C. I. Wu

Publication List Details

Period

2000 - 2000

Number

44

Co-Authors

Abstract (2000)

Aln Surfaces, C. I. Wu, A. Kahn

www.elsevier.nlrlocaterapsusc Negative electron affinity and electron emission at cesiated

Sexual isolation in Drosophila melanogaster: a possible case of incipient speciation.

Wu, C I, Hollocher, H, Begun, D J, Aquadro, C F, Xu, Y, Wu, M L

It is generally believed that Drosophila melanogaster has no closely related species with which it can produce the viable and fertile hybrids that are essential for the genetic analysis of...

Evidence for higher rates of nucleotide substitution in rodents than in man.

Wu, C I, Li, W H

When the coding regions of 11 genes from rodents (mouse or rat) and man are compared with those from another mammalian species (usually bovine), it is found that rodents evolve significantly faster...

Inferences of Species Phylogeny in Relation to Segregation of Ancient Polymorphisms

Wu, C. I.

Standard formulas of gene frequency change under genetic drift are used to derive the probability of obtaining incorrect phylogenetic information for three species due to segregation of ancient...

An Empirical Test of the Meiotic Drive Models of Hybrid Sterility: Sex-Ratio Data from Hybrids between Drosophila Simulans and Drosophila Sechellia

Johnson, N. A., Wu, C. I.

Recently, there has been much discussion regarding the hypothesis that divergence of meiotic drive systems in isolated populations can generate the patterns of reproductive isolation observed in...

Genetics of Reproductive Isolation in the Drosophila Simulans Clade: DNA Marker-Assisted Mapping and Characterization of a Hybrid-Male Sterility Gene, Odysseus (Ods)

Perez, D. E., Wu, C. I., Johnson, N. A., Wu, M. L.

In this study, we address the question of whether there exist major genes that cause complete male sterility in the interspecific hybrids of Drosophila and, if they do, how these genes may be...

The Effects of Interspecific Y Chromosome Replacements on Hybrid Sterility within the Drosophila Simulans Clade

Johnson, N. A., Hollocher, H., Noonburg, E., Wu, C. I.

We attempted to introgress Y chromosomes between three sibling species of Drosophila: D. simulans, D. sechellia and D. mauritiana. Four D. sechellia Y chromosomes were introgressed into D. simulans...

Population Genetics of Tandem Repeats in Centromeric Heterochromatin: Unequal Crossing over and Chromosomal Divergence at the Responder Locus of Drosophila Melanogaster

Cabot, E. L., Doshi, P., Wu, M. L., Wu, C. I.

The Responder (Rsp) locus in Drosophila melanogaster is the target locus of segregation distortion and is known to be comprised of a tandem array of 120-bp repetitive sequences. In this study, we...

Characterization of Two Segregation Distorter Revertants: Evidence That the Tandem Duplication Is Necessary for Sd Activity in Drosophila Melanogaster

Palopoli, M. F., Doshi, P., Wu, C. I.

Segregation Distorter (SD) is a naturally occurring system of meiotic drive in Drosophila melanogaster. Males heterozygous for an SD second chromosome and a normal homolog (SD(+)) transmit...

Genetics of Reproductive Isolation in the Drosophila Simulans Clade: Complex Epistasis Underlying Hybrid Male Sterility

Cabot, E. L., Davis, A. W., Johnson, N. A., Wu, C. I.

We have analyzed the sterility associated with introgressions of the distal one-fourth of the X chromosome from either Drosophila mauritiana or Drosophila sechellia into the genome of Drosophila...

Evidence for Complex Genic Interactions between Conspecific Chromosomes Underlying Hybrid Female Sterility in the Drosophila Simulans Clade

Davis, A. W., Noonburg, E. G., Wu, C. I.

F(1) hybrid females between the sibling species Drosophila simulans, Drosophila mauritiana and Drosophila sechellia are completely fertile. However, we have found that female sterility can be...

Genetics of Hybrid Male Sterility between Drosophila Sibling Species: A Complex Web of Epistasis Is Revealed in Interspecific Studies

Palopoli, M. F., Wu, C. I.

To study the genetic differences responsible for the sterility of their male hybrids, we introgressed small segments of an X chromosome from Drosophila simulans into a pure Drosophila mauritiana...

Further Characterization of the Odysseus Locus of Hybrid Sterility in Drosophila: One Gene Is Not Enough

Perez, D. E., Wu, C. I.

Previously we mapped by genetical and molecular means a gene that contributes to hybrid-male sterility between Drosophila mauritiana and D. simulans to the cytological interval of 16D. In this...

The Genetics of Reproductive Isolation in the Drosophila Simulans Clade: X Vs. Autosomal Effects and Male Vs. Female Effects

Hollocher, H., Wu, C. I.

A strong effect of homozygous autosomal regions on reproductive isolation was found for crosses between the species in the Drosophila simulans clade. Second chromosome regions were introgressed from...

The Broom of the Sorcerer's Apprentice: The Fine Structure of a Chromosomal Region Causing Reproductive Isolation between Two Sibling Species of Drosophila

Davis, A. W., Wu, C. I.

How many genes contribute to reproductive isolation between closely related species? We determined the number of genes located in the 9D-12B region of the Drosophila mauritiana X chromosome that...

Rapid Evolution of a Coadapted Gene Complex: Evidence from the Segregation Distorter (Sd) System of Meiotic Drive in Drosophila Melanogaster

Palopoli, M. F., Wu, C. I.

Segregation Distorter (SD) is a system of meiotic drive found in natural populations of Drosophila melanogaster. Males heterozygous for an SD second chromosome and a normal homologue (SD(+)) produce...

Discord between the Phylogenies Inferred from Molecular versus Functional Data: Uneven Rates of Functional Evolution or Low Levels of Gene Flow?

Palopoli, M. F., Davis, A. W., Wu, C. I.

According to measures of molecular divergence, the three species of the Drosophila simulans clade are closely related to and essentially equidistant from each other. We introgressed 10% of the D....

Incipient Speciation by Sexual Isolation in Drosophila Melanogaster: Extensive Genetic Divergence without Reinforcement

Hollocher, H., Ting, C. T., Wu, M. L., Wu, C. I.

The collection of Drosophila melanogaster from Zimbabwe and nearby regions (the Z-type) yield females who would not mate with the cosmopolitan D. melanogaster males (the M-type). To dissect the...

Hitchhiking under positive Darwinian selection.

Fay, J C, Wu, C I

Positive selection can be inferred from its effect on linked neutral variation. In the restrictive case when there is no recombination, all linked variation is removed. If recombination is present...

Positive and negative selection on the human genome.

Fay, J C, Wyckoff, G J, Wu, C I

The distinction between deleterious, neutral, and adaptive mutations is a fundamental problem in the study of molecular evolution. Two significant quantities are the fraction of DNA variation in...

Modeling linkage disequilibrium between a polymorphic marker locus and a locus affecting complex dichotomous traits in natural populations.

Luo, Z W, Wu, C I

Linkage disequilibrium is an important topic in evolutionary and population genetics. An issue yet to be settled is the theory required to extend the linkage disequilibrium analysis to complex...

Sexual isolation in Drosophila melanogaster: a possible case of incipient speciation.

Wu, C I, Hollocher, H, Begun, D J, Aquadro, C F, Xu, Y, Wu, M L

It is generally believed that Drosophila melanogaster has no closely related species with which it can produce the viable and fertile hybrids that are essential for the genetic analysis of...

Evidence for higher rates of nucleotide substitution in rodents than in man.

Wu, C I, Li, W H

When the coding regions of 11 genes from rodents (mouse or rat) and man are compared with those from another mammalian species (usually bovine), it is found that rodents evolve significantly faster...

Inferences of Species Phylogeny in Relation to Segregation of Ancient Polymorphisms

Wu, C. I.

Standard formulas of gene frequency change under genetic drift are used to derive the probability of obtaining incorrect phylogenetic information for three species due to segregation of ancient...

An Empirical Test of the Meiotic Drive Models of Hybrid Sterility: Sex-Ratio Data from Hybrids between Drosophila Simulans and Drosophila Sechellia

Johnson, N. A., Wu, C. I.

Recently, there has been much discussion regarding the hypothesis that divergence of meiotic drive systems in isolated populations can generate the patterns of reproductive isolation observed in...

Genetics of Reproductive Isolation in the Drosophila Simulans Clade: DNA Marker-Assisted Mapping and Characterization of a Hybrid-Male Sterility Gene, Odysseus (Ods)

Perez, D. E., Wu, C. I., Johnson, N. A., Wu, M. L.

In this study, we address the question of whether there exist major genes that cause complete male sterility in the interspecific hybrids of Drosophila and, if they do, how these genes may be...

The Effects of Interspecific Y Chromosome Replacements on Hybrid Sterility within the Drosophila Simulans Clade

Johnson, N. A., Hollocher, H., Noonburg, E., Wu, C. I.

We attempted to introgress Y chromosomes between three sibling species of Drosophila: D. simulans, D. sechellia and D. mauritiana. Four D. sechellia Y chromosomes were introgressed into D. simulans...

Population Genetics of Tandem Repeats in Centromeric Heterochromatin: Unequal Crossing over and Chromosomal Divergence at the Responder Locus of Drosophila Melanogaster

Cabot, E. L., Doshi, P., Wu, M. L., Wu, C. I.

The Responder (Rsp) locus in Drosophila melanogaster is the target locus of segregation distortion and is known to be comprised of a tandem array of 120-bp repetitive sequences. In this study, we...

Characterization of Two Segregation Distorter Revertants: Evidence That the Tandem Duplication Is Necessary for Sd Activity in Drosophila Melanogaster

Palopoli, M. F., Doshi, P., Wu, C. I.

Segregation Distorter (SD) is a naturally occurring system of meiotic drive in Drosophila melanogaster. Males heterozygous for an SD second chromosome and a normal homolog (SD(+)) transmit...

Genetics of Reproductive Isolation in the Drosophila Simulans Clade: Complex Epistasis Underlying Hybrid Male Sterility

Cabot, E. L., Davis, A. W., Johnson, N. A., Wu, C. I.

We have analyzed the sterility associated with introgressions of the distal one-fourth of the X chromosome from either Drosophila mauritiana or Drosophila sechellia into the genome of Drosophila...

Evidence for Complex Genic Interactions between Conspecific Chromosomes Underlying Hybrid Female Sterility in the Drosophila Simulans Clade

Davis, A. W., Noonburg, E. G., Wu, C. I.

F(1) hybrid females between the sibling species Drosophila simulans, Drosophila mauritiana and Drosophila sechellia are completely fertile. However, we have found that female sterility can be...

Genetics of Hybrid Male Sterility between Drosophila Sibling Species: A Complex Web of Epistasis Is Revealed in Interspecific Studies

Palopoli, M. F., Wu, C. I.

To study the genetic differences responsible for the sterility of their male hybrids, we introgressed small segments of an X chromosome from Drosophila simulans into a pure Drosophila mauritiana...

Further Characterization of the Odysseus Locus of Hybrid Sterility in Drosophila: One Gene Is Not Enough

Perez, D. E., Wu, C. I.

Previously we mapped by genetical and molecular means a gene that contributes to hybrid-male sterility between Drosophila mauritiana and D. simulans to the cytological interval of 16D. In this...

The Genetics of Reproductive Isolation in the Drosophila Simulans Clade: X Vs. Autosomal Effects and Male Vs. Female Effects

Hollocher, H., Wu, C. I.

A strong effect of homozygous autosomal regions on reproductive isolation was found for crosses between the species in the Drosophila simulans clade. Second chromosome regions were introgressed from...

The Broom of the Sorcerer's Apprentice: The Fine Structure of a Chromosomal Region Causing Reproductive Isolation between Two Sibling Species of Drosophila

Davis, A. W., Wu, C. I.

How many genes contribute to reproductive isolation between closely related species? We determined the number of genes located in the 9D-12B region of the Drosophila mauritiana X chromosome that...

Rapid Evolution of a Coadapted Gene Complex: Evidence from the Segregation Distorter (Sd) System of Meiotic Drive in Drosophila Melanogaster

Palopoli, M. F., Wu, C. I.

Segregation Distorter (SD) is a system of meiotic drive found in natural populations of Drosophila melanogaster. Males heterozygous for an SD second chromosome and a normal homologue (SD(+)) produce...

Discord between the Phylogenies Inferred from Molecular versus Functional Data: Uneven Rates of Functional Evolution or Low Levels of Gene Flow?

Palopoli, M. F., Davis, A. W., Wu, C. I.

According to measures of molecular divergence, the three species of the Drosophila simulans clade are closely related to and essentially equidistant from each other. We introgressed 10% of the D....

Incipient Speciation by Sexual Isolation in Drosophila Melanogaster: Extensive Genetic Divergence without Reinforcement

Hollocher, H., Ting, C. T., Wu, M. L., Wu, C. I.

The collection of Drosophila melanogaster from Zimbabwe and nearby regions (the Z-type) yield females who would not mate with the cosmopolitan D. melanogaster males (the M-type). To dissect the...

Hitchhiking under positive Darwinian selection.

Fay, J C, Wu, C I

Positive selection can be inferred from its effect on linked neutral variation. In the restrictive case when there is no recombination, all linked variation is removed. If recombination is present...

Positive and negative selection on the human genome.

Fay, J C, Wyckoff, G J, Wu, C I

The distinction between deleterious, neutral, and adaptive mutations is a fundamental problem in the study of molecular evolution. Two significant quantities are the fraction of DNA variation in...

Modeling linkage disequilibrium between a polymorphic marker locus and a locus affecting complex dichotomous traits in natural populations.

Luo, Z W, Wu, C I

Linkage disequilibrium is an important topic in evolutionary and population genetics. An issue yet to be settled is the theory required to extend the linkage disequilibrium analysis to complex...

Gametic incompatibilities between races of Drosophila melanogaster.

Alipaz, J A, Wu, C I, Karr, T L

Reproductive-isolating mechanisms between nascent species may involve sperm-egg recognition and have been best described in externally fertilizing organisms where such recognition is essential in...