Re-annotation and re-analysis of the Campylobacter jejuniNCTC11168 genome sequence (2007)
Gundogdu, Ozan, Bentley, Stephen D, Holden, Matt T, Parkhill, Julian, Dorrell, Nick, Wren, Brendan W
Abstract Background Campylobacter jejuni is the leading bacterial cause of human gastroenteritis in the developed world. To improve our understanding of this important human pathogen, the C. jejuni...
Nicholas R. Thomson, Sarah Howard, Brendan W. Wren, Lisa Crossman, Gregory L. Challis, ...
The human enteropathogen, Yersinia enterocolitica, is a significant link in the range of Yersinia pathologies extending from mild gastroenteritis to bubonic plague. Comparison at the genomic level is...
Karlyshev, Andrey V., Wren, Brendan W.
We have recently demonstrated that most strains of Campylobacter jejuni produce capsular polysaccharide (CPS), which can be detected by immunoblotting with homologous Penner antisera on...
Brás, Ana M., Chatterjee, Shimonti, Wren, Brendan W., Newell, Diane G., Ketley, Julian M.
Campylobacter jejuni colonizes the intestines of domestic and wild animals and is a common cause of human diarrheal disease. We identified a two-component regulatory system, designated the RacR-RacS...
Allan, Elaine, Dorrell, Nick, Foynes, Susan, Anyim, Martin, Wren, Brendan W.
We investigated the roles of fliF, fliS, flhB, fliQ, fliG, and fliI of Helicobacter pylori, predicted by homology to encode structural components of the flagellar basal body and export apparatus....
Prentice, Michael B., James, Keith D., Parkhill, Julian, Baker, Stephen G., Stevens, Kim, Simmonds, Mark N., ...
Population genetic studies suggest that Yersinia pestis, the cause of plague, is a clonal pathogen that has recently emerged from Yersinia pseudotuberculosis. Plasmid acquisition is likely to have...
Ward, Stephen J., Douce, Gill, Dougan, Gordon, Wren, Brendan W.
Fourteen of the 38 C-terminal repeats from Clostridium difficile toxin A (14CDTA) were cloned and expressed either with an N-terminal polyhistidine tag (14CDTA-HIS) or fused to the nontoxic binding...
Foynes, Susan, Dorrell, Nick, Ward, Stephen J., Stabler, Richard A., McColm, Andy A., Rycroft, Andrew N., ...
Infection of the mucous layer of the human stomach by Helicobacter pylori requires the bacterium to be motile and presumably chemotactic. Previous studies have shown that fully functional flagella...
Oyston, Petra C. F., Dorrell, Nick, Williams, Kerstin, Li, Shu-Rui, Green, Michael, Titball, Richard W., ...
The two-component regulatory system PhoPQ has been identified in many bacterial species. However, the role of PhoPQ in regulating virulence gene expression in pathogenic bacteria has been...
Martino, M. Celeste, Stabler, Richard A., Zhang, Zun W., Farthing, Michael J. G., Wren, Brendan W., Dorrell, Nick
Hemolysins have been found to possess a variety of functions in bacteria, including a role in virulence. Helicobacter pylori demonstrates hemolytic activity when cultured on unlysed blood agar plates...
Demonstration of Polysaccharide Capsule in Campylobacter jejuni Using Electron Microscopy
Karlyshev, Andrey V., McCrossan, Maria V., Wren, Brendan W.
Recently, we reported that Campylobacter jejuni, an important gastrointestinal pathogen, has the genetic determinants to produce a capsular polysaccharide (Karlyshev et al., Mol. Microbiol....
Ward, Stephen J., Douce, Gill, Figueiredo, Dayse, Dougan, Gordon, Wren, Brendan W.
The C-terminal repeat domain of Clostridium difficile toxin A harbors toxin-neutralizing epitopes and is considered to be a candidate component of a vaccine against C. difficile-associated disease...
Dorrell, Nick, Mangan, Joseph A., Laing, Kenneth G., Hinds, Jason, Linton, Dennis, Al-Ghusein, Hasan, ...
Campylobacter jejuni is the leading cause of bacterial food-borne diarrhoeal disease throughout the world, and yet is still a poorly understood pathogen. Whole genome microarray comparisons of 11 C....
Hinchliffe, Stewart J., Isherwood, Karen E., Stabler, Richard A., Prentice, Michael B., Rakin, Alexander, Nichols, Richard A., ...
Yersinia pestis, the causative agent of plague, diverged from Yersinia pseudotuberculosis, an enteric pathogen, an estimated 1500–20,000 years ago. Genetic characterization of these closely related...
Jones, Michael A., Marston, Kerrie L., Woodall, Claire A., Maskell, Duncan J., Linton, Dennis, Karlyshev, Andrey V., ...
The genome sequence of the human pathogen Campylobacter jejuni NCTC11168 has been determined recently, but studies on colonization and persistence in chickens have been limited due to reports that...
Moen, Birgitte, Oust, Astrid, Langsrud, Øyvind, Dorrell, Nick, Marsden, Gemma L., Hinds, Jason, ...
Explorative approaches such as DNA microarray experiments are becoming increasingly important in microbial research. Despite these major technical advancements, approaches to study multifactor...
Zilbauer, Matthias, Dorrell, Nick, Boughan, Parjeet K., Harris, Andrew, Wren, Brendan W., Klein, Nigel J., ...
Campylobacter jejuni is the most prevalent cause of bacterial diarrhea worldwide. Despite the serious health problems caused by this bacterium, human innate immune responses to C. jejuni infection...
Erickson, David L., Jarrett, Clayton O., Wren, Brendan W., Hinnebusch, B. Joseph
Yersinia pestis, the agent of plague, is usually transmitted by fleas. To produce a transmissible infection, Y. pestis colonizes the flea midgut and forms a biofilm in the proventricular valve, which...
Champion, Olivia L., Gaunt, Michael W., Gundogdu, Ozan, Elmi, Abdi, Witney, Adam A., Hinds, Jason, ...
Campylobacter jejuni is the predominant cause of bacterial gastroenteritis worldwide, but traditional typing methods are unable to discriminate strains from different sources that cause disease in...
Howard, Sarah L., Gaunt, Michael W., Hinds, Jason, Witney, Adam A., Stabler, Richard, Wren, Brendan W.
Yersinia enterocolitica, an important cause of human gastroenteritis generally caused by the consumption of livestock, has traditionally been categorized into three groups with respect to...
Karlyshev, Andrey V., Wren, Brendan W.
We have recently demonstrated that most strains of Campylobacter jejuni produce capsular polysaccharide (CPS), which can be detected by immunoblotting with homologous Penner antisera on...
Brás, Ana M., Chatterjee, Shimonti, Wren, Brendan W., Newell, Diane G., Ketley, Julian M.
Campylobacter jejuni colonizes the intestines of domestic and wild animals and is a common cause of human diarrheal disease. We identified a two-component regulatory system, designated the RacR-RacS...
Allan, Elaine, Dorrell, Nick, Foynes, Susan, Anyim, Martin, Wren, Brendan W.
We investigated the roles of fliF, fliS, flhB, fliQ, fliG, and fliI of Helicobacter pylori, predicted by homology to encode structural components of the flagellar basal body and export apparatus....
Prentice, Michael B., James, Keith D., Parkhill, Julian, Baker, Stephen G., Stevens, Kim, Simmonds, Mark N., ...
Population genetic studies suggest that Yersinia pestis, the cause of plague, is a clonal pathogen that has recently emerged from Yersinia pseudotuberculosis. Plasmid acquisition is likely to have...
Ward, Stephen J., Douce, Gill, Dougan, Gordon, Wren, Brendan W.
Fourteen of the 38 C-terminal repeats from Clostridium difficile toxin A (14CDTA) were cloned and expressed either with an N-terminal polyhistidine tag (14CDTA-HIS) or fused to the nontoxic binding...
Foynes, Susan, Dorrell, Nick, Ward, Stephen J., Stabler, Richard A., McColm, Andy A., Rycroft, Andrew N., ...
Infection of the mucous layer of the human stomach by Helicobacter pylori requires the bacterium to be motile and presumably chemotactic. Previous studies have shown that fully functional flagella...
Oyston, Petra C. F., Dorrell, Nick, Williams, Kerstin, Li, Shu-Rui, Green, Michael, Titball, Richard W., ...
The two-component regulatory system PhoPQ has been identified in many bacterial species. However, the role of PhoPQ in regulating virulence gene expression in pathogenic bacteria has been...
Martino, M. Celeste, Stabler, Richard A., Zhang, Zun W., Farthing, Michael J. G., Wren, Brendan W., Dorrell, Nick
Hemolysins have been found to possess a variety of functions in bacteria, including a role in virulence. Helicobacter pylori demonstrates hemolytic activity when cultured on unlysed blood agar plates...
Demonstration of Polysaccharide Capsule in Campylobacter jejuni Using Electron Microscopy
Karlyshev, Andrey V., McCrossan, Maria V., Wren, Brendan W.
Recently, we reported that Campylobacter jejuni, an important gastrointestinal pathogen, has the genetic determinants to produce a capsular polysaccharide (Karlyshev et al., Mol. Microbiol....
Ward, Stephen J., Douce, Gill, Figueiredo, Dayse, Dougan, Gordon, Wren, Brendan W.
The C-terminal repeat domain of Clostridium difficile toxin A harbors toxin-neutralizing epitopes and is considered to be a candidate component of a vaccine against C. difficile-associated disease...
Dorrell, Nick, Mangan, Joseph A., Laing, Kenneth G., Hinds, Jason, Linton, Dennis, Al-Ghusein, Hasan, ...
Campylobacter jejuni is the leading cause of bacterial food-borne diarrhoeal disease throughout the world, and yet is still a poorly understood pathogen. Whole genome microarray comparisons of 11 C....
Hinchliffe, Stewart J., Isherwood, Karen E., Stabler, Richard A., Prentice, Michael B., Rakin, Alexander, Nichols, Richard A., ...
Yersinia pestis, the causative agent of plague, diverged from Yersinia pseudotuberculosis, an enteric pathogen, an estimated 1500–20,000 years ago. Genetic characterization of these closely related...
Jones, Michael A., Marston, Kerrie L., Woodall, Claire A., Maskell, Duncan J., Linton, Dennis, Karlyshev, Andrey V., ...
The genome sequence of the human pathogen Campylobacter jejuni NCTC11168 has been determined recently, but studies on colonization and persistence in chickens have been limited due to reports that...
Moen, Birgitte, Oust, Astrid, Langsrud, Øyvind, Dorrell, Nick, Marsden, Gemma L., Hinds, Jason, ...
Explorative approaches such as DNA microarray experiments are becoming increasingly important in microbial research. Despite these major technical advancements, approaches to study multifactor...
Zilbauer, Matthias, Dorrell, Nick, Boughan, Parjeet K., Harris, Andrew, Wren, Brendan W., Klein, Nigel J., ...
Campylobacter jejuni is the most prevalent cause of bacterial diarrhea worldwide. Despite the serious health problems caused by this bacterium, human innate immune responses to C. jejuni infection...
Champion, Olivia L., Gaunt, Michael W., Gundogdu, Ozan, Elmi, Abdi, Witney, Adam A., Hinds, Jason, ...
Campylobacter jejuni is the predominant cause of bacterial gastroenteritis worldwide, but traditional typing methods are unable to discriminate strains from different sources that cause disease in...
Erickson, David L., Jarrett, Clayton O., Wren, Brendan W., Hinnebusch, B. Joseph
Yersinia pestis, the agent of plague, is usually transmitted by fleas. To produce a transmissible infection, Y. pestis colonizes the flea midgut and forms a biofilm in the proventricular valve, which...
Howard, Sarah L., Gaunt, Michael W., Hinds, Jason, Witney, Adam A., Stabler, Richard, Wren, Brendan W.
Yersinia enterocolitica, an important cause of human gastroenteritis generally caused by the consumption of livestock, has traditionally been categorized into three groups with respect to...
Thomson, Nicholas R, Howard, Sarah, Wren, Brendan W, Holden, Matthew T. G, Crossman, Lisa, Challis, Gregory L, ...
The human enteropathogen, Yersinia enterocolitica, is a significant link in the range of Yersinia pathologies extending from mild gastroenteritis to bubonic plague. Comparison at the genomic level is...
Re-annotation and re-analysis of the Campylobacter jejuni NCTC11168 genome sequence
Gundogdu, Ozan, Bentley, Stephen D, Holden, Matt T, Parkhill, Julian, Dorrell, Nick, Wren, Brendan W