Ononeze, V., Murphy, A.W., MacFarlane, A., Byrne, M., Bradley, C.
Qualitative theories of illness experience are about the individual interpretations of the psychosocial and cultural aspects of living with illness. Thus, they contribute to a better understanding of...
Response Characteristics of Thermoresponsive Polymers Using Nanomechanical Cantilever Sensors (2009)
Bradley, C., Jalili, N., Nett, S. K., Chu, L. Q., Förch, Renate, Gutmann, Jochen S., ...
Bradley, C, Rahman, A, Hubbard, A
No abstract available.
Bradley, C, Gilbride, Charles J.B.
Insulin therapy becomes essential for many people with Type 2 diabetes. After starting insulin, people with diabetes that is poorly controlled with oral agents typically report improved well-being...
McMillan, Carolyn, Bradley, C, Razvi, Salman, Weaver, Jolanta
This paper reports the psychometric properties of two new condition-specific questionnaires: 1) the 18-item ThyDQoL individualised measure of perceived impact of hypothyroidism on quality of life...
C.: Ontologies, dialogue and knowledge maturing: Towards a mashup and design study (2008)
A. Ravenscroft, S. Braun, J. Cook, A. Schmidt, J. Bimrose, A. Brown, ...
This paper proposes an initial design study to examine and test some of the key concepts and issues within a large-scale European research project that is exploring and aiming to realise learning as...
Extent of satisfaction with tablets and food-timing in sulphonylurea-treated diabetes (2007)
Woodcock, A, Charlton, M, Bradley, C
This study measured patient views about following tablet-taking and food-timing recommendations in Type 2 diabetes. Two new questionnaires were validated. Outpatients with Type 2 diabetes treated...
Bradley , C, Plowright, Rosalind, Stewart , John, Valentine, John, Witthaus, Elke
The results of using status measures to identify any changes in treatment satisfaction strongly suggest a need for specific change instruments designed to overcome the ceiling effects frequently...
Diabetes mellitus is a chronic disorder, characterised by raised glucose levels in blood (hyperglycaemia) and urine (glycosuria). The cause may be inherited and/or acquired deficiency of insulin...
This chapter provides an overview of the role of psychological stress in Type 1 diabetes. Studies relating to stress and Type 1 diabetes onset and control, as well as the evidence relating to stress...
Quality of Life and Health Economic Assessments of Age-Related Macular Degeneration (2007)
Covert, D, Berdeaux, G, Mitchell, J, Bradley, C, Barnes, R
In this article, we review measures of patient-reported outcomes that can show whether a treatment for age-related macular degeneration also provides patient-perceived benefits. In addition, we look...
Development of the Well-being questionaire short-form in Japanese: the W-BQ12 (2006)
Bradley, C, Barendse, S, Ishii, H, Riazi, A
Background: The Well-being questionaire (W-BQ) was designed to measure psychological well-being in people with diabetes. This study aimed to develop a Japanese version and a short form of the W-BQ....
Bradley, C, McMillan, C V, Gibney, J, Russell-Jones, D L, Sonksen, P H
Background: Psychometric properties of two measures of psychological well-being were evaluated for adults with growth hormone deficiency (GHD): the General Well-being Index, (GWBI) – British...
Bradley, C, McMillan, C, Razvi, S, Weaver, J
Objective: To demonstrate the application of a Bayesian mixed treatment comparison (MTC) model to synthesize data from clinical trials to inform decisions based on all relevant evidence. Methods: The...
I have a particular interest in the FDA's guidance on patient-reported outcome (PRO measures as I specialize in the design, development and use of such measures and license them to pharmaceutical...
Bradley, C, DAFNE, Study Group
Objectives: To evaluate whether a course teaching flexible intensive insulin adjustment can improve both glycaemic control and quality of life in type 1 diabetes. Design: randomized design with...
Development of the new Retinopathy Treatment Satisfaction Questionnaire (ReTSQ) (2005)
Woodcock, A, Bradley, C, Plowright, R, Kennedy-Martin, T, Hirsch, A, Ffytche, T
Objective: To incorporate patients' views in the design of a measure of satisfaction with treatment for diabetic retinopathy, to be used in evaluation of currently available and anticipated new...
Peer support for people newly diagnosed with macular degeneration: a pilot study (2005)
Bradley, C, Bradley, P, Mitchell, J
To conduct a pilot study of peer group support and information provision to help newly diagnosed patients to adjust to macular degeneration (MD). Twelve patients were randomised to two groups. For...
Measuring quality of life in macular disease:what use are utilities? (2005)
Background: Utility values are often used as measures of quality of life (QoL). This study compared the suitability of time trade-off (TTO) values with the MacDQoL. Participants completed the MacDQoL...
Reactions to treatment debriefing among the participants of a placebo controlled trial (2005)
Di Blasi, Z., Crawford, F., Bradley, C., Kleijnen, J.
Background: A significant proportion of trial participants respond to placebos for a variety of conditions. Despite the common conduct of these trials and the strong emphasis placed on informed...
Background: The MacDQoL is an individualized measure of the impact of macular degeneration (MD) on quality of life (QoL). there is preliminary evidence of its psychometric properties with sensitivity...
Bradley, C, Speight, J, Barendse, S
Background: Quality and effectiveness of care can be enhanced through the use of condition-specific measures of satisfaction with treatment. The aim of the present study was to design and develop a...
Riazi, Afsane, Pickup, John, Bradley, C
The aim of this study was to investigate the relationships between daily stress and glycaemic control in 54 people with Type 1 diabetes over 21 days. Measures included daily reports of stress...
Bradley, C, McMillan, C V, Datta, J, Honeyford, R J, Madge, N J H
Background: This study evaluated the psychometric properties of the ADDQoL-Teen, an innovative individualized, patient-centred questionnaire measuring perceived impact of diabetes mellitus on quality...
The expression of aversion to medicines in general practice consultations (2004)
Britten, N., Stevenson, F., Gafaranga, J., Barry, C., Bradley, C.
Although the relevance of patients’ views about medicines for their medicine taking behaviour is now well established, little is known about the ways in which these views are discussed in primary...
Bradley, C, Woodcock, A, McMillan, C V, Razvi, S, Weaver, J U
Introduction: This paper reports work undertaken to design two new condition-specific questionnaires for use in hypothyroidism: the Underactive Thyroid-Dependent Quality of Life Questionnaire...
Using stable isotopes of water to infer wetland hydrological dynamics (2004)
Clay, A., Bradley, C., Gerrard, A. J., Leng, M. J.
This paper considers the potential of oxygen and hydrogen isotope ratios to identify spatial and temporal changes in the water source of a lowland headwater wetland situated adjacent to the River...
Using stable isotopes of water to infer wetland hydrological dynamics (2004)
Clay, A., Bradley, C., Gerrard, A. J., Leng, M. J.
This paper considers the potential of oxygen and hydrogen isotope ratios to identify spatial and temporal changes in the water source of a lowland headwater wetland situated adjacent to the River...
Bradley, C, Giannoulis, M, Martin, F, McMillan, C, Sonksen, P H
Background: There is increasing interest in hormone replacement therapy to improve health and quality of life (QoL) of older men with age-related decline in hormone levels. This paper reports the...
Editorial. Not-only-a-title (2003)
In the course of eliciting feedback on possible titles for this new journal the comments revealed a fascinating range of views on the terminology commonly used and abused in the literature. We...
Bradley, C, McMillan, C V, Gibney, J, Healy, M-L, Russell-Jones, D L, Sönksen, P H
Objective: Growth hormone (GH) is known to be required for physical well-being. Whilst it is also widely believed to be important for quality of life (QoL) and psychological health, there is less...
Evaluation of two health status measures in adults with growth hormone deficiency (2003)
Bradley, C, McMillan, C V, Gibney, J, Russell-Jones, D L, Sönksen, P H
Objective: To evaluate the psychometric properties of two health status measures for adults with growth hormone deficiency (GHD): Nottingham Health Profile (NHP) and Short Form Health Survey (SF-36)....
Many of the early rapid responses to the DAFNE trial paper (1) [see bmj.com] claimed that improved quality of life (QoL) resulting from flexible intensified insulin treatment was well established...
DAFNE: author's response to electronic letters from 5th October to 22nd October 2002 (2002)
The rapid responses received following the publication of the DAFNE trial reflect the controversy surrounding the current inadequate management of Type 1 diabetes. [1] While it is true that the...
BACKGROUND: Recent progress in predictive techniques allows people at risk of developing type 1 diabetes to be identified in a pre-symptomatic stage and prevention trials to be implemented. The...
Bradley, C, Anderson, S J, Ffytche, T, Bradley, P, Mitchell, J
Aim: To investigate the experiences of people with macular disease within the British healthcare system. Method: The Macular Disease Society Questionnaire, a self completion questionnaire designed to...
The ADKnowl: identifying knowledge deficits in diabetes care (2001)
Aim: To present the ADKnowl measure of diabetes-related knowledge and evaluate its use in identifying the nature and extent of patient and health professional knowledge deficits. Method: The ADKnowl...
Bradley, C, Stewart, J, Witthaus, E
Aims: To assess satisfaction with treatment and psychological well-being associated with insulin glargine and NPH. Insulin glargine, a new long-acting insulin analogue, provides constant, peakless...
I was asked by the editorial board of Health Psychology Update to contribute to the centenary issue of Update by writing about a publication that inspired, impressed, or simply interested me. The...
Importance of differentiating health status from quality of life (2001)
Of nine exhibits in the Quality of Life with Diabetes poster event at the recent European Association for the Study of Diabetes meeting in Jerusalem,1 five used measures of health status (EQ5D and...
Psychological issues in clinical trial design (1997)
Randomised control trial (RCT) designs are widely regarded as the trial design of choice, believed to offer greater internal validity than non-random trials. However, where patients have preferences...
Tisdale, M., Larder, B. A., Lowe, D. M., Stammers, D. K., Purifoy, D. J. M., Ertl, P., ...
The reverse transcriptase (RT) of HIV is an important target for chemotherapy as demonstrated by the effective treatment of AIDS patients with zidovudine, a potent inhibitor of RT. Structural studies...
Why do so few patients appeal against detention under Section 2 of the Mental Health Act?
Bradley, C., Marshall, M., Gath, D.
OBJECTIVE--To determine why most patients do not exercise their right of appeal against detention under section 2 of the Mental Health Act 1983. DESIGN--Part one--retrospective analysis of the...
S.K. Nett, C. Bradley, M. Memesa, Y. Cheng, ...
Poster
S.K. Nett, C. Bradley, M. Memesa, Y. Cheng, ...
Poster
The role of GSK-3 in synaptic plasticity
Peineau, S, Bradley, C, Taghibiglou, C, Doherty, A, Bortolotto, Z A, Wang, Y T, ...
Glycogen synthase kinase-3 (GSK-3), an important component of the glycogen metabolism pathway, is highly expressed in the CNS. It has been implicated in major neurological disorders including...
The interaction of normal (CHO-K1) and multidrug-resistant (Adrr) Chinese hamster ovary cells was examined in mixed monolayer and spheroid culture. In order to assess the individual response of the...
Joffe, J. K., Perren, T. J., Bradley, C., Primrose, J., Hallam, S., Ward, U., ...
The combination of 5-fluorouracil (5-FU) and interferon-alpha (IFN-alpha) has reported activity in the treatment of advanced colorectal carcinoma. Laboratory studies of IFN-beta suggest that this...
Modified de Gramont with oxaliplatin in the first-line treatment of advanced colorectal cancer
Braun, M S, Adab, F, Bradley, C, McAdam, K, Thomas, G, Wadd, N J, ...
Rustin, G J S, Bradley, C, Galbraith, S, Stratford, M, Loadman, P, Waller, S, ...
The purpose of this phase I, dose-escalation study was to determine the toxicity, maximum tolerated dose, pharmacokinetics, and pharmacodynamic end points of 5,6-dimethylxanthenone acetic acid...