Solid-State Organization of Semifluorinated Alkanes Probed by F-19 MAS NMR Spectroscopy (2009)
Lee, Y. J., Clark, C. G., Graf, Robert, Wagner, Manfred, Müllen, Klaus, Spiess, Hans Wolfgang
Thermodynamic, structural, and nanomechanical properties of a fluorous biphasic material (2008)
Nunez, E., Clark, C. G., Cheng, W., Best, A., Floudas, G., Semenov, A. N., ...
Solvophobically-driven 3-D self-assembly of "exploded''-type polyphenylene dendrimers (2007)
Clark, C. G., Wenzel, R. J., Andreitchenko, E. V., Steffen, W., Zenobi, R., Müllen, Klaus
Terminology for Blastocystis subtypes - a consensus (2007)
Stensvold, C. R., Suresh, G. K., Tan, K. S. W., Thompson, R. C., Traub, R. J., Viscogliosi, E., ...
Blastocystis is a ubiquitous enteric protistan parasite that has extensive genetic diversity and infects humans and many other animals. Distinct molecular methodologies developed to detect variation...
Terminology for Blastocystis subtypes - a consensus (2007)
Stensvold, C. R., Suresh, G. K., Tan, K. S. W., Thompson, R. C., Traub, R. J., Viscogliosi, E., ...
Blastocystis is a ubiquitous enteric protistan parasite that has extensive genetic diversity and infects humans and many other animals. Distinct molecular methodologies developed to detect variation...
Schema: An Architecture for Knowledge Based CAD, (2002)
Schema provides an integrated environment for all aspects of the synthesis and analysis of electronic designs from PC boards through circuit and mask design of VLSI devices. It simplifies the...
Cruse, J.P., Lewin, M.R., Clark, C.G.
The theory that bile salts may be colon tumour promoters was tested in the dimethylhydrazine (DMH)-induced rat colon cancer model. Fifty Wistar rats were randomly allocated to one of five...
Lewin, M.R., Ferulano, G.P., Cruse, J.P., Clark, C.G.
The theory that endogenous factors in the intestinal contents may be pathogenic during large bowel carcinogenesis was tested in the dimethylhydrazine (DMH)-induced rat colon cancer model. Thirty...
OBSERVATIONS ON THE HUMAN CARDIA AT OPERATION (1962)
The pressure required to overcome resistance at the oesophagogastric junction was measured at operation in fifteen subjects and found to be 20 cm H, O from both oeso-phageal and gastric aspects....
Acknowledgements for Brush's article "Gravitation" (1929 paper), 1929 (1929)
Typed letter from C. G. Clark to Charles F., Sr., thanking Brush for sending to Clark a copy of the paper, entitled Gravitation, by Brush
Direct evidence for secondary loss of mitochondria in Entamoeba histolytica.
Archezoan protists are though to represent lineages that diverged from other eukaryotes before acquisition of the mitochondrion and other organelles. The parasite Entamoeba histolytica was originally...
Comparison of Molecular Methods for Typing Vibrio parahaemolyticus
Marshall, S., Clark, C. G., Wang, G., Mulvey, M., Kelly, M. T., Johnson, W. M.
An outbreak of Vibrio parahaemolyticus gastroenteritis on Canada’s west coast in 1997 emphasized the need to develop molecular methods for differentiation and typing of these organisms. Isolates...
The 70-kilodalton pertussis toxin-binding protein in Jurkat cells.
Armstrong, G D, Clark, C G, Heerze, L D
125I-ASD photoaffinity-labeling derivatives of pertussis toxin (125I-ASD-PT) or lipopolysaccharide (125I-ASD-LPS) labeled similar 70-kDa proteins in Jurkat cells, a cell line derived from human CD4+...
Expression and characterization of the eaeA gene product of Escherichia coli serotype O157:H7.
Louie, M, De Azavedo, J C, Handelsman, M Y, Clark, C G, Ally, B, Dytoc, M, ...
In enteropathogenic Escherichia coli, the eaeA gene produces a 94-kDa outer membrane protein called intimin which has been shown to be necessary but not sufficient to produce the...
Lectinlike properties of pertussis toxin.
Tyrrell, G J, Peppler, M S, Bonnah, R A, Clark, C G, Chong, P, Armstrong, G D
We have examined the lectinlike properties of pertussis toxin by binding-inhibition assays and affinity chromatography of goose erythrocyte membranes. Although pertussis toxin and wheat germ...
Lymphocyte receptors for pertussis toxin.
We have investigated human T-lymphocyte receptors for pertussis toxin by affinity isolation and photoaffinity labeling procedures. T lymphocytes were obtained from peripheral human blood, surface...
Clark, C G, Tague, B W, Ware, V C, Gerbi, S A
Based upon the three experimentally derived models of E. coli 23S rRNA (1-3) and the partial model for yeast 26S rRNA (4), which was deduced by homology to E. coli, we derived a secondary structure...
Sequence analysis of 28S ribosomal DNA from the amphibian Xenopus laevis.
Ware, V C, Tague, B W, Clark, C G, Gourse, R L, Brand, R C, Gerbi, S A
We have determined the complete nucleotide sequence of Xenopus laevis 28S rDNA (4110 bp). In order to locate evolutionarily conserved regions within rDNA, we compared the Xenopus 28S sequence to...
rRNA genes of Naegleria gruberi are carried exclusively on a 14-kilobase-pair plasmid.
An extrachromosomal DNA was discovered in Naegleria gruberi. The 3,000 to 5,000 copies per cell of this 14-kilobase-pair circular plasmid carry all the 18S, 28S, and 5.8S rRNA genes. The presence of...
Diverticula, neoplasia, or both? Early detection of carcinoma in sigmoid diverticular disease.
Boulos, P B, Cowin, A P, Karamanolis, D G, Clark, C G
In 105 patients with symptomatic sigmoid diverticular disease, colonoscopy revealed an associated frequency of carcinoma of seven (6.6%) (Dukes A in 4, B in 2, and C in 1) and adenomas in 29 (27.6%),...
Survey of management in acute upper gastrointestinal haemorrhage1
Thomas, G E, Cotton, P B, Clark, C G, Boulos, P B
The answers to a questionnaire concerning attitudes of members of the British Society of Gastroenterology to the management of acute upper gastrointestinal bleeding are analysed. In the majority of...
Gastric Acid Secretion and Diagnosis of Zollinger-Ellison Syndrome
Lewin, M. R., Stagg, B. H., Clark, C. G.
One hundred and fifty patients suspected of having Zollinger-Ellison syndrome were investigated. High plasma gastrin levels were found in 23 and in 16 a diagnosis of Zollinger-Ellison syndrome was...
Natural history and prognosis of recurrent breast cancer.
Karabali-Dalamaga, S, Souhami, R L, O'Higgins, N J, Soumilas, A, Clark, C G
Patterns of recurrent disease were analysed in 603 patients with breast cancer. The time of onset, frequency of recurrence, and survival after recurrence were not influenced by age or menopausal...
Direct evidence for secondary loss of mitochondria in Entamoeba histolytica.
Archezoan protists are though to represent lineages that diverged from other eukaryotes before acquisition of the mitochondrion and other organelles. The parasite Entamoeba histolytica was originally...
Comparison of Molecular Methods for Typing Vibrio parahaemolyticus
Marshall, S., Clark, C. G., Wang, G., Mulvey, M., Kelly, M. T., Johnson, W. M.
An outbreak of Vibrio parahaemolyticus gastroenteritis on Canada’s west coast in 1997 emphasized the need to develop molecular methods for differentiation and typing of these organisms. Isolates...
The 70-kilodalton pertussis toxin-binding protein in Jurkat cells.
Armstrong, G D, Clark, C G, Heerze, L D
125I-ASD photoaffinity-labeling derivatives of pertussis toxin (125I-ASD-PT) or lipopolysaccharide (125I-ASD-LPS) labeled similar 70-kDa proteins in Jurkat cells, a cell line derived from human CD4+...
Expression and characterization of the eaeA gene product of Escherichia coli serotype O157:H7.
Louie, M, De Azavedo, J C, Handelsman, M Y, Clark, C G, Ally, B, Dytoc, M, ...
In enteropathogenic Escherichia coli, the eaeA gene produces a 94-kDa outer membrane protein called intimin which has been shown to be necessary but not sufficient to produce the...
Lectinlike properties of pertussis toxin.
Tyrrell, G. J., Peppler, M. S., Bonnah, R. A., Clark, C. G., Chong, P., Armstrong, G. D.
We have examined the lectinlike properties of pertussis toxin by binding-inhibition assays and affinity chromatography of goose erythrocyte membranes. Although pertussis toxin and wheat germ...
Lymphocyte receptors for pertussis toxin.
We have investigated human T-lymphocyte receptors for pertussis toxin by affinity isolation and photoaffinity labeling procedures. T lymphocytes were obtained from peripheral human blood, surface...
Clark, C G, Tague, B W, Ware, V C, Gerbi, S A
Based upon the three experimentally derived models of E. coli 23S rRNA (1-3) and the partial model for yeast 26S rRNA (4), which was deduced by homology to E. coli, we derived a secondary structure...
Sequence analysis of 28S ribosomal DNA from the amphibian Xenopus laevis.
Ware, V C, Tague, B W, Clark, C G, Gourse, R L, Brand, R C, Gerbi, S A
We have determined the complete nucleotide sequence of Xenopus laevis 28S rDNA (4110 bp). In order to locate evolutionarily conserved regions within rDNA, we compared the Xenopus 28S sequence to...
rRNA genes of Naegleria gruberi are carried exclusively on a 14-kilobase-pair plasmid.
An extrachromosomal DNA was discovered in Naegleria gruberi. The 3,000 to 5,000 copies per cell of this 14-kilobase-pair circular plasmid carry all the 18S, 28S, and 5.8S rRNA genes. The presence of...
Diverticula, neoplasia, or both? Early detection of carcinoma in sigmoid diverticular disease.
Boulos, P B, Cowin, A P, Karamanolis, D G, Clark, C G
In 105 patients with symptomatic sigmoid diverticular disease, colonoscopy revealed an associated frequency of carcinoma of seven (6.6%) (Dukes A in 4, B in 2, and C in 1) and adenomas in 29 (27.6%),...
Survey of management in acute upper gastrointestinal haemorrhage1
Thomas, G E, Cotton, P B, Clark, C G, Boulos, P B
The answers to a questionnaire concerning attitudes of members of the British Society of Gastroenterology to the management of acute upper gastrointestinal bleeding are analysed. In the majority of...
Gastric Acid Secretion and Diagnosis of Zollinger-Ellison Syndrome
Lewin, M. R., Stagg, B. H., Clark, C. G.
One hundred and fifty patients suspected of having Zollinger-Ellison syndrome were investigated. High plasma gastrin levels were found in 23 and in 16 a diagnosis of Zollinger-Ellison syndrome was...
Natural history and prognosis of recurrent breast cancer.
Karabali-Dalamaga, S, Souhami, R L, O'Higgins, N J, Soumilas, A, Clark, C G
Patterns of recurrent disease were analysed in 603 patients with breast cancer. The time of onset, frequency of recurrence, and survival after recurrence were not influenced by age or menopausal...
Conservative surgery for bleeding peptic ulcer.
Carruthers, R. K., Giles, G. R., Clark, C. G., Goligher, J. C.
Pugh, S, Williams, S E, Lewin, M R, Ishaque, M, Barton, T P, Bose, K, ...
We tested the hypothesis that the production of prostaglandin E2 (PGE2) is impaired in duodenal ulcer disease and affected by treatment and healing. This was investigated by a study of maximal PGE2...
Lipodystrophy, pancreatitis, and eosinophilia.
Smith, P M, Morgans, M E, Clark, C G, Lennard-Jones, J E, Gunnlaugsson, O, Jonasson, T A
Two patients suffering from partial lipodystrophy, pancreatitis, and recurrent eosinophilia are described. In one patient the duodenum and the terminal ileum were narrowed, the appearances suggesting...
Psychiatric disorders after surgery for duodenal ulcer
A prospective trial was conducted to determine the relationship between personality type and the results of surgery for peptic ulcer. Previous investigations had suggested that patients with an...
Archampong, E. Q., Harris, J., Clark, C. G.
An `in-vitro' technique is described for measuring quantitatively the absorption and secretion of water and electrolytes, the short circuiting current, and the simultaneous bidirectional flux rates...
Plasma gastrin and acid secretion in man following stimulation by food, meat extract, and insulin
Wyllie, J. H., Boulos, P. B., Lewin, M. R., Stagg, B. H., Clark, C. G.
A radioimmunoassay for gastrin was set up and its sensitivity and specificity were studied. The assay was then used to investigate the plasma gastrin responses in man to a normal meal and to...
Effect of proximal gastric vagotomy on gastric acid secretion and plasma gastrin
Clark, C. G., Lewin, M. R., Stagg, B. H., Wyllie, J. H.
Sixteen patients underwent proximal gastric vagotomy (highly selective vagotomy) for chronic duodenal ulceration. All were subjected to preoperative and postoperative acid secretion studies. A...
Gallbladder function, cholesterol stones, and bile composition.
Antsaklis, G, Lewin, M R, Sutor, D J, Cowie, A G, Clark, C G
Gallbladder bile obtained at operation from five patients with no symptoms of biliary disease was undersaturated with cholesterol in every case. However, gallbladder bile from patients with stones...
The cardiac sphincter in the cat
A study of the function of the lower end of the oesophagus in the cat confirms that it behaves as a true physiological sphincter, even though histological evidence for such a structure is absent....
The late prognosis of perforated duodenal ulcer
Dean, A. C. B., Clark, C. G., Sinclair-Gieben, A. H.
One hundred and seventy cases of perforated duodenal ulcer have been followed up after eight to 10 years. Simple suture of the perforation is recommended. The decision to perform elective surgery is...
Jayaraj, A P, Tovey, F I, Clark, C G
In India there are regions of high incidence and regions of low incidence of duodenal ulcer. Rats prefed for two weeks on diets from low incidence areas developed significantly fewer rumenal ulcers...
Cruse, J P, Lewin, M R, Clark, C G
Cholesterol feeding of rats with colon cancer induced by dimethylhydrazine results in reduced survival and an increased incidence of metastatic colon cancer. As cholesterol may be implicated in the...
Proximal gastric vagotomy after five years.
Storey, D W, Boulos, P B, Ward, M W, Clark, C G
A follow-up of 93 patients with chronic duodenal ulceration treated by proximal gastric vagotomy without drainage five to nine years previously shows a high incidence of confirmed recurrent...
Effect of sodium taurocholate on gastric secretion in patients with duodenal ulceration
Lewin, M R, Pifano, E, Daniel, R D, Boulos, P B, Clark, C G
The effect of sodium taurocholate instillation on the stimulated stomachs of patients with duodenal ulceration has been investigated. Instillation into the stomach of sodium taurocholate...
Danzi, M, Lewin, M R, Cruse, J P, Clark, C G
The effects of combination chemotherapy with 5FU and BCNU on rats with dimethylhydrazine (DMH)-induced colon cancer were investigated in a long term survival study. Eighty Wistar rats received a...
Histochemical changes in mucus in duodenal ulceration.
Morrissey, S M, Ward, P M, Jayaraj, A P, Tovey, F I, Clark, C G
In duodenal ulceration the Alcian blue staining acid mucosubstances in goblet cells are reduced and the goblet cells themselves disappear. At the same time periodic acid-Schiff (PAS) staining neutral...
Endoscopic laser palliation for advanced malignant dysphagia.
Bown, S G, Hawes, R, Matthewson, K, Swain, C P, Barr, H, Boulos, P B, ...
Palliative treatment of malignant dysphagia aims to optimise swallowing for the maximum time possible with the minimum of general distress to these seriously ill patients. Thirty four patients...
Endoscopic laser treatment of vascular anomalies of the upper gastrointestinal tract.
Bown, S G, Swain, C P, Storey, D W, Collins, C, Matthewson, K, Salmon, P R, ...
Vascular anomalies of the gastrointestinal tract are an important source of both acute and chronic blood loss. They present difficult management problems as they are often multiple, involving more...
Vertical banded gastroplasty in the treatment of morbid obesity: results of three year follow up.
Carr, N D, Harrison, R A, Tomkins, A, Baughen, R, Demmer, S, Godfrey, J, ...
Vertical banded gastroplasty has replaced jejunoileal bypass in the surgical treatment of morbid obesity. Although this procedure carries a low incidence of early postoperative complications there is...
Tovey, F I, Husband, E M, Yiu, Y C, Baker, L, McPhail, G, Lewin, M R, ...
Forty six patients with endoscopically diagnosed duodenal ulceration were randomly allocated to treatment with either sucralfate 1 g qds (n = 24) or cimetidine 200 mg tds and 400 mg nocte (n = 22)....
Mode of action of histamine in causing gastric secretion in man
Clark, C. G., Curnow, V. June, Murray, J. G., Stephens, F. O., Wyllie, J. H.
Action of gastrin on the lower oesophageal sphincter in man
Giles, G. R., Mason, M. C., Humphries, C., Clark, C. G.
Both hog gastrin and synthetic gastrin stimulate the cardiac sphincter to increase tone and augment the resistance to reflux. Endogenous gastrin has a similar effect, and gastrin also stimulates the...
Effect of pH changes on the cardiac sphincter
Giles, G. R., Humphries, C., Mason, M. C., Clark, C. G.
In 16 normal subjects the pressure characteristics of the cardiac sphincter have been examined. The effect of perfusing the gastric aspect of the sphincter mucosa has been studied by comparing the...
Constipation — a simple approach to treatment
A simple method of treating patients with constipation is outlined and has been used successfully in 40 patients with severe primary constipation or constipation associated with diverticular disease.
Goligher, J. C., Pulvertaft, C. N., De Dombal, F. T., Clark, C. G., Conyers, J. H., Duthie, H. L., ...
Is chronic detergent ingestion harmful to the gut?
Mercurius-Taylor, L A, Jayaraj, A P, Clark, C G
Synthetic detergents are used in large quantities as household and industrial cleaners. Because of the common practice of leaving dishes washed in detergent solutions to dry without rinsing these...
Vertical banded gastroplasty: operation for morbid obesity.
Modern stapling equipment makes it possible to perform the vertical banded gastroplasty without major technical difficulties. Follow-up to date confirms its efficacy as a weight reducing procedure in...
The diagnosis of Ménétrier's disease.
Ward, N. W., Sarner, M., Whittaker, M. G., Clark, C. G.
Two cases of Ménétrier's disease are reported to illustrate the clinical presentation and diagnosis of this unusual condition. The literature has been reviewed of all the reported cases to...
The possibility of dietary protective factors in duodenal ulcer
Tovey, F. I., Jayaraj, A. Paul, Clark, C. G.
Rats fed on a supplement of raw cabbage, brinjal, dhal or powdered milk given in addition to a staple rice or laboratory stock diet show a high degree of protection against experimental ulceration...
Jayaraj, A. P., Tovey, F. I., Clark, C. G.
Rats pre-fed on a South Indian diet show a much higher incidence of ulceration of the stomach after pyloric ligation than those on a North Indian diet. Removing vegetables and pulses from the North...
Photodynamic therapy in the normal rat colon with phthalocyanine sensitisation.
Barr, H., Tralau, C. J., MacRobert, A. J., Krasner, N., Boulos, P. B., Clark, C. G., ...
Photodynamic therapy (PDT) involves the interaction of light with an administered photosensitising agent to produce cellular destruction. It has promising potential for the local and endoscopic...