Climate Dynamics �2002) 18: 403±420 DOI 10.1007/s00382-001-0188-6 (2009)
M. K. Davey, M. Huddleston, K. R. Sperber, P. Braconnot, F. Bryan, D. Chen, ...
STOIC: a study of coupled model climatology and variability in tropical ocean regions
The Global Longitudinal Study of Osteoporosis in Women (GLOW): rationale and study design (2009)
Hooven, F.H., Adachi, J.D., Adami, S., Boonen, S., Compston, J., Cooper, C., ...
Summary: the Global Longitudinal study of Osteoporosis in Women (GLOW) is a prospective cohort study involving 723 physicians and 60,393 women subjects ≥55 years. The data will provide insights...
Health researchers' attitudes towards public involvement in health research (2009)
Thompson, J., Barber, R., Ward, P.R., Boote, J., Cooper, C., Armitage, C.J., ...
Objective: To investigate health researchers' attitudes to involving the public in research. Background: Public involvement in research is encouraged by the Department of Health in the UK. Despite...
Knowledge transfer in a tourism destination: the effects of a network structure (2009)
Tourism destinations have a necessity to innovate to remain competitive in an increasingly global environment. A pre-requisite for innovation is the understanding of how destinations source, share...
Baird, J., Cooper, C., Margetts, B.M., Barker, M., Inskip, H.M.
Observational evidence suggests that improving the diets of women of child-bearing age from disadvantaged backgrounds might be an important component of public health strategies aimed at reducing the...
Long-term outcome following total knee arthroplasty: a controlled longitudinal study (2009)
Cushnaghan, J., Bennett, J., Reading, I., Croft, P., Byng, P., Cox, K., ...
Objectives: to assess long-term outcome and predictors of prognosis following total knee arthroplasty (TKA) for osteoarthritis. Methods: we followed-up 325 patients from 3 English health districts...
Abdin-Mohamed, M., Jameson, K., Dennison, E.M., Cooper, C., Arden, N.K.
Objectives: radiographic osteoarthritis (ROA) has previously been shown to be associated with an increase in areal bone mineral density (BMD) as assessed by dual energy X-ray absorptiometry (DXA)....
Cranney, A., Wells, G.A., Yetisir, L., Adami, S., Cooper, C., Delmas, P.D., ...
Summary: this analysis was conducted to assess the effect of high versus lower doses of ibandronate on nonvertebral fractures. The results were adjusted for clinical fracture, age, and bone density....
Abdin-Mohamed, M., Jameson, K., Dennison, E.M, Cooper, C., Arden, N.K.
Objectives: Radiographic osteoarthritis (ROA) has previously been shown to be associated with an increase in areal bone mineral density (BMD) as assessed by dual energy X-ray absorptiometry (DXA)....
Background. Penetrating chest trauma is a leading cause of admission to South African emergency departments. The resultant pneumo-/haemothoraces are currently routinely treated by means of standard...
The SF-36: a simple, effective measure of mobility-disability for epidemiological studies (2009)
Syddall, H.E, Martin, H.J., Harwood, R.H., Cooper, C., Aihie Sayer, A.
Developmental origins of osteoporosis: the role of maternal nutrition (2009)
Cooper, C., Harvey, N., Cole, Z., Hanson, M., Dennison, E.
Osteoporosis is a major cause of morbidity and mortality through its association with age-related fractures. Although most effort in fracture prevention has been directed at retarding the rate of...
Common variants at only two loci, FTO and MC4R, have been reproducibly associated with body mass index (BMI) in humans. To identify additional loci, we conducted meta-analysis of 15 genome-wide...
The SF-36: a simple, effective measure of mobility disability for epidemiological studies (2009)
Syddall, H.E., Martin, H.J., Harwood, R.H., Cooper, C., Aihie Sayer, A.
Background Mobility disability is a major problem in older people. Numerous scales exist for the measurement of disability but often these do not permit comparisons between study groups. The physical...
Cranney, A, Wells, G A, Yetisir, E, Adami, S, Cooper, C, Delmas, P D, ...
SUMMARY: This analysis was conducted to assess the effect of high versus lower doses of ibandronate on nonvertebral fractures. The results were adjusted for clinical fracture, age, and bone density....
Developmental origins of osteoporotic fracture (2009)
Cooper, C., Westlake, S., Harvey, N., Dennison, E.
Osteoporosis is a skeletal disorder characterised by low bone mass and micro-architectural deterioration of bone tissue with a consequent increase in bone fragility and susceptibility to fracture.1...
Martin, H.J., Syddall, H.E., Dennison, E.M., Cooper, C., Sayer, A.A.
Background: reduced physical performance and physical activity have serious health consequences, but adult determinants do not fully explain variation in older people. Objective: our objective was to...
Adams, J., Burridge, J., Mullee, M., Hammond, A., Cooper, C.
Objective. To evaluate the effectiveness of static resting splints in early RA. Methods. A multicentre, randomized, trial was conducted. Patients (n = 120) received either static resting splints...
Early nutritional compromise affects the mechanical properties of sheep spines (2008)
Pollintine, P., Barrett, G.W., Millais, I.E., Green, L.R., Cooper, C., Lanham, S.A., ...
The influence of early nutritional compromise on bone structure and strength (2008)
Pollintine, P., Cooper, I., Anderson, H.L., Green, L.R., Cooper, C., Lanham, S.A., ...
The degree distribution of the generalized duplication (2008)
G. Bebek, P. Berenbrink, C. Cooper, T. Friedetzky, J. H. Nadeau, S. C. Sahinalp
model
The degree distribution of the generalized duplication (2008)
G. Bebek, P. Berenbrink, C. Cooper, T. Friedetzky, J. Nadeau, S. C. Sahinalp
model
Individualizing the risks and benefits of postmenopausal hormone therapy (2008)
Staa, T.P. Van, Cooper, C., Barlow, D., Leufkens, H.G.M.
Objective: The objective was to develop an individualized risk-benefit model quantifying the impact of combined use of estrogen and progestogen on chronic diseases. Design: The study population...
Destination networks: Four Australian cases (2008)
Scott, N., Cooper, C., Baggio, R.
Tourism involves a network of organizations interacting to produce a service. This paper examines the structural properties of interorganizational networks within destinations. Network analysis...
Defining knowledge management (KM) activities: Towards consensus (2008)
Purpose – The purpose of the paper is to present a vocabulary of terms that clearly define knowledge management (KM) activities in order to move towards consensus in the adoption of a common...
Edwards, C.J., Syddall, H., Jameson, K., Williams, E.L., Polosa, R., Goswami, R., ...
Objectives: There has been limited success defining environmental factors important in the development of antiphospholipid (Hughes) syndrome (APS). Recent work suggests that the perinatal environment...
European guidance for the diagnosis and management of osteoporosis in postmenopausal women. (2008)
Kanis, J A, Burlet, N, Cooper, C, Delmas, P D, Reginster, Jean-Yves, Borgstrom, F, ...
SUMMARY: Guidance is provided in a European setting on the assessment and treatment of postmenopausal women with or at risk from osteoporosis. INTRODUCTION: The European Foundation for Osteoporosis...
Adams, J., Burridge, J., Mullee, M., Hammond, A., Cooper, C.
Objective. To evaluate the effectiveness of static resting splints in early RA. Methods. A multicentre, randomized, trial was conducted. Patients (n = 120) received either static resting splints...
Involving consumers successfully in NHS research: a national survey (2007)
Barber, R., Boote, J., Cooper, C.
Objectives: To investigate how far and in what way consumers are involved in NHS research. Background: There is guidance from the UK Department of Health on involving consumers in research, but it is...
Generating and Counting Large Binary Flowgraphs (2007)
In a previous paper ([5]) we considered unlabelled owgraphs for a model of binary logic without the constraints of structured programming. The number of such owgraphs is asymptotic to (3:4n) n=2,...
Grip strength and the metabolic syndrome: findings from the Hertfordshire Cohort Study (2007)
Sayer, A.A., Syddall, H.E., Dennison, E.M., Martin, H.J., Phillips, D.I.W., Cooper, C., ...
Introduction: Sarcopenia, the loss of muscle mass and strength with age, is significantly associated with type 2 diabetes in older people. Aim: To determine whether there is a relationship between...
Anxiety and panic fear in adults with asthma: prevalence in primary care (2007)
Cooper, C., Parry, G., Saul, C., Morice, A., Hutchcroft, B., Moore, J., ...
BACKGROUND: Patients may find it difficult to distinguish between the symptoms of anxiety and those of asthma. Findings are equivocal on whether there is a specific link between anxiety and asthma....
Lipid profile, obesity and bone mineral density: the Hertfordshire Cohort Study (2007)
Dennison, E.M., Syddall, H.E., Aihie Sayer, A., Martin, H.J., Cooper, C.
Background: Body mass index (BMI) and bone mineral density (BMD) are positively correlated in several studies, but few data relate bone density, lipid profile and anthropometric measures. Aim: To...
Liu, B., Balkwill, A., Banks, E., Cooper, C., Green, J., Beral, V., ...
Objectives. To examine the effect of height, weight and body mass index (BMI) on the risk of hip and knee replacement in middle-aged women. Methods. In a prospective cohort study 490 532 women aged...
Livingston, G., Walker, A.E., Katona, C.L.E., Cooper, C.
Objective: To investigate in a longitudinal cohort of people with Alzheimer’s disease whether taking antipsychotics is associated with more rapid cognitive deterioration. Method: From a sample of...
Livingston, G., Walker, A.E., Katona, C.L.E., Cooper, C.
Objective: To investigate in a longitudinal cohort of people with Alzheimer’s disease whether taking antipsychotics is associated with more rapid cognitive deterioration. Method: From a sample of...
Use of beta-2 agonists and risk of hip/femur fracture: a population-based case-control study (2007)
Vries, F. De, Pouwels, S., Bracke, M., Leufkens, H.G.M., Cooper, C., Lammers, J.W.J., ...
Introduction Administration of beta-2 agonists decreased bone mineral density in rats. But the association between bronchodilators and fracture risk has not been studied in humans. Objectives To...
Vries, F. De, Pouwels, S., Lammers, J.W.J., Leufkens, H.G.M., Bracke, M., Cooper, C., ...
Background. Patients using higher dosages of inhaled or oral glucocorticoids (GCs) have an increased risk of hip/femur fractures. The role of the underlying disease in the aetiology of this increased...
Fracture Risk With Intermittent High-Dose Oral Glucocorticoid Therapy (2007)
Vries, F. De, Bracke, M., Leufkens, H.G.M., Lammers, J.W.J., Cooper, C., Staa, T.P. Van
Objective. To evaluate the risk of fracture in patients receiving intermittent therapy with high-dose oral glucocorticoids (GCs). Methods. The study group comprised 191,752 patients from the UK...
Staa, T.P. Van, Geusens, P., Boonen, A., Leufkens, H.G.M., Cooper, C.
Objectives. There are few data on the cost-effectiveness of bisphosphonates with oral glucocorticoids (GCs). An individual patient-based pharmaco-economic model was developed. Methods. Data were...
Kanis, J.A., Oden, A., Johnell, O., Johansson, H., Laet, C. De, Brown, J., ...
BMD and clinical risk factors predict hip and other osteoporotic fractures. The combination of clinical risk factors and BMD provide higher specificity and sensitivity than either alone. Introduction...
Edwards, C.J., Cooper, C., Fisher, D., Field, M., Staa, T.P. Van, Arden, N.K.
Objective. To evaluate the effect of disease-modifying antirheumatic drugs (DMARDs) on the likelihood of patients with rheumatoid arthritis (RA) developing septic arthritis (SA). Methods. The United...
Lithium use and the risk of fractures (2007)
Wilting, I., Vries, F. De, Cooper, C., Heerdink, E.R., Leufkens, H.G.M., ...
A recent study reported a decreased risk of fractures among lithium users. We conducted a case–control study within the UK General Practice Research Database, comparing never, ever, current, recent...
Prison privatisation in Scotland (2007)
The Scottish Parliament recently considered proposals, which, if implemented, would lead to a considerable expansion of prison privatization. Both the Scottish Prison Service and the Scottish...
A spatial web graph model with local influence regions (2007)
W. Aiello, A. Bonato, C. Cooper, J. Janssen
regions
Smith, H., Anderson, F., Raphael, H., Maslin, P., Crozier, S., Cooper, C.
Objectives. Low trauma fractures in older people incur enormous physical, social and economic costs. Previous research indicates that an annual intramuscular injection of vitamin D may reduce...
Van Staa, T. P., Geusens, P., Zhang, B., Leufkens, H. G. M., Boonen, A., Cooper, C.
Objectives. There are few data on the cost-effectiveness of bisphosphonates with oral glucocorticoids (GCs). An individual patient-based pharmaco-economic model was developed. Methods. Data were...
Singing synthesis with an evolved physical model (2006)
Cooper, C., Murphy, D.T., Howard, D., Tyrrell, A.
A two-dimensional physical model of the human vocal tract is described. Such a system promises increased realism and control in the synthesis of both speech and singing. However, the parameters...
Intrauterine programming of skeletal development: a longitudinal study (2006)
Lanham, S., Roberts, C., Perry, M.J., Cooper, C., Oreffo, R.O.C.
Singing synthesis with an evolved physical model (2006)
Cooper, C., Murphy, D., Howard, D., Tyrrell, A.
A two-dimensional physical model of the human vocal tract is described. Such a system promises increased realism and control in the synthesis of both speech and singing. However, the parameters...
Carrivick, L., Rogers, S., Clark, J., Campbell, C., Girolami, M., Cooper, C.
We apply a new Bayesian data analysis technique (Latent Process Decomposition) to four recent microarray datasets for breast cancer. Compared to hierarchical cluster analysis, for example, this...
Carrivick, L., Rogers, S., Clark, J., Campbell, C., Girolami, M., Cooper, C.
We apply a new Bayesian data analysis technique (Latent Process Decomposition) to four recent microarray datasets for breast cancer. Compared to hierarchical cluster analysis, for example, this...
Bischoff-Ferrari, H A, Cooper, C, Lips, P, Ljunggren, O, Meunier, P J, ...
Osteoporotic fractures are an extremely common and serious health problem in the elderly. This article presents the rationale for calcium and vitamin D supplementation in the prevention and treatment...
Boonen, S, Bischoff-Ferrari, HA, Cooper, C, Lips, P, Ljunggren, O, Meunier, PJ, ...
Osteoporotic fractures are an extremely common and serious health problem in the elderly. This article presents the rationale for calcium and vitamin D supplementation in the prevention and treatment...
Reginster, Jean-Yves, Adami, S, Lakatos, P, Greenwald, M, Stepan, JJ, Silverman, SL, ...
BACKGROUND: Reducing bisphosphonate dosing frequency may improve suboptimal adherence to treatment and therefore therapeutic outcomes in postmenopausal osteoporosis. Once-monthly oral ibandronate has...
Boote, J., Barber, R., Cooper, C.
Consumer involvement in NHS research is Department of Health policy within the UK. Despite the existence of policy directives and guidance, until recently there has been no consensus among consumers...
Reginster, Jean-Yves, Felsenberg, D, Cooper, C, Stakkestad, JA, Miller, PD, Kendler, DL, ...
Oral daily and weekly bisphosphonates represent the current mainstay of treatment for postmenopausal osteoporosis (PMO). However, the inconvenience of frequent dosing is known to negatively affect...
Armbrecht, G, Felsenberg, D, Lunt, M, Weber, K, ...
INTRODUCTION: Vertebral fracture is a strong risk factor for future spine and hip fractures; yet recent data suggest that only 5-20% of subjects with a spine fracture are identified in primary care....
Staa, T.P. Van, Geusens, P., Kanis, J.A., Leufkens, H.G.M., Gehlbach, S., Cooper, C.
Background: Simple tools are needed to identify patients at high risk of fracture. Aim: To develop a simple clinical tool for assessing 5-year risk of fracture. Design: Cohort study. Methods: The...
Vries, F. De, Vries, C. De, Cooper, C., Leufkens, H.G.M., Staa, T.P. Van
Background: Two recent case–control studies by Meier et al. and van Staa et al. used the UK General Practice Research Database (GPRD) to examine the association between the use of statins and the...
Clinical assessment of the long-term risk of fracture in patients with rheumatoid arthritis. (2006)
Staa, T.P. Van, Geusens, P., Bijlsma, J.W.J., Leufkens, H.G.M., Cooper, C.
Objective. To determine whether patients with rheumatoid arthritis (RA) have an increased risk of fracture, and to estimate their long-term absolute fracture risk. Methods. We studied patients with...
Knowledge management and tourism (2006)
The study and practice of knowledge management has grown rapidly since the 90s, driven by social, economic, and technological trends. Tourism has been slow in adopting this app oach due to not only a...
Costello, P., Rowlerson, A., Braddick, L., Burrage, D., Cooper, C., Hanson, M.A., ...
Epidemiological studies have shown that small size at birth is associated with reduced muscle strength (Sayer et al. 2004) and type 2 diabetes (Hales et al. 1991) in adulthood. In sheep, reduced...
Reid, D. M., Mackay, I., Wilkinson, S., Miller, C., Schuette, D. G., Compston, J., ...
Osteoporosis is a common disease with a strong genetic component characterized by reduced bone mass and an increased risk of fragility fractures. Bone mineral density (BMD) is the most important...
Van Staa, T. P., Geusens, P., Zhang, B., Leufkens, H. G. M., Boonen, A., Cooper, C.
Objectives. There are few data on the cost-effectiveness of bisphosphonates with oral glucocorticoids (GCs). An individual patient-based pharmaco-economic model was developed. Methods. Data were...
Van Staa, T.P., Geusens, P., Kanis, J.A., Leufkens, H.G.M., Gehlbach, S., Cooper, C.
Background: Simple tools are needed to identify patients at high risk of fracture. Aim: To develop a simple clinical tool for assessing 5-year risk of fracture. Design: Cohort study. Methods: The...
Jakob, F., Marín, F., Martín-Mola, E., Torgerson, D., Fardellone, P., Adami, S., ...
Background: Osteoporotic fractures remain a major public health problem. Currently available osteoporosis therapies significantly reduce the risk of fractures, but up to 50% of patients have an...
Jakob, F., Marín, F., Martín-Mola, E., Torgerson, D., Fardellone, P., Adami, S., ...
Background: Osteoporotic fractures remain a major public health problem. Currently available osteoporosis therapies significantly reduce the risk of fractures, but up to 50% of patients have an...
Van Staa, T.P., Geusens, P., Kanis, J.A., Leufkens, H.G.M., Gehlbach, S., Cooper, C.
Background: Simple tools are needed to identify patients at high risk of fracture. Aim: To develop a simple clinical tool for assessing 5-year risk of fracture. Design: Cohort study. Methods: The...
Does admission grip strength predict length of stay in hospitalised older patients? (2006)
Kerr, A., Syddall, H. E., Cooper, C., Turner, G. F., Briggs, R. S., Sayer, A. Aihie
Van Staa, T. P., Geusens, P., Zhang, B., Leufkens, H. G. M., Boonen, A., Cooper, C.
Objectives. There are few data on the cost-effectiveness of bisphosphonates with oral glucocorticoids (GCs). An individual patient-based pharmaco-economic model was developed. Methods. Data were...
Jakob, F., Marín, F., Martín-Mola, E., Torgerson, D., Fardellone, P., Adami, S., ...
Background: Osteoporotic fractures remain a major public health problem. Currently available osteoporosis therapies significantly reduce the risk of fractures, but up to 50% of patients have an...
Van Staa, T.P., Geusens, P., Kanis, J.A., Leufkens, H.G.M., Gehlbach, S., Cooper, C.
Background: Simple tools are needed to identify patients at high risk of fracture. Aim: To develop a simple clinical tool for assessing 5-year risk of fracture. Design: Cohort study. Methods: The...
Open Overlay Support for the Divergent Grid (2005)
Coulson, G., Grace, P., Blair, G., Porter, B., Cai, W., Duce, D., ...
Miller, PD, McClung, MR, Macovei, LV, Stakkestad, JA, Luckey, M, Bonvoisin, B, ...
Introduction: Suboptimal adherence to daily and weekly oral bisphosphonates can potentially compromise therapeutic outcomes in postmenopausal osteoporosis. Although yet to be prospectively shown in...
Knowledge for Networked Destinations (2005)
Cooper, C., Scott, Noel Robert
Tourism is becoming of increasing importance for economic growth and has led to wide research advances in several areas of the industry. The economic importance of tourism has caused governments and...
Knowledge for Networked Destinations (2005)
Cooper, C., Scott, Noel Robert
Tourism is becoming of increasing importance for economic growth and has led to wide research advances in several areas of the industry. The economic importance of tourism has caused governments and...
Hamilton Cycles in Random Lifts of Graphs (2005)
K. Burgin, P. Chebolu, C. Cooper, A. M. Frieze
An n-lift of a graph K, is a graph with vertex set V (K) × [n] and for each edge (i, j) ∈ E(K) there is a perfect matching between {i} × [n] and {j} × [n]. If these matchings are chosen...
Ralston, S. H., Galwey, N., MacKay, I., Albagha, O. M. E., Cardon, L., Compston, J. E., ...
Osteoporosis is a common disease with a strong genetic component, characterized by reduced bone mass and an increased risk of fracture. Bone mineral density (BMD) is a highly heritable trait and a...
Cohort Profile: The Hertfordshire Cohort Study (2005)
Syddall, HE, Aihie Sayer, A, Dennison, EM, Martin, HJ, Barker, DJP, Cooper, C, ...
Syddall, H. E., Sayer, A. Aihie, Simmonds, S. J., Osmond, C., Cox, V., Dennison, E. M., ...
Low birth weight, a marker of adverse intrauterine circumstances, is known to be associated with a range of disease outcomes in later life, including coronary heart disease, hypertension, type 2...
Is it time for more rheumatologists to embrace osteoarthritis? (2005)
Birrell, F., Arden, N. K., Conaghan, P. G., Cooper, C., Dieppe, P., Doherty, M.
Edwards, C. J., Arden, N. K., Fisher, D., Saperia, J. C., Reading, I., Van Staa, T. P., ...
Objectives. To describe the use of disease-modifying anti-rheumatic drugs (DMARDs) in the treatment of rheumatoid arthritis (RA) and changing trends in their use. Methods. We used the General...
Arden, N. K., Price, C., Reading, I., Stubbing, J., Hazelgrove, J., Dunne, C., ...
Objective. To determine the effectiveness and predictors of response to lumbar epidural corticosteroid injections (ESI) in patients with sciatica. We performed a 12-month, multicentre, double-blind,...
Is it time for more rheumatologists to embrace osteoarthritis? (2005)
Birrell, F., Arden, N. K., Conaghan, P. G., Cooper, C., Dieppe, P., Doherty, M.
Epidemiology of osteoporotic fracture: looking to the future (2005)
This paper reviews the recent literature on candidate genes, anthropometric and environmental factors, and the evolving area of intrauterine fetal programming with regard to the development of...
Cohort Profile: The Hertfordshire Cohort Study (2005)
Syddall, H. E., Sayer, A. Aihie, Dennison, E. M., Martin, H. J., Barker, D. J. P., Cooper, C., ...
Geusens, P., Pols, H.A.P., De Laet, C., Leufkens, H.G.M., Cooper, C.
Background: Previous analyses of risk factors for glucocorticoid (GC)-induced osteoporosis have focused on the estimation of relative rather than absolute fracture probability. Aim: To estimate risk...
GRIDKIT: pluggable overlay networks for grid computing (2004)
Grace, P., Coulson, G., Blair, G., Mathy, L., Yeung, W., Cai, W., ...
What does it mean to involve consumers successfully in NHS research? A consensus study (2004)
Telford, R., Boote, J., Cooper, C.
Objective: To obtain consensus on the principles and indicators of successful consumer involvement in NHS research. Design: Consensus methods were used. An expert workshop, employing the nominal...
Circulating cortisone, biochemical bone markers and bone density (2004)
Cooper, M.S., Syddall, H.E., Wood, P.J., Stewart, P.M., Cooper, C., Dennison, E.M.
Circulating cortisone, biochemical bone markers and bone density (2004)
Cooper, M.S., Syddall, H.E., Wood, P.J., Stewart, P.M., Cooper, C., Dennison, E.M.
Influence of LRP5 gene polymorphisms on the normal variation of bone mineral density (2004)
Koay, MA, Duncan, EL, Ralston, SH, Compston, JE, Cooper, C, Keen, R, ...
Influence of LRP5 polymorphisms on normal variation in BMD (2004)
Koay, MA, Woon, PY, Zhang, Y, Miles, LJ, Duncan, EL, Ralston, SH, ...
Genetic studies based on cohorts with rare and extreme bone phenotypes have shown that the LRP5 gene is an important genetic modulator of BMD. Using family-based and case-control approaches, this...
The variance in self reported hand function in early rheumatoid arthritis (2004)
Adams, J., Burridge, J., Hammond, A., Mullee, M., Cooper, C.
Bone mineral status in immigrant Indo-Asian women (2004)
Mehta, G., Taylor, P., Petley, G., Dennison, E., Cooper, C., Walker-Bone, K.
Background: Indo-Asian immigrants are known to be at high risk of metabolic bone disease, but the prevalence of osteoporosis in this population is unknown. Aim: To compare the bone mineral at the...
The use of conventional and complementary treatments for knee osteoarthritis in the community (2004)
Jordan, K. M., Sawyer, S., Coakley, P., Smith, H. E., Cooper, C., Arden, N. K.
Objectives. The aim of the survey was to assess the prevalence of clinically diagnosed knee osteoarthritis (OA) in two general practice populations in the Wessex region (practice A: a deprived urban...
Gaunt, T.R., Chen, X.H., King, T.H.T., Voropanov, A., Shu, Y., Rodriguez, S., ...
The GH-CSH gene cluster on human chromosome 17q23 encodes genes for growth hormone (GH1), chorionic somatomammotrophin (CSH1, 2 and 5, placental lactogens) and placental GH variant (GH2). We have...
A study of mitochondrial DNA mutations in peripheral lymphocytes in an aging cohort (2003)
Zhang, B., Ye, S., Sayer, A.A., Hammans, S.R., Adio, S., Hinks, L.J., ...
Somatic mutation in the mitochondrial genome occurs much more rapidly than in the nuclear genome and is a feature, possibly contributory, of the aging of cells and tissues. Identifying mitochondrial...
Use of alpha-blockers and the risk of hip/femur fractures (2003)
Souverein, P.C., Staa, T.P. Van, Egberts, A.C.G., Cooper, C.
Objective. To study the association between use of α-blockers and risk of hip/femur fractures. Design. Population-based case–control study. Setting. General Practice Research Database. Subjects....
Inflammatory bowel disease and the risk of fracture. (2003)
Staa, T.P. Van, Cooper, C., Samuels Brusse, L., Leufkens, H.G.M., Javaid, M.K., Arden, N.K.
Background & Aims: Although patients with inflammatory bowel disease (IBD) have reduced bone mass, there is controversy whether there is an increased risk of fracture. This study examines the risk of...
Neutropenia and Agranulocytosis in England and Wales: Incidence and Risk factors (2003)
Staa, T.P. Van, Boulton, F., Cooper, C., Hagenbeek, A., Inskip, H., Leufkens, H.G.M.
The objectives of this study were to estimate the incidence of idiosyncratic neutropenia and agranulocytosis in England and Wales and to evaluate their risk factors and outcomes. The study was...
The use of inhaled corticosteroids in the United Kingdom and the Netherlands (2003)
Leufkens, H.G.M., Staa, T.P. Van, Cooper, C., Lammers, J.W.J., Suissa, S.
This study examined the utilisation patterns of inhaled corticosteroids in England/Wales and the Netherlands. Computerised medical records fromthe GPRD (U.K.) and PHARMO (the Netherlands) databases...
Inhaled corticosteroids and hip fracture: disease or drugs? (2003)
Staa, T.P. Van, Leufkens, H.G.M., Cooper, C.
Hubbard and colleagues report a study using the General Practice Research Database exploring the relationship between inhaled corticosteroids and the risk of hip fracture. In so doing, they replicate...
Children and the risk of fractures caused by oral corticosteroids (2003)
Staa, T.P. Van, Cooper, C., Leufkens, H.G.M., Bishop, N.
Oral corticosteroids are known to increase the risk of fracture in adults, but their effects in children remain uncertain. The medical records of general practitioners in the United Kingdom (from the...
Staa, T.P. Van, Cooper, C., Barton, I., Cohen, S., Reid, D.M., Laan, R.F.
Objective. To evaluate predictors of vertebral fractures, including a threshold for bone mineral density (BMD), in patients receiving oral glucocorticoids (GCs). Methods. Data were obtained from 2...
Colles' fracture as an early and sensitive marker of skeletal fragility in men (2003)
HAENTJENS, P, JOHNELL, O, COOPER, C, Kaufman, Jean, VANDERSCHUEREN, D, BOONEN, S
Polymorphism of the IGF2 gene, birth weight and grip strength in adult men (2003)
Sayer, A.A., Syddall, H., O'Dell, S. ., Chen, X. ., Briggs, P.J., Briggs, R., ...
The use of conventional and complementary treatments for knee osteoarthritis in the community (2003)
Jordan, K. M., Sawyer, S., Coakley, P., Smith, H. E., Cooper, C., Arden, N. K.
Objectives. The aim of the survey was to assess the prevalence of clinically diagnosed knee osteoarthritis (OA) in two general practice populations in the Wessex region (practice A: a deprived urban...
The use of conventional and complementary treatments for knee osteoarthritis in the community (2003)
Jordan, K. M., Sawyer, S., Coakley, P., Smith, H. E., Cooper, C., Arden, N. K.
Objectives. The aim of the survey was to assess the prevalence of clinically diagnosed knee osteoarthritis (OA) in two general practice populations in the Wessex region (practice A: a deprived urban...
Consumer involvement in health research: a review and research agenda (2002)
Boote, J., Telford, R., Cooper, C.
The involvement of consumers in health research is now Department of Health policy within the UK. Despite the existence of policy directives, there is a dearth of knowledge on the effects of such...
Mutations of the BRAF gene in human cancer (2002)
Davies, H., Bignell, G.R., Cox, C., Stephens, P., Edkins, S., Clegg, S., ...
Cancers arise owing to the accumulation of mutations in critical genes that alter normal programmes of cell proliferation, differentiation and death. As the first stage of a systematic genome-wide...
Critical accounting in Scotland (2002)
This paper considers the contemporary role of critical academic accountants. Arguably, academics have been to some extent cut off from the "real world" writing fairly inaccessible papers for each...
STOIC: a study of coupled model climatology and variability in tropical ocean regions (2002)
Davey, M.K., Huddleston, M., Sperber, K., Braconnot, P., Bryan, F., Chen, D., ...
We describe the behaviour of 23 dynamical ocean-atmosphere models, in the context of comparison with observations in a common framework. Fields of tropical sea surface temperature (SST), surface wind...
Locus of control and well-being at work: how generalizable are western findings. (2002)
Spector, PE, Cooper, C, Sanchez, JI, O'Driscoll, M, Sparks, K
Incidence and Natural History of Paget's Disease of Bone in England and Wales (2002)
Staa, T.P. Van, Selby, P., Leufkens, H.G.M., Lyles, K, Sprafka, J.M., Cooper, C.
This study used a large, primary care, record-linkage resource (the General Practice Research Database [GPRD]) to evaluate the incidence, clinical presentation, and natural history of Paget’s...
Does a Fracture at One Site Predict Later Fractures at Other Sites? A British Cohort Study (2002)
Staa, T.P. Van, Leufkens, H.G.M., Cooper, C.
The extent to which a fracture at one skeletal site predicts further fractures at other sites remains uncertain. We addressed this issue using information from the UK General Practice Research...
The Epidemiology of Corticosteroid-Induced Osteoporosis : a Meta-analysis (2002)
Staa, T.P. Van, Leufkens, H.G.M., Cooper, C.
Studies of oral corticosteroid dose and loss of bone mineral density have reported inconsistent results. In this meta-analysis, we used information from 66 papers on bone density and 23 papers on...
Utility of medical and drug history in fracture risk prediction among men and women (2002)
Staa, T.P. Van, Leufkens, H.G.M., Cooper, C.
Preventive strategies against osteoporotic fracture depend, in part, on the availability of simple risk prediction tools whereby pharmacological therapy may be targeted to those at greatest risk. The...
Mutations of the BRAF gene in human cancer (2002)
Davies, H., Bignell, G.R., Cox, C., Stephens, P., Edkins, S., Clegg, S., ...
Cancers arise owing to the accumulation of mutations in critical genes that alter normal programmes of cell proliferation, differentiation and death. As the first stage of a systematic genome-wide...
Consumer involvement in health research: fact or fiction? (2002)
Telford, R., Beverley, C.A., Cooper, C., Boote, J.
Consumer involvement is now firmly established as National Health Service (NHS) R&D policy. This study identified the range and diversity of current NHS research projects involving consumers within...
Size at birth, adult intestinal calcium absorption and 1,25(OH)2 vitamin D (2002)
Arden, N.K., Major, P., Poole, J.R., Keen, R.W., Vaja, S., Swaminathan, R., ...
Background: Adult bone mineral status is modified by early environmental influences, but the mechanism of this phenomenon is unknown. Intestinal calcium absorption and vitamin D metabolism are...
Design and implementation of TOAST: an adaptive distributed multimedia middleware platform (2001)
Fitzpatrick, T., Blair, G., Coulson, G., Gallop, J., Cooper, C., Duce, D., ...
Report of quality of service think tank, UKERNA QoS think tank report (2001)
Edwards, C., Butler, J., Chown, T., Cooper, C., Couzens, J., Jeffreys, P., ...
Use of Inhaled Corticosteroids and Risk of Fractures (2001)
Staa, T.P. Van, Leufkens, H.G.M., Cooper, C.
Treatment with systemic corticosteroids is known to increase the risk of fractures but little is known of the fracture risks associated with inhaled corticosteroids. A retrospective cohort study was...
Public health impact of adverse bone effects of oral corticosteroids (2001)
Staa, T.P. Van, Abenhaim, L., Zhang, B, Cooper, C., Leufkens, H.G.M.
Aims: The objective of this study was to estimate the number of fractures attributed to oral corticosteroid use. Methods: Information was obtained from the General Practice Research Database which...
Epidemiology of fractures in England and Wales (2001)
Staa, T.P. Van, Dennison, E.M., Leufkens, H.G.M., Cooper, C.
Records from the General Practice Research Database were used to derive age- and gender-specific fracture incidence rates for England and Wales during the period 1988–1998. In total, 103,052 men...
Predicting radiographic hip osteoarthritis from range of movement (2001)
Birrell, F., Croft, P., Cooper, C., Hosie, G., Macfarlane, G., Silman, A.
Objectives. The primary objective was to test the hypothesis that new attenders in primary care with hip pain and radiographic osteoarthritis (OA) have a decreased range of movement...
Use of keyboards and symptoms in the neck and arm: evidence from a national survey (2001)
Palmer, K. T., Cooper, C., Walker-Bone, K., Syddall, H., Coggon, D.
The objective of this study was to examine the relationship between upper limb symptoms and keyboard use in a population survey. A questionnaire was mailed to 21 201 subjects aged 16–64 years,...
Exposure to hand-transmitted vibration and pain in the neck and upper limbs (2001)
Palmer, K. T., Griffin, M. J., Syddall, H. E., Pannett, B., Cooper, C., Coggon, D.
Workers exposed to hand‐transmitted vibration (HTV) often experience aches and pains in the upper limbs, but there have been few studies of the pattern and severity of symptoms, or their...
Eastell, R., Reid, D.M., Compston, J., Cooper, C., Fogelman, I., Francis, R.M., ...
The burden of non‐vertebral fractures is enormous. Hip fractures account for nearly 10% of all fractures (and a much greater proportion in the elderly), while wrist fractures...
Structuring for Extensibility - Adapting the Past to Fit the Future (2000)
Blair, G., Coulson, G., Fitzpatrick, T., Gallop, J., Cooper, C., Johnson, I., ...
From Taylorism to Ms Taylor: the transformation of the accounting craft (2000)
The history of professionally qualified accountants and their regulatory processes command considerable attention in the academic accounting literature. In contrast, "non-qualified", clerical...
Use of Nonsteroidal Anti-inflammatory Drug an Risk of Fractures (2000)
Staa, T.P. Van, Leufkens, H.G.M., Cooper, C.
In animal models, prostaglandin synthesis has been found to mediate bone metabolism. Nonsteroidal anti-inflammatory drugs (NSAIDs), given their inhibitory effects of prostaglandin synthesis, may play...
Semi-rigid column base connections in pultruded GRP frame structures. (2000)
A review of moment–rotation tests on bolted connections between pultruded Glass Reinforced Plastic (GRP) Wide Flange (WF) sections highlights the lack of test data on column–base connections....
On the Rank of Random Matrices (2000)
Let M = (m ij) be a random nn matrix over GF(2). Each matrix entry m ij is independently and identically distributed, with Pr(m ij = 0) = 1 p(n) and Pr(m ij = 1) = p(n). The probability that the...
Use of oral corticosteroids in the United Kingdom (2000)
Van Staa, T.P., Leufkens, H.G.M., Abenhaim, L., Begaud, B., Zhang, B., Cooper, C.
Administration of oral corticosteroids is associated with the development of osteoporosis and an increased risk of fractures. However, the size of the treated sub‐population who would benefit...
Lau, E. C., Cooper, C., Lam, D., Chan, V. N. H., Tsang, K. K., Sham, A.
In 1998, a case-control study was conducted in Hong Kong on hospital patients with osteoarthritis of the hip (n = 138) and osteoarthritis of the knee (n = 658). Age- and sex-matched...
Radiographic change is common in new presenters in primary care with hip pain (2000)
Birrell, F., Croft, P., Cooper, C., Hosie, G., Macfarlane, G. J., Silman, A.
Objective. To determine the prevalence of radiographic osteoarthritis in subjects with hip pain newly presenting to primary care. Methods. The study was cross‐sectional in design, set in...
Climate Dynamics �2001) 18: 255±276 Ó Springer-Verlag 2001 (2000)
M. Latif, K. Sperber, J. Arblaster, P. Braconnot, D. Chen, A. Colman, ...
Abstract An ensemble of twenty four coupled oceanatmosphere models has been compared with respect to their performance in the tropical Paci®c. The coupled models span a large portion of the...
Edge disjoint Hamilton cycles in sparse random graphs of minimum degree at least k (1999)
B. Bollobas, C. Cooper, T. I. Fenner, A.M. Frieze
Let G n;m;k denote the space of simple graphs with n vertices, m edges and minimum degree at least k, each graph G being equiprobable. Let G have property A k if G contains b(k 1)=2c edge disjoint...
Asymptotics for dependent sums of random vectors. Random Structures and Algorithms (1999)
We consider sequences of length m of n-tuples each with k non-zero entries chosen randomly from an Abelian group or finite field. For what values of m does there exist a subsequence which is zero-sum...
Upper limb disorder due to manual pipetting (1998)
This case report describes the occurrence of non-specific upper limb symptoms, in a 47-year-old female scientific officer, associated with manual pipetting. The discussion considers the difficulty of...
Smedley, D, Hamoudi, R, Clark, J, Warren, W, Abdul-Rauf, M, Somers, G, ...
Acetabular dysplasia and hip osteoarthritis in Britain and Japan (1998)
Yoshimura, N, Campbell, L, Hashimoto, T, Kinoshita, H, Okayasu, T, Wilman, C, ...
Management of male osteoporosis: report of the UK Consensus Group (1998)
Eastell, R, Boyle, IT, Compston, J, Cooper, C, Fogelman, I, Francis, RM, ...
Will Elderly Women Wear Hip Protectors to Prevent Hip Fracture? (1997)
Villar, M.T.A., Thompson, P.W., Hill, P., Inskip, H., Cooper, C.
Anthropometric Measurements and Vertebral Deformities (1997)
Johnell, O., O'Neill, T., Felsenberg, D., Kanis, J., Cooper, C., Silman, A. J., ...
To investigate the association between anthropometric indices and morphometrically determined vertebral deformity, the authors carried out a cross-sectional study using data from the European...
Recommendations for the registration of drugs used in the treatment of osteoarthritis. (1996)
DOUGADOS, M, DEVOGELAER, JP, ANNEFELDT, M, AVOUAC, B, BOUVENOT, G, COOPER, C, ...
THE FUNCTIONAL AND PSYCHOLOGICAL OUTCOMES OF JUVENILE CHRONIC ARTHRITIS IN YOUNG ADULTHOOD (1994)
DAVID, J., COOPER, C., HICKEY, L., LLOYD, J., DORÉ, C., McCULLOUGH, C., ...
The functional and psychological outcome of 43 patients with polyarticular juvenile arthritis was assessed in order to evaluate the impact of disease on their quality of life. Mean disease duration...
O'NEILL, T W, COOPER, C, CANNATA, J B, LOPEZ, J B DIAZ, HOSZOWSKI, K, JOHNELL, O, ...
Background. The European Vertebral Osteoporosis Study Group (EVOS) developed a questionnaire, back translated into 14 different European languages, for use in a multinational epidemiological study of...
Asymptotic enumeration of Predicate-Junction (1993)
We consider unlabelled flowgraphs for a model of binary logic without the constraints of structured programming. The number of such flowgraphs is asymptotic to (3.4n) n/2, where n is the number of...
HEIGHT, OCCUPATION AND BACK PAIN IN A NATIONAL PROSPECTIVE STUDY (1993)
KUH, D. J. L., COGGAN, D., MANN, S., COOPER, C., YUSUF, E.
Back pain is an important public health problem but there is a paucity of knowledge about risk factors and causal mechanisms. Previous studies have shown that tall men are more at risk of back pain,...
KNEE PAIN AND DISABILITY IN THE COMMUNITY (1992)
McALINDON, T. E., COOPER, C., KIRWAN, J. R., DIEPPE, P. A.
In order to investigate the strength of any relationship between knee pain and disability, a postal questionnaire was sent to 2102 men and women aged over 55 registered at a general practice in...
IS THE HIP INVOLVED IN GENERALIZED OSTEOARTHRITIS? (1992)
CROFT, P., COOPER, C., WICKHAM, C., COGGON, D.
Elbow pain is a common complaint and elbow hyperostosis a frequent radiological condition. However, little is known about the association between the clinical and radiological findings. To evaluate...
Space subdivision and distributed databases in a multiprocessor raytracer (1991)
This thesis deals with computer generated images. The thesis begins with an overview of a generalised computer graphics system, including a brief survey of typical methods for generating...
Space subdivision and distributed databases in a multiprocessor raytracer (1991)
This thesis deals with computer generated images. The thesis begins with an overview of a generalised computer graphics system, including a brief survey of typical methods for generating...
Space subdivision and distributed databases in a multiprocessor raytracer (1991)
This thesis deals with computer generated images. The thesis begins with an overview of a generalised computer graphics system, including a brief survey of typical methods for generating...
Space subdivision and distributed databases in a multiprocessor raytracer (1991)
This thesis deals with computer generated images. The thesis begins with an overview of a generalised computer graphics system, including a brief survey of typical methods for generating...
Hip Fracture in Hong Kong and Britain (1990)
LAU, E M C, COOPER, C, WICKHAM, C, DONNAN, S, BARKER, D J P
Hip fractures in elderly people are an important public health problem in many Western populations. Little is known of their epidemiology in Oriental populations. A comparative study of hip fracture...
Muscle Strength, Activity, Housing and the Risk of Falls in Elderly People (1989)
WICKHAM, C., COOPER, C., MARGETTS, B. M., BARKER, D. J. P.
In a national survey in Britain, 983 elderly people randomly selected from eight areas were asked about falls they had had in the past. The independent association of social and physical variables...
WOOD, D. J., COOPER, C., STEVENS, J., EDWARDSON, J.
The relationship between bone mass and dementia in elderly hip fracture patients from areas with different aluminium concentrations in water supplies has been investigated, to determine whether a...
Abstracts of scientific presentations (1986)
Clark, J., Munitz, H. A., Benjamin, S. B., Frager, J., Janower, M. L., Wolf, E. L., ...
Peer Reviewed
Facilitating quality use of medicines between hospital and community (Med-E-Support)
Peterson, GM, Luttrell, D, Hughes, J, Raymond, K, Tompson, AJ, Jackson, SL, ...
Moinuddin, M.M, Jameson, K.A, Syddall, H.E, Sayer, A. Aihie, Martin, H.J, Robinson, S, ...
We looked for interaction between early environment and adult lifestyle in determination of bone mineral content (BMC) and bone mineral density (BMD) among 498 men and 468 women for whom birth...
European guidance for the diagnosis and management of osteoporosis in postmenopausal women
Kanis, J. A., Burlet, N., Cooper, C., Delmas, P. D., Borgstrom, F., ...
Growth and infectious exposure during infancy and the risk of rheumatoid factor in adult life
Edwards, C J, Goswami, R, Goswami, P, Syddall, H, Dennison, E M, Arden, N K, ...
The Global Longitudinal Study of Osteoporosis in Women (GLOW): rationale and study design
Hooven, F. H., Adachi, J. D., Adami, S., Boonen, S., Compston, J., Cooper, C., ...
Antipsychotic use and the risk of hip/femur fracture: a population-based case–control study
Pouwels, S., Van Staa, T. P., Egberts, A. C. G., Leufkens, H. G. M., Cooper, C., De Vries, F.