Birnberg, Tal, Bar-On, Liat, Sapoznikov, Anita, Caton, Michele L., Cervantes-Barragán, Luisa, Makia, Divine, ...
Dendritic cells are critically involved in the promotion and regulation of Tcell responses. Here, we report a mouse strain that lacks conventional CD11chi dendritic cells (cDCs) because of...
Roland Züst, Luisa Cervantes-Barragán, Thomas Kuri, Gjon Blakqori, Friedemann Weber, Burkhard Ludewig, ...
Attenuated viral vaccines can be generated by targeting essential pathogenicity factors. We report here the rational design of an attenuated recombinant coronavirus vaccine based on a deletion in the...
Towards a Coronavirus-Based HIV Multigene Vaccine (2006)
Klara K. Eriksson, Divine Makia, Reinhard Maier, Burkhard Ludewig, Volker Thiel
Human immunodeficiency virus (HIV) infection represents one of the major health threats in the developing world. The costly treatment of infected individuals with multiple highly efficient anti-HIV...
Towards a Coronavirus-Based HIV Multigene Vaccine (2006)
Klara K. Eriksson, Divine Makia, Reinhard Maier, Burkhard Ludewig, Volker Thiel
Human immunodeficiency virus (HIV) infection represents one of the major health threats in the developing world. The costly treatment of infected individuals with multiple highly efficient anti-HIV...
Immunopathological Basis of Virus-induced Myocarditis (2004)
Reinhard Maier, Philippe Krebs, Burkhard Ludewig
Heart diseases are an important cause of morbidity and mortality in industrialized countries. Dilated cardiomyopathy (DCM), one of the most common heart diseases, may be the consequence of...
Immunopathological Basis of Virus-induced Myocarditis (2004)
Reinhard Maier, Philippe Krebs, Burkhard Ludewig
Heart diseases are an important cause of morbidity and mortality in industrialized countries. Dilated cardiomyopathy (DCM), one of the most common heart diseases, may be the consequence of...
Berlin, Freie Univ., Diss., 1995.
Ludewig, Burkhard, Freigang, Stefan, Jäggi, Martin, Kurrer, Michael O., Pei, Yao-Chang, Vlk, Lenka, ...
Arterial inflammatory responses are thought to be a significant component of atherosclerotic disease. We describe here, using a transgenic approach, the mutual perpetuation of immune-mediated...
Immune surveillance against a solid tumor fails because of immunological ignorance
Ochsenbein, Adrian F., Klenerman, Paul, Karrer, Urs, Ludewig, Burkhard, Pericin, Marcus, Hengartner, Hans, ...
Many peripheral solid tumors such as sarcomas and carcinomas express tumor-specific antigens that can serve as targets for immune effector T cells. Nevertheless, overall immune surveillance against...
Dendritic Cells Efficiently Induce Protective Antiviral Immunity
Ludewig, Burkhard, Ehl, Stephan, Karrer, Urs, Odermatt, Bernhard, Hengartner, Hans, Zinkernagel, Rolf M.
Cytotoxic T lymphocytes (CTL) are essential for effective immunity to various viral infections. Because of the high speed of viral replication, control of viral infections imposes demanding...
Underwhelming the Immune Response: Effect of Slow Virus Growth on CD8+-T-Lymphocyte Responses
Bocharov, Gennady, Ludewig, Burkhard, Bertoletti, Antonio, Klenerman, Paul, Junt, Tobias, Krebs, Philippe, ...
The speed of virus replication has typically been seen as an advantage for a virus in overcoming the ability of the immune system to control its population growth. Under some circumstances, the...
Underwhelming the Immune Response: Effect of Slow Virus Growth on CD8+-T-Lymphocyte Responses
Bocharov, Gennady, Ludewig, Burkhard, Bertoletti, Antonio, Klenerman, Paul, Junt, Tobias, Krebs, Philippe, ...
Chen, Lili, Gui, Chunshan, Luo, Xiaomin, Yang, Qingang, Günther, Stephan, Scandella, Elke, ...
The 3C-like proteinase (3CLpro) of severe acute respiratory syndrome-associated coronavirus (SARS-CoV) is one of the most promising targets for anti-SARS-CoV drugs due to its crucial role in the...
Selective Replication of Coronavirus Genomes That Express Nucleocapsid Protein
Schelle, Barbara, Karl, Nadja, Ludewig, Burkhard, Siddell, Stuart G., Thiel, Volker
The coronavirus nucleocapsid (N) protein is a structural protein that forms a ribonucleoprotein complex with genomic RNA. In addition to its structural role, it has been described as an RNA-binding...
Microchimerism maintains deletion of the donor cell–specific CD8+ T cell repertoire
Bonilla, Weldy V., Geuking, Markus B., Aichele, Peter, Ludewig, Burkhard, Hengartner, Hans, Zinkernagel, Rolf M.
Rare cases of stable allograft acceptance after discontinuation of immunosuppression are often accompanied by macrochimerism (> 1% donor cells in blood) or microchimerism (< 1% donor cells in blood)....
Züst, Roland, Cervantes-Barragán, Luisa, Kuri, Thomas, Blakqori, Gjon, Weber, Friedemann, Ludewig, Burkhard, ...
Attenuated viral vaccines can be generated by targeting essential pathogenicity factors. We report here the rational design of an attenuated recombinant coronavirus vaccine based on a deletion in the...
Molecular Characterization of Virus-induced Autoantibody Responses
Ludewig, Burkhard, Krebs, Philippe, Metters, Helen, Tatzel, Jutta, Türeci, Özlem, Sahin, Ugur
Here we present a comprehensive molecular mapping of virus-induced autoimmune B cell responses obtained by serological identification of antigens by recombinant expression cloning analysis....
Towards a Coronavirus-Based HIV Multigene Vaccine
Eriksson, Klara K., Makia, Divine, Maier, Reinhard, Ludewig, Burkhard, Thiel, Volker
Human immunodeficiency virus (HIV) infection represents one of the major health threats in the developing world. The costly treatment of infected individuals with multiple highly efficient anti-HIV...
Immunopathological Basis of Virus-induced Myocarditis
Maier, Reinhard, Krebs, Philippe, Ludewig, Burkhard
Heart diseases are an important cause of morbidity and mortality in industrialized countries. Dilated cardiomyopathy (DCM), one of the most common heart diseases, may be the consequence of...
Ludewig, Burkhard, Ochsenbein, Adrian F., Odermatt, Bernhard, Paulin, Denise, Hengartner, Hans, Zinkernagel, Rolf M.
Vaccination with dendritic cells (DCs) presenting tumor antigens induces primary immune response or amplifies existing cytotoxic antitumor T cell responses. This study documents that antitumor...
Ludewig, Burkhard, Odermatt, Bernhard, Landmann, Salome, Hengartner, Hans, Zinkernagel, Rolf M.
Activation of autoreactive T cells can lead to autoimmune diseases such as insulin-dependent diabetes mellitus (IDDM). The initiation and maintenance of IDDM by dendritic cells (DC), the most potent...
Eriksson, Klara Kristin, Cervantes-Barragán, Luisa, Ludewig, Burkhard, Thiel, Volker
Viral infection of the liver can lead to severe tissue damage when high levels of viral replication and spread in the organ are coupled with strong induction of inflammatory responses. Here we report...
Zinkernagel, Martin S., Bolinger, Beatrice, Krebs, Philippe, Onder, Lucas, Miller, Simone, Ludewig, Burkhard
The infection of humans with the rodent-borne lymphocytic choriomeningitis virus (LCMV) can lead to central nervous system disease in adults or severe neurological disease with hydrocephalus and...