Cool and menthol receptor TRPM8 in human urinary bladder disorders and clinical correlations. (2006)
Mukerji, G., Yiangou, Y., Corcoran, S., Selmer, I. S., Smith, G. D., Benham, C. D., ...
TRPC5 ion channel is a sensor of extracellular lysophosphatidylcholine. (2006)
Flemming, P.K., Dedman, A., Xu, S., Li, J., Zeng, F., Naylor, J., ...
Original article can be found at: http://www.jbc.org/ Copyright by The American Society for Biochemistry and Molecular Biology. DOI: 10.1074/jbc.M510301200 [Full text of this article is not available...
Hill, K., Tigue, N., Kelsell, R.E., Benham, C.D., McNulty, S., Schaefer, M., ...
Original article can be found at: http://www.sciencedirect.com/science/journal/00283908 Copyright Elsevier Ltd. DOI: 10.1016/j.neuropharm.2005.08.021 [Full text of this article is not available in...
Fonfria, E., Mattei, C., Hill, K., Brown, J.T., Randall, A.D., Benham, C.D., ...
Original article can be found at: http://www.informaworld.com/smpp/title~content=t713597278 Copyright Informa / Taylor and Francis Group. DOI: 10.1080/10799890600637522 [Full text of this article is...
Tissue distribution profiles of the human TRPM cation channel family. (2006)
Fonfria, E., Murdock, P., Cusdin, F.S., Benham, C.D., Kelsell, R.E., McNulty, S.
Original article can be found at: http://www.informaworld.com/smpp/title~content=t713597278 Copyright Informa / Taylor and Francis Group. DOI: 10.1080/10799890600637506 [Full text of this article is...
Simple recipe for blocking ion channels. (2005)
Original article can be found at: http://www.nature.com/nbt/index.html Copyright Nature Publishing Group. DOI: 10.1038/nbt1005-1234 [Full text of this article is not available in the UHRA]
Fonfria, E., Marshall, I.C.B., Boyfield, I., Skaper, S.D., Hughes, J.P., Owen, D., ...
‘The definitive version is available at www.blackwell-synergy.com '. Copyright by Blackwell Publishing. DOI: 10.1111/j.1471-4159.2005.03396.x [Full text of this article is not available in the UHRA]
Flufenamic acid is a pH-dependent antagonist of TRPM2 channels. (2004)
Hill, K., Benham, C.D., McNulty, S., Randall, A.D.
Original article can be found at: http://www.sciencedirect.com/science/journal/00283908 Copyright Elsevier Ltd. DOI: 10.1016/j.neuropharm.2004.04.014 [Full text of this article is not available in...
Fonfria, E., Marshall, I.C.B., Benham, C.D., Boyfield, I., Brown, J.D., Hill, K., ...
Original article can be found at: http://www.nature.com/bjp/index.html Copyright British Pharmacological Society and Nature Publishing Group. DOI: 10.1038/sj.bjp.0705914 [Full text of this article is...
Characterization of the human HCN1 subunit and its inhibition by capsazepine. (2004)
Gill, C.H., Bates, S.A., Owen, D., Larkman, P., Cairns, W., Yusuf, S., ...
Original article can be found at: http://www.nature.com/bjp/index.html Copyright British Pharmacological Society and Nature Publishing Group. DOI: 10.1038/sj.bjp.0705945 [Full text of this article is...
Roberts, J.C., Davis, J.B., Benham, C.D.
Original article can be found at: http://www.sciencedirect.com/science/journal/00068993 Copyright Elsevier B.V. DOI: 10.1016/j.brainres.2003.10.001 [Full text of this article is not available in the...
Cater, H., Chandratheva, A., Benham, C.D., Morrison, B., Sundstrom, L.
‘The definitive version is available at www.blackwell-synergy.com '. Copyright by Blackwell Publishing. DOI: 10.1046/j.1471-4159.2003.02100.x [Full text of this article is not available in the UHRA]
mRNA distribution analysis of TRPC family in human CNS and peripheral tissues. (2002)
Riccio, A., Medhurst, A.D., Mattei, C., Kelsell, R. E., Calver, A. R., Randall, A. D., ...
The diversity in the vanilloid receptor family of ion channels. (2002)
Gunthorpe, M.J., Benham, C.D., Randall, A.D., Davis, J.B.
Original article can be found at: http://www.sciencedirect.com/science/journal/01656147 Copyright Elsevier Ltd. DOI: 10.1016/S0165-6147(02)01999-5 [Full text of this article is not available in the...
Vanilloid and TRP channels: a family of lipid gated cation channels. (2002)
Benham, C.D., Davis, J.B., Randall, A.D.
Original article can be found at: http://www.sciencedirect.com/science/journal/00283908 Copyright Elsevier Ltd. DOI: 10.1016/S0028-3908(02)00047-3 [Full text of this article is not available in the...
A method for combining propidium iodide staining with immunohistochemistry. (2002)
Brana, C., Benham, C.D., Sundstrom, L.
Original article can be found at: http://www.sciencedirect.com/science/journal/1385299X Copyright Elsevier B.V. DOI: 10.1016/S1385-299X(02)00201-5 [Full text of this article is not available in the...
SB-334867-A antagonises orexin mediated excitation in the locus coeruleus. (2002)
Soffin, E.M., Evans, M.L., Gill, C.H., Harries, M., Benham, C.D., Davies, C.H.
Original article can be found at: http://www.sciencedirect.com/science/journal/00283908 Copyright Elsevier Ltd. DOI: 10.1016/S0028-3908(01)00156-3 [Full text of this article is not available in the...
Activation of TRPV4 channels (hVRL-2/mTrp12) by phorbol derivatives. (2002)
Watanabe, H., Davis, J.B., Smart, D., Jerman, J.C., Smith, G.D., Hayes, P., ...
The original article can be found at: http://www.jbc.org/ Copyright by The American Society for Biochemistry and Molecular Biology. DOI: 10.1074/jbc.M200062200 [Full text of this article is not...
Cater, H.L., Benham, C.D., Sundstrom, L.E.
The effects of energy substrate removal and metabolic pathway block have been examined on neuronal and glial survival in organotypic slice cultures of rat hippocampus. Slice cultures resisted 24 h of...
Tetrodotoxin resistant sodium channels in pain. (2001)
Original article can be found at: http://www.sciencedirect.com/science/journal/14714892 Copyright Elsevier Ltd. DOI: 10.1016/S1471-4892(01)00015-7 [Full text of this article is not available in the...
Mutation of Histidine 286 of the human P2X4 receptor leads to loss of pH sensitivity. (2000)
Clarke, C. E., Benham, C. D., Bridges, A., Sanger, G., George, A. R., Meadows, H. J.
Meadows, H.J., Benham, C.D., Cairns, W., Gloger, I., Jennings, C., Medhurst, A.D., ...
“The original publication is available at www.springerlink.com”. Copyright Springer. DOI: 10.1007/s004240050997 [Full text of this article is not available in the UHRA]
Rank-order inhibition by ω-conotoxins in human and animal autonomic nerve preparations. (2000)
Sanger, G., Ellis, E.S., Harries, M., Tilford, N.S., Wardle, K.A., Benham, C.D.
Original article can be found at: http://www.sciencedirect.com/science/journal/00142999 Copyright Elsevier B.V. DOI: 10.1016/S0014-2999(99)00830-4 [Full text of this article is not available in the...
Campbell, C.A., Barone, F.C., Benham, C.D., Hadingham, S.J., Harries, M., Hills, J.M., ...
Original article can be found at: http://www.sciencedirect.com/science/journal/00142999 Copyright Elsevier B.V. DOI: 10.1016/S0014-2999(00)00470-2 [Full text of this article is not available in the...
Cloning and functional expression of a human orthologue of the rat vanilloid receptor-1. (2000)
Hayes, P., Meadows, H.J., Gunthorpe, M.J., Harries, M., Duckworth, M., Cairns, W., ...
Original article can be found at: http://www.sciencedirect.com/science/journal/03043959 Copyright International Association for the Study of Pain. DOI: 10.1016/S0304-3959(00)00353-5 [Full text of...
Ray, A., Owen, D., Evans, M.L., Davis, J.B., Benham, C.D.
Original article can be found at: http://www.sciencedirect.com/science/journal/00068993 Copyright Elsevier B.V. DOI: 10.1016/S0006-8993(00)02230-7 [Full text of this article is not available in the...
Recent advances in the molecular understanding of voltage gated Ca2+ channels. (1999)
Original article can be found at: http://www.sciencedirect.com/science/journal/10447431 Copyright Elsevier Inc. DOI: 10.1006/mcne.1999.0795 [Full text of this article is not available in the UHRA]
Orexin-A activates locus coeruleus cell firing and increases arousal in the rat. (1999)
Hagan, J.J., Leslie, R.A., Patel, S., Evans, M.L., Wattam, T.A., Holmes, S., ...
Original article can be found at: http://www.pnas.org/ Copyright by The National Academy of Sciences [Full text of this article is not available in the UHRA]
‘The definitive version is available at www.blackwell-synergy.com '. Copyright Blackwell Publishing. DOI: 10.1111/j.1749-6632.1999.tb11291.x [Full text of this article is not available in the UHRA]
Brana, C., Benham, C.D., Sundstrom, L.
‘The definitive version is available at www.blackwell-synergy.com '. Copyright Blackwell Publishing. DOI: 10.1046/j.1460-9568.1999.00653.x [Full text of this article is not available in the UHRA]
Caesar, M., Evans, M.L., Benham, C.D.
Original article can be found at: http://www.sciencedirect.com/science/journal/03043940 Copyright Elsevier Ireland Ltd. DOI: 10.1016/S0304-3940(99)00514-5 [Full text of this article is not available...
Meadows, H.J., Blackburn, T.B., Pritchett, D., Benham, C.D.
Original article can be found at: http://www.nature.com/bjp/index.html Copyright British Pharmacological Society and Nature Publishing Group. DOI: 10.1038/sj.bjp.0701721 [Full text of this article is...
Meadows, H.J., Harries, M., Thompson, M., Benham, C.D.
Original article can be found at: http://www.nature.com/bjp/index.html Copyright Nature Publishing Group and British Pharmacological Society. DOI: 10.1038/sj.bjp.0701251 [Full text of this article is...
Furosemide inhibits regenerative cortical spreading depression in anaesthetised cats. (1997)
Read, S.J., Smith, M.I., Benham, C.D., Hunter, A.J., Parsons, A.A.
‘The definitive version is available at www.blackwell-synergy.com '. Copyright Blackwell Publishing. DOI: 10.1046/j.1468-2982.1997.1708826.x [Full text of this article is not available in the UHRA]
Wood, N., Barone, F.C., Benham, C.D., Brown, T.H., Campbell, C.A., Cooper, D.C., ...
Original article can be found at: http://www.nature.com/jcbfm/index.html Copyright Nature Publishing Group and International Society for Cerebral Blood Flow and Metabolism. DOI:...
Pringle, A. K., Sim, L., Kennedy, J., Wilde, G. J. C., Benham, C. D., Iannotti, F., ...
Copyright American Heart Association [Full text of this article is not available in the UHRA]
Barone, F. C., Lysko, P. G., Price, W. J., Feuerstein, G., Benham, C. D., Harrison, D. C., ...
Original article can be found at: http://stroke.ahajournals.org/ Copyright American Heart Association. [Full text of this article is not available in the UHRA]
SB 201823-A, A neuronal Ca antagonist is neuroprotective in two models of cerebral ischaemia. (1993)
Benham, C.D., Brown, T.H., Cooper, D.C., Evans, M.L., Harries, M., Herdon, H.J., ...
Original article can be found at: http://www.sciencedirect.com/science/journal/00283908 Copyright Elsevier Ltd. DOI: 10.1016/0028-3908(93)90019-Y [Full text of this article is not available in the...
ATP joins the fast lane. (1992)
Original article can be found at: http://www.nature.com/nature/index.html Copyright Nature Publishing Group. DOI: 10.1038/359103a0 [Full text of this article is not available in the UHRA]
Benham, C.D., Evans, M.L., McBain, C.J.
‘The definitive version is available at www.blackwell-synergy.com '. / PubMed Central Copyright Blackwell Publishing/ Physiological Society [Full text of this article is not available in the UHRA]
Bouvier, M.M., Evans, M.L., Benham, C.D.
‘The definitive version is available at www.blackwell-synergy.com '. Copyright Blackwell Publishing. DOI: 10.1111/j.1460-9568.1991.tb00090.x [Full text of this article is not available in the UHRA]
Benham, C.D., Bouvier, M.M., Evans, M.L.
Copyright Springer. [Full text of this article is not available in the UHRA]
SK&F 96365, a novel inhibitor of receptor mediated calcium entry. (1990)
Merritt, J. E., Armstrong, P. A., Benham, C. D., Hallam, T. J., Jacob, R. J., Jaxa-Chamiec, A., ...
Copyright Portland Press [Full text of this article is not available in the UHRA]
ATP gated channels in vascular smooth muscle cells. (1990)
‘The definitive version is available at www.blackwell-synergy.com '. Copyright Blackwell Publishing. DOI: 10.1111/j.1749-6632.1990.tb37679.x [Full text of this record is not available in UHRA]
Amedee, T., Benham, C.D., Bolton, T.B., Byrne, N.G., Large, W.A.
‘The definitive version is available at www.blackwell-synergy.com '. / PubMed Central Copyright The Physiological Society/ Blackwell Publishing. [Full text of this article is not available in the...
‘The definitive version is available at www.blackwell-synergy.com '. / PubMed Central. Copyright Blackwell/ The Physiological Society [Full text of this article is not available in the UHRA]
‘The definitive version is available at www.blackwell-synergy.com '. / PubMed Central Copyright The Physiological Society/ Blackwell Publishing [Full text of this article is not available in the...
‘The definitive version is available at www.blackwell-synergy.com '. / PubMed Central. Copyright The Physiological Society / Blackwell Publishing [Full text of this article is not available in the...
Mason, W.T., Rawlings, S.R., Cobbett, P., Sikdar, S.K., Zorec, R., Akerman, S.N., ...
[Full text of this article is not available in the UHRA]
‘The definitive version is available at www.blackwell-synergy.com '. / PubMed Central Copyright The Physiological Society/ Blackwell Publishing [Full text of this article is not available in the...
A novel receptor-operated Ca2+-permeable channel activated by ATP in smooth muscle. (1987)
Original article can be found at: http://www.nature.com/nature/index.html Copyright Nature Publishing Group. DOI: 10.1038/328275a0 [Full text of this article is not available in the UHRA]
Inward rectification in freshly isolated single smooth muscle cells of the rabbit jejunum. (1987)
Benham, C.D., Bolton, T.B., Denbigh, J.S., Lang, R.J.
‘The definitive version is available at www.blackwell-synergy.com '. / PubMed Central Copyright The Physiological Society/ Blackwell Publishing [Full text of this article is not available in the...
Benham, C.D., Bolton, T.B., Byrne, N.G., Large, W.A.
‘The definitive version is available at www.blackwell-synergy.com '. / PubMed Central Copyright The Physiological Society/ Blackwell Publishing [Full text of this article is not available in the...
Benham, C.D., Hess, P., Tsien, R.W.
Original article can be found at: http://ovidsp.tx.ovid.com/spa/ovidweb.cgi Copyright American Heart Association, Inc. [Full text of this article is not available in the UHRA]
Bolton, T.B., Lang, R.J., Takewaki, T., Benham, C. D.
Copyright Lippincott Williams & Wilkins [Full text of this article is not available in the UHRA]
‘The definitive version is available at www.blackwell-synergy.com '. / PubMed Central Copyright The Physiological Society / Blackwell Publishing [Full text of this article is not available in the...
Benham, C.D., Bolton, T.B., Lang, R.J., Takewaki, T.
‘The definitive version is available at www.blackwell-synergy.com '. / PubMed Central Copyright The Physiological Society / Blackwell Publishing [Full text of this article is not available in the...
Benham, C.D., Bolton, T.B., Lang, R.J., Takewaki, T.
“The original publication is available at www.springerlink.com" Copyright Springer. DOI: 10.1007/BF00584088 [Full text of this article is not available in the UHRA]
Benham, C.D., Bolton, T.B., Lang, R.J.
Original article can be found at: http://www.nature.com/nature/index.html Copyright Nature Publishing Group. DOI: 10.1038/316345a0 [Full text of this article is not available in the UHRA]
Bolton, T.B., Lang, R.J., Takewaki, T., Benham, C.D.
“The original publication is available at www.springerlink.com”. Copyright Springer. DOI: 10.1007/BF01970006 [Full text of this article is not available in the UHRA]
‘The definitive version is available at www.blackwell-synergy.com '. / PubMed Central Copyright The Physiological Society/ Blackwell Publishing [Full text of this article is not available in the...
SK&F 96365, a novel inhibitor of receptor-mediated calcium entry.
Merritt, J E, Armstrong, W P, Benham, C D, Hallam, T J, Jacob, R, Jaxa-Chamiec, A, ...
A novel inhibitor of receptor-mediated calcium entry (RMCE) is described. SK&F 96365 (1-(beta-[3-(4-methoxy-phenyl)propoxy]-4-methoxyphenethyl)-1H- imidazole hydrochloride) is structurally distinct...
Mahoney, M G, Slakey, L L, Benham, C D, Gross, D J
In response to extracellular application of 50 microM ATP, all individual porcine aortic smooth muscle cells respond with rapid rises from basal [Ca2+]i to peak [Ca2+]i within 5 s. The time from...
Benham, C D, Evans, M L, McBain, C J
1. We have used a combination of microfluorimetry and patch-clamp techniques to investigate cytoplasmic Ca2+ ([Ca2+]i) buffering in response to physiological Ca2+ loads in neurones cultured from the...
1. Whole-cell membrane current recordings under voltage clamp were made at room temperature from dispersed single cells of longitudinal smooth muscle of rabbit jejunum and dispersed single smooth...
Inward rectification in freshly isolated single smooth muscle cells of the rabbit jejunum.
Benham, C D, Bolton, T B, Denbigh, J S, Lang, R J
1. Single smooth muscle cells were obtained by collagenase digestion of longitudinal muscle of rabbit jejunum. Membrane potential or current under voltage clamp was recorded by patch-clamp technique...
1. Intracellular free calcium (Ca2+i) was estimated in single GH3 cells by dual wavelength emission spectrofluorimetry using the Ca2+ indicator dye Indo-1, while cells were held under voltage clamp...
1. Sodium-calcium exchange was studied in single enzymatically isolated cells of the guinea-pig ureter using the Ca2(+)-sensitive fluorescent dye Indo-1 to monitor the intracellular Ca2+...
Amédée, T, Benham, C D, Bolton, T B, Byrne, N G, Large, W A
1. The action of noradrenaline on cells isolated from the rabbit ear artery was studied with the whole-cell configuration of the patch clamp technique. In normal potassium-containing solutions at a...
1. A combination of the techniques of microspectrofluorimetry and whole-cell patch clamp was used to investigate changes in cytoplasmic Ca2+ concentration (Cai2+) in single arterial smooth muscle...
Noradrenaline modulation of calcium channels in single smooth muscle cells from rabbit ear artery.
1. Whole-cell recordings of voltage-gated Ca2+ current in single smooth muscle cells from rabbit ear artery were obtained with 110 mM-Ba2+ as charge carrier. 2. Noradrenaline (NA, 1-20 microM)...
Benham, C D, Bolton, T B, Byrne, N G, Large, W A
1. Adenosine triphosphate (ATP), applied in the bathing solution or ionophoretically, depolarized freshly dispersed single arterial smooth muscle cells obtained by collagenase and elastase treatment...
Benham, C D, Bolton, T B, Lang, R J, Takewaki, T
Single-channel studies were made using the patch-clamp technique of K channels in dispersed single smooth muscle cells from rabbit longitudinal jejunal muscle and guinea-pig small (less than 0.2 mm...
1. The patch-clamp technique was used to study single channel currents in membrane patches of longitudinal smooth muscle cells of rabbit jejunum dispersed by collagenase treatment. Recordings were...
SK&F 96365, a novel inhibitor of receptor-mediated calcium entry.
Merritt, J E, Armstrong, W P, Benham, C D, Hallam, T J, Jacob, R, Jaxa-Chamiec, A, ...
A novel inhibitor of receptor-mediated calcium entry (RMCE) is described. SK&F 96365 (1-(beta-[3-(4-methoxy-phenyl)propoxy]-4-methoxyphenethyl)-1H- imidazole hydrochloride) is structurally distinct...
Benham, C D, Evans, M L, McBain, C J
1. We have used a combination of microfluorimetry and patch-clamp techniques to investigate cytoplasmic Ca2+ ([Ca2+]i) buffering in response to physiological Ca2+ loads in neurones cultured from the...
1. Whole-cell membrane current recordings under voltage clamp were made at room temperature from dispersed single cells of longitudinal smooth muscle of rabbit jejunum and dispersed single smooth...
Inward rectification in freshly isolated single smooth muscle cells of the rabbit jejunum.
Benham, C D, Bolton, T B, Denbigh, J S, Lang, R J
1. Single smooth muscle cells were obtained by collagenase digestion of longitudinal muscle of rabbit jejunum. Membrane potential or current under voltage clamp was recorded by patch-clamp technique...
1. Intracellular free calcium (Ca2+i) was estimated in single GH3 cells by dual wavelength emission spectrofluorimetry using the Ca2+ indicator dye Indo-1, while cells were held under voltage clamp...
1. Sodium-calcium exchange was studied in single enzymatically isolated cells of the guinea-pig ureter using the Ca2(+)-sensitive fluorescent dye Indo-1 to monitor the intracellular Ca2+...
Amédée, T, Benham, C D, Bolton, T B, Byrne, N G, Large, W A
1. The action of noradrenaline on cells isolated from the rabbit ear artery was studied with the whole-cell configuration of the patch clamp technique. In normal potassium-containing solutions at a...
1. A combination of the techniques of microspectrofluorimetry and whole-cell patch clamp was used to investigate changes in cytoplasmic Ca2+ concentration (Cai2+) in single arterial smooth muscle...
Noradrenaline modulation of calcium channels in single smooth muscle cells from rabbit ear artery.
1. Whole-cell recordings of voltage-gated Ca2+ current in single smooth muscle cells from rabbit ear artery were obtained with 110 mM-Ba2+ as charge carrier. 2. Noradrenaline (NA, 1-20 microM)...
Benham, C D, Bolton, T B, Byrne, N G, Large, W A
1. Adenosine triphosphate (ATP), applied in the bathing solution or ionophoretically, depolarized freshly dispersed single arterial smooth muscle cells obtained by collagenase and elastase treatment...
Benham, C D, Bolton, T B, Lang, R J, Takewaki, T
Single-channel studies were made using the patch-clamp technique of K channels in dispersed single smooth muscle cells from rabbit longitudinal jejunal muscle and guinea-pig small (less than 0.2 mm...
1. The patch-clamp technique was used to study single channel currents in membrane patches of longitudinal smooth muscle cells of rabbit jejunum dispersed by collagenase treatment. Recordings were...
Mahoney, M G, Slakey, L L, Benham, C D, Gross, D J
In response to extracellular application of 50 microM ATP, all individual porcine aortic smooth muscle cells respond with rapid rises from basal [Ca2+]i to peak [Ca2+]i within 5 s. The time from...
Meadows, H J, Harries, M H, Thompson, M, Benham, C D
4-Amino-7-hydroxy-2-methyl-5,6,7,8,-tetrahydrobenzo[b]thieno[2,3-b]pyridine-3-carboxylic acid, but-2-ynyl ester (SB-205384) and other γ-aminobutyric acidA (GABAA) receptor modulators were tested for...
SB-205384: a GABAA receptor modulator with novel mechanism of action that shows subunit selectivity
Meadows, H J, Kumar, C S, Pritchett, D B, Blackburn, T P, Benham, C D
SB-205384, and its (+) enantiomer (+)-SB-205384 were tested for their modulatory effects on human GABAA receptor subunit combinations expressed in Xenopus oocytes by electrophysiological methods.The...
A comparison was made of the actions of substance P, prostaglandin F2 alpha (PGF2 alpha), histamine and carbachol on the membrane potential and conductance of the longitudinal smooth muscle of the...
Mutation of histidine 286 of the human P2X4 purinoceptor removes extracellular pH sensitivity
Clarke, C E, Benham, C D, Bridges, A, George, A R, Meadows, H J
Effects of external pH on the human P2X4 purinoceptor, an ATP-activated ion channel, were studied using the Xenopus oocyte expression system.Changing the external pH from 7·4 to 6·5 significantly...
Cater, H L, Benham, C D, Sundstrom, L E
The effects of energy substrate removal and metabolic pathway block have been examined on neuronal and glial survival in organotypic slice cultures of rat hippocampus.Slice cultures resisted 24 h of...