Brett S. Lowe

Defining Childhood Severe Falciparum Malaria for Intervention Studies (2007)

Philip Bejon, James A. Berkley, Tabitha Mwangi, Edna Ogada, Isaiah Mwangi, Kathryn Maitland, ...

BackgroundClinical trials of interventions designed to prevent severe falciparum malaria in children require a clear endpoint. The internationally accepted definition of severe malaria is sensitive,...

Antibody Recognition of Plasmodium falciparum Erythrocyte Surface Antigens in Kenya: Evidence for Rare and Prevalent Variants

Bull, Peter C., Lowe, Brett S., Kortok, Moses, Marsh, Kevin

Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) is the name given to a family of parasite proteins that are inserted into the infected erythrocyte surface. Studies using agglutination...

Use of clinical syndromes to target antibiotic prescribing in seriously ill children in malaria endemic area: observational study

Berkley, James A, Maitland, Kathryn, Mwangi, Isaiah, Ngetsa, Caroline, Mwarumba, Saleem, Lowe, Brett S, ...

Objectives To determine how well antibiotic treatment is targeted by simple clinical syndromes and to what extent drug resistance threatens affordable antibiotics.

Progressive Increase in Antimicrobial Resistance among Invasive Isolates of Haemophilus influenzae Obtained from Children Admitted to a Hospital in Kilifi, Kenya, from 1994 to 2002

Scott, J. Anthony G., Mwarumba, Salim, Ngetsa, Caroline, Njenga, Salome, Lowe, Brett S., Slack, Mary P. E., ...

Etest susceptibilities to amoxicillin, chloramphenicol, and trimethoprim-sulfamethoxazole of 240 invasive isolates of Haemophilus influenzae cultured from children in rural Kenya were 66%, 66%, and...

Antibody Recognition of Plasmodium falciparum Erythrocyte Surface Antigens in Kenya: Evidence for Rare and Prevalent Variants

Bull, Peter C., Lowe, Brett S., Kortok, Moses, Marsh, Kevin

Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) is the name given to a family of parasite proteins that are inserted into the infected erythrocyte surface. Studies using agglutination...

Use of clinical syndromes to target antibiotic prescribing in seriously ill children in malaria endemic area: observational study

Berkley, James A, Maitland, Kathryn, Mwangi, Isaiah, Ngetsa, Caroline, Mwarumba, Saleem, Lowe, Brett S, ...

Objectives To determine how well antibiotic treatment is targeted by simple clinical syndromes and to what extent drug resistance threatens affordable antibiotics.

Progressive Increase in Antimicrobial Resistance among Invasive Isolates of Haemophilus influenzae Obtained from Children Admitted to a Hospital in Kilifi, Kenya, from 1994 to 2002

Scott, J. Anthony G., Mwarumba, Salim, Ngetsa, Caroline, Njenga, Salome, Lowe, Brett S., Slack, Mary P. E., ...

Etest susceptibilities to amoxicillin, chloramphenicol, and trimethoprim-sulfamethoxazole of 240 invasive isolates of Haemophilus influenzae cultured from children in rural Kenya were 66%, 66%, and...

Defining Childhood Severe Falciparum Malaria for Intervention Studies

Bejon, Philip, Berkley, James A, Mwangi, Tabitha, Ogada, Edna, Mwangi, Isaiah, Maitland, Kathryn, ...

The accepted definition of severe malaria is appropriate for clinical purposes, but Philip Bejon and colleagues show its specificity in clinical trials may be improved by a parasite density threshold...