Bruce Poppe

Genome profiling of acute myelomonocytic leukemia: alteration of the MYB locus in MYST3-linked cases (2009)

Murati, A, Gervais, C, Carbuccia, N, Finetti, P, Cervera, N, Adelaide, J, ...

The t(8; 16)(p11; p13) is a rare translocation involved in de novo and therapy-related myelomonocytic and monocytic acute leukemia. It fuses two genes encoding histone acetyltransferases (HATs),...

EVI1activation in blast crisis CML due to juxtaposition to the rare 17q22 partner region as part of a 4-way variant translocation t(9;22) (2008)

De Weer, An, Poppe, Bruce, Cauwelier, Barbara, Carlier, Andre, Dierick, Jan, Verhasselt, Bruno, ...

Abstract Background Variant translocations t(9;22) occur in 5 to 10% of newly diagnosed CMLs and additional genetic changes are present in 60–80% of patients in blast crisis (BC). Here, we report...

EVII activation in blast crisis CML due to juxtaposition to the rare 17q22 partner region as part of a 4-way variant translocation t(9;22) (2008)

De Weer, An, Poppe, Bruce, Cauwelier, Barbara, CARLIER, A, DIERICK, J, Verhasselt, Bruno, ...

Background: Variant translocations t( 9; 22) occur in 5 to 10% of newly diagnosed CMLs and additional genetic changes are present in 60 - 80% of patients in blast crisis ( BC). Here, we report on a...

EVI1 overexpression in t(3;17) positive myeloid malignancies results from juxtaposition of EVI1 to the MSI2 locus at 17q22 (2008)

De Weer, An, Speleman, Franki, Cauwelier, Barbara, Van Roy, Nadine, Yigit, Nurten, Verhasselt, Bruno, ...

Chromosomal translocations involving the EVI1 locus are a recurrent finding in myeloid leukemia and are associated with poor prognosis. In this study, we performed a detailed molecular...

Two-tier approach for the detection of alpha-galactosidase A deficiency in kidney transplant recipients (2008)

De Schoenmakere, Gert, Poppe, Bruce, Wuyts, Birgitte, Claes, Kathleen, Cassiman, David, Maes, Bart, ...

Background. Anderson-Fabry disease (AFD) is an X-linked condition originating from a deficiency in alpha-galactosidase, a lysosomal enzyme. Multi-organ involvement ensues in early adulthood and vital...

EVII activation in blast crisis CML due to juxtaposition to the rare 17q22 partner region as part of a 4-way variant translocation t(9;22) (2008)

De Weer, An, Poppe, Bruce, Cauwelier, Barbara, Carlier, Andre, Dierick, Jan, Verhasselt, Bruno, ...

Background: Variant translocations t( 9; 22) occur in 5 to 10% of newly diagnosed CMLs and additional genetic changes are present in 60 - 80% of patients in blast crisis ( BC). Here, we report on a...

EVI1 overexpression in t(3;17) positive myeloid malignancies results from juxtaposition of EVI1 to the MSI2 locus at 17q22 (2008)

De Weer, An, Speleman, Franki, Cauwelier, Barbara, Van Roy, Nadine, Yigit, Nurten, Verhasselt, Bruno, ...

Chromosomal translocations involving the EVI1 locus are a recurrent finding in myeloid leukemia and are associated with poor prognosis. In this study, we performed a detailed molecular...

Copy number alterations and copy number variation in cancer: close encounters of the bad kind (2008)

Speleman, Franki, Kumps, Candy, Buysse, Karen, Poppe, Bruce, Menten, Björn, De Preter, Katleen

Recent studies have unveiled copy number variants (CNVs) as an important source of genetic variation. Many of these CNVs contain coding sequences, which have been shown to be dosage sensitive....

Two-tier approach for the detection of alpha-galactosidase A deficiency in a predominantly female haemodialysis population (2008)

Terryn, Wim, Poppe, Bruce, Wuyts, Birgitte, Claes, Kathleen, Maes, Bart, Verbeelen, Dierik, ...

Introduction. Fabry's disease (AFD) is an X-linked lysosomal storage disease, resulting from a deficiency in alpha-galactosidase A (AGALA). Untreated, this leads to precocious failure of vital organ...

Two-tier approach for the detection of alpha-galactosidase A deficiency in kidney transplant recipients (2008)

Schoenmakere, Gert De, Poppe, Bruce, Wuyts, Birgitte, Claes, Kathleen, Cassiman, David, Maes, Bart, ...

Background. Anderson–Fabry disease (AFD) is an X-linked condition originating from a deficiency in alpha-galactosidase, a lysosomal enzyme. Multi-organ involvement ensues in early adulthood and...

Clinical, cytogenetic and molecular characteristics of 14 T-ALL patients carrying the TCRb-HOXA rearrangement : a study of the Groupe Francophone de Cytogénétique Hématologique (GFCH). (2007)

Cauwelier, B, Cavé, H, Gervais, C, Lessard, M, Barin, C, Perot, C, ...

Recently, we and others described a new chromosomal rearrangement, that is, inv( 7)( p15q34) and t( 7; 7)( p15; q34) involving the T-cell receptor beta ( TCR beta) ( 7q34) and the HOXA gene locus (...

ALK activation by the CLTC-ALK fusion is a recurrent event in large B-cell lymphoma (2003)

Van Krieken, Han, Verhasselt, Bruno, Simons, Annet, ...

We present 3 cases of large B-cell lymphoma (LBCL) with a granular cytoplasmic staining for anaplastic lymphoma kinase (ALK). All of the cases showed striking similarities in morphology and...

Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes (2002)

Vandesompele, Jo, De Preter, Katleen, Pattyn, Filip, Poppe, Bruce, Van Roy, Nadine, De Paepe, Anne, ...

Abstract Background Gene-expression analysis is increasingly important in biological research, with real-time reverse transcription PCR (RT-PCR) becoming the method of choice for high-throughput and...

Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes

Vandesompele, Jo, De Preter, Katleen, Pattyn, Filip, Poppe, Bruce, Van Roy, Nadine, De Paepe, Anne, ...

Using real-time reverse transcription PCR ten housekeeping genes from different abundance and functional classes in various human tissues were evaluated. The conventional use of a single gene for...

Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes

Vandesompele, Jo, De Preter, Katleen, Pattyn, Filip, Poppe, Bruce, Van Roy, Nadine, De Paepe, Anne, ...

Using real-time reverse transcription PCR ten housekeeping genes from different abundance and functional classes in various human tissues were evaluated. The conventional use of a single gene for...