Bruce E. Maryanoff

Design, synthesis, and biological characterization of a peptide-mimetic antagonist for a tethered-ligand receptor

Andrade-Gordon, Patricia, Maryanoff, Bruce E., Derian, Claudia K., Zhang, Han-Cheng, Addo, Michael F., Darrow, Andrew L., ...

Protease-activated receptors (PARs) represent a unique family of seven-transmembrane G protein-coupled receptors, which are enzymatically cleaved to expose a truncated extracellular N terminus that...

Crystal structure of human carbonic anhydrase II complexed with an anti-convulsant sugar sulphamate.

Recacha, Rosario, Costanzo, Michael J, Maryanoff, Bruce E, Chattopadhyay, Debasish

The fructose-based sugar sulphamate RWJ-37497, a potent analogue of the widely used anti-epileptic drug topiramate, possesses anti-convulsant and carbonic anhydrase-inhibitory activities. We have...

Design, synthesis, and biological characterization of a peptide-mimetic antagonist for a tethered-ligand receptor

Andrade-Gordon, Patricia, Maryanoff, Bruce E., Derian, Claudia K., Zhang, Han-Cheng, Addo, Michael F., Darrow, Andrew L., ...

Protease-activated receptors (PARs) represent a unique family of seven-transmembrane G protein-coupled receptors, which are enzymatically cleaved to expose a truncated extracellular N terminus that...

Crystal structure of human carbonic anhydrase II complexed with an anti-convulsant sugar sulphamate.

Recacha, Rosario, Costanzo, Michael J, Maryanoff, Bruce E, Chattopadhyay, Debasish

The fructose-based sugar sulphamate RWJ-37497, a potent analogue of the widely used anti-epileptic drug topiramate, possesses anti-convulsant and carbonic anhydrase-inhibitory activities. We have...

Thrombogenic collagen-mimetic peptides: Self-assembly of triple helix-based fibrils driven by hydrophobic interactions

Cejas, Mabel A., Kinney, William A., Chen, Cailin, Vinter, Jeremy G., Almond, Harold R., Balss, Karin M., ...

Collagens are integral structural proteins in animal tissues and play key functional roles in cellular modulation. We sought to discover collagen model peptides (CMPs) that would form triple helices...