Memory representations of musical tempo: Stable or adaptive? (2006)
Strauss, S., Vitouch, O., Ladinig, O., Augustin, D., Carbon, C., Leder, H.
Joly-Guillou, M. L., Wolff, M., Farinotti, R., Bryskier, A., Carbon, C.
We evaluated the in vivo activity of levofloxacin alone or in combination with imipenem or amikacin in a mouse model of Acinetobacter baumannii pneumonia using a susceptible strain and one with...
Muller-Serieys, C., Decré, D., Benoit, C., Bigot, C., Maubert, B., Carbon, C.
The aim of this study was to assess the serum bactericidal activity (SBA) of levofloxacin compared with that of ofloxacin against methicillin-resistant Staphylococcus aureus (MRSA) isolates. Serum...
Carbon, C., Hotton, J. M., Pépin, L. F., Wohlhuter, C., Souêtre, E., Hardens, M., ...
The economic impacts in terms of cost and effectiveness (speed of resolution of symptoms) of 3- and 5-day courses of azithromycin and a 10-day course of roxithromycin were compared in a randomized,...
Carbon, C., Chatelin, A., Bingen, E., Zuck, P., Rio, Y., Guetat, F., ...
A 10-day course of penicillin is the antibiotic regimen currently recommended by the American Heart Association (AHA) as treatment for patients with tonsillitis caused by group A β-haemolytic...
LEDESERT, B., LOMBRAIL, P., YENI, P., CARBON, C., BRODIN, M.
The impact of a multi-dimensional geriatric assessment (MDGA) programme on the reorientation of the elderly person at discharge is described. One hundred and six elderly persons from a hospital...
Fantin, Bruno, Farinotti, R., Thabaut, A., Carbon, C.
The conditions for the emergence of resistance to cefpirome and ceftazidime were studied in rabbits with experimental aortic endocarditis due to Pseudomonas aeruginosa. The MIC of cefpirome was 16...
Two hundred and seventy-six hospitalized patients with severe infection (complicated UTI, pneumonia, skin and soft tissue infection or septicaemia) were randomly allocated to receive either 1g or 2g...
Reappraisal of amoxycillin absorption kinetics (1991)
Westphal, J. F., Deslandes, A., Brogard, J. M., Carbon, C.
Interest in the intestinal absorption mechanisms of drugs has increased because transepithelial passage across the gut does not necessarily follow a passive diffusion process. Amoxycillin, like other...
Enhanced interstitial ampicillin levels after oral bacampicillin (1976)
CARBON, C., CONTREPOIS, A., BEAUVAIS, C., LAMOTTE-BARRILLON, S.
Azoulay-Dupuis, E., Rieux, V., Muffat-Joly, M., Bédos, J. P., Vallée, E., Rivier, C., ...
We examined the relationship between penicillin susceptibility, peritoneal virulence in Swiss mice, and capsular type in a selection of 122 clinical Streptococcus pneumoniae isolates belonging to 24...
Dupont, H., Carbon, C., Carlet, J.
In a randomized trial conducted in 35 centers, we compared the clinical efficacy and safety of piperacillin plus tazobactam (TAZ) alone (monotherapy [MT]) versus those of TAZ combined with amikacin...
Join-Lambert, O. F., Michéa-Hamzehpour, M., Köhler, T., Chau, F., Faurisson, F., Dautrey, S., ...
The ability of trovafloxacin and ciprofloxacin to select efflux mutants in vivo was studied in a model of acute Pseudomonas aeruginosa pneumonia in rats. Twelve hours after intratracheal inoculation...
Influence of Renal Failure on Ciprofloxacin Pharmacokinetics in Rats
Nouaille-Degorce, B., Veau, C., Dautrey, S., Tod, M., Laouari, D., Carbon, C., ...
Ciprofloxacin pharmacokinetics have been shown to be modified in patients with renal failure (e.g., the intestinal secretion of ciprofloxacin is increased). This study investigated the influence of...
Plantefeve, G., Dupont, H., Hubert, V., Garry, L., Poüs, C., Carbon, C., ...
The relationship between virulence and chromosomal elements containing glycopeptide resistance genes was experimentally assessed for two transconjugant strains of Enterococcus faecalis (VanA and VanB...
Intestinal elimination of sparfloxacin, fleroxacin, and ciprofloxacin in rats.
Rubinstein, E, Dautrey, S, Farinoti, R, St Julien, L, Ramon, J, Carbon, C
The intestinal transepithelial elimination of sparfloxacin and fleroxacin was compared with that of ciprofloxacin in a rat model following a single parenteral administration of 25 mg of each of the...
Fantin, B, Leclercq, R, Merlé, Y, Saint-Julien, L, Veyrat, C, Duval, J, ...
In order to determine the microbiological and pharmacokinetic parameters that best predicted the in vivo antistaphylococcal activity of the streptogramin RP 59500 (quinupristin-dalfopristin), we...
Verdon, R, Polianski, J, Gaudebout, C, Marche, C, Garry, L, Carbon, C, ...
In the dexamethasone-treated rat model of cryptosporidiosis, paromomycin was effective at a dosage of 50 mg/kg/day or more for ileal infection and 200 mg/kg/day or more for cecal infection. At 1 and...
Vignes, S, Fantin, B, Elbim, C, Walker, F, Gougerot-Pocidalo, M A, Carbon, C
The effect of human recombinant granulocyte colony-stimulating factor (hrG-CSF) in rabbits with aortic endocarditis due to Pseudomonas aeruginosa was investigated. hrG-CSF significantly increased the...
Excretion of ciprofloxacin into the large bowel of the rabbit.
Ramon, J, Dautrey, S, Farinoti, R, Carbon, C, Rubinstein, E
The intestinal elimination of ciprofloxacin in the large bowel was studied in a rabbit model. Segments from the cecum, colon, and sigmoid colon along with their intact blood vessels were isolated and...
Chemlal, K, Saint-Julien, L, Joly, V, Farinotti, R, Seta, N, Yeni, P, ...
Amphotericin B (AmB) and fluconazole, administered intraperitoneally for 7 days, were compared in a rabbit model for Candida albicans endocarditis. When given early, AmB was more effective than...
Fantin, B, Pierre, J, Castéla-Papin, N, Saint-Julien, L, Drugeon, H, Farinotti, R, ...
The activity of penicillin, alone and in combination with sulbactam, against a heterogeneously methicillin-resistant, penicillinase-producing clinical isolate of Staphylococcus aureus and its...
Barry, B, Muffat-Joly, M, Bauchet, J, Faurisson, F, Gehanno, P, Pocidalo, J J, ...
We used a gerbil model of otitis media to assess the efficacy of single-dose ceftriaxone against three Streptococcus pneumoniae strains highly resistant to penicillin (MICs, 4 to 8 micrograms/ml) and...
Crémieux, A C, Mghir, A S, Bleton, R, Manteau, M, Belmatoug, N, Massias, L, ...
Using a new rabbit model of methicillin-susceptible Staphylococcus aureus knee prosthesis infection, we compared the efficacies of sparfloxacin (50 mg/kg of body weight subcutaneously, twice a day)...
Intestinal elimination of ofloxacin enantiomers in the rat: evidence of a carrier-mediated process.
Rabbaa, L, Dautrey, S, Colas-Linhart, N, Carbon, C, Farinotti, R
The aim of this work was to examine the mechanism involved in intestinal elimination of the two optical isomers of ofloxacin in the rat. An intestinal segment was isolated in situ and perfused with...
Darras-Joly, C, Bédos, J P, Sauve, C, Moine, P, Vallée, E, Carbon, C, ...
In vivo synergy with beta-lactam antibiotics and aminoglycosides has been studied only with penicillin-susceptible Streptococcus pneumoniae strains. We evaluated the interaction between amoxicillin...
Sauve, C, Azoulay-Dupuis, E, Moine, P, Darras-Joly, C, Rieux, V, Carbon, C, ...
We previously demonstrated the efficacy of ceftriaxone (CRO), at 50 mg/kg of body weight every 12 h, against a highly penicillin-resistant (MIC, 4 micrograms/ml) Streptococcus pneumoniae strain with...
Caulin, E, Coutrot, A, Carbon, C, Collatz, E
The effect of production of the aminoglycoside 6'-N-acetyltransferase [AAC(6')-IB] in Klebsiella pneumoniae on the outcome of amikacin and isepamicin treatment of rabbits with experimental...
Deslandes, A, Camus, F, Lacroix, C, Carbon, C, Farinotti, R
We compared the effects of nifedipine and diltiazem on the uptake of cefpodoxime proxetil (CP). The study was aimed at establishing the impact of increased mesenteric blood flow due to calcium...
Joly-Guillou, M L, Wolff, M, Pocidalo, J J, Walker, F, Carbon, C
Acinetobacter baumannii is responsible for severe nosocomial pneumonia. To evaluate new therapeutic regimens for infections due to multiresistant strains and to study the pharmacodynamic properties...
Fantin, B, Leclercq, R, Garry, L, Carbon, C
The influence of inducible cross-resistance to macrolides, lincosamides, and streptogramin B (MLS(B)) type antibiotics (inducible MLS(B) phenotype) on the activity of quinupristin-dalfopristin was...
Absorption of ofloxacin isomers in the rat small intestine.
Rabbaa, L, Dautrey, S, Colas-Linhart, N, Carbon, C, Farinotti, R
Ofloxacin, a chiral fluoroquinolone, possesses two optical isomers. The antibacterial activity of S-(-)-ofloxacin is 8 to 128 times higher than that of R-(+)-ofloxacin. In the rat, a saturable...
We evaluated the effect of repeated oral doses (5 days of treatment) on the kinetics of lomefloxacin in volunteers and compared the kinetics after two different regimens, i.e., 400 mg once daily and...
Fantin, B, Pangon, B, Potel, G, Caron, F, Vallée, E, Vallois, J M, ...
We studied the efficacy of sulbactam, a beta-lactamase inhibitor, in combination with ceftriaxone in vitro and in experimental endocarditis due to an Escherichia coli strain producing an...
Caron, F, Gutmann, L, Bure, A, Pangon, B, Vallois, J M, Pechinot, A, ...
We studied the activity of the combination of sulbactam and ceftriaxone against a Klebsiella pneumoniae strain producing TEM-3, a new extended-broad-spectrum beta-lactamase, in an endocarditis model....
The penicillin-aminoglycoside combination is recommended for the treatment of systemic enterococcal infections. However, the optimal dosing regimen of the aminoglycoside remains to be elucidated. We...
Fantin, B, Pangon, B, Potel, G, Vallois, J M, Caron, F, Bure, A, ...
We evaluated the activities of ceftriaxone (15 mg/kg), netilmicin (6 mg/kg), and their combination given intramuscularly once daily for 4 days for the treatment of experimental Escherichia coli...
Reduction in biliary excretion of ceftriaxone by diclofenac in rabbits.
Merle-Melet, M, Seta, N, Farinotti, R, Carbon, C
The effects of diclofenac, a nonsteroidal anti-inflammatory drug, on biliary excretion of ceftriaxone were evaluated in rabbits. In a previous study, we demonstrated that diclofenac increased the...
Evidence of the proinflammatory role of Enterococcus faecalis in polymicrobial peritonitis in rats.
Montravers, P, Mohler, J, Saint Julien, L, Carbon, C
Although the role of members of the Enterobacteriaceae and anaerobes in the pathogenesis of intra-abdominal infections has been extensively demonstrated, the role played by enterococci in these...
Pangon, B, Joly, V, Vallois, J M, Abel, L, Buré, A, Brion, N, ...
To determine the influence of in vitro activity, pharmacokinetic properties, and therapeutic regimen on the antibacterial effect in vivo, we compared three cephalosporins, cefotiam, cefmenoxime, and...
Alteration of gentamicin and cefazolin kinetics with control of the hypothyroid state in humans.
Chanson, P, Joly, V, Contrepois, A, Garaud, J J, Bauchet, J, Mohler, J, ...
We studied the effect of the control of the hypothyroid state in humans on the pharmacokinetic parameters of cefazolin and gentamicin after a single intravenous injection. These two antibiotics were...
Joly, V, Pangon, B, Vallois, J M, Abel, L, Brion, N, Bure, A, ...
In a rabbit model of Escherichia coli endocarditis, we studied the penetration into infected vegetations and the antibacterial effect of ceftriaxone. Ceftriaxone was given at different dosages, alone...
Pharmacokinetics of ofloxacin after single and multiple intravenous infusions in healthy subjects.
Farinotti, R, Trouvin, J H, Bocquet, V, Vermerie, N, Carbon, C
The pharmacokinetics of ofloxacin were investigated in eight healthy male volunteers. A single infusion (200 mg over 0.5 h) was performed on day 1, followed by a washout period of 2 weeks. Repeated...
Carbon, C, Dromer, F, Brion, N, Cremieux, A C, Contrepois, A
Excretion of ceftazidime (C), a new cephalosporin antibiotic, has been reported to occur unexpectedly through glomerular filtration only, without being significantly affected by probenecid. We...
Bouvet, A, Cremieux, A C, Contrepois, A, Vallois, J M, Lamesch, C, Carbon, C
Six different antibiotic treatment regimens were compared for efficacy in rabbits with endocarditis induced by inoculation with a nutritionally variant strain of streptococcus. Seven untreated...
Renal disposition of gentamicin, dibekacin, tobramycin, netilmicin, and amikacin in humans.
Contrepois, A, Brion, N, Garaud, J J, Faurisson, F, Delatour, F, Levy, J C, ...
The tubular disposition of five aminoglycosides was studied in humans to establish a possible relationship between tubular reabsorption and the nephrotoxicity that has been described in the...
Effects of urinary pH on renal interactions between probenecid and cefsulodin in rabbits.
Dromer, F, Contrepois, A, Brion, N, Klein, C, Carbon, C
The effect of urinary pH on renal interaction of cefsulodin and probenecid was tested in rabbits. Probenecid was reabsorbed in acidic urine (fractional excretion [FE] = 8 +/- 4%) and secreted in...
Brion, N, Barge, J, Godefroy, I, Dromer, F, Dubois, C, Contrepois, A, ...
The role of the tubular reabsorption of aminoglycosides in nephrotoxicity was considered. The tubular reabsorption rate, fractional reabsorption, and net balance, expressed as the excreted to infused...
Effects of furosemide, piretanide, and water loading on urinary excretion of cefazolin in humans.
Morgant, C, Contrepois, A, Chau, N P, Romaru, A, Fourtillan, J B, Carbon, C
Antibiotics and diuretics are often prescribed concomitantly for humans. We compared the effects of two potent loop diuretics, furosemide and piretanide, with those of water loading on the urinary...
Effects of diltiazem on netilmicin-induced nephrotoxicity in rabbits.
Lortholary, O, Blanchet, F, Nochy, D, Heudes, D, Seta, N, Amirault, P, ...
Aminoglycoside nephrotoxicity remains a common clinical problem and is the major cause of acute toxic renal failure in hospitalized patients. In recent studies, calcium channel blockers gave...
Dextranase enhances antibiotic efficacy in experimental viridans streptococcal endocarditis.
Mghir, A S, Cremieux, A C, Jambou, R, Muffat-Joly, M, Pocidalo, J J, Carbon, C
In endocarditis, exopolysaccharide production by viridans streptococci has been associated with delayed antimicrobial efficacy in cardiac vegetations. We compared the efficacies of temafloxacin alone...
Influence of diet on experimental toxicity of amphotericin B deoxycholate.
Chavanet, P, Joly, V, Rigaud, D, Bolard, J, Carbon, C, Yeni, P
The effects of pre- and postprandial levels of lipids in serum on the experimental in vivo and in vitro toxicities of amphotericin B deoxycholate (AmB-d) were studied. Normal OF1 mice were tested at...
Mohler, J, Fantin, B, Mainardi, J L, Carbon, C
The kinetics of tumor necrosis factor (TNF) levels in serum during therapy with cell wall-active agents (ceftriaxone, imipenem) and gentamicin were investigated in rabbits with experimental...
Joly, V, Bolard, J, Saint-Julien, L, Carbon, C, Yeni, P
We studied the influence of the lipid/amphotericin B (AMB) ratio and the phospholipid type on the in vitro renal cell toxicity and antifungal efficacy of lipid-associated AMB (L-AMB). L-AMB was...
Carbon, C, Léophonte, P, Petitpretz, P, Chauvin, J P, Hazebroucq, J
Temafloxacin, a new fluoroquinolone, was compared with amoxicillin in the treatment of adult hospitalized patients with community-acquired pneumonia. In this double-blind, multicenter study, patients...
Mentec, H, Vallois, J M, Bure, A, Saleh-Mghir, A, Jehl, F, Carbon, C
The efficacy of tazobactam, a beta-lactamase inhibitor, in combination with piperacillin, was studied in vitro and in rabbit experimental endocarditis due to a Klebsiella pneumoniae strain (KpR)...
Fantin, B, Leclercq, R, Duval, J, Carbon, C
The usefulness of fusidic acid, alone or combined with vancomycin, was investigated for the therapy of experimental endocarditis caused in rabbits by a methicillin-resistant strain of Staphylococcus...
Endotoxin-tobramycin additive toxicity on renal proximal tubular cells in culture.
Joly, V, Bergeron, Y, Bergeron, M G, Carbon, C
Aminoglycoside-induced renal damage is enhanced in animals with Escherichia coli pyelonephritis. Bacterial endotoxin is liberated during antibiotic therapy. The toxic effect of endotoxin and...
Longuet, P, Joly, V, Amirault, P, Seta, N, Carbon, C, Yeni, P
Amphotericin B (AMB), either alone or incorporated into small unilamellar vesicles of pure dipalmitoylphosphatidyl choline (DPPC SUV-AMB), was administered intravenously to male Sprague-Dawley rats...
Fantin, B, Leclercq, R, Arthur, M, Duval, J, Carbon, C
Emergence of vancomycin-resistant strains among enterococci raises a new clinical challenge. Rabbits with aortic endocarditis were infected with Enterococcus faecium BM4172, a clinical strain...
Potel, G, Chau, N P, Pangon, B, Fantin, B, Vallois, J M, Faurisson, F, ...
The relative importance of pharmacokinetic and pharmacodynamic parameters for the feasibility of a single daily dose (SDD) of antibiotics remains to be established. Therefore, we studied the...
Cremieux, A C, Saleh-Mghir, A, Vallois, J M, Maziere, B, Muffat-Joly, M, Devine, C, ...
Temafloxacin, a new fluoroquinolone, alone or in combination with tobramycin, was compared with penicillin, tobramycin, and their combination in the therapy of rabbits with endocarditis caused by...
Caron, F, Kitzis, M D, Gutmann, L, Cremieux, A C, Maziere, B, Vallois, J M, ...
Using an experimental endocarditis model, we studied the activity of daptomycin used alone or in combination with gentamicin against an Enterococcus faecium strain that was highly resistant to...
Saint-Julien, L, Joly, V, Seman, M, Carbon, C, Yeni, P
The in vitro and in vivo toxicities and activities of MS-8209, a new hydrosoluble amphotericin B (deoxycholate-amphotericin B [D-AmB]; Fungizone) derivative, were studied. In vitro, MS-8209 was less...
Dromer, F, Salamero, J, Contrepois, A, Carbon, C, Yeni, P
Two monoclonal immunoglobulin G1 antibodies reacting with Cryptococcus neoformans capsular polysaccharide (CNPS) were produced in mice by using a carefully defined procedure for immunization with...
Dromer, F, Charreire, J, Contrepois, A, Carbon, C, Yeni, P
Humoral immunity does not play a prominent role during experimental cryptococcosis. However, previous studies have shown that immunoglobulin G (IgG) anti-Cryptococcus neoformans antibodies can...
Saleh-Mghir, A, Cremieux, A C, Vallois, J M, Muffat-Joly, M, Devine, C, Carbon, C
The combination of penicillin and aminoglycoside is the recommended therapy for endocarditis caused by nutritionally variant streptococci (NVS). However, the optimal aminoglycoside dosing regimen...
Duverne, C, Bouten, A, Deslandes, A, Westphal, J F, Trouvin, J H, Farinotti, R, ...
We studied the action of nifedipine on the bioavailability of cefixime, a molecule absorbed via the gut wall dipeptide carrier system in the rat, and on the bioavailability of D-xylose, which is...
Joly, V, Farinotti, R, Saint-Julien, L, Chéron, M, Carbon, C, Yeni, P
We compared the experimental toxicities and activities of deoxycholate amphotericin B (d-AmB) dissolved in glucose (Dd-AmB) or mixed with 20% Intralipid (ILd-AmB). In vitro, ILd-AmB against renal...
Fantin, B, Leclercq, R, Ottaviani, M, Vallois, J M, Maziere, B, Duval, J, ...
We evaluated the in vivo activity and the diffusion of radiolabelled RP 57669 (RPI) and RP 54476 (RPII), the two components of the injectable streptogramin RP 59500, alone or in combination, in...
Intestinal elimination of ciprofloxacin in rabbits.
Ramon, J, Dautrey, S, Farinoti, R, Carbon, C, Rubinstein, E
The intestinal transepithelial elimination of ciprofloxacin was studied in a rabbit model. Jejunal, ileal, and cecal segments along with their intact blood vessels were isolated and perfused, and...
Carbon, C, Contrepois, A, Lamotte-Barrillon, S
We compared the penetration of five aminoglycosides into interstitial fluid (IF). IF was obtained in rabbits from Silastic tissue cages. Intramuscular injections were made: 1.5 mg/kg per dose for...
Azoulay-Dupuis, E., Rieux, V., Muffat-Joly, M., Bédos, J. P., Vallée, E., Rivier, C., ...
We examined the relationship between penicillin susceptibility, peritoneal virulence in Swiss mice, and capsular type in a selection of 122 clinical Streptococcus pneumoniae isolates belonging to 24...
Dupont, H., Carbon, C., Carlet, J.
In a randomized trial conducted in 35 centers, we compared the clinical efficacy and safety of piperacillin plus tazobactam (TAZ) alone (monotherapy [MT]) versus those of TAZ combined with amikacin...
Join-Lambert, O. F., Michéa-Hamzehpour, M., Köhler, T., Chau, F., Faurisson, F., Dautrey, S., ...
The ability of trovafloxacin and ciprofloxacin to select efflux mutants in vivo was studied in a model of acute Pseudomonas aeruginosa pneumonia in rats. Twelve hours after intratracheal inoculation...
Influence of Renal Failure on Ciprofloxacin Pharmacokinetics in Rats
Nouaille-Degorce, B., Veau, C., Dautrey, S., Tod, M., Laouari, D., Carbon, C., ...
Ciprofloxacin pharmacokinetics have been shown to be modified in patients with renal failure (e.g., the intestinal secretion of ciprofloxacin is increased). This study investigated the influence of...
Plantefeve, G., Dupont, H., Hubert, V., Garry, L., Poüs, C., Carbon, C., ...
The relationship between virulence and chromosomal elements containing glycopeptide resistance genes was experimentally assessed for two transconjugant strains of Enterococcus faecalis (VanA and VanB...
Intestinal elimination of sparfloxacin, fleroxacin, and ciprofloxacin in rats.
Rubinstein, E, Dautrey, S, Farinoti, R, St Julien, L, Ramon, J, Carbon, C
The intestinal transepithelial elimination of sparfloxacin and fleroxacin was compared with that of ciprofloxacin in a rat model following a single parenteral administration of 25 mg of each of the...
Fantin, B, Leclercq, R, Merlé, Y, Saint-Julien, L, Veyrat, C, Duval, J, ...
In order to determine the microbiological and pharmacokinetic parameters that best predicted the in vivo antistaphylococcal activity of the streptogramin RP 59500 (quinupristin-dalfopristin), we...
Verdon, R, Polianski, J, Gaudebout, C, Marche, C, Garry, L, Carbon, C, ...
In the dexamethasone-treated rat model of cryptosporidiosis, paromomycin was effective at a dosage of 50 mg/kg/day or more for ileal infection and 200 mg/kg/day or more for cecal infection. At 1 and...
Vignes, S, Fantin, B, Elbim, C, Walker, F, Gougerot-Pocidalo, M A, Carbon, C
The effect of human recombinant granulocyte colony-stimulating factor (hrG-CSF) in rabbits with aortic endocarditis due to Pseudomonas aeruginosa was investigated. hrG-CSF significantly increased the...
Excretion of ciprofloxacin into the large bowel of the rabbit.
Ramon, J, Dautrey, S, Farinoti, R, Carbon, C, Rubinstein, E
The intestinal elimination of ciprofloxacin in the large bowel was studied in a rabbit model. Segments from the cecum, colon, and sigmoid colon along with their intact blood vessels were isolated and...
Chemlal, K, Saint-Julien, L, Joly, V, Farinotti, R, Seta, N, Yeni, P, ...
Amphotericin B (AmB) and fluconazole, administered intraperitoneally for 7 days, were compared in a rabbit model for Candida albicans endocarditis. When given early, AmB was more effective than...
Fantin, B, Pierre, J, Castéla-Papin, N, Saint-Julien, L, Drugeon, H, Farinotti, R, ...
The activity of penicillin, alone and in combination with sulbactam, against a heterogeneously methicillin-resistant, penicillinase-producing clinical isolate of Staphylococcus aureus and its...
Barry, B, Muffat-Joly, M, Bauchet, J, Faurisson, F, Gehanno, P, Pocidalo, J J, ...
We used a gerbil model of otitis media to assess the efficacy of single-dose ceftriaxone against three Streptococcus pneumoniae strains highly resistant to penicillin (MICs, 4 to 8 micrograms/ml) and...
Crémieux, A C, Mghir, A S, Bleton, R, Manteau, M, Belmatoug, N, Massias, L, ...
Using a new rabbit model of methicillin-susceptible Staphylococcus aureus knee prosthesis infection, we compared the efficacies of sparfloxacin (50 mg/kg of body weight subcutaneously, twice a day)...
Intestinal elimination of ofloxacin enantiomers in the rat: evidence of a carrier-mediated process.
Rabbaa, L, Dautrey, S, Colas-Linhart, N, Carbon, C, Farinotti, R
The aim of this work was to examine the mechanism involved in intestinal elimination of the two optical isomers of ofloxacin in the rat. An intestinal segment was isolated in situ and perfused with...
Darras-Joly, C, Bédos, J P, Sauve, C, Moine, P, Vallée, E, Carbon, C, ...
In vivo synergy with beta-lactam antibiotics and aminoglycosides has been studied only with penicillin-susceptible Streptococcus pneumoniae strains. We evaluated the interaction between amoxicillin...
Sauve, C, Azoulay-Dupuis, E, Moine, P, Darras-Joly, C, Rieux, V, Carbon, C, ...
We previously demonstrated the efficacy of ceftriaxone (CRO), at 50 mg/kg of body weight every 12 h, against a highly penicillin-resistant (MIC, 4 micrograms/ml) Streptococcus pneumoniae strain with...
Caulin, E, Coutrot, A, Carbon, C, Collatz, E
The effect of production of the aminoglycoside 6'-N-acetyltransferase [AAC(6')-IB] in Klebsiella pneumoniae on the outcome of amikacin and isepamicin treatment of rabbits with experimental...
Deslandes, A, Camus, F, Lacroix, C, Carbon, C, Farinotti, R
We compared the effects of nifedipine and diltiazem on the uptake of cefpodoxime proxetil (CP). The study was aimed at establishing the impact of increased mesenteric blood flow due to calcium...
Joly-Guillou, M L, Wolff, M, Pocidalo, J J, Walker, F, Carbon, C
Acinetobacter baumannii is responsible for severe nosocomial pneumonia. To evaluate new therapeutic regimens for infections due to multiresistant strains and to study the pharmacodynamic properties...
Fantin, B, Leclercq, R, Garry, L, Carbon, C
The influence of inducible cross-resistance to macrolides, lincosamides, and streptogramin B (MLS(B)) type antibiotics (inducible MLS(B) phenotype) on the activity of quinupristin-dalfopristin was...
Absorption of ofloxacin isomers in the rat small intestine.
Rabbaa, L, Dautrey, S, Colas-Linhart, N, Carbon, C, Farinotti, R
Ofloxacin, a chiral fluoroquinolone, possesses two optical isomers. The antibacterial activity of S-(-)-ofloxacin is 8 to 128 times higher than that of R-(+)-ofloxacin. In the rat, a saturable...
We evaluated the effect of repeated oral doses (5 days of treatment) on the kinetics of lomefloxacin in volunteers and compared the kinetics after two different regimens, i.e., 400 mg once daily and...
Fantin, B, Pangon, B, Potel, G, Caron, F, Vallée, E, Vallois, J M, ...
We studied the efficacy of sulbactam, a beta-lactamase inhibitor, in combination with ceftriaxone in vitro and in experimental endocarditis due to an Escherichia coli strain producing an...
Caron, F, Gutmann, L, Bure, A, Pangon, B, Vallois, J M, Pechinot, A, ...
We studied the activity of the combination of sulbactam and ceftriaxone against a Klebsiella pneumoniae strain producing TEM-3, a new extended-broad-spectrum beta-lactamase, in an endocarditis model....
The penicillin-aminoglycoside combination is recommended for the treatment of systemic enterococcal infections. However, the optimal dosing regimen of the aminoglycoside remains to be elucidated. We...
Fantin, B, Pangon, B, Potel, G, Vallois, J M, Caron, F, Bure, A, ...
We evaluated the activities of ceftriaxone (15 mg/kg), netilmicin (6 mg/kg), and their combination given intramuscularly once daily for 4 days for the treatment of experimental Escherichia coli...
Reduction in biliary excretion of ceftriaxone by diclofenac in rabbits.
Merle-Melet, M, Seta, N, Farinotti, R, Carbon, C
The effects of diclofenac, a nonsteroidal anti-inflammatory drug, on biliary excretion of ceftriaxone were evaluated in rabbits. In a previous study, we demonstrated that diclofenac increased the...
Evidence of the proinflammatory role of Enterococcus faecalis in polymicrobial peritonitis in rats.
Montravers, P, Mohler, J, Saint Julien, L, Carbon, C
Although the role of members of the Enterobacteriaceae and anaerobes in the pathogenesis of intra-abdominal infections has been extensively demonstrated, the role played by enterococci in these...
Pangon, B, Joly, V, Vallois, J M, Abel, L, Buré, A, Brion, N, ...
To determine the influence of in vitro activity, pharmacokinetic properties, and therapeutic regimen on the antibacterial effect in vivo, we compared three cephalosporins, cefotiam, cefmenoxime, and...
Alteration of gentamicin and cefazolin kinetics with control of the hypothyroid state in humans.
Chanson, P, Joly, V, Contrepois, A, Garaud, J J, Bauchet, J, Mohler, J, ...
We studied the effect of the control of the hypothyroid state in humans on the pharmacokinetic parameters of cefazolin and gentamicin after a single intravenous injection. These two antibiotics were...
Joly, V, Pangon, B, Vallois, J M, Abel, L, Brion, N, Bure, A, ...
In a rabbit model of Escherichia coli endocarditis, we studied the penetration into infected vegetations and the antibacterial effect of ceftriaxone. Ceftriaxone was given at different dosages, alone...
Pharmacokinetics of ofloxacin after single and multiple intravenous infusions in healthy subjects.
Farinotti, R, Trouvin, J H, Bocquet, V, Vermerie, N, Carbon, C
The pharmacokinetics of ofloxacin were investigated in eight healthy male volunteers. A single infusion (200 mg over 0.5 h) was performed on day 1, followed by a washout period of 2 weeks. Repeated...
Carbon, C, Dromer, F, Brion, N, Cremieux, A C, Contrepois, A
Excretion of ceftazidime (C), a new cephalosporin antibiotic, has been reported to occur unexpectedly through glomerular filtration only, without being significantly affected by probenecid. We...
Bouvet, A, Cremieux, A C, Contrepois, A, Vallois, J M, Lamesch, C, Carbon, C
Six different antibiotic treatment regimens were compared for efficacy in rabbits with endocarditis induced by inoculation with a nutritionally variant strain of streptococcus. Seven untreated...
Renal disposition of gentamicin, dibekacin, tobramycin, netilmicin, and amikacin in humans.
Contrepois, A, Brion, N, Garaud, J J, Faurisson, F, Delatour, F, Levy, J C, ...
The tubular disposition of five aminoglycosides was studied in humans to establish a possible relationship between tubular reabsorption and the nephrotoxicity that has been described in the...
Effects of urinary pH on renal interactions between probenecid and cefsulodin in rabbits.
Dromer, F, Contrepois, A, Brion, N, Klein, C, Carbon, C
The effect of urinary pH on renal interaction of cefsulodin and probenecid was tested in rabbits. Probenecid was reabsorbed in acidic urine (fractional excretion [FE] = 8 +/- 4%) and secreted in...
Brion, N, Barge, J, Godefroy, I, Dromer, F, Dubois, C, Contrepois, A, ...
The role of the tubular reabsorption of aminoglycosides in nephrotoxicity was considered. The tubular reabsorption rate, fractional reabsorption, and net balance, expressed as the excreted to infused...
Effects of furosemide, piretanide, and water loading on urinary excretion of cefazolin in humans.
Morgant, C, Contrepois, A, Chau, N P, Romaru, A, Fourtillan, J B, Carbon, C
Antibiotics and diuretics are often prescribed concomitantly for humans. We compared the effects of two potent loop diuretics, furosemide and piretanide, with those of water loading on the urinary...
Effects of diltiazem on netilmicin-induced nephrotoxicity in rabbits.
Lortholary, O, Blanchet, F, Nochy, D, Heudes, D, Seta, N, Amirault, P, ...
Aminoglycoside nephrotoxicity remains a common clinical problem and is the major cause of acute toxic renal failure in hospitalized patients. In recent studies, calcium channel blockers gave...
Dextranase enhances antibiotic efficacy in experimental viridans streptococcal endocarditis.
Mghir, A S, Cremieux, A C, Jambou, R, Muffat-Joly, M, Pocidalo, J J, Carbon, C
In endocarditis, exopolysaccharide production by viridans streptococci has been associated with delayed antimicrobial efficacy in cardiac vegetations. We compared the efficacies of temafloxacin alone...
Influence of diet on experimental toxicity of amphotericin B deoxycholate.
Chavanet, P, Joly, V, Rigaud, D, Bolard, J, Carbon, C, Yeni, P
The effects of pre- and postprandial levels of lipids in serum on the experimental in vivo and in vitro toxicities of amphotericin B deoxycholate (AmB-d) were studied. Normal OF1 mice were tested at...
Mohler, J, Fantin, B, Mainardi, J L, Carbon, C
The kinetics of tumor necrosis factor (TNF) levels in serum during therapy with cell wall-active agents (ceftriaxone, imipenem) and gentamicin were investigated in rabbits with experimental...
Joly, V, Bolard, J, Saint-Julien, L, Carbon, C, Yeni, P
We studied the influence of the lipid/amphotericin B (AMB) ratio and the phospholipid type on the in vitro renal cell toxicity and antifungal efficacy of lipid-associated AMB (L-AMB). L-AMB was...
Carbon, C, Léophonte, P, Petitpretz, P, Chauvin, J P, Hazebroucq, J
Temafloxacin, a new fluoroquinolone, was compared with amoxicillin in the treatment of adult hospitalized patients with community-acquired pneumonia. In this double-blind, multicenter study, patients...
Mentec, H, Vallois, J M, Bure, A, Saleh-Mghir, A, Jehl, F, Carbon, C
The efficacy of tazobactam, a beta-lactamase inhibitor, in combination with piperacillin, was studied in vitro and in rabbit experimental endocarditis due to a Klebsiella pneumoniae strain (KpR)...
Fantin, B, Leclercq, R, Duval, J, Carbon, C
The usefulness of fusidic acid, alone or combined with vancomycin, was investigated for the therapy of experimental endocarditis caused in rabbits by a methicillin-resistant strain of Staphylococcus...
Endotoxin-tobramycin additive toxicity on renal proximal tubular cells in culture.
Joly, V, Bergeron, Y, Bergeron, M G, Carbon, C
Aminoglycoside-induced renal damage is enhanced in animals with Escherichia coli pyelonephritis. Bacterial endotoxin is liberated during antibiotic therapy. The toxic effect of endotoxin and...
Longuet, P, Joly, V, Amirault, P, Seta, N, Carbon, C, Yeni, P
Amphotericin B (AMB), either alone or incorporated into small unilamellar vesicles of pure dipalmitoylphosphatidyl choline (DPPC SUV-AMB), was administered intravenously to male Sprague-Dawley rats...
Fantin, B, Leclercq, R, Arthur, M, Duval, J, Carbon, C
Emergence of vancomycin-resistant strains among enterococci raises a new clinical challenge. Rabbits with aortic endocarditis were infected with Enterococcus faecium BM4172, a clinical strain...
Potel, G, Chau, N P, Pangon, B, Fantin, B, Vallois, J M, Faurisson, F, ...
The relative importance of pharmacokinetic and pharmacodynamic parameters for the feasibility of a single daily dose (SDD) of antibiotics remains to be established. Therefore, we studied the...
Cremieux, A C, Saleh-Mghir, A, Vallois, J M, Maziere, B, Muffat-Joly, M, Devine, C, ...
Temafloxacin, a new fluoroquinolone, alone or in combination with tobramycin, was compared with penicillin, tobramycin, and their combination in the therapy of rabbits with endocarditis caused by...
Caron, F, Kitzis, M D, Gutmann, L, Cremieux, A C, Maziere, B, Vallois, J M, ...
Using an experimental endocarditis model, we studied the activity of daptomycin used alone or in combination with gentamicin against an Enterococcus faecium strain that was highly resistant to...
Saint-Julien, L, Joly, V, Seman, M, Carbon, C, Yeni, P
The in vitro and in vivo toxicities and activities of MS-8209, a new hydrosoluble amphotericin B (deoxycholate-amphotericin B [D-AmB]; Fungizone) derivative, were studied. In vitro, MS-8209 was less...
Dromer, F, Salamero, J, Contrepois, A, Carbon, C, Yeni, P
Two monoclonal immunoglobulin G1 antibodies reacting with Cryptococcus neoformans capsular polysaccharide (CNPS) were produced in mice by using a carefully defined procedure for immunization with...
Dromer, F, Charreire, J, Contrepois, A, Carbon, C, Yeni, P
Humoral immunity does not play a prominent role during experimental cryptococcosis. However, previous studies have shown that immunoglobulin G (IgG) anti-Cryptococcus neoformans antibodies can...
Saleh-Mghir, A, Cremieux, A C, Vallois, J M, Muffat-Joly, M, Devine, C, Carbon, C
The combination of penicillin and aminoglycoside is the recommended therapy for endocarditis caused by nutritionally variant streptococci (NVS). However, the optimal aminoglycoside dosing regimen...
Duverne, C, Bouten, A, Deslandes, A, Westphal, J F, Trouvin, J H, Farinotti, R, ...
We studied the action of nifedipine on the bioavailability of cefixime, a molecule absorbed via the gut wall dipeptide carrier system in the rat, and on the bioavailability of D-xylose, which is...
Joly, V, Farinotti, R, Saint-Julien, L, Chéron, M, Carbon, C, Yeni, P
We compared the experimental toxicities and activities of deoxycholate amphotericin B (d-AmB) dissolved in glucose (Dd-AmB) or mixed with 20% Intralipid (ILd-AmB). In vitro, ILd-AmB against renal...
Fantin, B, Leclercq, R, Ottaviani, M, Vallois, J M, Maziere, B, Duval, J, ...
We evaluated the in vivo activity and the diffusion of radiolabelled RP 57669 (RPI) and RP 54476 (RPII), the two components of the injectable streptogramin RP 59500, alone or in combination, in...
Intestinal elimination of ciprofloxacin in rabbits.
Ramon, J, Dautrey, S, Farinoti, R, Carbon, C, Rubinstein, E
The intestinal transepithelial elimination of ciprofloxacin was studied in a rabbit model. Jejunal, ileal, and cecal segments along with their intact blood vessels were isolated and perfused, and...
Carbon, C, Contrepois, A, Lamotte-Barrillon, S
We compared the penetration of five aminoglycosides into interstitial fluid (IF). IF was obtained in rabbits from Silastic tissue cages. Intramuscular injections were made: 1.5 mg/kg per dose for...
Active intestinal elimination of ciprofloxacin in rats: modulation by different substrates
Dautrey, S, Felice, K, Petiet, A, Lacour, B, Carbon, C, Farinotti, R
Two in vivo models, in the rat, were used to investigate, in the presence of different substrates, the overall and net intestinal elimination of ciprofloxacin: an open-intestinal perfusion model and...
LACROIX, C, CHAU, F, CARBON, C, SINET, M, DEROUIN, F
We studied susceptibility to experimental systemic cryptococcosis in mice previously infected with the retroviral complex LP-BM5 (responsible for murine AIDS). LP-BM5 was inoculated to C57B1/6 mice...