Johnson, Dustin L, Stone, Chris B, Bulir, David C, Coombes, Brian K, Mahony, James B
Abstract Background We have shown previously that Chlamydophila pneumoniae contains a dual-specific Ser/Thr protein kinase that phosphorylates CdsD, a structural component of the type III secretion...
Osborne, Suzanne E, Coombes, Brian K
Abstract Background The survival of Salmonella enterica within the intracellular host niche requires highly co-ordinated expression of virulence effectors predominantly regulated by the SsrAB...
factors in Salmonella enterica serovar Typhimurium (2009)
Bmc Microbiology, Suzanne E Osborne, Brian K Coombes, Suzanne E Osborne, Brian K Coombes
Research article RpoE fine tunes expression of a subset of SsrB-regulated virulence
Wickham, Mark E, Brown, Nat F, Provias, John, Finlay, B Brett, Coombes, Brian K
Abstract Background Salmonella meningitis is a rare and serious infection of the central nervous system following acute Salmonella enterica sepsis. For this pathogen, no appropriate model has been...
Wickham, Mark E., Brown, Nathaniel Francis, Provias, John, Finlay, B. Brett, Coombes, Brian K.
BACKGROUND: Salmonella meningitis is a rare and serious infection of the central nervous system following acute Salmonella enterica sepsis. For this pathogen, no appropriate model has been reported...
Wickham, Mark E., Brown, Nathaniel Francis, Provias, John, Finlay, B. Brett, Coombes, Brian K.
BACKGROUND: Salmonella meningitis is a rare and serious infection of the central nervous system following acute Salmonella enterica sepsis. For this pathogen, no appropriate model has been reported...
Virulence is positively selected by transmission success between mammalian hosts (2007)
Wickham, Mark E., Brown, Nathaniel Francis, Boyle, Erin C., Coombes, Brian K., Finlay, B. Brett
Virulence, defined as damage to the host, is a trait of pathogens that evolutionary theory suggests benefits the pathogen in the ''struggle for existence'' [1]. Pathogens employ virulence mechanisms...
Coombes, Brian K., Lowden, Michael J., Bishop, Jenna L., Wickham, Mark E., Brown, Nathaniel Francis, Duong, Nancy, ...
Bacterial pathogens use horizontal gene transfer to acquire virulence factors that influence host colonization, alter virulence traits, and ultimately shape the outcome of disease following...
Virulence is positively selected by transmission success between mammalian hosts (2007)
Wickham, Mark E., Brown, Nathaniel Francis, Boyle, Erin C., Coombes, Brian K., Finlay, B. Brett
Virulence, defined as damage to the host, is a trait of pathogens that evolutionary theory suggests benefits the pathogen in the ''struggle for existence'' [1]. Pathogens employ virulence mechanisms...
Coombes, Brian K., Lowden, Michael J., Bishop, Jenna L., Wickham, Mark E., Brown, Nathaniel Francis, Duong, Nancy, ...
Bacterial pathogens use horizontal gene transfer to acquire virulence factors that influence host colonization, alter virulence traits, and ultimately shape the outcome of disease following...
Virulence is positively selected by transmission success between mammalian hosts (2007)
Wickham, Mark E., Brown, Nathaniel Francis, Boyle, Erin C., Coombes, Brian K., Finlay, B. Brett
Virulence, defined as damage to the host, is a trait of pathogens that evolutionary theory suggests benefits the pathogen in the ''struggle for existence'' [1]. Pathogens employ virulence mechanisms...
Coombes, Brian K., Lowden, Michael J., Bishop, Jenna L., Wickham, Mark E., Brown, Nathaniel Francis, Duong, Nancy, ...
Bacterial pathogens use horizontal gene transfer to acquire virulence factors that influence host colonization, alter virulence traits, and ultimately shape the outcome of disease following...
Wickham, Mark E., Brown, Nathaniel Francis, Provias, John, Finlay, B. Brett, Coombes, Brian K.
BACKGROUND: Salmonella meningitis is a rare and serious infection of the central nervous system following acute Salmonella enterica sepsis. For this pathogen, no appropriate model has been reported...
Virulence is positively selected by transmission success between mammalian hosts (2007)
Wickham, Mark E., Brown, Nathaniel Francis, Boyle, Erin C., Coombes, Brian K., Finlay, B. Brett
Virulence, defined as damage to the host, is a trait of pathogens that evolutionary theory suggests benefits the pathogen in the ''struggle for existence'' [1]. Pathogens employ virulence mechanisms...
Coombes, Brian K., Lowden, Michael J., Bishop, Jenna L., Wickham, Mark E., Brown, Nathaniel Francis, Duong, Nancy, ...
Bacterial pathogens use horizontal gene transfer to acquire virulence factors that influence host colonization, alter virulence traits, and ultimately shape the outcome of disease following...
Crossing the Line: Selection and Evolution of Virulence Traits (2006)
Nat F. Brown, Mark E. Wickham, Brian K. Coombes, B. Brett Finlay
The evolution of pathogens presents a paradox. Pathogenic species are often absolutely dependent on their host species for their propagation through evolutionary time, yet the pathogenic lifestyle...
Brown, Nathaniel Francis, Szeto, Jason, Jiang, Xiuju, Coombes, Brian K., Finlay, B. Brett, Brumell, John H.
Salmonella enterica serovar Typhimurium is a facultative intracellular pathogen causing disease in several hosts. These bacteria use two distinct type III secretion systems that inject effector...
Wickham, Mark E., Lupp, Claudia, Mascarenhas, Mariola, Vazquez, Alejandra, Coombes, Brian K., Brown, Nathaniel Francis, ...
Although O157:H7 Shiga toxin–producing Escherichia coli (STEC) are the predominant cause of hemolytic-uremic syndrome (HUS) in the world, non-O157:H7 serotypes are a medically important cause of...
Brown, Nathaniel Francis, Szeto, Jason, Jiang, Xiuju, Coombes, Brian K., Finlay, B. Brett, Brumell, John H.
Salmonella enterica serovar Typhimurium is a facultative intracellular pathogen causing disease in several hosts. These bacteria use two distinct type III secretion systems that inject effector...
Wickham, Mark E., Lupp, Claudia, Mascarenhas, Mariola, Vazquez, Alejandra, Coombes, Brian K., Brown, Nathaniel Francis, ...
Although O157:H7 Shiga toxin–producing Escherichia coli (STEC) are the predominant cause of hemolytic-uremic syndrome (HUS) in the world, non-O157:H7 serotypes are a medically important cause of...
Brown, Nathaniel Francis, Szeto, Jason, Jiang, Xiuju, Coombes, Brian K., Finlay, B. Brett, Brumell, John H.
Salmonella enterica serovar Typhimurium is a facultative intracellular pathogen causing disease in several hosts. These bacteria use two distinct type III secretion systems that inject effector...
Wickham, Mark E., Lupp, Claudia, Mascarenhas, Mariola, Vazquez, Alejandra, Coombes, Brian K., Brown, Nathaniel Francis, ...
Although O157:H7 Shiga toxin–producing Escherichia coli (STEC) are the predominant cause of hemolytic-uremic syndrome (HUS) in the world, non-O157:H7 serotypes are a medically important cause of...
Brown, Nathaniel Francis, Szeto, Jason, Jiang, Xiuju, Coombes, Brian K., Finlay, B. Brett, Brumell, John H.
Salmonella enterica serovar Typhimurium is a facultative intracellular pathogen causing disease in several hosts. These bacteria use two distinct type III secretion systems that inject effector...
Wickham, Mark E., Lupp, Claudia, Mascarenhas, Mariola, Vazquez, Alejandra, Coombes, Brian K., Brown, Nathaniel Francis, ...
Although O157:H7 Shiga toxin–producing Escherichia coli (STEC) are the predominant cause of hemolytic-uremic syndrome (HUS) in the world, non-O157:H7 serotypes are a medically important cause of...
Salmonella Pathogenicity Island 2 Is Expressed Prior to Penetrating the Intestine (2005)
Nat F. Brown, Bruce A. Vallance, Brian K. Coombes, Yanet Valdez, Bryan A. Coburn, B. Brett Finlay
Salmonella enterica serovar Typhimurium is a facultative intracellular pathogen that causes disease in mice that resembles human typhoid. Typhoid pathogenesis consists of distinct phases in the...
Salmonella pathogenicity island 2 is expressed prior to penetrating the intestine (2005)
Brown, Nathaniel Francis, Vallance, Bruce A., Coombes, Brian K., Vandez, Yanet, Coburn, Bryan A., Finlay, B. Brett
Salmonella enterica serovar Typhimurium is a facultative intracellular pathogen that causes disease in mice that resembles human typhoid. Typhoid pathogenesis consists of distinct phases in the...
Salmonella pathogenicity island 2 is expressed prior to penetrating the intestine (2005)
Brown, Nathaniel Francis, Vallance, Bruce A., Coombes, Brian K., Vandez, Yanet, Coburn, Bryan A., Finlay, B. Brett
Yes
Salmonella pathogenicity island 2 is expressed prior to penetrating the intestine (2005)
Brown, Nathaniel Francis, Vallance, Bruce A., Coombes, Brian K., Vandez, Yanet, Coburn, Bryan A., Finlay, B. Brett
Salmonella enterica serovar Typhimurium is a facultative intracellular pathogen that causes disease in mice that resembles human typhoid. Typhoid pathogenesis consists of distinct phases in the...
Coombes, Brian K., Lowden, Michael J., Wickham, Mark E., Brown, Nathaniel Francis, Finlay, B. Brett
Short RNA regulatory molecules, microRNAs, and short interfering RNAs participate in a range of developmental gene networks by base-pairing with their target sequences. Consistent with these...
Coombes, Brian K., Wickham, Mark E., Brown, Nathaniel Francis, Lemire, Sebastien, Bossi, Lionello, Hsiao, William W. L., ...
Salmonella enterica serovar Typhimurium is lysogenized by several temperate bacteriophages that encode lysogenic conversion genes, which can act as virulence factors during infection and contribute...
Coombes, Brian K., Lowden, Michael J., Wickham, Mark E., Brown, Nathaniel Francis, Finlay, B. Brett
Short RNA regulatory molecules, microRNAs, and short interfering RNAs participate in a range of developmental gene networks by base-pairing with their target sequences. Consistent with these...
Coombes, Brian K., Wickham, Mark E., Brown, Nathaniel Francis, Lemire, Sebastien, Bossi, Lionello, Hsiao, William W. L., ...
Salmonella enterica serovar Typhimurium is lysogenized by several temperate bacteriophages that encode lysogenic conversion genes, which can act as virulence factors during infection and contribute...
Coombes, Brian K., Lowden, Michael J., Wickham, Mark E., Brown, Nathaniel Francis, Finlay, B. Brett
Short RNA regulatory molecules, microRNAs, and short interfering RNAs participate in a range of developmental gene networks by base-pairing with their target sequences. Consistent with these...
Coombes, Brian K., Wickham, Mark E., Brown, Nathaniel Francis, Lemire, Sebastien, Bossi, Lionello, Hsiao, William W. L., ...
Salmonella enterica serovar Typhimurium is lysogenized by several temperate bacteriophages that encode lysogenic conversion genes, which can act as virulence factors during infection and contribute...
Salmonella pathogenicity island 2 is expressed prior to penetrating the intestine (2005)
Brown, Nathaniel Francis, Vallance, Bruce A., Coombes, Brian K., Vandez, Yanet, Coburn, Bryan A., Finlay, B. Brett
Salmonella enterica serovar Typhimurium is a facultative intracellular pathogen that causes disease in mice that resembles human typhoid. Typhoid pathogenesis consists of distinct phases in the...
Coombes, Brian K., Lowden, Michael J., Wickham, Mark E., Brown, Nathaniel Francis, Finlay, B. Brett
Short RNA regulatory molecules, microRNAs, and short interfering RNAs participate in a range of developmental gene networks by base-pairing with their target sequences. Consistent with these...
Coombes, Brian K., Wickham, Mark E., Brown, Nathaniel Francis, Lemire, Sebastien, Bossi, Lionello, Hsiao, William W. L., ...
Salmonella enterica serovar Typhimurium is lysogenized by several temperate bacteriophages that encode lysogenic conversion genes, which can act as virulence factors during infection and contribute...
Coombes, Brian K., Brown, Nathaniel Francis, Vandez, Yanet, Brumell, John H., Finlay, B. Brett
Salmonella pathogenicity island (SPI)-2 is pivotal to the intracellular survival of Salmonella and for virulence in mammals. SPI-2 encodes virulence factors (called effectors) that are translocated...
Coombes, Brian K., Brown, Nathaniel Francis, Vandez, Yanet, Brumell, John H., Finlay, B. Brett
Salmonella pathogenicity island (SPI)-2 is pivotal to the intracellular survival of Salmonella and for virulence in mammals. SPI-2 encodes virulence factors(called effectors) that are translocated...
Coombes, Brian K., Brown, Nathaniel Francis, Vandez, Yanet, Brumell, John H., Finlay, B. Brett
Salmonella pathogenicity island (SPI)-2 is pivotal to the intracellular survival of Salmonella and for virulence in mammals. SPI-2 encodes virulence factors (called effectors) that are translocated...
Coombes, Brian K., Brown, Nathaniel Francis, Vandez, Yanet, Brumell, John H., Finlay, B. Brett
Salmonella pathogenicity island (SPI)-2 is pivotal to the intracellular survival of Salmonella and for virulence in mammals. SPI-2 encodes virulence factors (called effectors) that are translocated...
Coombes, Brian K., Brown, Nathaniel Francis, Kujat-Choy, Sonya, Vallance, Bruce A., Finlay, B. Brett
The Salmonella pathogenicity island-2 (SPI2) is a virulence locus on the bacterial chromosome required for intracellular proliferation and systemic infection in mice. Cell culture models and a murine...
Coombes, Brian K., Brown, Nathaniel Francis, Kujat-Choy, Sonya, Vallance, Bruce A., Finlay, B. Brett
The Salmonella pathogenicity island-2 (SPI2) is a virulence locus on the bacterial chromosome required for intracellular proliferation and systemic infection in mice. Cell culture models and a murine...
Coombes, Brian K., Brown, Nathaniel Francis, Kujat-Choy, Sonya, Vallance, Bruce A., Finlay, B. Brett
The Salmonella pathogenicity island-2 (SPI2) is a virulence locus on the bacterial chromosome required for intracellular proliferation and systemic infection in mice. Cell culture models and a murine...
Coombes, Brian K., Brown, Nathaniel Francis, Kujat-Choy, Sonya, Vallance, Bruce A., Finlay, B. Brett
The Salmonella pathogenicity island-2 (SPI2) is a virulence locus on the bacterial chromosome required for intracellular proliferation and systemic infection in mice. Cell culture models and a murine...
Coombes, Brian K., Mahony, James B.
An association of Chlamydia pneumoniae with atherosclerosis and coronary heart disease has been determined epidemiologically and by the detection of C. pneumoniae organisms in atherosclerotic lesions...
Coombes, Brian K., Mahony, James B.
Strong epidemiological and pathological evidence supports a role for Chlamydia pneumoniae infection in atherosclerosis and human coronary heart disease. Animal models have shown that C. pneumoniae...
Coombes, Brian K., Coburn, Bryan A., Potter, Andrew A., Gomis, Susantha, Mirakhur, Kuldip, Li, Yuling, ...
We have developed a novel ileal loop model for use in calves to analyze the contribution of Salmonella enterica serovar Typhimurium type III secretion systems to disease processes in vivo. Our model...
Salmonella Pathogenicity Island 2 Is Expressed Prior to Penetrating the Intestine
Brown, Nat F, Vallance, Bruce A, Coombes, Brian K, Valdez, Yanet, Coburn, Bryan A, Finlay, B. Brett
Salmonella enterica serovar Typhimurium is a facultative intracellular pathogen that causes disease in mice that resembles human typhoid. Typhoid pathogenesis consists of distinct phases in the...
Crossing the Line: Selection and Evolution of Virulence Traits
Brown, Nat F, Wickham, Mark E, Coombes, Brian K, Finlay, B. Brett
The evolution of pathogens presents a paradox. Pathogenic species are often absolutely dependent on their host species for their propagation through evolutionary time, yet the pathogenic lifestyle...
Coombes, Brian K., Wickham, Mark E., Lowden, Michael J., Brown, Nat F., Finlay, B. Brett
Salmonella enterica relies on a type III secretion system encoded in Salmonella pathogenicity island-2 (SPI-2) to survive and replicate within macrophages at systemic sites during typhoid. SPI-2...
Coombes, Brian K., Mahony, James B.
An association of Chlamydia pneumoniae with atherosclerosis and coronary heart disease has been determined epidemiologically and by the detection of C. pneumoniae organisms in atherosclerotic lesions...
Coombes, Brian K., Mahony, James B.
Strong epidemiological and pathological evidence supports a role for Chlamydia pneumoniae infection in atherosclerosis and human coronary heart disease. Animal models have shown that C. pneumoniae...
Coombes, Brian K., Coburn, Bryan A., Potter, Andrew A., Gomis, Susantha, Mirakhur, Kuldip, Li, Yuling, ...
We have developed a novel ileal loop model for use in calves to analyze the contribution of Salmonella enterica serovar Typhimurium type III secretion systems to disease processes in vivo. Our model...
Salmonella Pathogenicity Island 2 Is Expressed Prior to Penetrating the Intestine
Brown, Nat F, Vallance, Bruce A, Coombes, Brian K, Valdez, Yanet, Coburn, Bryan A, Finlay, B. Brett
Salmonella enterica serovar Typhimurium is a facultative intracellular pathogen that causes disease in mice that resembles human typhoid. Typhoid pathogenesis consists of distinct phases in the...
Coombes, Brian K., Wickham, Mark E., Lowden, Michael J., Brown, Nat F., Finlay, B. Brett
Salmonella enterica relies on a type III secretion system encoded in Salmonella pathogenicity island-2 (SPI-2) to survive and replicate within macrophages at systemic sites during typhoid. SPI-2...
Crossing the Line: Selection and Evolution of Virulence Traits
Brown, Nat F, Wickham, Mark E, Coombes, Brian K, Finlay, B. Brett
The evolution of pathogens presents a paradox. Pathogenic species are often absolutely dependent on their host species for their propagation through evolutionary time, yet the pathogenic lifestyle...
Coombes, Brian K., Lowden, Michael J., Bishop, Jennifer L., Wickham, Mark E., Brown, Nat F., Duong, Nancy, ...
Bacterial pathogens use horizontal gene transfer to acquire virulence factors that influence host colonization, alter virulence traits, and ultimately shape the outcome of disease following...
Silphaduang, Umaporn, Mascarenhas, Mariola, Karmali, Mohamed, Coombes, Brian K.
The Hha/YmoA family of nucleoid-associated proteins is involved in gene regulation in enterobacteria. In Salmonella enterica serovar Typhimurium, virulence genes required for intracellular growth are...
Coombes, Brian K., Wickham, Mark E., Mascarenhas, Mariola, Gruenheid, Samantha, Finlay, B. Brett, Karmali, Mohamed A.
Shiga toxin-producing Escherichia coli (STEC) strains are commensal bacteria in cattle with high potential for environmental and zoonotic transmission to humans. Although O157:H7 is the most common...
Salmonella enterica Serovar Senftenberg Human Clinical Isolates Lacking SPI-1▿
Hu, Qinghua, Coburn, Bryan, Deng, Wanyin, Li, Yuling, Shi, Xiaolu, Lan, Quanxue, ...
Nontyphoidal Salmonella species cause gastrointestinal disease worldwide. The prevailing theory of Salmonella enteropathogenesis is that bacterial invasion of the intestinal epithelium is essential...
Ashkar, Ali A., Mossman, Karen L., Coombes, Brian K., Gyles, Carlton L., Mackenzie, Randy
Components of bacteria have been shown to induce innate antiviral immunity via Toll-like receptors (TLRs). We have recently shown that FimH, the adhesin portion of type 1 fimbria, can induce the...
Pathogenic adaptation of intracellular bacteria by rewiring a cis-regulatory input function
Osborne, Suzanne E., Walthers, Don, Tomljenovic, Ana M., Mulder, David T., Silphaduang, Uma, Duong, Nancy, ...
The acquisition of DNA by horizontal gene transfer enables bacteria to adapt to previously unexploited ecological niches. Although horizontal gene transfer and mutation of protein-coding sequences...
Role of RpoS in the Virulence of Citrobacter rodentium▿
Dong, Tao, Coombes, Brian K., Schellhorn, Herb E.
Citrobacter rodentium is a mouse enteropathogen that is closely related to Escherichia coli and causes severe colonic hyperplasia and bloody diarrhea. C. rodentium infection requires expression of...
Ashkar, Ali A., Reid, Sarah, Verdu, Elena F., Zhang, Kun, Coombes, Brian K.
Control of bacterial colonization at mucosal surfaces depends on rapid activation of the innate immune system. Interleukin-15 (IL-15) directs the development, maturation, and function of a population...
Szeto, Jason, Namolovan, Anton, Osborne, Suzanne E., Coombes, Brian K., Brumell, John H.
Intracellular Salmonella enterica serovar Typhimurium (serovar Typhimurium) occupies a Salmonella-containing vacuole (SCV) where bacterial effector proteins are secreted into the host cell using type...