Somatic mutations affect key pathways in lung adenocarcinoma (2008)
Ding, Li, Getz, Gad, Wheeler, David A., Mardis, Elaine R., McLellan, Michael D., Cibulskis, Kristian, ...
Determining the genetic basis of cancer requires comprehensive analyses of large collections of histopathologically well- classified primary tumours. Here we report the results of a collaborative...
Panos Fidias, Jeffrey G. Supko, Renato Martins, Anthony Boral, Robert Carey, Michael Grossbard, ...
Purpose: Our aim was to evaluate the efficacy, toxicity, and pharmacokinetic behavior of single-agent paclitaxel given weekly to elderly patients with lung cancer. Experimental Design: Previously...
Somatic mutations affect key pathways in lung adenocarcinoma (2008)
Ding, Li, Getz, Gad, Wheeler, David A., Mardis, Elaine R., McLellan, Michael D., Cibulskis, Kristian, ...
Characterizing the cancer genome in lung adenocarcinoma (2007)
Weir, Barbara A., Woo, Michele S., Getz, Gad, Perner, Sven, Ding, Li, Beroukhim, Rameen, ...
Somatic alterations in cellular DNA underlie almost all human cancers(1). The prospect of targeted therapies(2) and the development of high-resolution, genome-wide approaches(3-8) are now spurring...
Characterizing the cancer genome in lung adenocarcinoma (2007)
Weir, Barbara A., Woo, Michele S., Getz, Gad, Perner, Sven, Ding, Li, Beroukhim, Rameen, ...
Mukohara, Toru, Engelman, Jeffrey A., Hanna, Nasser H., Yeap, Beow Y., Kobayashi, Susumu, Lindeman, Neal, ...
Background: Many patients with non–small-cell lung cancer (NSCLC) who achieve radiographic responses to treatment with the epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors...
Chen, T. Timothy, Chute, John P., Feigal, Ellen, Johnson, Bruce E., Simon, Richard
Background: Many more phase II studies have favorable outcomes than the subsequent phase III trials. We used historical data from phase II and phase III studies for patients with extensive-stage...
Second Lung Cancers in Patients After Treatment for an Initial Lung Cancer (1998)
Background: Prospectively and retrospectively identified patient cohorts that were successfully treated for primary lung cancer have been followed to document the rate of development of and the...
Kelley, Michael J., Nakagawa, Kazuhiko, Steinberg, Seth M., Mulshine, James L., Kamb, Alexander, Johnson, Bruce E.
Background: The CDKN2 gene encodes the human cyclin-dependent kinase 4 inhibitor. This inhibitor protein is believed to be a tumor suppressor that plays an essential role in cell cycle regulation....
Obesity and Therapy-Related Toxicity in Patients Treated for Small-Cell Lung Cancer (1995)
Georgiadis, Mark S., Steinberg, Seth M., Hankins, Lynn A., Ihde, Daniel C., Johnson, Bruce E.
Background Obese individuals have altered pharmacokinetics for many medications when compared with the non-obese. For the oncologist treating an obese cancer patient, these changes in drug...
Winter, Stefan F., Sekido, Yoshitaka, Minna, John D., McIntire, Donald, Johnson, Bruce E., Gazdar, Adi F., ...
Background: The frequency and clinical relevance of human anti-tumor immune responses is not well known, and few target antigens have been identified. Purpose: This study was designed to determine...
Asymptotic tests for the equality of several correlation matrices /--Bruce E. Johnson. (1992)
Thesis (Ph. D.)--Bowling Green State University, 1993.
Gazdar, Adi F., Steinberg, Seth M., Russell, Edward K., Linnoila, R. Ilona, Oie, Herbert K., Ghosh, Bimal C., ...
We devised a novel clinical protocol for extensive-stage small cell lung cancer (SCLC), selecting chemotherapy whenever possible on the basis of in vitro drug-sensitivity testing (DST) of individual...
Bliss, David P., Battey, James F., Linnoila, R. Ilona, Birrer, Michael J., Gazdar, Adi F., Johnson, Bruce E.
Hyponatremia in patients with small cell lung cencer can be caused by tumor production of arginine vasopression (AVP) and result in the sundrome of inappropriate antidiuretic hormone. In evaluating...
MDR1 Gene Expression in Lung Cancer (1989)
Lai, Shinn-Liang, Goldstein, Lori J., Gottesman, Michael M., Pastan, Ira, Tsai, Chun-Ming, Johnson, Bruce E., ...
The MDR1 gene (also known as PGY1) is frequently overexpressed in multidrug-resistant cell lines. We investigated the role of MDR1 gene expression in lung cancer by performing RNA slot blot analysis...
Johnson, Bruce E., Whang-Peng, Jacqueline, Naylor, Susan L., Zbar, Berton, Brauch, Hiltrud, Lee, Elaine, ...
In small cell lung carcinoma, one of the short arms of chromosome 3 is typically lost. To investigate chromosome 3 in extrapulmonary small cell carcinoma, we used DNA probes that detect...
Typescript (photocopy).
Ivanov, Sergey V., Kuzmin, Igor, Wei, Ming-Hui, Pack, Svetlana, Geil, Laura, Johnson, Bruce E., ...
To discover genes involved in von Hippel-Lindau (VHL)-mediated carcinogenesis, we used renal cell carcinoma cell lines stably transfected with wild-type VHL-expressing transgenes. Large-scale RNA...
Bhattacharjee, Arindam, Richards, William G., Staunton, Jane, Li, Cheng, Monti, Stefano, Vasa, Priya, ...
We have generated a molecular taxonomy of lung carcinoma, the leading cause of cancer death in the United States and worldwide. Using oligonucleotide microarrays, we analyzed mRNA expression levels...
Engelman, Jeffrey A., Jänne, Pasi A., Mermel, Craig, Pearlberg, Joseph, Mukohara, Toru, Fleet, Christina, ...
Therapies that target the EGF receptor (EGFR), such as gefitinib (IRESSA), are effective in a subset of patients with advanced non-small cell lung cancer (NSCLC). The differences in intracellular...
Engelman, Jeffrey A., Mukohara, Toru, Zejnullahu, Kreshnik, Lifshits, Eugene, Borrás, Ana M., Gale, Christopher-Michael, ...
EGFR is frequently mutated and amplified in lung adenocarcinomas sensitive to EGFR inhibitors gefitinib and erlotinib. A secondary mutation, T790M, has been associated with acquired resistance but...
Ivanov, Sergey V., Kuzmin, Igor, Wei, Ming-Hui, Pack, Svetlana, Geil, Laura, Johnson, Bruce E., ...
To discover genes involved in von Hippel-Lindau (VHL)-mediated carcinogenesis, we used renal cell carcinoma cell lines stably transfected with wild-type VHL-expressing transgenes. Large-scale RNA...
Bhattacharjee, Arindam, Richards, William G., Staunton, Jane, Li, Cheng, Monti, Stefano, Vasa, Priya, ...
We have generated a molecular taxonomy of lung carcinoma, the leading cause of cancer death in the United States and worldwide. Using oligonucleotide microarrays, we analyzed mRNA expression levels...
Engelman, Jeffrey A., Jänne, Pasi A., Mermel, Craig, Pearlberg, Joseph, Mukohara, Toru, Fleet, Christina, ...
Therapies that target the EGF receptor (EGFR), such as gefitinib (IRESSA), are effective in a subset of patients with advanced non-small cell lung cancer (NSCLC). The differences in intracellular...
Engelman, Jeffrey A., Mukohara, Toru, Zejnullahu, Kreshnik, Lifshits, Eugene, Borrás, Ana M., Gale, Christopher-Michael, ...
EGFR is frequently mutated and amplified in lung adenocarcinomas sensitive to EGFR inhibitors gefitinib and erlotinib. A secondary mutation, T790M, has been associated with acquired resistance but...