The VIZIER project: Preparedness against pathogenic RNA viruses (2008)
Gorbalenya, AE, Snijder, EJ, Leontovich, AM, Poupon, A, De Lamballerie, X, ...
Life-threatening RNA viruses emerge regularly, and often in an unpredictable manner. Yet, the very few drugs available against known RNA viruses have sometimes required decades of research for...
Dolk, E., Vliet, C. Van, Perez, J.M.J., Vriend, G., Darbon, H., Ferrat, G., ...
In a previous study we have shown that llama VHH antibody fragments are able to bind their antigen after a heat shock of 90°C, in contrast to the murine monoclonal antibodies. However, the molecular...
Isolation of llama antibody fragments for prevention of dandruff by phage display in shampoo (2005)
Dolk, E., Vaart, M. Van Der, Lutje Hulsik, D., Vriend, G., Haard, H. De, Spinelli, S., ...
PRUDÃENCIO, M, BESSON, S, CABRITO, I, BROWN, K, Samyn, Bart, ...
Crystal structure of cutinase covalently inhibited by a triglyceride analogue (1997)
LONGHI, S., MANNESSE, M., VERHEIJ, H. M., DE-HAAS, G. H., EGMOND, M., KNOOPS-MOUTHUY, E., ...
Correlation of exons with structural domains in alcohol dehydrogenase.
Brändén, C I, Eklund, H, Cambillau, C, Pryor, A J
The intron/exon arrangement in the gene sequence of maize alcohol dehydrogenase has been compared to the three dimensional structure of liver alcohol dehydrogenase. The co-enzyme binding domain is...
Conformational and functional similarities between glutaredoxin and thioredoxins.
Eklund, H, Cambillau, C, Sjöberg, B M, Holmgren, A, Jörnvall, H, Höög, J O, ...
The tertiary structures of thioredoxin from Escherichia coli and bacteriophage T4 have been compared and aligned giving a common fold of 68 C alpha atoms with a root mean square difference of 2.6 A....
Zeggari, M, Esteve, J P, Rauly, I, Cambillau, C, Mazarguil, H, Dufresne, M, ...
We have previously shown that somatostatin promotes the stimulation of a membrane tyrosine phosphatase activity in pancreatic cells. To gain insight into the mechanism of somatostatin action, we...
Gastinel, L N, Cambillau, C, Bourne, Y
beta1,4-galactosyltransferase T1 (beta4Gal-T1, EC 2.4.1.90/38), a Golgi resident membrane-bound enzyme, transfers galactose from uridine diphosphogalactose to the terminal beta-N-acetylglucosamine...
Brown, K, Pompeo, F, Dixon, S, Mengin-Lecreulx, D, Cambillau, C, Bourne, Y
N-acetylglucosamine 1-phosphate uridyltransferase (GlmU) is a cytoplasmic bifunctional enzyme involved in the biosynthesis of the nucleotide-activated UDP-GlcNAc, which is an essential precursor for...
Correlation of exons with structural domains in alcohol dehydrogenase.
Brändén, C I, Eklund, H, Cambillau, C, Pryor, A J
The intron/exon arrangement in the gene sequence of maize alcohol dehydrogenase has been compared to the three dimensional structure of liver alcohol dehydrogenase. The co-enzyme binding domain is...
Conformational and functional similarities between glutaredoxin and thioredoxins.
Eklund, H, Cambillau, C, Sjöberg, B M, Holmgren, A, Jörnvall, H, Höög, J O, ...
The tertiary structures of thioredoxin from Escherichia coli and bacteriophage T4 have been compared and aligned giving a common fold of 68 C alpha atoms with a root mean square difference of 2.6 A....
Zeggari, M, Esteve, J P, Rauly, I, Cambillau, C, Mazarguil, H, Dufresne, M, ...
We have previously shown that somatostatin promotes the stimulation of a membrane tyrosine phosphatase activity in pancreatic cells. To gain insight into the mechanism of somatostatin action, we...
Gastinel, L N, Cambillau, C, Bourne, Y
beta1,4-galactosyltransferase T1 (beta4Gal-T1, EC 2.4.1.90/38), a Golgi resident membrane-bound enzyme, transfers galactose from uridine diphosphogalactose to the terminal beta-N-acetylglucosamine...
Brown, K, Pompeo, F, Dixon, S, Mengin-Lecreulx, D, Cambillau, C, Bourne, Y
N-acetylglucosamine 1-phosphate uridyltransferase (GlmU) is a cytoplasmic bifunctional enzyme involved in the biosynthesis of the nucleotide-activated UDP-GlcNAc, which is an essential precursor for...
Flavocytochrome b2 from Saccharomyces cerevisiae catalyzes the oxidation of L-lactate to pyruvate and the electron transfer to cytochrome c in the mitochondrial intermembrane space. It is a...
Crystallographic study of the structure of colipase and of the interaction with pancreatic lipase.
Egloff, M. P., Sarda, L., Verger, R., Cambillau, C., Van Tilbeurgh, H.
Colipase (Mr 10 kDa) confers catalytic activity to pancreatic lipase under physiological conditions (high bile salt concentrations). Previously determined 3-A-resolution X-ray structures of...
Crystal structure of cutinase covalently inhibited by a triglyceride analogue.
Longhi, S., Mannesse, M., Verheij, H. M., De Haas, G. H., Egmond, M., Knoops-Mouthuy, E., ...
Cutinase from Fusarium solani is a lipolytic enzyme that hydrolyses triglycerides efficiently. All the inhibited forms of lipolytic enzymes described so far are based on the use of small...