R., Williamson, Donald H., Moore, Peter W., Cowman, Alan F., Crabb, Brendan S.
Transfection of the human malaria parasite Plasmodium falciparum is currently performed with circularised plasmids that are maintained episomally in parasites under drug selection but which are...
Hinton, Tracey M., Li, Feng, Crabb, Brendan S.
Equine rhinitis A virus (ERAV) has recently been classified as an aphthovirus, a genus otherwise comprised of the different serotypes of Foot-and-mouth disease virus (FMDV). FMDV initiates...
Warner, Simone, Hartley, Carol A., Stevenson, Rachel A., Ficorilli, Nino, Varrasso, Annalisa, Studdert, Michael J., ...
Equine rhinitis A virus (ERAV) is a respiratory pathogen of horses and is classified as an Aphthovirus, the only non-Foot-and-mouth disease virus (FMDV) member of this genus. In FMDV, virion protein...
O’Donnell, Rebecca A., Freitas-Junior, Lúcio H., Preiser, Peter R., Williamson, Donald H., Duraisingh, Manoj, McElwain, Terry F., ...
Bacterial plasmids introduced into the human malaria parasite Plasmodium falciparum replicate well but are poorly segregated during mitosis. In this paper, we screened a random P.falciparum genomic...
Baldi, Deborah L., Good, Robert, Duraisingh, Manoj T., Crabb, Brendan S., Cowman, Alan F.
The low-molecular-mass rhoptry complex of Plasmodium falciparum consists of three proteins, rhoptry-associated protein 1 (RAP1), RAP2, and RAP3. The genes encoding RAP1 and RAP2 are known; however,...
RAP1 controls rhoptry targeting of RAP2 in the malaria parasite Plasmodium falciparum
Baldi, Deborah L., Andrews, Katherine T., Waller, Ross F., Roos, David S., Howard, Randall F., Crabb, Brendan S., ...
Rhoptry associated protein 1 (RAP1) and 2 (RAP2), together with a poorly described third protein RAP3, form the low molecular weight complex within the rhoptries of Plasmodium falciparum. These...
Plasmodium falciparum virulence determinants unveiled
Crabb, Brendan S, Cowman, Alan F
The human malaria parasite Plasmodium falciparum, has many sequences and genes that play key roles in pathogenesis and immune evasion. We must understand the functions of these elements if the...
Corran, Patrick H., O'Donnell, Rebecca A., Todd, Jim, Uthaipibull, Chairat, Holder, Anthony A., Crabb, Brendan S., ...
In a cross-sectional survey of 187 Gambian children and adults, we have analyzed prevalence, fine specificity, and 19-kilodalton merozoite surface protein 1 (MSP-119)-specific erythrocyte invasion...
Tivendale, Kelly A., Allen, Joanne L., Ginns, Carol A., Crabb, Brendan S., Browning, Glenn F.
Avian pathogenic Escherichia coli (APEC) is an economically important respiratory pathogen of chickens worldwide. Factors previously associated with the virulence of APEC include adhesins,...
Meissner, Markus, Krejany, Efrosinia, Gilson, Paul R., Soldati, Dominique, Crabb, Brendan S.
Genetic manipulation has revolutionized research in the Apicomplexan parasite Plasmodium falciparum, the most important causative agent of malaria. However, to date no techniques have been...
Several Recombinant Capsid Proteins of Equine Rhinitis A Virus Show Potential as Diagnostic Antigens
Li, Fan, Stevenson, Rachel A., Crabb, Brendan S., Studdert, Michael J., Hartley, Carol A.
Equine rhinitis A virus (ERAV) is a significant pathogen of horses and is also closely related to Foot-and-mouth disease virus (FMDV). Despite these facts, knowledge of the prevalence and importance...
Drew, Damien R., Sanders, Paul R., Crabb, Brendan S.
To date, the following seven glycosylphosphatidylinositol (GPI)-anchored merozoite antigens have been described in Plasmodium falciparum: merozoite-associated surface protein 1 (MSP-1), MSP-2, MSP-4,...
Trafficking of STEVOR to the Maurer's clefts in Plasmodium falciparum-infected erythrocytes
Przyborski, Jude M, Miller, Susanne K, Pfahler, Judith M, Henrich, Philipp P, Rohrbach, Petra, Crabb, Brendan S, ...
The human malarial parasite Plasmodium falciparum exports proteins to destinations within its host erythrocyte, including cytosol, surface and membranous profiles of parasite origin termed Maurer's...
Promising Functional Readouts of Immunity in a Blood-Stage Malaria Vaccine Trial
Crabb, Brendan S, Beeson, James G
The authors discuss results from an early trial of a vaccine based on Plasmodium MSP-3 protein reported by Pierre Druilhe and colleagues.
Sanders, Paul R., Kats, Lev M., Drew, Damien R., O'Donnell, Rebecca A., O'Neill, Matthew, Maier, Alexander G., ...
Targeted gene disruption has proved to be a powerful approach for studying the function of important ligands involved in erythrocyte invasion by the extracellular merozoite form of the human malaria...
Embryonic age influences the capacity for cytokine induction in chicken thymocytes
Peters, Michelle A, Browning, Glenn F, Washington, Elizabeth A, Crabb, Brendan S, Kaiser, Pete
Thymocyte responses to functional activation are of relevance to the evaluation of the efficacy of in ovo immunotherapies and vaccines in chickens. In this study we have demonstrated differences in...
Cowman, Alan F, Baldi, Deborah L, Duraisingh, Manoj, Healer, Julie, Mills, Kerry E, O'Donnell, Rebecca A, ...
Malaria is a major human health problem and is responsible for over 2 million deaths per year. It is caused by a number of species of the genus Plasmodium, and Plasmodium falciparum is the causative...
The Importance of Human FcγRI in Mediating Protection to Malaria
McIntosh, Richard S, Shi, Jianguo, Jennings, Richard M, Chappel, Jonathan C, Smith, Tim, ...
The success of passive immunization suggests that antibody-based therapies will be effective at controlling malaria. We describe the development of fully human antibodies specific for Plasmodium...
Towards a Vaccine against Plasmodium vivax Malaria
Beeson, James G, Crabb, Brendan S
The authors discuss a new study that suggests thatPlasmodium vivax Duffy-binding protein could be a candidate antigen for developing aP. vivax vaccine.
Voss, Till S, Tonkin, Christopher J, Marty, Allison J, Thompson, Jennifer K, Healer, Julie, Crabb, Brendan S, ...
Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1), encoded by the var gene family, undergoes antigenic variation and plays an important role in chronic infection and severe malaria. Only...
McCoubrie, Joanne E., Miller, Susanne K., Sargeant, Tobias, Good, Robert T., Hodder, Anthony N., Speed, Terence P., ...
Serine repeat antigens (SERAs) are a family of secreted “cysteine-like” proteases of Plasmodium parasites. Several SERAs possess an atypical active-site serine residue in place of the canonical...
O'Donnell, Rebecca A., Drew, Damien R., Thomson, Russell, Speed, Terence P., Crabb, Brendan S.
Antibodies capable of inhibiting the invasion of Plasmodium merozoites into erythrocytes are present in individuals that are clinically immune to the malaria parasite. Those targeting the 19-kD...
O'Donnell, Rebecca A., Burt, Rachel A., Bockarie, Moses, Reeder, John C., Cowman, Alan F., ...
Antibodies that bind to antigens expressed on the merozoite form of the malaria parasite can inhibit parasite growth by preventing merozoite invasion of red blood cells. Inhibitory antibodies are...
Young, Louise J., Wilson, Nicholas S., Schnorrer, Petra, Mount, Adele, Lundie, Rachel J., La Gruta, Nicole L., ...
When dendritic cells (DCs) encounter signals associated with infection or inflammation, they become activated and undergo maturation. Mature DCs are very efficient at presenting antigens captured in...
Maier, Alexander G., Rug, Melanie, O'Neill, Matthew T., Brown, Monica, Chakravorty, Srabasti, Szestak, Tadge, ...
A major part of virulence for Plasmodium falciparum malaria infection, the most lethal parasitic disease of humans, results from increased rigidity and adhesiveness of infected host red cells. These...
Fairlie, W. Douglas, Spurck, Tim P., McCoubrie, Joanne E., Gilson, Paul R., Miller, Susanne K., McFadden, Geoffrey I., ...
The serine repeat antigen (SERA) proteins of the malaria parasites Plasmodium spp. contain a putative enzyme domain similar to that of papain family cysteine proteases. In Plasmodium falciparum...
Lundie, Rachel J., Davey, Gayle M., Nie, Catherine Q., Hansen, Diana S., Lau, Lei Shong, ...
Although CD8+ T cells do not contribute to protection against the blood stage of Plasmodium infection, there is mounting evidence that they are principal mediators of murine experimental cerebral...
Nie, Catherine Q., Bernard, Nicholas J., Norman, M. Ursula, Amante, Fiona H., Lundie, Rachel J., Crabb, Brendan S., ...
Plasmodium falciparum malaria causes 660 million clinical cases with over 2 million deaths each year. Acquired host immunity limits the clinical impact of malaria infection and provides protection...
Kadekoppala, Madhusudan, O'Donnell, Rebecca A., Grainger, Munira, Crabb, Brendan S., Holder, Anthony A.
Merozoite surface proteins have been implicated in the initial attachment to the host red blood cell membrane that begins the process of invasion, an important step in the life cycle of the malaria...
Molecular genetics and comparative genomics reveal RNAi is not functional in malaria parasites
Baum, Jake, Papenfuss, Anthony T., Mair, Gunnar R., Janse, Chris J., Vlachou, Dina, Waters, Andrew P., ...
Techniques for targeted genetic disruption in Plasmodium, the causative agent of malaria, are currently intractable for those genes that are essential for blood stage development. The ability to use...
Temporal stability of naturally acquired immunity to Merozoite Surface Protein-1 in Kenyan Adults
Dent, Arlene E, Chelimo, Kiprotich, Sumba, Peter O, Spring, Michele D, Crabb, Brendan S, Moormann, Ann M, ...
A Novel Family of Apicomplexan Glideosome-associated Proteins with an Inner Membrane-anchoring Role*
Bullen, Hayley E., Tonkin, Christopher J., O'Donnell, Rebecca A., Tham, Wai-Hong, Papenfuss, Anthony T., Gould, Sven, ...
The phylum Apicomplexa are a group of obligate intracellular parasites responsible for a wide range of important diseases. Central to the lifecycle of these unicellular parasites is their ability to...