Bruno Pradines

Atypical aetiology of a conjugal fever: autochthonous airport malaria between Paris and French Riviera: a case report (2009)

Pomares-Estran, Christelle, Delaunay, Pascal, Mottard, Annie, Cua, Eric, Roger, Pierre-Marie, Pradines, Bruno, ...

Abstract Endemic malaria has been eradicated from France, but some falciparum malaria cases have been described in patients who have never travelled outside the country. Ms. V. 21 year-old and Mr. M....

Malaria transmission in Dakar: A two-year survey (2008)

Pagès, Frederic, Texier, Gaetan, Pradines, Bruno, Gadiaga, Libasse, Machault, Vanessa, Jarjaval, Fanny, ...

Abstract Background According to entomological studies conducted over the past 30 years, there was low malaria transmission in suburb of Dakar but little evidence of it in the downtown area. However;...

Antimalarial drug use in general populations of tropical Africa (2008)

Gardella, Florence, Assi, Serge, Simon, Fabrice, Bogreau, Hervé, Eggelte, Teunis, Ba, Fatou, ...

Abstract Background The burden of Plasmodium falciparum malaria has worsened because of the emergence of chloroquine resistance. Antimalarial drug use and drug pressure are critical factors...

Influence of oxygen on asexual blood cycle and susceptibility of Plasmodium falciparumto chloroquine: requirement of a standardized in vitroassay (2007)

Briolant, Sébastien, Parola, Philippe, Fusaï, Thierry, Madamet-Torrentino, Marilyn, Baret, Eric, Mosnier, Joël, ...

Abstract Objective The main objective of this study was to assess the influence of gas mixtures on in vitro Plasmodium falciparum growth and 50% inhibitory concentration (IC 50 ) for chloroquine....

Assessment of Plasmodium falciparumresistance to ferroquine (SSR97193) in field isolates and in W2 strain under pressure (2006)

Daher, Wassim, Biot, Christophe, Fandeur, Thierry, Jouin, Helene, Pelinski, Lydie, Viscogliosi, Eric, ...

Abstract Background Ferroquine (FQ), or SSR97193, is a novel antimalarial drug currently in phase I clinical trials. FQ is a unique organometallic compound designed to overcome the chloroquine (CQ)...

Assessment of Plasmodium falciparum resistance to ferroquine (SSR97193) in field isolates and in W2 strain under pressure. (2006)

Daher, Wassim, Biot, Christophe, Fandeur, Thierry, Jouin, Helene, Pelinski, Lydie, Viscogliosi, Eric, ...

BACKGROUND: Ferroquine (FQ), or SSR97193, is a novel antimalarial drug currently in phase I clinical trials. FQ is a unique organometallic compound designed to overcome the chloroquine (CQ)...

Assessment of Plasmodium falciparum resistance to ferroquine (SSR97193) in field isolates and in W2 strain under pressure. (2006)

Daher, Wassim, Biot, Christophe, Fandeur, Thierry, Jouin, Helene, Pelinski, Lydie, Viscogliosi, Eric, ...

BACKGROUND: Ferroquine (FQ), or SSR97193, is a novel antimalarial drug currently in phase I clinical trials. FQ is a unique organometallic compound designed to overcome the chloroquine (CQ)...

Assessment of Plasmodium falciparum resistance to ferroquine (SSR97193) in field isolates and in W2 strain under pressure. (2006)

Daher, Wassim, Biot, Christophe, Fandeur, Thierry, Jouin, Helene, Pelinski, Lydie, Viscogliosi, Eric, ...

BACKGROUND: Ferroquine (FQ), or SSR97193, is a novel antimalarial drug currently in phase I clinical trials. FQ is a unique organometallic compound designed to overcome the chloroquine (CQ)...

Assessment of Plasmodium falciparum resistance to ferroquine (SSR97193) in field isolates and in W2 strain under pressure. (2006)

Daher, Wassim, Biot, Christophe, Fandeur, Thierry, Jouin, Helene, Pelinski, Lydie, Viscogliosi, Eric, ...

BACKGROUND: Ferroquine (FQ), or SSR97193, is a novel antimalarial drug currently in phase I clinical trials. FQ is a unique organometallic compound designed to overcome the chloroquine (CQ)...

Apparent absence of atovaquone/proguanil resistance in 477 Plasmodium falciparum isolates from untreated French travellers (2006)

Musset, Lise, Pradines, Bruno, Parzy, Daniel, Durand, Rémy, Bigot, Patricia, Le Bras, Jacques

Objectives: We examined the atovaquone in vitro susceptibility and the cytochrome b (cytb) gene polymorphism of African Plasmodium falciparum isolates during the first years of...

Apparent absence of atovaquone/proguanil resistance in 477 Plasmodium falciparum isolates from untreated French travellers (2005)

Musset, Lise, Pradines, Bruno, Parzy, Daniel, Durand, Rémy, Bigot, Patricia, Le Bras, Jacques

Objectives: We examined the atovaquone in vitro susceptibility and the cytochrome b (cytb) gene polymorphism of African Plasmodium falciparum isolates during the first years of atovaquone/proguanil...

In Vitro Activities of Benflumetol against 158 Senegalese Isolates of Plasmodium falciparum in Comparison with Those of Standard Antimalarial Drugs

Pradines, Bruno, Tall, Adama, Fusai, Thierry, Spiegel, Andre, Hienne, Remi, Rogier, Christophe, ...

The 50% inhibitory concentration (IC50s) of benflumetol (range, 12.5 to 240 nM; mean, 55.1 nM) for 158 Senegalese isolates were evaluated. Ten isolates (6%) showed decreased susceptibility to...

In Vitro Activities of Antibiotics against Plasmodium falciparum Are Inhibited by Iron

Pradines, Bruno, Rogier, Christophe, Fusai, Thierry, Mosnier, Joel, Daries, William, Barret, Eric, ...

The in vitro activities of cyclines (tetracycline, doxycycline, minocycline, oxytetracycline, and rolitetracycline), macrolides (erythromycin, spiramycin, roxithromycin, and lincomycin), quinolones...

In Vitro Potentiation of Antibiotic Activities by a Catecholate Iron Chelator against Chloroquine-Resistant Plasmodium falciparum

Pradines, Bruno, Ramiandrasoa, Florence, Rolain, Jean Marc, Rogier, Christophe, Mosnier, Joel, Daries, William, ...

FR160, a catechol iron chelator, and tetracyclines or norfloxacin exert in vitro additive or synergistic activity against a chloroquine-resistant Plasmodium falciparum clone. FR160 shows antagonistic...

In Vitro Increase in Chloroquine Accumulation Induced by Dihydroethano- and Ethenoanthracene Derivatives in Plasmodium falciparum-Parasitized Erythrocytes

Pradines, Bruno, Alibert, Sandrine, Houdoin, Carole, Santelli-Rouvier, Christiane, Mosnier, Joel, Fusai, Thierry, ...

The effects of a series of dihydroethano- and ethenoanthracene derivatives on chloroquine (CQ) accumulation in CQ-susceptible strain 3D7 and CQ-resistant clone W2 were assessed. The levels of CQ...

Dihydroethanoanthracene Derivatives as In Vitro Malarial Chloroquine Resistance Reversal Agents

Millet, Julie, Torrentino-Madamet, Marylin, Alibert, Sandrine, Rogier, Christophe, Santelli-Rouvier, Christiane, Mosnier, Joel, ...

The ability of four 9,10-dihydroethanoanthracene derivatives (BG920, BG932, BG958, and BG996), as well as verapamil and promethazine, to reverse chloroquine resistance was assessed against 24...

Polymorphism in Plasmodium falciparum Drug Transporter Proteins and Reversal of In Vitro Chloroquine Resistance by a 9,10-Dihydroethanoanthracene Derivative

Millet, Julie, Alibert, Sandrine, Torrentino-Madamet, Marylin, Rogier, Christophe, Santelli-Rouvier, Christiane, Bigot, Patricia, ...

BG958 reverses resistance in chloroquine-resistant isolates from different countries. Five mutations in the Plasmodium falciparum crt (pfcrt) gene resulting in the amino acid changes K76T, M74I,...

Prevalence of In Vitro Resistance to Eleven Standard or New Antimalarial Drugs among Plasmodium falciparum Isolates from Pointe-Noire, Republic of the Congo

Pradines, Bruno, Hovette, Philippe, Fusai, Thierry, Atanda, Henri Léonard, Baret, Eric, Cheval, Philippe, ...

We determined the level of in vitro resistance of Plasmodium falciparum parasites to standard antimalarial drugs, such as chloroquine, quinine, amodiaquine, halofantrine, mefloquine, cycloguanil, and...

In Vitro Activities of Benflumetol against 158 Senegalese Isolates of Plasmodium falciparum in Comparison with Those of Standard Antimalarial Drugs

Pradines, Bruno, Tall, Adama, Fusai, Thierry, Spiegel, Andre, Hienne, Remi, Rogier, Christophe, ...

The 50% inhibitory concentration (IC50s) of benflumetol (range, 12.5 to 240 nM; mean, 55.1 nM) for 158 Senegalese isolates were evaluated. Ten isolates (6%) showed decreased susceptibility to...

In Vitro Activities of Antibiotics against Plasmodium falciparum Are Inhibited by Iron

Pradines, Bruno, Rogier, Christophe, Fusai, Thierry, Mosnier, Joel, Daries, William, Barret, Eric, ...

The in vitro activities of cyclines (tetracycline, doxycycline, minocycline, oxytetracycline, and rolitetracycline), macrolides (erythromycin, spiramycin, roxithromycin, and lincomycin), quinolones...

In Vitro Potentiation of Antibiotic Activities by a Catecholate Iron Chelator against Chloroquine-Resistant Plasmodium falciparum

Pradines, Bruno, Ramiandrasoa, Florence, Rolain, Jean Marc, Rogier, Christophe, Mosnier, Joel, Daries, William, ...

FR160, a catechol iron chelator, and tetracyclines or norfloxacin exert in vitro additive or synergistic activity against a chloroquine-resistant Plasmodium falciparum clone. FR160 shows antagonistic...

In Vitro Increase in Chloroquine Accumulation Induced by Dihydroethano- and Ethenoanthracene Derivatives in Plasmodium falciparum-Parasitized Erythrocytes

Pradines, Bruno, Alibert, Sandrine, Houdoin, Carole, Santelli-Rouvier, Christiane, Mosnier, Joel, Fusai, Thierry, ...

The effects of a series of dihydroethano- and ethenoanthracene derivatives on chloroquine (CQ) accumulation in CQ-susceptible strain 3D7 and CQ-resistant clone W2 were assessed. The levels of CQ...

Dihydroethanoanthracene Derivatives as In Vitro Malarial Chloroquine Resistance Reversal Agents

Millet, Julie, Torrentino-Madamet, Marylin, Alibert, Sandrine, Rogier, Christophe, Santelli-Rouvier, Christiane, Mosnier, Joel, ...

The ability of four 9,10-dihydroethanoanthracene derivatives (BG920, BG932, BG958, and BG996), as well as verapamil and promethazine, to reverse chloroquine resistance was assessed against 24...

Polymorphism in Plasmodium falciparum Drug Transporter Proteins and Reversal of In Vitro Chloroquine Resistance by a 9,10-Dihydroethanoanthracene Derivative

Millet, Julie, Alibert, Sandrine, Torrentino-Madamet, Marylin, Rogier, Christophe, Santelli-Rouvier, Christiane, Bigot, Patricia, ...

BG958 reverses resistance in chloroquine-resistant isolates from different countries. Five mutations in the Plasmodium falciparum crt (pfcrt) gene resulting in the amino acid changes K76T, M74I,...

Prevalence of In Vitro Resistance to Eleven Standard or New Antimalarial Drugs among Plasmodium falciparum Isolates from Pointe-Noire, Republic of the Congo

Pradines, Bruno, Hovette, Philippe, Fusai, Thierry, Atanda, Henri Léonard, Baret, Eric, Cheval, Philippe, ...

We determined the level of in vitro resistance of Plasmodium falciparum parasites to standard antimalarial drugs, such as chloroquine, quinine, amodiaquine, halofantrine, mefloquine, cycloguanil, and...

In Vitro Activity of Ferroquine Is Independent of Polymorphisms in Transport Protein Genes Implicated in Quinoline Resistance in Plasmodium falciparum▿

Henry, Maud, Briolant, Sébastien, Fontaine, Albin, Mosnier, Joel, Baret, Eric, Amalvict, Rémy, ...

The in vitro activity of ferroquine (FQ) (SR97193), a 4-aminoquinoline antimalarial compound that contains a ferrocenic nucleus, against 15 Plasmodium falciparum strains was assessed and compared...

Multinormal In Vitro Distribution Model Suitable for the Distribution of Plasmodium falciparum Chemosusceptibility to Doxycycline▿

Briolant, Sébastien, Baragatti, Meili, Parola, Philippe, Simon, Fabrice, Tall, Adama, Sokhna, Cheikh, ...

The distribution and range of 50% inhibitory concentrations (IC50s) of doxycycline were determined for 747 isolates obtained between 1997 and 2006 from patients living in Senegal, Republic of the...

Atypical aetiology of a conjugal fever: autochthonous airport malaria between Paris and French Riviera: a case report

Pomares-Estran, Christelle, Delaunay, Pascal, Mottard, Annie, Cua, Eric, Roger, Pierre-Marie, Pradines, Bruno, ...

Endemic malaria has been eradicated from France, but some falciparum malaria cases have been described in patients who have never travelled outside the country. Ms. V. 21 year-old and Mr. M. 23...

Plasmodium falciparum Na+/H+ Exchanger 1 Transporter Is Involved in Reduced Susceptibility to Quinine ▿

Henry, Maud, Briolant, Sébastien, Zettor, Agnès, Pelleau, Stéphane, Baragatti, Meili, Baret, Eric, ...

Polymorphisms in the Plasmodium falciparum crt (Pfcrt), Pfmdr1, and Pfmrp genes were not significantly associated with quinine (QN) 50% inhibitory concentrations (IC50s) in 23 strains of Plasmodium...