BURNING VELOCITY, EFFECT OF MOLECULAR STRUCTURE, (2005)
A simple and reliable method was worked out for calculating burning velocity from flame dimensions. The report presents the procedure, with data demonstrating the errors involved, a comparison with...
CARBON DISULFIDE FLAMES, INFLUENCE OF MOISTURE, (1998)
Gibbs,C. J., King,I. R., Calcote,H. F.
The burning velocity of carbon disulfide - air flames increases exponentially as the concentration of water is reduced so that on a Bunsen burner for very dry mixtures flash back was inescapable....
EXPERIMENTAL KURU IN THE CHIMPANZEE: A NEUROPATHOLOGICAL STUDY (1973)
BECK, ELISABETH, DANIEL, P. M., ASHER, D. M., GAJDUSEK, D. C., GIBBS, C. J.
CREUTZFELDT-JAKOB DISEASE: THE NEUROPATHOLOGY OF A TRANSMISSION EXPERIMENT (1969)
BECK, ELISABETH, DANIEL, P. M., MATTHEWS, W. B., STEVENS, D. L., ALPERS, M. P., ASHER, D. M., ...
Venkateshan, C N, Narayanan, R, Espey, M G, Moffett, J R, Gajdusek, D C, Gibbs, C J, ...
Quinolinate (Quin), a metabolite in the kynurenine pathway of tryptophan degradation and a neurotoxin that appears to act through the N-methyl-D-aspartate receptor system, was localized in cultured...
Cervenáková, L, Brown, P, Goldfarb, L G, Nagle, J, Pettrone, K, Rubenstein, R, ...
Based on the analysis of genomic DNA from single healthy animals of each of five primate species, nucleotide and predicted amino acid sequences of the infectious amyloid precursor gene of higher apes...
Gibbs, C J, Peters, R, Gravell, M, Johnson, B K, Jensen, F C, Carlo, D J, ...
Two human immunodeficiency virus (HIV)-seropositive chimpanzees (A-3 and A-86c) infected 4 yr earlier with HIV, along with one uninfected animal (A-36), were inoculated intramuscularly three times in...
Goldfarb, L G, Brown, P, McCombie, W R, Goldgaber, D, Swergold, G D, Wills, P R, ...
The PRNP gene, encoding the amyloid precursor protein that is centrally involved in Creutzfeldt-Jakob disease (CJD), has an unstable region of five variant tandem octapeptide coding repeats between...
Safar, J, Wang, W, Padgett, M P, Ceroni, M, Piccardo, P, Zopf, D, ...
A highly purified fraction obtained from scrapie (263-K strain)-infected hamsters' brains by an alternative procedure without proteinase K treatment contained a protease-resistant form of the scrapie...
Nara, P L, Robey, W G, Arthur, L O, Asher, D M, Wolff, A V, Gibbs, C J, ...
Persistent infection by human immunodeficiency virus (HIV-1) in the chimpanzee may be valuable for immunopathologic and potential vaccine evaluation. Two HIV strains, the tissue culture-derived human...
Kuroda, Y, Gibbs, C J, Amyx, H L, Gajdusek, D C
The mode of replication of the "unconventional virus" of Creutzfeldt-Jakob disease was studied in BALB/c mice infected intracerebrally. Virus was detected in the brain, spleen, lung, thymus, liver,...
Lee, P W, Gibbs, C J, Gajdusek, D C, Yanagihara, R
Antisera prepared against 16 strains of hantaviruses isolated from patients with hemorrhagic fever with renal syndrome (HFRS) or from rodents captured in HFRS-endemic and nonendemic regions were...
Goudsmit, J, Debouck, C, Meloen, R H, Smit, L, Bakker, M, Asher, D M, ...
Chimpanzees are susceptible to infection by divergent strains of human immunodeficiency virus type 1 (HIV-1), none of which cause clinical or immunological abnormalities. Chimpanzees were inoculated...
Sarin, P S, Rodgers-Johnson, P, Sun, D K, Thornton, A H, Morgan, O S, Gibbs, W N, ...
The isolation and characterization of a human T-cell lymphotropic retrovirus related to human T-cell lymphotropic virus type I (HTLV-I) from cerebrospinal fluid of a Jamaican patient with tropical...
Guiroy, D C, Miyazaki, M, Multhaup, G, Fischer, P, Garruto, R M, Beyreuther, K, ...
The presence of abundant intraneuronal amyloid in the form of neurofibrillary tangles (NFT) in the brains of Guamanian parkinsonism-dementia patients and the absence of extraneuronal amyloid in the...
Monoclonal antibody analysis of keratin expression in the central nervous system.
Franko, M C, Gibbs, C J, Rhoades, D A, Gajdusek, D C
A monoclonal antibody directed against a 65-kDa brain protein demonstrates an epitope found in keratin from human epidermis. By indirect immunofluorescence, the antibody decorates intracytoplasmic...
Goudsmit, J, Epstein, L G, Paul, D A, Van Der Helm, H J, Dawson, G J, Asher, D M, ...
The presence of human immunodeficiency virus (HIV) antigens in cerebrospinal fluid (CSF) was associated with progressive encephalopathy in adult and pediatric patients with acquired immunodeficiency...
Monoclonal antibody specific for myelin glycoprotein P0: derivation and characterization.
Franko, M C, Koski, C L, Gibbs, C J, McFarlin, D E, Gajdusek, D C
A monoclonal antibody was produced against the major structural glycoprotein (P0) of human peripheral nervous system myelin. The hybridomas were generated by fusion of mouse myeloma line NS-1 with...
Evidence for an unconventional virus in mouse-adapted Creutzfeldt-Jakob disease.
Kingsbury, D T, Smeltzer, D A, Amyx, H L, Gibbs, C J, Gajdusek, D C
Homogenates of a human brain from a case of Creutzfeldt-Jakob disease and a homogenate of mouse brains from mouse passage 1 of the disease in mice contained no detectable conventional viruses. Both...
Method for preparing cultures of central neurons: cytochemical and immunochemical studies.
Sotelo, J, Gibbs, C J, Gajdusek, D C, Toh, B H, Wurth, M
We report a simplified method for culturing fetal central nervous system cells predominantly inducing neurons that grow, differentiate, and live in vitro for as long as 10 weeks. These central...
Propagation of Korean hemorrhagic fever virus in laboratory rats.
Lee, P W, Amyx, H L, Gibbs, C J, Gajdusek, D C, Lee, H W
Korean hemorrhagic fever virus (KHFV) has been adapted to the Wistar and Fisher strains of rats. Infection was detected by the appearance of specific antigen in the lung tissue of the infected rats...
Cell fusion induced by scrapie and Creutzfeldt-Jakob virus-infected brain preparations.
Kidson, C, Moreau, M C, Asher, D M, Brown, P W, Coon, H G, Gajdusek, D C, ...
Cell fusion was induced by brain extracts containing the scrapie virus and the virus of Creutzfeldt-Jakob disease. The assay involved quantitation of colony-forming ability in a double selection...
Gibbs, C J, Gajdusek, D C, Latarjet, R
The titers of several preparations of kuru. Creutzfeldt-Jacob disease, and scrapie viruses were reduced by only 1/10th or less by high doses of gamma radiation of 50 kGy and by only 1/10th-1/1000th...
Monoclonal antibodies specific for Hantaan virus.
Franko, M C, Gibbs, C J, Lee, P W, Gajdusek, D C
Six hybridoma cell line producing monoclonal antibodies to Hantaan virus were established by fusion of NS-1 mouse myeloma cells with spleen cells of mice immunized with Hantaan virus strain 76-118....
Toh, B H, Gibbs, C J, Gajdusek, D C, Goudsmit, J, Dahl, D
Sera from 65 patients with spongiform virus encephalopathies (29 with kuru, 36 with Creutzfeldt-Jakob disease), 79 with other neurologic diseases, and 65 control subjects were examined for reactivity...
Toh, B H, Gibbs, C J, Gajdusek, D C, Tuthill, D D, Dahl, D
Sera from 46 chimpanzees with spongiform encephalopathy (18 kuru, 28 Creutzfeldt-Jakob disease) and sera from 12 sheep with natural scrapie were tested for reactivity with immunoblots of...
Isolation and characterization of two new herpes-like viruses from capuchin monkeys.
Lewis, M A, Frye, L D, Gibbs, C J, Chou, S M, Cutchins, E C, Gajdusek, D C, ...
Two herpes-like viruses were isolated from capuchin monkey (Cebus apella) brain and (Cebus albifrons) spleen cell cultures, respectively. Both isolates induced similar cytopathic effects consisting...
Antigenic relationship of human foamy virus to the simian foamy viruses.
Nemo, G J, Brown, P W, Gibbs, C J, Gajdusek, D C
A foamy virus isolated by Achong et al. from a human nasopharyngeal carcinoma was studied to determine its antigenic relationship to the eight known simiam foamy viruses (SFV). Using reciprocal...
Persistent shedding of adenovirus in urine of chimpanzees.
Asher, D M, Hooks, J J, Amyx, H L, Luber, N P, Asher, L V, Gibbs, C J, ...
A new adenovirus, designated Pan 11, was isolated repeatedly from the urine of several chimpanzees for more than 1 year. One chimpanzee had chronic interstitial nephritis; the others were healthy....
Antibodies in urine of chimpanzees with chronic adenoviral viruria.
Ashner, L V, Asher, D M, Shah, K V, Amyx, H L, Gibbs, C J, Gajdusek, D C
Many chimpanzees have naturally occurring chronic intermittent viruria with an adenovirus of a new type called Pan 11. Small amounts of neutralizing antibodies to Pan 11 adenovirus were found in the...
Isolation of a New Simian Foamy Virus from a Spider Monkey Brain Culture
Hooks, John J., Gibbs, C. J., Chou, S., Howk, R., Lewis, M., Gajdusek, D. C.
A syncytium-forming (foamy) virus was isolated from a spider monkey brain cell culture. Cytopathic effect was observed both in the brain culture and in human embryonic kidney cells. Neutralizing...
Antibodies to neurofilament protein in retinitis pigmentosa.
Galbraith, G M, Emerson, D, Fudenberg, H H, Gibbs, C J, Gajdusek, D C
Antibodies reactive with heterologous neural tissue were detected by indirect immunofluorescence microscopy in the sera of 17 of 34 patients with retinitis pigmentosa, one of 30 normal control sera,...
Osteomalacia in Paget's disease treated with short term, high dose sodium etidronate.
Gibbs, C J, Aaron, J E, Peacock, M
Eleven patients with Paget's disease treated with sodium etidronate 20 mg/kg/day for two and four weeks showed significant reductions in plasma alkaline phosphatase activity and urinary...
Venkateshan, C N, Narayanan, R, Espey, M G, Moffett, J R, Gajdusek, D C, Gibbs, C J, ...
Quinolinate (Quin), a metabolite in the kynurenine pathway of tryptophan degradation and a neurotoxin that appears to act through the N-methyl-D-aspartate receptor system, was localized in cultured...
Cervenáková, L, Brown, P, Goldfarb, L G, Nagle, J, Pettrone, K, Rubenstein, R, ...
Based on the analysis of genomic DNA from single healthy animals of each of five primate species, nucleotide and predicted amino acid sequences of the infectious amyloid precursor gene of higher apes...
Gibbs, C J, Peters, R, Gravell, M, Johnson, B K, Jensen, F C, Carlo, D J, ...
Two human immunodeficiency virus (HIV)-seropositive chimpanzees (A-3 and A-86c) infected 4 yr earlier with HIV, along with one uninfected animal (A-36), were inoculated intramuscularly three times in...
Goldfarb, L G, Brown, P, McCombie, W R, Goldgaber, D, Swergold, G D, Wills, P R, ...
The PRNP gene, encoding the amyloid precursor protein that is centrally involved in Creutzfeldt-Jakob disease (CJD), has an unstable region of five variant tandem octapeptide coding repeats between...
Safar, J, Wang, W, Padgett, M P, Ceroni, M, Piccardo, P, Zopf, D, ...
A highly purified fraction obtained from scrapie (263-K strain)-infected hamsters' brains by an alternative procedure without proteinase K treatment contained a protease-resistant form of the scrapie...
Nara, P L, Robey, W G, Arthur, L O, Asher, D M, Wolff, A V, Gibbs, C J, ...
Persistent infection by human immunodeficiency virus (HIV-1) in the chimpanzee may be valuable for immunopathologic and potential vaccine evaluation. Two HIV strains, the tissue culture-derived human...
Kuroda, Y, Gibbs, C J, Amyx, H L, Gajdusek, D C
The mode of replication of the "unconventional virus" of Creutzfeldt-Jakob disease was studied in BALB/c mice infected intracerebrally. Virus was detected in the brain, spleen, lung, thymus, liver,...
Lee, P W, Gibbs, C J, Gajdusek, D C, Yanagihara, R
Antisera prepared against 16 strains of hantaviruses isolated from patients with hemorrhagic fever with renal syndrome (HFRS) or from rodents captured in HFRS-endemic and nonendemic regions were...
Goudsmit, J, Debouck, C, Meloen, R H, Smit, L, Bakker, M, Asher, D M, ...
Chimpanzees are susceptible to infection by divergent strains of human immunodeficiency virus type 1 (HIV-1), none of which cause clinical or immunological abnormalities. Chimpanzees were inoculated...
Sarin, P S, Rodgers-Johnson, P, Sun, D K, Thornton, A H, Morgan, O S, Gibbs, W N, ...
The isolation and characterization of a human T-cell lymphotropic retrovirus related to human T-cell lymphotropic virus type I (HTLV-I) from cerebrospinal fluid of a Jamaican patient with tropical...
Guiroy, D C, Miyazaki, M, Multhaup, G, Fischer, P, Garruto, R M, Beyreuther, K, ...
The presence of abundant intraneuronal amyloid in the form of neurofibrillary tangles (NFT) in the brains of Guamanian parkinsonism-dementia patients and the absence of extraneuronal amyloid in the...
Monoclonal antibody analysis of keratin expression in the central nervous system.
Franko, M C, Gibbs, C J, Rhoades, D A, Gajdusek, D C
A monoclonal antibody directed against a 65-kDa brain protein demonstrates an epitope found in keratin from human epidermis. By indirect immunofluorescence, the antibody decorates intracytoplasmic...
Goudsmit, J, Epstein, L G, Paul, D A, Van Der Helm, H J, Dawson, G J, Asher, D M, ...
The presence of human immunodeficiency virus (HIV) antigens in cerebrospinal fluid (CSF) was associated with progressive encephalopathy in adult and pediatric patients with acquired immunodeficiency...
Monoclonal antibody specific for myelin glycoprotein P0: derivation and characterization.
Franko, M C, Koski, C L, Gibbs, C J, McFarlin, D E, Gajdusek, D C
A monoclonal antibody was produced against the major structural glycoprotein (P0) of human peripheral nervous system myelin. The hybridomas were generated by fusion of mouse myeloma line NS-1 with...
Evidence for an unconventional virus in mouse-adapted Creutzfeldt-Jakob disease.
Kingsbury, D T, Smeltzer, D A, Amyx, H L, Gibbs, C J, Gajdusek, D C
Homogenates of a human brain from a case of Creutzfeldt-Jakob disease and a homogenate of mouse brains from mouse passage 1 of the disease in mice contained no detectable conventional viruses. Both...
Method for preparing cultures of central neurons: cytochemical and immunochemical studies.
Sotelo, J, Gibbs, C J, Gajdusek, D C, Toh, B H, Wurth, M
We report a simplified method for culturing fetal central nervous system cells predominantly inducing neurons that grow, differentiate, and live in vitro for as long as 10 weeks. These central...
Propagation of Korean hemorrhagic fever virus in laboratory rats.
Lee, P W, Amyx, H L, Gibbs, C J, Gajdusek, D C, Lee, H W
Korean hemorrhagic fever virus (KHFV) has been adapted to the Wistar and Fisher strains of rats. Infection was detected by the appearance of specific antigen in the lung tissue of the infected rats...
Cell fusion induced by scrapie and Creutzfeldt-Jakob virus-infected brain preparations.
Kidson, C, Moreau, M C, Asher, D M, Brown, P W, Coon, H G, Gajdusek, D C, ...
Cell fusion was induced by brain extracts containing the scrapie virus and the virus of Creutzfeldt-Jakob disease. The assay involved quantitation of colony-forming ability in a double selection...
Gibbs, C J, Gajdusek, D C, Latarjet, R
The titers of several preparations of kuru. Creutzfeldt-Jacob disease, and scrapie viruses were reduced by only 1/10th or less by high doses of gamma radiation of 50 kGy and by only 1/10th-1/1000th...
Monoclonal antibodies specific for Hantaan virus.
Franko, M C, Gibbs, C J, Lee, P W, Gajdusek, D C
Six hybridoma cell line producing monoclonal antibodies to Hantaan virus were established by fusion of NS-1 mouse myeloma cells with spleen cells of mice immunized with Hantaan virus strain 76-118....
Toh, B H, Gibbs, C J, Gajdusek, D C, Goudsmit, J, Dahl, D
Sera from 65 patients with spongiform virus encephalopathies (29 with kuru, 36 with Creutzfeldt-Jakob disease), 79 with other neurologic diseases, and 65 control subjects were examined for reactivity...
Toh, B H, Gibbs, C J, Gajdusek, D C, Tuthill, D D, Dahl, D
Sera from 46 chimpanzees with spongiform encephalopathy (18 kuru, 28 Creutzfeldt-Jakob disease) and sera from 12 sheep with natural scrapie were tested for reactivity with immunoblots of...
Isolation and characterization of two new herpes-like viruses from capuchin monkeys.
Lewis, M A, Frye, L D, Gibbs, C J, Chou, S M, Cutchins, E C, Gajdusek, D C, ...
Two herpes-like viruses were isolated from capuchin monkey (Cebus apella) brain and (Cebus albifrons) spleen cell cultures, respectively. Both isolates induced similar cytopathic effects consisting...
Antigenic relationship of human foamy virus to the simian foamy viruses.
Nemo, G J, Brown, P W, Gibbs, C J, Gajdusek, D C
A foamy virus isolated by Achong et al. from a human nasopharyngeal carcinoma was studied to determine its antigenic relationship to the eight known simiam foamy viruses (SFV). Using reciprocal...
Persistent shedding of adenovirus in urine of chimpanzees.
Asher, D M, Hooks, J J, Amyx, H L, Luber, N P, Asher, L V, Gibbs, C J, ...
A new adenovirus, designated Pan 11, was isolated repeatedly from the urine of several chimpanzees for more than 1 year. One chimpanzee had chronic interstitial nephritis; the others were healthy....
Antibodies in urine of chimpanzees with chronic adenoviral viruria.
Ashner, L V, Asher, D M, Shah, K V, Amyx, H L, Gibbs, C J, Gajdusek, D C
Many chimpanzees have naturally occurring chronic intermittent viruria with an adenovirus of a new type called Pan 11. Small amounts of neutralizing antibodies to Pan 11 adenovirus were found in the...
Isolation of a New Simian Foamy Virus from a Spider Monkey Brain Culture
Hooks, John J., Gibbs, C. J., Chou, S., Howk, R., Lewis, M., Gajdusek, D. C.
A syncytium-forming (foamy) virus was isolated from a spider monkey brain cell culture. Cytopathic effect was observed both in the brain culture and in human embryonic kidney cells. Neutralizing...
Antibodies to neurofilament protein in retinitis pigmentosa.
Galbraith, G M, Emerson, D, Fudenberg, H H, Gibbs, C J, Gajdusek, D C
Antibodies reactive with heterologous neural tissue were detected by indirect immunofluorescence microscopy in the sera of 17 of 34 patients with retinitis pigmentosa, one of 30 normal control sera,...
Osteomalacia in Paget's disease treated with short term, high dose sodium etidronate.
Gibbs, C J, Aaron, J E, Peacock, M
Eleven patients with Paget's disease treated with sodium etidronate 20 mg/kg/day for two and four weeks showed significant reductions in plasma alkaline phosphatase activity and urinary...
Safar, J., Roller, P. P., Gajdusek, D. C., Gibbs, C. J.
The scrapie amyloid (prion) protein (PrP27-30) is the protease-resistant core of a larger precursor (PrPSc) and a component of the infectious scrapie agent; the potential to form amyloid is a result...
Premenstrual exacerbation of asthma.
Gibbs, C J, Coutts, I I, Lock, R, Finnegan, O C, White, R J
Questionnaires and twice daily peak expiratory flow measurements were used to evaluate the effects of the menstrual cycle in asthmatic women. Forty per cent of women reported premenstrual...
Gibbs, C J, Asher, D M, Kobrine, A, Amyx, H L, Sulima, M P, Gajdusek, D C
Stereotactic multicontact electrodes used to probe the cerebral cortex of a middle aged woman with progressive dementia were previously implicated in the accidental transmission of Creutzfeldt-Jakob...
Spontaneous healing of osteitis fibrosa cystica in primary hyperparathyroidism.
Gibbs, C. J., Millar, J. G., Smith, J.
A 24-year-old man with primary hyperparathyroidism and osteitis fibrosa cystica developed acute hypocalcaemia. Spontaneous healing of his bone disease was confirmed radiographically and by correction...
Hypercalcaemia due to sarcoidosis corrects with bisphosphonate treatment.
We report a case of sarcoid hypercalcaemia treated with the bisphosphonate, APD [(3-amino-1-hydroxypropylidene)-1,1-bisphosphonate]. Investigations showed that the hypercalcaemia was associated with...
Cohen, M. S., Casals, J., Hsiung, G. D., Kwei, H. E., Chin, C. C., Ge, H. C., ...
Between July 1975 and April 1980, 71 patients were admitted to the Second Attached Hospital of Hubei Provincial Medical College in Wuchang with the diagnosis of epidemic hemorrhagic fever (EHF). The...