Pourquier, P, Jensen, A D, Gong, S S, Pommier, Y, Rogler, C E
In this study, we report that eukaryotic topoisomerase I (top1) can linearize the open circular DNA of duck hepatitis B virus (DHBV). Using synthetic oligonucleotides mimicking the three-strand flap...
Gong, S S, Jensen, A D, Wang, H, Rogler, C E
While the cytoplasmic phase of the hepadnavirus replication cycle is well understood, very little is known about the nuclear phase. In contrast to retroviruses, proviral integration is not required...
Gong, S S, Jensen, A D, Rogler, C E
Hepatocellular carcinoma is the culmination of a series of genetic events which progressively alter the phenotype of a hepatocyte toward malignancy. Hepadnaviral DNA integrations are agents of...
Dandri, M, Schirmacher, P, Rogler, C E
The woodchuck hepatitis virus (WHV) X gene (WHx) is required for infectivity of WHV in woodchucks, and the gene encodes a broadly acting transcription factor. Several lines of evidence from cell...
Yang, D, Faris, R, Hixson, D, Affigne, S, Rogler, C E
N-myc2 and insulin-like growth factor II (IGF-II) are coordinately overexpressed in the great majority of altered hepatic foci, which are the earliest precancerous lesions observed in the liver of...
The hepatitis B virus (HBV) precore protein inhibits HBV replication in transgenic mice.
Guidotti, L G, Matzke, B, Pasquinelli, C, Shoenberger, J M, Rogler, C E, Chisari, F V
In this study, we examined the ability of the hepatitis B virus (HBV) precore, envelope, and X gene products to modulate HBV replication in the livers of transgenic mice that replicate the virus....
Petersen, J, Dandri, M, Bürkle, A, Zhang, L, Rogler, C E
Persistent hepadnavirus infection leads to oxidative stress and DNA damage through increased production of toxic oxygen radicals. In addition, hepadnaviral DNA integrations into chromosomal DNA can...
Guidotti, L G, Martinez, V, Loh, Y T, Rogler, C E, Chisari, F V
Transgenic mice that express the hepatitis B virus core protein were used to examine factors that influence the intracellular localization of nucleocapsid particles in the primary hepatocyte in vivo....
Topoisomerase I-mediated integration of hepadnavirus DNA in vitro.
Hepadnaviruses integrate in cellular DNA via an illegitimate recombination mechanism, and clonally propagated integrations are present in most hepatocellular carcinomas which arise in hepadnavirus...
Features of two hepatitis B virus (HBV) DNA integrations suggest mechanisms of HBV integration.
Hino, O, Ohtake, K, Rogler, C E
Two integrated hepatitis B virus (HBV) DNA molecules were cloned from two primary hepatocellular carcinomas each containing only a single integration. One integration (C3) contained a single linear...
Fu, X X, Su, C Y, Lee, Y, Hintz, R, Biempica, L, Snyder, R, ...
Insulinlike growth factor II (IGF-II) is a highly mitogenic fetal growth factor suspected of regulating the growth of a wide spectrum of tissues via an autocrine or paracrine mode of action or both....
We have isolated and determined the structure of a recombinant clone in lambda phage Charon 30 which contains woodchuck hepatitis virus sequences integrated in woodchuck genomic DNA sequences. This...
Neel, B G, Gasic, G P, Rogler, C E, Skalka, A M, Ju, G, Hishinuma, F, ...
We isolated molecular clones of the provirus-host cell junctions (tumor junction fragments) from two avian leukosis virus-induced lymphomas and compared the structures of these clones with a clone of...
We cloned several unique forms of woodchuck hepatitis virus, a DNA virus closely related to hepatitis B virus, from a chronically infected woodchuck liver. Each of the three clones contained more...
Hepatitis B virus integration site in hepatocellular carcinoma at chromosome 17;18 translocation.
Hino, O, Shows, T B, Rogler, C E
Integrated hepatitis B virus (HBV) DNA is almost invariably found in hepatocellular carcinomas (HCC) which develop in HBV carriers. Integrated HBV DNAs from two single-integration HCCs (C3 and C4)...
Pourquier, P, Jensen, A D, Gong, S S, Pommier, Y, Rogler, C E
In this study, we report that eukaryotic topoisomerase I (top1) can linearize the open circular DNA of duck hepatitis B virus (DHBV). Using synthetic oligonucleotides mimicking the three-strand flap...
Gong, S S, Jensen, A D, Wang, H, Rogler, C E
While the cytoplasmic phase of the hepadnavirus replication cycle is well understood, very little is known about the nuclear phase. In contrast to retroviruses, proviral integration is not required...
Gong, S S, Jensen, A D, Rogler, C E
Hepatocellular carcinoma is the culmination of a series of genetic events which progressively alter the phenotype of a hepatocyte toward malignancy. Hepadnaviral DNA integrations are agents of...
Dandri, M, Schirmacher, P, Rogler, C E
The woodchuck hepatitis virus (WHV) X gene (WHx) is required for infectivity of WHV in woodchucks, and the gene encodes a broadly acting transcription factor. Several lines of evidence from cell...
Yang, D, Faris, R, Hixson, D, Affigne, S, Rogler, C E
N-myc2 and insulin-like growth factor II (IGF-II) are coordinately overexpressed in the great majority of altered hepatic foci, which are the earliest precancerous lesions observed in the liver of...
The hepatitis B virus (HBV) precore protein inhibits HBV replication in transgenic mice.
Guidotti, L G, Matzke, B, Pasquinelli, C, Shoenberger, J M, Rogler, C E, Chisari, F V
In this study, we examined the ability of the hepatitis B virus (HBV) precore, envelope, and X gene products to modulate HBV replication in the livers of transgenic mice that replicate the virus....
Petersen, J, Dandri, M, Bürkle, A, Zhang, L, Rogler, C E
Persistent hepadnavirus infection leads to oxidative stress and DNA damage through increased production of toxic oxygen radicals. In addition, hepadnaviral DNA integrations into chromosomal DNA can...
Guidotti, L G, Martinez, V, Loh, Y T, Rogler, C E, Chisari, F V
Transgenic mice that express the hepatitis B virus core protein were used to examine factors that influence the intracellular localization of nucleocapsid particles in the primary hepatocyte in vivo....
Topoisomerase I-mediated integration of hepadnavirus DNA in vitro.
Hepadnaviruses integrate in cellular DNA via an illegitimate recombination mechanism, and clonally propagated integrations are present in most hepatocellular carcinomas which arise in hepadnavirus...
Features of two hepatitis B virus (HBV) DNA integrations suggest mechanisms of HBV integration.
Hino, O, Ohtake, K, Rogler, C E
Two integrated hepatitis B virus (HBV) DNA molecules were cloned from two primary hepatocellular carcinomas each containing only a single integration. One integration (C3) contained a single linear...
Fu, X X, Su, C Y, Lee, Y, Hintz, R, Biempica, L, Snyder, R, ...
Insulinlike growth factor II (IGF-II) is a highly mitogenic fetal growth factor suspected of regulating the growth of a wide spectrum of tissues via an autocrine or paracrine mode of action or both....
We have isolated and determined the structure of a recombinant clone in lambda phage Charon 30 which contains woodchuck hepatitis virus sequences integrated in woodchuck genomic DNA sequences. This...
Neel, B G, Gasic, G P, Rogler, C E, Skalka, A M, Ju, G, Hishinuma, F, ...
We isolated molecular clones of the provirus-host cell junctions (tumor junction fragments) from two avian leukosis virus-induced lymphomas and compared the structures of these clones with a clone of...
We cloned several unique forms of woodchuck hepatitis virus, a DNA virus closely related to hepatitis B virus, from a chronically infected woodchuck liver. Each of the three clones contained more...
Hepatitis B virus integration site in hepatocellular carcinoma at chromosome 17;18 translocation.
Hino, O, Shows, T B, Rogler, C E
Integrated hepatitis B virus (HBV) DNA is almost invariably found in hepatocellular carcinomas (HCC) which develop in HBV carriers. Integrated HBV DNAs from two single-integration HCCs (C3 and C4)...
Schirmacher, P., Held, W. A., Yang, D., Biempica, L., Rogler, C. E.
In a major urinary protein (MUP)-promoter/simian virus 40 (SV40)Tag transgenic mouse line (MT-D2) the liver-directed, androgen-regulated transgene expression leads to synchronized pathology resulting...