Cuomo, C.A., Güldener, U., Xu, J.R., Trail, F., Turgeon, B.G.
We sequenced and annotated the genome of the filamentous fungus Fusarium graminearum, a major pathogen of cultivated cereals. Very few repetitive sequences were detected, and the process of...
DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage (2006)
Zody, M.C., Garber, M., Adams, D.J., Sharpe, T., Harrow, J., Lupski, J.R., ...
Chromosome 17 is unusual among the human chromosomes in many respects. It is the largest human autosome with orthology to only a single mouse chromosome1, mapping entirely to the distal half of mouse...
McBlane, J.F., Gent, D.C. Van, Ramsden, D.A., Romeo, C., Cuomo, C.A., Gellert, M., ...
Formation of double-strand breaks at recombination signal sequences is an early step in V(D)J recombination. Here we show that purified RAG1 and RAG2 proteins are sufficient to carry out this...
Rch1, a protein that specifically interacts with the RAG-1 recombination-activating protein.
Cuomo, C A, Kirch, S A, Gyuris, J, Brent, R, Oettinger, M A
RAG1 and RAG2 are lymphoid-specific genes that together induce V(D)J recombinase activity in a variety of nonlymphoid cell types. While no other lymphoid-specific factors are required to induce...
DNA sequence and structure requirements for cleavage of V(D)J recombination signal sequences.
Cuomo, C A, Mundy, C L, Oettinger, M A
Purified RAG1 and RAG2 proteins can cleave DNA at V(D)J recombination signals. In dissecting the DNA sequence and structural requirements for cleavage, we find that the heptamer and nonamer motifs of...
Analysis of regions of RAG-2 important for V(D)J recombination.
The recombinase activating genes RAG-1 and RAG-2 operate together to activate V(D)J recombination, and thus play an essential role in the generation of immune system diversity. As a first step in...
Rch1, a protein that specifically interacts with the RAG-1 recombination-activating protein.
Cuomo, C A, Kirch, S A, Gyuris, J, Brent, R, Oettinger, M A
RAG1 and RAG2 are lymphoid-specific genes that together induce V(D)J recombinase activity in a variety of nonlymphoid cell types. While no other lymphoid-specific factors are required to induce...
DNA sequence and structure requirements for cleavage of V(D)J recombination signal sequences.
Cuomo, C A, Mundy, C L, Oettinger, M A
Purified RAG1 and RAG2 proteins can cleave DNA at V(D)J recombination signals. In dissecting the DNA sequence and structural requirements for cleavage, we find that the heptamer and nonamer motifs of...
Analysis of regions of RAG-2 important for V(D)J recombination.
The recombinase activating genes RAG-1 and RAG-2 operate together to activate V(D)J recombination, and thus play an essential role in the generation of immune system diversity. As a first step in...