Funes, J.M., Quintero, M., Henderson, S., Martinez, D., Qureshi, U., Westwood, C., ...
An increased dependency on glycolysis for ATP production is considered to be a hallmark of tumor cells. Whether this increase in glycolytic activity is due mainly to inherent metabolic alterations or...
Small-molecule mimics of an α-helix for efficient transport of proteins into cells (2007)
Okuyama, M., Laman, H., Kingsbury, S.R., Visintin, C., Leo, E., Eward, K.L., ...
We designed and synthesized small-molecule mimics of an alpha-helical peptide protein transduction domain (PTD). These small-molecule carriers, which we termed SMoCs, are easily coupled to...
Small-molecule mimics of an α-helix for efficient transport of proteins into cells (2007)
Okuyama, M., Laman, H., Kingsbury, S.R., Visintin, C., Leo, E., Eward, K.L., ...
We designed and synthesized small-molecule mimics of an alpha-helical peptide protein transduction domain (PTD). These small-molecule carriers, which we termed SMoCs, are easily coupled to...
Small-molecule mimics of an α-helix for efficient transport of proteins into cells (2007)
Okuyama, M., Laman, H., Kingsbury, S.R., Visintin, C., Leo, E., Eward, K.L., ...
We designed and synthesized small-molecule mimics of an alpha-helical peptide protein transduction domain (PTD). These small-molecule carriers, which we termed SMoCs, are easily coupled to...
Brachyury, a crucial regulator of notochordal development, is a novel biomarker for chordomas (2006)
Vujovic, S., Henderson, S., Presneau, N., Odell, E., Jacques, T.S., Tirabosco, R., ...
Chordomas are malignant tumours that occur along the spine and are thought to derive from notochordal remnants. There is significant morphological variability between and within chordomas, with some...
Newton, R., Carpenter, L., Casabonne, D., Beral, V., Babiker, A., Darbyshire, J., ...
Antibody titres against Kaposi's sarcoma associated herpesvirus (KSHV or human herpesvirus 8 (HHV-8)) and Epstein–Barr virus (EBV) were examined in people who subsequently developed Kaposi's...
A molecular map of mesenchymal tumors (2005)
Henderson, S.R., Guiliano, D., Presneau, N., McLean, S., Frow, R., Vujovic, S., ...
Background: Bone and soft tissue tumors represent a diverse group of neoplasms thought to derive from cells of the mesenchyme or neural crest. Histological diagnosis is challenging due to the poor or...
Inhibiting primary effusion lymphoma by lentiviral vectors encoding short hairpin RNA (2005)
Godfrey, A., Anderson, J., Papanastasiou, A., Takeuchi, Y., Boshoff, C.
We use lentiviral-delivered RNA interference (RNAi) to inhibit the growth of a model of primary effusion lymphoma (PEL) in vitro and in vivo. RNAi is a phenomenon allowing the sequence-specific...
Sharp, T.V., Munoz, F., Bourboulia, D., Presneau, N., Darai, E., Wang, H., ...
LIM domains-containing protein 1 (LIMD1) is encoded at chromosome 3p21.3, a region commonly deleted in many solid malignancies. However, the function of LIMD1 is unknown. Here we show that LIMD1...
Wang, H., Trotter, M.W.B., Lagos, D., Bourboulia, D., Henderson, S., Mäkinen, T., ...
The biology of Kaposi sarcoma is poorly understood because the dominant cell type in Kaposi sarcoma lesions is not known1, 2, 3, 4. We show by gene expression microarrays that neoplastic cells of...
Bourboulia, D., Aldam, D., Lagos, D., Allen, E., Williams, I., Cornforth, D., ...
Objective: To investigate the effect of highly active antiretroviral therapy (HAART) on Kaposi sarcoma-associated herpesvirus (KSHV) DNA load, anti-KSHV antibody responses and KSHV-specific CD8 T...
Jenner, R.G., Maillard, K., Cattini, N., Weiss, R.A., Boshoff, C., Wooster , R., ...
Kaposi's sarcoma-associated herpesvirus is associated with three human tumors: Kaposi's sarcoma, and the B cell lymphomas, plasmablastic lymphoma associated with multicentric Castleman's disease, and...
Wang, H., Sharp, T.V., Koumi, A., Koentges, G., Boshoff, C.
We have investigated the expression and function of a novel protein encoded by open reading frame (ORF) K7 of Kaposi's sarcoma-associated herpesvirus (KSHV). Computational analyses revealed that K7...
Davidovici, B., Karakis, I., Bourboulia, D., Ariad, S., Zong, J., Benharroch, D., ...
Background: The incidence of classic Kaposi's sarcoma among Jews in Israel is among the highest in the developed world. Kaposi's sarcoma-associated herpesvirus (KSHV or human herpesvirus 8) is...
Kaposi's sarcoma-associated herpesvirus and Kaposi's sarcoma in Africa (1996)
Chang, Y, Ziegler, J, Wabinga, H, KatangoleMbidde, E, Boshoff, C, Schulz, T, ...
Background: Endemic Kaposi's sarcoma (KS) is a clinically and epidemiologically distinct human immunodeficiency virus negative form of KS occurring in Africa. Kaposi's sarcoma is now the most...
Secondary tumours following etoposide containing therapy for germ cell cancer (1995)
Boshoff, C., Begent, R. H. J., Oliver, R. T. D., Rustin, G. J., Newlands, E. S., Andrews, R., ...
Background Reports have implied etoposide as the cause of secondary leukaemia in patients treated for germ cell cancer. Patients and methods Between 1979 and 1992, 679 male patients with germ cell...
Godden-Kent, D, Talbot, S J, Boshoff, C, Chang, Y, Moore, P, Weiss, R A, ...
Kaposi's sarcoma-associated herpesvirus (KSHV or human herpesvirus 8) is a novel gammaherpesvirus implicated in the cause of Kaposi's sarcoma and certain malignancies of lymphatic origin. One of the...
Degradation of p27(Kip) cdk inhibitor triggered by Kaposi's sarcoma virus cyclin-cdk6 complex.
Ellis, M, Chew, Y P, Fallis, L, Freddersdorf, S, Boshoff, C, Weiss, R A, ...
The Kaposi's sarcoma-associated human herpesvirus 8 (KSHV/HHV8) encodes a protein similar to cellular cyclins. This cyclin is most closely related to cellular D-type cyclins, but biochemically it...
Godden-Kent, D, Talbot, S J, Boshoff, C, Chang, Y, Moore, P, Weiss, R A, ...
Kaposi's sarcoma-associated herpesvirus (KSHV or human herpesvirus 8) is a novel gammaherpesvirus implicated in the cause of Kaposi's sarcoma and certain malignancies of lymphatic origin. One of the...
Degradation of p27(Kip) cdk inhibitor triggered by Kaposi's sarcoma virus cyclin-cdk6 complex.
Ellis, M, Chew, Y P, Fallis, L, Freddersdorf, S, Boshoff, C, Weiss, R A, ...
The Kaposi's sarcoma-associated human herpesvirus 8 (KSHV/HHV8) encodes a protein similar to cellular cyclins. This cyclin is most closely related to cellular D-type cyclins, but biochemically it...
Epidemiology and pathogenesis of Kaposi's sarcoma-associated herpesvirus.
Kaposi's sarcoma (KS) occurs in Europe and the Mediterranean countries (classic KS) and Africa (endemic KS), immunosuppressed patients (iatrogenic or post-transplant KS) and those with acquired...
Characterisation of the anti-apoptotic function of survivin-ΔEx3 during TNFα−mediated cell death
Malcles, M-H, Wang, H-W, Koumi, A, Tsai, Y-H, Yu, M, Godfrey, A, ...
Survivin is an oncogenic protein involved in cell division and acts as an anti-apoptotic factor. It is highly expressed in most cancers and is associated with chemotherapy resistance, increased...
Newton, R, Carpenter, L, Casabonne, D, Beral, V, Babiker, A, Darbyshire, J, ...
Antibody titres against Kaposi's sarcoma associated herpesvirus (KSHV or human herpesvirus 8 (HHV-8)) and Epstein–Barr virus (EBV) were examined in people who subsequently developed Kaposi's...
Whitby, D, Luppi, M, Sabin, C, Barozzi, P, Biase, A R Di, Balli, F, ...
Human herpesvirus 8 (HHV-8), also known as Kaposi's sarcoma associated herpesvirus (KSHV), has been shown to be the causative agent for Kaposi's sarcoma (KS) and to be more prevalent in populations...
The epidemiology of conjunctival squamous cell carcinoma in Uganda
Newton, R, Ziegler, J, Ateenyi-Agaba, C, Bousarghin, L, Casabonne, D, Beral, V, ...
As part of a larger investigation of cancer in Uganda, we conducted a case–control study of conjunctival squamous cell carcinoma in adults presenting at hospitals in Kampala. Participants were...
Ablashi, D, Chatlynne, L, Cooper, H, Thomas, D, Yadav, M, Norhanom, A W, ...
Seroprevalence of HHV-8 has been studied in Malaysia, India, Sri Lanka, Thailand, Trinidad, Jamaica and the USA, in both healthy individuals and those infected with HIV. Seroprevalence was found to...
Eisen, T, Boshoff, C, Mak, I, Sapunar, F, Vaughan, M M, Pyle, L, ...
To grow and metastasize, solid tumours must develop their own blood supply by neo-angiogenesis. Thalidomide inhibits the processing of mRNA encoding peptide molecules including tumour necrosis...
The epidemiology of conjunctival squamous cell carcinoma in Uganda
Newton, R, Ziegler, J, Ateenyi-Agaba, C, Bousarghin, L, Casabonne, D, Beral, V, ...