Brian M. Skehan

Insulin receptor tyrosine kinase substrate links the E. coli O157:H7 actin assembly effectors Tir and EspF(U) during pedestal formation (2009)

Vingadassalom, Didier F., Kazlauskas, Arunas, Skehan, Brian M., Cheng, Hui-Chun, Magoun, Loranne, Robbins, Douglas, ...

Enterohemorrhagic Escherichia coli O157:H7 translocates 2 effectors to trigger localized actin assembly in mammalian cells, resulting in filamentous actin "pedestals." One effector, the...

Hierarchical regulation of WASP/WAVE proteins (2008)

Padrick, Shae B., Cheng, Hui-Chun, Ismail, Ayman M., Panchal, Sanjay C., Doolittle, Lynda K., Kim, Soyeon, ...

Members of the Wiskott-Aldrich syndrome protein (WASP) family control actin dynamics in eukaryotic cells by stimulating the actin nucleating activity of the Arp2/3 complex. The prevailing paradigm...

Structural mechanism of WASP activation by the enterohaemorrhagic E. coli effector EspF(U) (2008)

Cheng, Hui-Chun, Skehan, Brian M., Campellone, Kenneth Geno, Leong, John M., Rosen, Michael K.

During infection, enterohaemorrhagic Escherichia coli (EHEC) takes over the actin cytoskeleton of eukaryotic cells by injecting the EspF(U) protein into the host cytoplasm. EspF(U) controls actin by...

Enterohaemorrhagic Escherichia coli Tir requires a C-terminal 12-residue peptide to initiate EspF-mediated actin assembly and harbours N-terminal sequences that influence pedestal length (2006)

Campellone, Kenneth Geno, Brady, Michael J., Alamares, Judith G., Rowe, Daniel C., Skehan, Brian M., Tipper, Donald J., ...

Enterohaemorrhagic Escherichia coli (EHEC) and enteropathogenic E. coli (EPEC) both utilize type III secretion systems that translocate the effector protein Tir into the plasma membrane of mammalian...