Thomson, K. S., Chartrand, S. A., Sanders, C. C., Block, S. L.
This in-vitro study was designed to compare the activity of levofloxacin with that of ciprofloxacin, ofloxacin, erythromycin, penicillin, amoxycillin, loracarbef, cefaclor, cefpodoxime, ceftriaxone,...
USA resistance patterns among UTI pathogens (1994)
Thomson, K. S., Sanders, W. E., Sanders, C. C.
The fluoroquinolones are a new, potent class of antimicrobials which are heavily prescribed in the United States. Resistance to these agents has developed primarily in organisms that are inherently...
Sanders, C. C., Sanders, W. E., Thomson, K. S., Iaconis, J. P.
The activity of meropenem, a new carbapenem, was determined against 82 Gram-negative bacteria in agar dilution tests. Many of these isolates were resistant to one or more β-lactam antibiotics and...
Sanders, C. C., Sanders, W. E.
The in-vitro activity, bactericidal potency, and enzyme stability of Sch 29482 (SCH) were determined in comparative tests with N-formimidoyl thienamycin and moxalactam. Broth dilution tests were...
Pitout, J. D. D., Thomson, K. S., Hanson, N. D., Ehrhardt, A. F., Moland, E. S., Sanders, C. C.
Although resistance to the expanded-spectrum cephalosporins among members of the family Enterobacteriaceae lacking inducible β-lactamases occurs virtually worldwide, little is known about this...
A test panel of 35 different beta-lactamases expressed in a common Escherichia coli host was created to compare the effect that each beta-lactamase had on susceptibility to various beta-lactam...
A mouse model of bacteremia was used to compare the efficacies of 1.5- and 3.0-g intravenous doses of ampicillin-sulbactam. Seven strains of Escherichia coli producing various levels of TEM-1...
New variant of TEM-10 beta-lactamase gene produced by a clinical isolate of proteus mirabilis.
Palzkill, T, Thomson, K S, Sanders, C C, Moland, E S, Huang, W, Milligan, T W
A clinical isolate of Proteus mirabilis was found to produce a new variant of the TEM-10 beta-lactamase gene. This is the first report of TEM-10 production by P. mirabilis and the first report of...
Sequencing and analysis of four new Enterobacter ampD Alleles.
Ehrhardt, A F, Sanders, C C, Romero, J R, Leser, J S
Sequences of ampD genes from wild-type, temperature-sensitive, and stably derepressed mutants of the wild-type strain of Enterobacter cloacae 029 and the hyperinducible strain E. cloacae 1194E were...
Alexov, M, Lister, P D, Sanders, C C
An in vitro pharmacokinetic model (IVPM) and a mouse model of lethal bacteremia were used to compare the pharmacodynamics of ampicillin-sulbactam when the two components were dosed simultaneously and...
Beta-lactamases and detection of beta-lactam resistance in Enterobacter spp.
Pitout, J D, Moland, E S, Sanders, C C, Thomson, K S, Fitzsimmons, S R
Enterobacter spp. are becoming increasingly frequent nosocomial pathogens, and beta-lactam-resistant strains are on the increase, especially among isolates recovered from intensive care units....
Trovafloxacin, a new fluoroquinolone with potent activity against Streptococcus pneumoniae.
Thomson, K S, Chartrand, S A, Sanders, C C, Block, S L
An in vitro study of the activity of 15 antibacterial agents against 202 recent pediatric isolates of Streptococcus pneumoniae from urban and rural Nebraska and rural Kentucky identified...
Lister, P D, Prevan, A M, Sanders, C C
An in vitro pharmacokinetic model was used to study the pharmacodynamics of piperacillin-tazobactam and piperacillin-sulbactam against gram-negative bacilli producing plasmid-encoded beta-lactamases....
Lister, P D, Pong, A, Chartrand, S A, Sanders, C C
To evaluate whether increased doses of amoxicillin should be used to treat acute pneumococcal otitis media, an in vitro pharmacokinetic model was used to evaluate the killing of pneumococci by...
Penicillin-binding proteins and induction of AmpC beta-lactamase.
Sanders, C C, Bradford, P A, Ehrhardt, A F, Bush, K, Young, K D, Henderson, T A, ...
In competition assays for radiolabeled penicillin, penicillin-binding proteins (PBPs) 4, 7a, and 7b showed very high affinities for strong inducers of AmpC beta-lactamase. Loss of PBP 4 resulted in...
Structure-activity studies of quinolone-penems in genetically defined strains of Escherichia coli.
Quinolonyl-beta-lactam antimicrobial agents (QLAs) contain quinolones chemically linked to beta-lactams, although the impact of linkage is poorly understood. Genetically defined Escherichia coli...
Purification and characterization of inducible beta-lactamases in Aeromonas spp.
beta-Lactamases from Aeromonas hydrophila and A. sobria were purified and characterized. Both species produced beta-lactamases that were inducible by either cefoxitin or imipenem. These species were...
Diverse potential of beta-lactamase inhibitors to induce class I enzymes.
The ability of various beta-lactamase inhibitors to induce class I beta-lactamases was assessed. Clavulanate was the most active compound, inducing Morganella morganii, Aeromonas caviae, and...
Thomson, K S, Weber, D A, Sanders, C C, Sanders, W E
Recent reports that members of the family Enterobacteriaceae that produce high levels of certain beta-lactamases are often resistant to ticarcillin-clavulanate prompted this study to assess the...
Clark, R B, Sanders, C C, Pakiz, C B, Hostetter, M K
In recent years, a number of clinical microbiology laboratories have isolated Pseudomonas aeruginosa with the unusual aminoglycoside disk diffusion result of resistance to both amikacin and...
The in vitro activity of four oral cephalosporins was assessed in dilution tests with 50 isolates of the family Enterobacteriaceae possessing well-characterized mechanisms of resistance to...
ampG is essential for high-level expression of AmpC beta-lactamase in Enterobacter cloacae.
Mutants of Enterobacter cloacae 55 were studied to delineate more completely the genetics of inducible expression of AmpC beta-lactamase. E. cloacae 55M-L, derived by mutagenesis from a mutant with...
Enterobacter spp.: pathogens poised to flourish at the turn of the century.
Knowledge of the genus Enterobacter and its role in human disease has expanded exponentially in recent years. The incidence of infection in the hospital and the community has increased. New clinical...
Leakage of beta-lactamase: a second mechanism for antibiotic potentiation by amdinocillin.
Sanders, C C, Sanders, W E, Goering, R V, McCloskey, R V
Discrepancies were observed between results of different beta-lactamase induction tests with amdinocillin, which appeared to be a strong inducer in whole-cell assays but a weak inducer in assays with...
Bakken, J S, Sanders, C C, Clark, R B, Hori, M
Use of cefoperazone in a patient with Aeromonas caviae in the respiratory tract selected a mutant that constitutively produced beta-lactamase. This mutant, in contrast to its parental strain with an...
Sanders, C C, Iaconis, J P, Bodey, G P, Samonis, G
Thirty-four clinical isolates of the family Enterobacteriaceae from the University of Texas M. D. Anderson Cancer Center appeared resistant to ticarcillin-potassium clavulanate in agar dilution and...
Dworzack, D L, Sanders, C C, Horowitz, E A, Allais, J M, Sookpranee, M, Sanders, W E, ...
The ability of a single oral 750-mg dose of ciprofloxacin to eradicate Neisseria meningitidis from persistent nasopharyngeal carriers was prospectively evaluated in a placebo-controlled, randomized,...
Heterogeneity of class I beta-lactamase expression in clinical isolates of Pseudomonas aeruginosa.
Sanders, C C, Gates, M L, Sanders, W E
Expression of chromosomal beta-lactamase was examined in 85 clinical isolates of Pseudomonas aeruginosa. beta-Lactamase assays with and without cefoxitin induction revealed four phenotypes of enzyme...
Sanders, C C, Sanders, W E, Goering, R V, Werner, V
The ability of three quinolones, two beta-lactams, and one aminoglycoside to select resistant mutants was examined in tests with 30 isolates of commonly encountered nosocomial pathogens....
Werner, V, Sanders, C C, Sanders, W E, Goering, R V
The chromosomal beta-lactamase and outer membrane proteins of Enterobacter cloacae were examined to determine their relative contributions to multiple antibiotic resistance in this organism. Mutants...
Horowitz, E A, Preheim, L C, Safranek, T J, Pugsley, M P, Sanders, C C, Bittner, M J
Sixty-seven patients with complicated urinary tract infections were randomized in double-blind fashion to ceftazidime or moxalactam (MOX). A total of 54 patients were evaluable, 27 in each group....
Evidence for multiple forms of type I chromosomal beta-lactamase in Pseudomonas aeruginosa.
Gates, M L, Sanders, C C, Goering, R V, Sanders, W E
The multiple stages of derepression of the type I chromosomal beta-lactamase in Pseudomonas aeruginosa were examined. Mutants partially and fully derepressed for beta-lactamase were selected from a...
Characterization of beta-lactamases in situ on polyacrylamide gels.
Sanders, C C, Sanders, W E, Moland, E S
An inhibitor-based characterization system which allowed the identification of beta-lactamases after isoelectric focusing on polyacrylamide gels was developed. This system, using potassium...
In vitro studies with Win 42122-2: comparison with gentamicin, netilmicin, and amikacin.
The in vitro activity of Win 42122-2 against gram-negative clinical isolates was compared in serial twofold broth dilution tests with gentamicin, netilmicin, and amikacin. Against 173...
The in vitro activity of mezlocillin was compared to penicillin G, ampicillin, carbenicillin, and ticarcillin in tests with 195 gram-positive bacteria and 20 Haemophilus influenzae. Against...
Goering, R V, Sanders, C C, Sanders, W E
The ability of cefoxitin to antagonize the in vivo efficacy of cefamandole and carbenicillin as predicted by in vitro assays was analyzed in experimental infections in mice. Cefoxitin was...
In vitro antagonism of beta-lactam antibiotics by cefoxitin.
Sanders, C C, Sanders, W E, Goering, R V
We assessed the extent and mechanisms of antagonism of beta-lactam antibiotics by cefoxitin. In tests with 41 gram-negative isolates, cefoxitin antagonized cephalothin, cefamandole, cefsulodin,...
Characterization of beta-lactamase induction in Enterobacter cloacae.
The induction of beta-lactamase was studied in a strain of Enterobacter cloacae. A wide variety of beta-lactam compounds were found to induce beta-lactamase in this organism, and the degree of...
Sanders, C C, Sanders, W E, Goering, R V
Previous studies in this and other laboratories have shown that derepression of beta-lactamases in strains of Enterobacter and Pseudomonas spp. is responsible for the rapid development of resistance...
Comparison of moxalactam and gentamicin in the treatment of complicated urinary tract infections.
Penn, R G, Preheim, L C, Sanders, C C, Giger, D K
Moxalactam and gentamicin were compared in a prospective, randomized study of 49 hospitalized patients with complicated urinary tract infections. Patients received parenteral moxalactam, 250 mg every...
Evaluation of Sch 29,482 in the eradication of Neisseria meningitidis from nasopharyngeal carriers.
Pugsley, M P, Dworzack, D L, Sanders, C C, Sanders, W E
Fifty-eight chronic carriers of Neisseria meningitidis were given 250 mg of Sch 29,482 or placebo orally every 6 h for 4 days. Although 22 of 29 subjects taking Sch 29,482 became culture negative...
Preheim, L C, Penn, R G, Sanders, C C, Goering, R V, Giger, D K
In four patients with Pseudomonas aeruginosa infections, the infecting strain developed resistance to moxalactam during therapy with this drug. In addition, P. aeruginosa isolates from two of these...
Use of a predictor panel to evaluate susceptibility testing methods for ampicillin-sulbactam.
A predictor panel of clinical isolates that produce a variety of types and amounts of beta-lactamases was used to assess the accuracies of a variety of susceptibility tests for ampicillin-sulbactam....
Decimal assay for additivity of drugs permits delineation of synergy and antagonism.
Sanders, C C, Sanders, W E, Moland, E S
Although there are many in vitro tests for drug interactions, few possess a linear, predictable dose-dependent end point or have a precise definition for additivity. Therefore, a new test with both...
Ceftazidime resistance in Hafnia alvei.
Thomson, K S, Sanders, C C, Washington, J A
Two morphotypes of Hafnia alvei differed in their susceptibilities to beta-lactam antibiotics. Both produced an inducible Bush group 1 beta-lactamase. Hyperinducibility of this enzyme was associated...
The proper disk mass for diffusion susceptibility tests with cefoperazone-sulbactam was determined by using a predictor panel of clinical isolates that included staphylococci and gram-negative...
The three-dimensional and clavulanate double-disk potentiation tests were compared as procedures for the detection of extended-spectrum beta-lactamase production in 32 strains of Escherichia coli and...
A predictor panel of clinical isolates that produce a variety of types and amounts of beta-lactamases was used to assess the accuracy of dilution and disk diffusion susceptibility tests for...
Sanders, C C, Barry, A L, Washington, J A, Shubert, C, Moland, E S, Traczewski, M M, ...
A three-phase analysis of the Vitek ESBL test and a double-disk (2 disk) test was performed to assess their ability to detect extended-spectrum beta-lactamases (ESBLs) in members of the family...
Vercauteren, E, Descheemaeker, P, Ieven, M, Sanders, C C, Goossens, H
Using a set of 33 well-defined extended-spectrum beta-lactamase (ESBL)-producing strains of Escherichia coli and Klebsiella pneumoniae, we compared three screening methods for ESBL detection: (i) a...
Coudron, P E, Moland, E S, Sanders, C C
A total of 907 consecutive isolates of members of the family Enterobacteriaceae recovered during a 20-week period were tested for production of extended-spectrum beta-lactamases (ESBLs) by the...
Altered phenotypes associated with ampD mutations in Enterobacter cloacae.
Korfmann, G, Sanders, C C, Moland, E S
A study was done to determine the genetic locus responsible for altered expression of AmpC beta-lactamase in Enterobacter cloacae 1194E and several mutants derived from E. cloacae 029. These...
Thomson, K S, Sanders, C C, Washington, J A
Two isolates of Klebsiella pneumoniae possessing both TEM-1 and SHV-2 beta-lactamases were isolated from patients at the Cleveland Clinic in 1988. The beta-lactamases were discriminated and...
Cavalieri, S J, Sanders, C C, New, C
The ability of beta-lactamase inhibitors to induce class I beta-lactamases in certain organisms in vitro suggests a potential for antagonism in vivo. Therefore, a study was designed to assess the...
Thomson, K S, Sanders, C C, Hayden, M E
A panel of 203 staphylococci, Enterobacteriaceae, Pseudomonas aeruginosa, and miscellaneous nonfermentative gram-negative bacilli were chosen for their various susceptibilities to ciprofloxacin. On...
Development and evaluation of a biochemical scheme for identification of endocervical lactobacilli.
Fagnant, J E, Sanders, C C, Sanders, W E
A biochemical scheme for the species identification of endocervical lactobacilli was developed and evaluated with 10 isolates obtained from the American Type Culture Collection (ATCC) and 106...
Dissociated resistance among fluoroquinolones.
A panel of 190 clinical isolates of staphylococci, enterococci, Streptococcus pneumoniae, members of the family Enterobacteriaceae, and nonfermentative gram-negative bacilli were examined by agar...
Saigh, J H, Sanders, C C, Sanders, W E
The ability of aerobic and facultatively anaerobic endocervical flora to inhibit the growth of Neisseria gonorrhoeae in vitro was assayed. Factors influencing the occurrence of inhibitory components...
Sanders, C C, Sanders, W E, Harrowe, D J
The effects of orally administered penicillin and tetracycline on the composition of the normal throat flora and its interference with the growth of group A streptococci were evaluated by throat...
Pitout, J. D. D., Thomson, K. S., Hanson, N. D., Ehrhardt, A. F., Moland, E. S., Sanders, C. C.
Although resistance to the expanded-spectrum cephalosporins among members of the family Enterobacteriaceae lacking inducible β-lactamases occurs virtually worldwide, little is known about this...
A test panel of 35 different beta-lactamases expressed in a common Escherichia coli host was created to compare the effect that each beta-lactamase had on susceptibility to various beta-lactam...
A mouse model of bacteremia was used to compare the efficacies of 1.5- and 3.0-g intravenous doses of ampicillin-sulbactam. Seven strains of Escherichia coli producing various levels of TEM-1...
New variant of TEM-10 beta-lactamase gene produced by a clinical isolate of proteus mirabilis.
Palzkill, T, Thomson, K S, Sanders, C C, Moland, E S, Huang, W, Milligan, T W
A clinical isolate of Proteus mirabilis was found to produce a new variant of the TEM-10 beta-lactamase gene. This is the first report of TEM-10 production by P. mirabilis and the first report of...
Sequencing and analysis of four new Enterobacter ampD Alleles.
Ehrhardt, A F, Sanders, C C, Romero, J R, Leser, J S
Sequences of ampD genes from wild-type, temperature-sensitive, and stably derepressed mutants of the wild-type strain of Enterobacter cloacae 029 and the hyperinducible strain E. cloacae 1194E were...
Alexov, M, Lister, P D, Sanders, C C
An in vitro pharmacokinetic model (IVPM) and a mouse model of lethal bacteremia were used to compare the pharmacodynamics of ampicillin-sulbactam when the two components were dosed simultaneously and...
Beta-lactamases and detection of beta-lactam resistance in Enterobacter spp.
Pitout, J D, Moland, E S, Sanders, C C, Thomson, K S, Fitzsimmons, S R
Enterobacter spp. are becoming increasingly frequent nosocomial pathogens, and beta-lactam-resistant strains are on the increase, especially among isolates recovered from intensive care units....
Trovafloxacin, a new fluoroquinolone with potent activity against Streptococcus pneumoniae.
Thomson, K S, Chartrand, S A, Sanders, C C, Block, S L
An in vitro study of the activity of 15 antibacterial agents against 202 recent pediatric isolates of Streptococcus pneumoniae from urban and rural Nebraska and rural Kentucky identified...
Lister, P D, Prevan, A M, Sanders, C C
An in vitro pharmacokinetic model was used to study the pharmacodynamics of piperacillin-tazobactam and piperacillin-sulbactam against gram-negative bacilli producing plasmid-encoded beta-lactamases....
Lister, P D, Pong, A, Chartrand, S A, Sanders, C C
To evaluate whether increased doses of amoxicillin should be used to treat acute pneumococcal otitis media, an in vitro pharmacokinetic model was used to evaluate the killing of pneumococci by...
Penicillin-binding proteins and induction of AmpC beta-lactamase.
Sanders, C C, Bradford, P A, Ehrhardt, A F, Bush, K, Young, K D, Henderson, T A, ...
In competition assays for radiolabeled penicillin, penicillin-binding proteins (PBPs) 4, 7a, and 7b showed very high affinities for strong inducers of AmpC beta-lactamase. Loss of PBP 4 resulted in...
Structure-activity studies of quinolone-penems in genetically defined strains of Escherichia coli.
Quinolonyl-beta-lactam antimicrobial agents (QLAs) contain quinolones chemically linked to beta-lactams, although the impact of linkage is poorly understood. Genetically defined Escherichia coli...
Purification and characterization of inducible beta-lactamases in Aeromonas spp.
beta-Lactamases from Aeromonas hydrophila and A. sobria were purified and characterized. Both species produced beta-lactamases that were inducible by either cefoxitin or imipenem. These species were...
Diverse potential of beta-lactamase inhibitors to induce class I enzymes.
The ability of various beta-lactamase inhibitors to induce class I beta-lactamases was assessed. Clavulanate was the most active compound, inducing Morganella morganii, Aeromonas caviae, and...
Thomson, K S, Weber, D A, Sanders, C C, Sanders, W E
Recent reports that members of the family Enterobacteriaceae that produce high levels of certain beta-lactamases are often resistant to ticarcillin-clavulanate prompted this study to assess the...
Clark, R B, Sanders, C C, Pakiz, C B, Hostetter, M K
In recent years, a number of clinical microbiology laboratories have isolated Pseudomonas aeruginosa with the unusual aminoglycoside disk diffusion result of resistance to both amikacin and...
The in vitro activity of four oral cephalosporins was assessed in dilution tests with 50 isolates of the family Enterobacteriaceae possessing well-characterized mechanisms of resistance to...
ampG is essential for high-level expression of AmpC beta-lactamase in Enterobacter cloacae.
Mutants of Enterobacter cloacae 55 were studied to delineate more completely the genetics of inducible expression of AmpC beta-lactamase. E. cloacae 55M-L, derived by mutagenesis from a mutant with...
Enterobacter spp.: pathogens poised to flourish at the turn of the century.
Knowledge of the genus Enterobacter and its role in human disease has expanded exponentially in recent years. The incidence of infection in the hospital and the community has increased. New clinical...
Leakage of beta-lactamase: a second mechanism for antibiotic potentiation by amdinocillin.
Sanders, C C, Sanders, W E, Goering, R V, McCloskey, R V
Discrepancies were observed between results of different beta-lactamase induction tests with amdinocillin, which appeared to be a strong inducer in whole-cell assays but a weak inducer in assays with...
Bakken, J S, Sanders, C C, Clark, R B, Hori, M
Use of cefoperazone in a patient with Aeromonas caviae in the respiratory tract selected a mutant that constitutively produced beta-lactamase. This mutant, in contrast to its parental strain with an...
Sanders, C C, Iaconis, J P, Bodey, G P, Samonis, G
Thirty-four clinical isolates of the family Enterobacteriaceae from the University of Texas M. D. Anderson Cancer Center appeared resistant to ticarcillin-potassium clavulanate in agar dilution and...
Dworzack, D L, Sanders, C C, Horowitz, E A, Allais, J M, Sookpranee, M, Sanders, W E, ...
The ability of a single oral 750-mg dose of ciprofloxacin to eradicate Neisseria meningitidis from persistent nasopharyngeal carriers was prospectively evaluated in a placebo-controlled, randomized,...
Heterogeneity of class I beta-lactamase expression in clinical isolates of Pseudomonas aeruginosa.
Sanders, C C, Gates, M L, Sanders, W E
Expression of chromosomal beta-lactamase was examined in 85 clinical isolates of Pseudomonas aeruginosa. beta-Lactamase assays with and without cefoxitin induction revealed four phenotypes of enzyme...
Sanders, C C, Sanders, W E, Goering, R V, Werner, V
The ability of three quinolones, two beta-lactams, and one aminoglycoside to select resistant mutants was examined in tests with 30 isolates of commonly encountered nosocomial pathogens....
Werner, V, Sanders, C C, Sanders, W E, Goering, R V
The chromosomal beta-lactamase and outer membrane proteins of Enterobacter cloacae were examined to determine their relative contributions to multiple antibiotic resistance in this organism. Mutants...
Horowitz, E A, Preheim, L C, Safranek, T J, Pugsley, M P, Sanders, C C, Bittner, M J
Sixty-seven patients with complicated urinary tract infections were randomized in double-blind fashion to ceftazidime or moxalactam (MOX). A total of 54 patients were evaluable, 27 in each group....
Evidence for multiple forms of type I chromosomal beta-lactamase in Pseudomonas aeruginosa.
Gates, M L, Sanders, C C, Goering, R V, Sanders, W E
The multiple stages of derepression of the type I chromosomal beta-lactamase in Pseudomonas aeruginosa were examined. Mutants partially and fully derepressed for beta-lactamase were selected from a...
Characterization of beta-lactamases in situ on polyacrylamide gels.
Sanders, C C, Sanders, W E, Moland, E S
An inhibitor-based characterization system which allowed the identification of beta-lactamases after isoelectric focusing on polyacrylamide gels was developed. This system, using potassium...
In vitro studies with Win 42122-2: comparison with gentamicin, netilmicin, and amikacin.
The in vitro activity of Win 42122-2 against gram-negative clinical isolates was compared in serial twofold broth dilution tests with gentamicin, netilmicin, and amikacin. Against 173...
The in vitro activity of mezlocillin was compared to penicillin G, ampicillin, carbenicillin, and ticarcillin in tests with 195 gram-positive bacteria and 20 Haemophilus influenzae. Against...
Goering, R V, Sanders, C C, Sanders, W E
The ability of cefoxitin to antagonize the in vivo efficacy of cefamandole and carbenicillin as predicted by in vitro assays was analyzed in experimental infections in mice. Cefoxitin was...
In vitro antagonism of beta-lactam antibiotics by cefoxitin.
Sanders, C C, Sanders, W E, Goering, R V
We assessed the extent and mechanisms of antagonism of beta-lactam antibiotics by cefoxitin. In tests with 41 gram-negative isolates, cefoxitin antagonized cephalothin, cefamandole, cefsulodin,...
Characterization of beta-lactamase induction in Enterobacter cloacae.
The induction of beta-lactamase was studied in a strain of Enterobacter cloacae. A wide variety of beta-lactam compounds were found to induce beta-lactamase in this organism, and the degree of...
Sanders, C C, Sanders, W E, Goering, R V
Previous studies in this and other laboratories have shown that derepression of beta-lactamases in strains of Enterobacter and Pseudomonas spp. is responsible for the rapid development of resistance...
Comparison of moxalactam and gentamicin in the treatment of complicated urinary tract infections.
Penn, R G, Preheim, L C, Sanders, C C, Giger, D K
Moxalactam and gentamicin were compared in a prospective, randomized study of 49 hospitalized patients with complicated urinary tract infections. Patients received parenteral moxalactam, 250 mg every...
Evaluation of Sch 29,482 in the eradication of Neisseria meningitidis from nasopharyngeal carriers.
Pugsley, M P, Dworzack, D L, Sanders, C C, Sanders, W E
Fifty-eight chronic carriers of Neisseria meningitidis were given 250 mg of Sch 29,482 or placebo orally every 6 h for 4 days. Although 22 of 29 subjects taking Sch 29,482 became culture negative...
Preheim, L C, Penn, R G, Sanders, C C, Goering, R V, Giger, D K
In four patients with Pseudomonas aeruginosa infections, the infecting strain developed resistance to moxalactam during therapy with this drug. In addition, P. aeruginosa isolates from two of these...
Use of a predictor panel to evaluate susceptibility testing methods for ampicillin-sulbactam.
A predictor panel of clinical isolates that produce a variety of types and amounts of beta-lactamases was used to assess the accuracies of a variety of susceptibility tests for ampicillin-sulbactam....
Decimal assay for additivity of drugs permits delineation of synergy and antagonism.
Sanders, C C, Sanders, W E, Moland, E S
Although there are many in vitro tests for drug interactions, few possess a linear, predictable dose-dependent end point or have a precise definition for additivity. Therefore, a new test with both...
Ceftazidime resistance in Hafnia alvei.
Thomson, K S, Sanders, C C, Washington, J A
Two morphotypes of Hafnia alvei differed in their susceptibilities to beta-lactam antibiotics. Both produced an inducible Bush group 1 beta-lactamase. Hyperinducibility of this enzyme was associated...
The proper disk mass for diffusion susceptibility tests with cefoperazone-sulbactam was determined by using a predictor panel of clinical isolates that included staphylococci and gram-negative...
The three-dimensional and clavulanate double-disk potentiation tests were compared as procedures for the detection of extended-spectrum beta-lactamase production in 32 strains of Escherichia coli and...
A predictor panel of clinical isolates that produce a variety of types and amounts of beta-lactamases was used to assess the accuracy of dilution and disk diffusion susceptibility tests for...
Sanders, C C, Barry, A L, Washington, J A, Shubert, C, Moland, E S, Traczewski, M M, ...
A three-phase analysis of the Vitek ESBL test and a double-disk (2 disk) test was performed to assess their ability to detect extended-spectrum beta-lactamases (ESBLs) in members of the family...
Vercauteren, E, Descheemaeker, P, Ieven, M, Sanders, C C, Goossens, H
Using a set of 33 well-defined extended-spectrum beta-lactamase (ESBL)-producing strains of Escherichia coli and Klebsiella pneumoniae, we compared three screening methods for ESBL detection: (i) a...
Coudron, P E, Moland, E S, Sanders, C C
A total of 907 consecutive isolates of members of the family Enterobacteriaceae recovered during a 20-week period were tested for production of extended-spectrum beta-lactamases (ESBLs) by the...
Altered phenotypes associated with ampD mutations in Enterobacter cloacae.
Korfmann, G, Sanders, C C, Moland, E S
A study was done to determine the genetic locus responsible for altered expression of AmpC beta-lactamase in Enterobacter cloacae 1194E and several mutants derived from E. cloacae 029. These...
Thomson, K S, Sanders, C C, Washington, J A
Two isolates of Klebsiella pneumoniae possessing both TEM-1 and SHV-2 beta-lactamases were isolated from patients at the Cleveland Clinic in 1988. The beta-lactamases were discriminated and...
Cavalieri, S J, Sanders, C C, New, C
The ability of beta-lactamase inhibitors to induce class I beta-lactamases in certain organisms in vitro suggests a potential for antagonism in vivo. Therefore, a study was designed to assess the...
Thomson, K S, Sanders, C C, Hayden, M E
A panel of 203 staphylococci, Enterobacteriaceae, Pseudomonas aeruginosa, and miscellaneous nonfermentative gram-negative bacilli were chosen for their various susceptibilities to ciprofloxacin. On...
Development and evaluation of a biochemical scheme for identification of endocervical lactobacilli.
Fagnant, J E, Sanders, C C, Sanders, W E
A biochemical scheme for the species identification of endocervical lactobacilli was developed and evaluated with 10 isolates obtained from the American Type Culture Collection (ATCC) and 106...
Dissociated resistance among fluoroquinolones.
A panel of 190 clinical isolates of staphylococci, enterococci, Streptococcus pneumoniae, members of the family Enterobacteriaceae, and nonfermentative gram-negative bacilli were examined by agar...
Saigh, J H, Sanders, C C, Sanders, W E
The ability of aerobic and facultatively anaerobic endocervical flora to inhibit the growth of Neisseria gonorrhoeae in vitro was assayed. Factors influencing the occurrence of inhibitory components...
Sanders, C C, Sanders, W E, Harrowe, D J
The effects of orally administered penicillin and tetracycline on the composition of the normal throat flora and its interference with the growth of group A streptococci were evaluated by throat...