Evidence for Plasmid-Mediated Toxin Production in Bacillus anthracis (2006)
Mikesell, Perry, Ivins, Bruce E., Ristroph, Joseph D., Dreier, Thomas M.
Pub. in Infection and Immunity, v39 n1 p371-376, Jan 1983.
Elaboration of Bacillus anthracis Antigens in a New, Defined Culture Medium (2006)
Ristroph, Joseph D., Ivins, Bruce E.
Pub. in Infection and Immunity, v39 n1 p483-486, Jan 1983.
Ristroph, Joseph D., Ivins, Bruce E.
Improved cultural conditions and a new, completely synthetic medium (R medium) were developed to facilitate the production of Bacillus anthracis holotoxin antigens. Levels of these antigens, up to...
Recent Advances in the Development of an Improved, Human Anthrax Vaccine (2005)
Ivins, Bruce E., Welkos, Susan L.
Human anthrax vaccines currently licensed in the United States and Western Europe consist of alum-precipitated or aluminum hydroxide-absorbed supernatant material from fermentor cultures of...
Plasmids, Pasteur, and Anthrax (2003)
Mikesell, Perry, Ivins, Bruce E., Ristroph, Joseph D., Vodkin, Michael H., Dreier, Thomas M.
Pub. in ASM News, v49 n7 p320-322 1983. Supersedes AD-A127 511.
Leppla, Stephen H., Ivins, Bruce E., Ezzell, John W., Jr.
Anthrax toxin is a key virulence factor of Bacillus anthracis. The three protein components of the toxin have been purified and shown to have similar molecular weights: protective antigen (PA),...
Ivins, Bruce E., Welkos, Susan L., Knudson, Gregory B., Little, Stephen F.
The safety and efficacy of five prototype, live anthrax vaccines were studied in Hartly guinea pigs and CBA/J and A/J mice. Two of the strains, Bacillus anthracis FD111 and FD112, are Aro-mutants...
Little,Stephen F., Hedlund,Kenneth W., Ivins,Bruce E., Ristroph,Joseph D., Seburn,Dale W.
The protective antigen and lethal factor components of anthrax toxin were isolated from Bacillus anthracis culture supernatants and separated using dye-ligand affinity chromatography. The two...
The Search for a New-Generation Human Anthrax Vaccine (2000)
Anthrax is a disease primarily of herbivores, but humans can become infected through contact with infected animals or animal products. The etiological agent, Bacillus anthracis, possesses two primary...
Transponson Tn916 Mutagenesis in Bacillus anthracis, (1998)
Ivins, Bruce E., Welkos, Susan L., Knudson, Gregory B., LeBlanc, Donald J.
Mutagenesis of Bacillus anthracis by the streptococcal tetracycline resistance transponson, Tn916, is described. Tn916 was transferred from Streptococcus faecalis strain DS16C1 to B. anthracis VNR-1...
Influence of Body Weight on the Response of Fischer 344 Rats to Anthrax Lethal Toxin, (1998)
Ivins, Bruce E., Ristroph, J. D., Nelson, Gene O.
Groups of Fisher 344 rats were injected intravenously with Bacillus anthracis culture supernatants containing crude anthrax toxin. Times to death of rats given identical toxin preparations varied...
Vietri, Nicholas J., Purcell, Bret K., Lawler, James V., Leffel, Elizabeth K., Rico, Pedro, Gamble, Christopher S., ...
Prevention of inhalational anthrax after Bacillus anthracis spore exposure requires a prolonged course of antibiotic prophylaxis. In response to the 2001 anthrax attack in the United States, ~10,000...
Singh, Yogendra, Ivins, Bruce E., Leppla, Stephen H.
Protective antigen (PA) of anthrax toxin is the major component of human anthrax vaccine. Currently available human vaccines in the United States and Europe consist of alum-precipitated supernatant...
Elaboration of Bacillus anthracis Antigens in a New, Defined Culture Medium
Ristroph, Joseph D., Ivins, Bruce E.
Improved culture conditions and a new, completely synthetic medium (R medium) were developed to facilitate the production of Bacillus anthracis holotoxin antigens. Levels of these antigens up to...
Xie, Hang, Gursel, Ihsan, Ivins, Bruce E., Singh, Manmohan, O'Hagan, Derek T., Ulmer, Jeffrey B., ...
To reduce the biothreat posed by anthrax, efforts are under way to improve the protection afforded by vaccination. This work examines the ability of immunostimulatory CpG oligodeoxynucleotides (ODN)...
Isolation and Characterization of Melanin-Producing (mel) Mutants of Vibrio cholerae
Ivins, Bruce E., Holmes, Randall K.
Vibrio cholerae strain Htx-3, a hypertoxinogenic mutant of V. cholerae 569B Inaba, produces a dark brown pigment under certain growth conditions, whereas strain 569B does not. We investigated the...
Vietri, Nicholas J., Purcell, Bret K., Lawler, James V., Leffel, Elizabeth K., Rico, Pedro, Gamble, Christopher S., ...
Prevention of inhalational anthrax after Bacillus anthracis spore exposure requires a prolonged course of antibiotic prophylaxis. In response to the 2001 anthrax attack in the United States,...
Singh, Yogendra, Ivins, Bruce E., Leppla, Stephen H.
Protective antigen (PA) of anthrax toxin is the major component of human anthrax vaccine. Currently available human vaccines in the United States and Europe consist of alum-precipitated supernatant...
Elaboration of Bacillus anthracis Antigens in a New, Defined Culture Medium
Ristroph, Joseph D., Ivins, Bruce E.
Improved culture conditions and a new, completely synthetic medium (R medium) were developed to facilitate the production of Bacillus anthracis holotoxin antigens. Levels of these antigens up to...
Xie, Hang, Gursel, Ihsan, Ivins, Bruce E., Singh, Manmohan, O'Hagan, Derek T., Ulmer, Jeffrey B., ...
To reduce the biothreat posed by anthrax, efforts are under way to improve the protection afforded by vaccination. This work examines the ability of immunostimulatory CpG oligodeoxynucleotides (ODN)...
Isolation and Characterization of Melanin-Producing (mel) Mutants of Vibrio cholerae
Ivins, Bruce E., Holmes, Randall K.
Vibrio cholerae strain Htx-3, a hypertoxinogenic mutant of V. cholerae 569B Inaba, produces a dark brown pigment under certain growth conditions, whereas strain 569B does not. We investigated the...
Vietri, Nicholas J., Purcell, Bret K., Lawler, James V., Leffel, Elizabeth K., Rico, Pedro, Gamble, Christopher S., ...
Prevention of inhalational anthrax after Bacillus anthracis spore exposure requires a prolonged course of antibiotic prophylaxis. In response to the 2001 anthrax attack in the United States,...
Heine, Henry S., Bassett, Jennifer, Miller, Lynda, Hartings, Justin M., Ivins, Bruce E., Pitt, M. Louise, ...
An anthrax spore aerosol infection mouse model was developed as a first test of in vivo efficacy of antibiotics identified as active against Bacillus anthracis. Whole-body, 50% lethal dose (LD50)...