Valsamakis, G., Anwar, A., Tomlinson, J. W., Shackleton, C. H., McTernan, P. G., Chetty, R., ...
Glucocorticoids play an important role in the pathogenesis of obesity and insulin resistance. Impaired conversion of cortisone (E) to cortisol (F) by the type 1 isoenzyme of 11ß-hydroxysteroid...
Valsamakis, G., Anwar, A., Tomlinson, J.W., Shackleton, C.H., McTernan, P.G., Chetty, R., ...
Glucocorticoids play an important role in the pathogenesis of obesity and insulin resistance. Impaired conversion of cortisone (E) to cortisol (F) by the type 1 isoenzyme of 11beta-hydroxysteroid...
Long-lived testosterone esters in the rat.
Borg, W, Shackleton, C H, Pahuja, S L, Hochberg, R B
Over the past decade it has become increasingly clear that steroid hormones are enzymatically esterified with fatty acids. These steroidal esters are the natural analogs of synthetic esters that are...
Trant, J M, Lorence, M C, Johnson, E F, Shackleton, C H, Mason, J I, Estabrook, R W
Cytochrome P450IIC5 (rabbit liver 21-hydroxylase) is unusual among hepatic forms of cytochromes P450 because it catalyzes the conversion of one active steroid hormone (progesterone) to another active...
Measurement of de novo hepatic lipogenesis in humans using stable isotopes.
Hellerstein, M K, Christiansen, M, Kaempfer, S, Kletke, C, Wu, K, Reid, J S, ...
Direct measurement of de novo lipogenesis has not previously been possible in humans. We measured de novo hepatic lipogenesis in normal men by means of stable isotopes and by combining the...
Syndrome of apparent mineralocorticoid excess. A defect in the cortisol-cortisone shuttle.
Stewart, P M, Corrie, J E, Shackleton, C H, Edwards, C R
The first adult case of 11 beta-hydroxysteroid dehydrogenase (11 beta-OHSD) deficiency is described. The impaired conversion of cortisol to cortisone (indicated by urinary cortisol and cortisone...
Park, O J, Cesar, D, Faix, D, Wu, K, Shackleton, C H, Hellerstein, M K
1. The effects of purified diets containing 70% glucose or 70% fructose on the activation state of hepatic pyruvate dehydrogenase (PDHa), activity of mitochondrial PDH kinase, plasma triacylglycerols...
Blackham, M, Cesar, D, Park, O J, Vary, T C, Wu, K, Kaempfer, S, ...
1. The effects of recombinant human tumour necrosis factor alpha (TNF) and murine interleukin-1 alpha (IL-1) on the activation state of the hepatic pyruvate dehydrogenase complex (PDHa), the activity...
Ceballos, N R, Shackleton, C H, Harnik, M, Cozza, E N, Gros, E G, Lantos, C P
A material isolated following pregnenolone incubations with toad (Bufo arenarum) inter-renal tissue at 28 degrees C has been identified as a 3 beta-hydroxy-5-ene analogue of aldosterone (3 beta, 11...
Hydrolysis of dietary flavonoid glycosides by strains of intestinal Bacteroides from humans.
Bokkenheuser, V D, Shackleton, C H, Winter, J
Rutin and quercitrin are hydrolysed to quercetin, and robinin is hydrolysed to kaempferol, by faecal flora from healthy subjects. The enzymes required for these hydrolyses, namely alpha-rhamnosidase...
Summerfield, J A, Billing, B H, Shackleton, C H
In this qualitative study of the pattern of bile acid excretion in cholestasis, methods are described for the isolation of bile acids from large volumes of urine and plasma. The bile acids were...
Molecular basis for hypertension in the "type II variant" of apparent mineralocorticoid excess.
Li, A, Tedde, R, Krozowski, Z S, Pala, A, Li, K X, Shackleton, C H, ...
The syndrome of apparent mineralocorticoid excess (AME) is a heritable form of hypertension in which cortisol acts as a potent mineralocorticoid. The type I variant results in a severe clinical and...
Long-lived testosterone esters in the rat.
Borg, W, Shackleton, C H, Pahuja, S L, Hochberg, R B
Over the past decade it has become increasingly clear that steroid hormones are enzymatically esterified with fatty acids. These steroidal esters are the natural analogs of synthetic esters that are...
Trant, J M, Lorence, M C, Johnson, E F, Shackleton, C H, Mason, J I, Estabrook, R W
Cytochrome P450IIC5 (rabbit liver 21-hydroxylase) is unusual among hepatic forms of cytochromes P450 because it catalyzes the conversion of one active steroid hormone (progesterone) to another active...
Measurement of de novo hepatic lipogenesis in humans using stable isotopes.
Hellerstein, M K, Christiansen, M, Kaempfer, S, Kletke, C, Wu, K, Reid, J S, ...
Direct measurement of de novo lipogenesis has not previously been possible in humans. We measured de novo hepatic lipogenesis in normal men by means of stable isotopes and by combining the...
Syndrome of apparent mineralocorticoid excess. A defect in the cortisol-cortisone shuttle.
Stewart, P M, Corrie, J E, Shackleton, C H, Edwards, C R
The first adult case of 11 beta-hydroxysteroid dehydrogenase (11 beta-OHSD) deficiency is described. The impaired conversion of cortisol to cortisone (indicated by urinary cortisol and cortisone...
Park, O J, Cesar, D, Faix, D, Wu, K, Shackleton, C H, Hellerstein, M K
1. The effects of purified diets containing 70% glucose or 70% fructose on the activation state of hepatic pyruvate dehydrogenase (PDHa), activity of mitochondrial PDH kinase, plasma triacylglycerols...
Blackham, M, Cesar, D, Park, O J, Vary, T C, Wu, K, Kaempfer, S, ...
1. The effects of recombinant human tumour necrosis factor alpha (TNF) and murine interleukin-1 alpha (IL-1) on the activation state of the hepatic pyruvate dehydrogenase complex (PDHa), the activity...
Ceballos, N R, Shackleton, C H, Harnik, M, Cozza, E N, Gros, E G, Lantos, C P
A material isolated following pregnenolone incubations with toad (Bufo arenarum) inter-renal tissue at 28 degrees C has been identified as a 3 beta-hydroxy-5-ene analogue of aldosterone (3 beta, 11...
Hydrolysis of dietary flavonoid glycosides by strains of intestinal Bacteroides from humans.
Bokkenheuser, V D, Shackleton, C H, Winter, J
Rutin and quercitrin are hydrolysed to quercetin, and robinin is hydrolysed to kaempferol, by faecal flora from healthy subjects. The enzymes required for these hydrolyses, namely alpha-rhamnosidase...
Summerfield, J A, Billing, B H, Shackleton, C H
In this qualitative study of the pattern of bile acid excretion in cholestasis, methods are described for the isolation of bile acids from large volumes of urine and plasma. The bile acids were...
Molecular basis for hypertension in the "type II variant" of apparent mineralocorticoid excess.
Li, A, Tedde, R, Krozowski, Z S, Pala, A, Li, K X, Shackleton, C H, ...
The syndrome of apparent mineralocorticoid excess (AME) is a heritable form of hypertension in which cortisol acts as a potent mineralocorticoid. The type I variant results in a severe clinical and...
Dillon, M J, Leonard, J V, Buckler, J M, Ogilvie, D, Lillystone, D, Honour, J W, ...
10 infants are described with pseudohypoaldosteronism, 5 in detail and a further 5 briefly. They all presented with hyperkalaemia, urinary salt-wasting disease, and ostensibly normal renal and...