C. G. M. Kallenberg

Publication List Details

Period

1995 - 2004

Number

41

Co-Authors

Staphylococcal superantigens and T cell expansions in Wegener's granulomatosis

POPA, E R, STEGEMAN, C A, BOS, N A, KALLENBERG, C G M, TERVAERT, J W Cohen

In Wegener's granulomatosis (WG), a form of autoimmune systemic vasculitis, chronic carriage of Staphylococcus aureus constitutes a risk factor for the development of exacerbations. Circulating T...

B cell epitope specificity in ANCA-associated vasculitis: does it matter?

VAN DER GELD, Y M, STEGEMAN, C A, KALLENBERG, C G M

Pauci-immune idiopathic small-vessel vasculitis is strongly associated with the presence of antineutrophil cytoplasm autoantibodies (ANCA). Antibodies to PR3 predominate in patients with Wegener's...

Catalase and α-enolase: two novel granulocyte autoantigens in inflammatory bowel disease (IBD)

Roozendaal, C, Zhao, M H, Horst, G, Lockwood, C M, Kleibeuker, J H, Limburg, P C, ...

In IBD, the target antigens of anti-neutrophil cytoplasmic autoantibodies (ANCA) have not been fully identified, which limits the analysis of the diagnostic significance as well as of the possible...

Levels of soluble FcγRIII correlate with disease severity in sepsis

Muller Kobold, A C, Zijlstra, J G, Koene, H R, DE Haas, M, Kallenberg, C G M, Cohen Tervaert, J W

Neutrophil activation is thought to play a crucial role in the pathogenesis of sepsis. During activation, neutrophils adhere to and migrate through the endothelium. Therefore, the amount of...

Are circulating neutrophils intravascularly activated in patients with anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitides?

MULLER KOBOLD, A C, MESANDER, G, STEGEMAN, C A, KALLENBERG, C G M, COHEN TERVAERT, J W

Vascular injury in vasculitis may be due to activation of circulating neutrophils resulting in their increased adhesiveness to locally activated endothelium (Shwartzman phenomenon). Previously, we...

Are anti-neutrophil cytoplasmic antibodies (ANCA) clinically useful in inflammatory bowel disease (IBD)?

Roozendaal, C, Kallenberg, C G M

Since the first detection of ANCA in IBD, numerous studies have dealt with their prevalence, antigenic specificities, clinical significance, pathophysiological role, and their induction. This review...

Characterization of monoclonal antibodies to proteinase 3 (PR3) as candidate tools for epitope mapping of human anti-PR3 autoantibodies

Van Der Geld, Y M, Limburg, P C, Kallenberg, C G M

Anti-neutrophil cytoplasmic antibodies directed against PR3 (PR3-ANCA) in patients with Wegener's granulomatosis are supposedly involved in the pathophysiology of this disease as different functional...

Staphylococcal acid phosphatase binds to endothelial cells via charge interaction; a pathogenic role in Wegener’s granulomatosis?

Brons, R H, Bakker, H I, Van Wijk, R T, Van Dijk, N W, Muller Kobold, A C, Limburg, P C, ...

The majority of patients with Wegener’s granulomatosis (WG) are chronic nasal carriers of Staphylococcus aureus. Chronic nasal carriage of S. aureus is associated with an increased risk of...

In vitro T lymphocyte responses to proteinase 3 (PR3) and linear peptides of PR3 in patients with Wegener's granulomatosis (WG)

Van Der Geld, Y M, Huitema, M G, Franssen, C F M, Van Der Zee, R, Limburg, P C, Kallenberg, C G M

T cell-mediated immunity is thought to play an important role in the pathogenesis of WG. In previous studies a minority of WG patients as well as some healthy controls showed in vitro proliferation...

Anti-CD3-induced and anti-Fas-induced apoptosis in systemic lupus erythematosus (SLE)

Bijl, M, Horst, G, Limburg, P C, Kallenberg, C G M

Disturbances in apoptosis or in the clearance of apoptotic material might result in increased presentation of autoantigens which could be relevant to the pathogenesis of SLE. Data concerning defects...

Interference of PR3-ANCA with the enzymatic activity of PR3: differences in patients during active disease or remission of Wegener's granulomatosis

Van Der Geld, Y M, Tool, A T J, Videler, J, De Haas, M, Cohen Tervaert, J W, Stegeman, C A, ...

Anti-neutrophil cytoplasmic antibodies (ANCA) against proteinase 3 (PR3) are strongly associated with Wegener's granulomatosis (WG) and are thought to be involved in its pathogenesis. Levels of...

Anti-dsDNA production coincides with concurrent B and T cell activation during development of active disease in systemic lupus erythematosus (SLE)

SPRONK, P E, HORST, G, VAN DER GUN, B T F, LIMBURG, P C, KALLENBERG, C G M

The objective was to serially analyse T and B cell activation in relation to autoantibody production during the development of relapses in SLE. In a prospective study we serially analysed, by flow...

Elastase, but not proteinase 3 (PR3), induces proteinuria associated with loss of glomerular basement membrane heparan sulphate after in vivo renal perfusion in rats

HEERINGA, P, VAN DEN BORN, J, BROUWER, E, DOLMAN, K M, KLOK, P A, HUITEMA, M G, ...

Elastase, but not PR3, induces proteinuria associated with loss of glomerular basement membrane (GBM) heparan sulphate after in vivo renal perfusion in rats. PR3 and elastase are cationic neutral...

Recombinant proteinase 3 (Wegener's antigen) expressed in Pichia pastoris is functionally active and is recognized by patient sera

HARMSEN, M C, HEERINGA, P, VAN DER GELD, Y M, HUITEMA, M G, KLIMP, A, TIRAN, A, ...

The open reading frame of human proteinase 3 (PR3) without the prepro-peptide was cloned and expressed in Escherichia coli (rcPR3) and in Pichia pastoris (rpPR3). The 6-histidine tagged rpPR3 was...