Bowman, J. C., Abruzzo, G. K., Anderson, J. W., Flattery, A. M., Gill, C. J., Pikounis, V. B., ...
Caspofungin acetate (MK-0991) is an antifungal antibiotic that inhibits the synthesis of 1,3-β-d-glucan, an essential component of the cell wall of several pathogenic fungi. Caspofungin acetate was...
Bartizal, K, Scott, T, Abruzzo, G K, Gill, C J, Pacholok, C, Lynch, L, ...
Lipopeptide L-733560 is a hybrid analog of L-731373 and L-705589. All are water-soluble semisynthetic pneumocandin Bo derivatives. In vitro susceptibility testing of L-705589, L-731373, and L-733560...
Abruzzo, G K, Flattery, A M, Gill, C J, Kong, L, Smith, J G, Krupa, D, ...
The activities of the water-soluble pneumocandin derivatives L-733560, L-705589, and L-731373 were evaluated in mouse models of disseminated aspergillosis, candidiasis, and cryptococcosis and were...
Flattery, A M, Abruzzo, G K, Gill, C J, Smith, J G, Bartizal, K
A new model for the evaluation of antifungal compounds against oropharyngeal and gastrointestinal mucosal colonization by Candida albicans was developed. To simulate the immune deficiency observed in...
Pharmacokinetics of L-749,345, a long-acting carbapenem antibiotic, in primates.
Sundelof, J G, Hajdu, R, Gill, C J, Thompson, R, Rosen, H, Kropp, H
L-749,345 is a carbapenem antibiotic, currently in phase II clinical trials, which possesses a broad antibacterial spectrum and extended half-life. The time courses of levels of the drugs in plasma...
In vitro preclinical evaluation studies with the echinocandin antifungal MK-0991 (L-743,872).
Bartizal, K, Gill, C J, Abruzzo, G K, Flattery, A M, Kong, L, Scott, P M, ...
The echinocandin MK-0991, formerly L-743,872, is a water-soluble lipopeptide that has been demonstrated in preclinical studies to have potent activity against Candida spp., Aspergillus fumigatus, and...
Abruzzo, G K, Flattery, A M, Gill, C J, Kong, L, Smith, J G, Pikounis, V B, ...
The in vivo activity of the Merck antifungal echinocandin drug candidate MK-0991 (L-743,872) was evaluated in mouse models of disseminated candidiasis, aspergillosis, and cryptococcosis. The...
Smith, J G, Kong, L, Abruzzo, G K, Gill, C J, Flattery, A M, Scott, P M, ...
Many animal models of Helicobacter infection have been described, including infection in rhesus monkeys, ferrets, gnotobiotic piglets, and mice. These animal models utilize a combination of detection...
A sensitive and specific PCR method to detect Helicobacter felis in a conventional mouse model.
Kong, L, Smith, J G, Bramhill, D, Abruzzo, G K, Bonfiglio, C, Cioffe, C, ...
Although many detection methods have been used to determine Helicobacter colonization in small animal models, the sensitivity and specificity of these detection methods are limited. To improve the...
Gill, C J, Shungu, D L, Ponticas, S
Seventy-four cefoxitin-resistant Bacteroides fragilis group isolates were tested by the serial twofold agar dilution method for susceptibility to imipenem and other agents in medium with and without...
Campos, J M, Gill, C J, Hare, R S, Miller, G H
The addition of NaCl to cation-supplemented Mueller-Hinton broth increased the MICs of gentamicin, amikacin, and netilmicin for coagulase-positive and -negative staphylococci in a...
Bactericidal activities of chloramphenicol and eleven other antibiotics against Salmonella spp.
Preblud, S R, Gill, C J, Campos, J M
The bactericidal activity of chloramphenicol against 27 strains of Salmonella typhi and 33 strains of S. enteritidis was compared with those of 11 other antibiotics. The geometric mean bactericidal...
Bowman, J. C., Abruzzo, G. K., Anderson, J. W., Flattery, A. M., Gill, C. J., Pikounis, V. B., ...
Caspofungin acetate (MK-0991) is an antifungal antibiotic that inhibits the synthesis of 1,3-β-d-glucan, an essential component of the cell wall of several pathogenic fungi. Caspofungin acetate was...
Bartizal, K, Scott, T, Abruzzo, G K, Gill, C J, Pacholok, C, Lynch, L, ...
Lipopeptide L-733560 is a hybrid analog of L-731373 and L-705589. All are water-soluble semisynthetic pneumocandin Bo derivatives. In vitro susceptibility testing of L-705589, L-731373, and L-733560...
Abruzzo, G K, Flattery, A M, Gill, C J, Kong, L, Smith, J G, Krupa, D, ...
The activities of the water-soluble pneumocandin derivatives L-733560, L-705589, and L-731373 were evaluated in mouse models of disseminated aspergillosis, candidiasis, and cryptococcosis and were...
Flattery, A M, Abruzzo, G K, Gill, C J, Smith, J G, Bartizal, K
A new model for the evaluation of antifungal compounds against oropharyngeal and gastrointestinal mucosal colonization by Candida albicans was developed. To simulate the immune deficiency observed in...
Pharmacokinetics of L-749,345, a long-acting carbapenem antibiotic, in primates.
Sundelof, J G, Hajdu, R, Gill, C J, Thompson, R, Rosen, H, Kropp, H
L-749,345 is a carbapenem antibiotic, currently in phase II clinical trials, which possesses a broad antibacterial spectrum and extended half-life. The time courses of levels of the drugs in plasma...
In vitro preclinical evaluation studies with the echinocandin antifungal MK-0991 (L-743,872).
Bartizal, K, Gill, C J, Abruzzo, G K, Flattery, A M, Kong, L, Scott, P M, ...
The echinocandin MK-0991, formerly L-743,872, is a water-soluble lipopeptide that has been demonstrated in preclinical studies to have potent activity against Candida spp., Aspergillus fumigatus, and...
Abruzzo, G K, Flattery, A M, Gill, C J, Kong, L, Smith, J G, Pikounis, V B, ...
The in vivo activity of the Merck antifungal echinocandin drug candidate MK-0991 (L-743,872) was evaluated in mouse models of disseminated candidiasis, aspergillosis, and cryptococcosis. The...
Smith, J G, Kong, L, Abruzzo, G K, Gill, C J, Flattery, A M, Scott, P M, ...
Many animal models of Helicobacter infection have been described, including infection in rhesus monkeys, ferrets, gnotobiotic piglets, and mice. These animal models utilize a combination of detection...
A sensitive and specific PCR method to detect Helicobacter felis in a conventional mouse model.
Kong, L, Smith, J G, Bramhill, D, Abruzzo, G K, Bonfiglio, C, Cioffe, C, ...
Although many detection methods have been used to determine Helicobacter colonization in small animal models, the sensitivity and specificity of these detection methods are limited. To improve the...
Gill, C J, Shungu, D L, Ponticas, S
Seventy-four cefoxitin-resistant Bacteroides fragilis group isolates were tested by the serial twofold agar dilution method for susceptibility to imipenem and other agents in medium with and without...
Campos, J M, Gill, C J, Hare, R S, Miller, G H
The addition of NaCl to cation-supplemented Mueller-Hinton broth increased the MICs of gentamicin, amikacin, and netilmicin for coagulase-positive and -negative staphylococci in a...
Bactericidal activities of chloramphenicol and eleven other antibiotics against Salmonella spp.
Preblud, S R, Gill, C J, Campos, J M
The bactericidal activity of chloramphenicol against 27 strains of Salmonella typhi and 33 strains of S. enteritidis was compared with those of 11 other antibiotics. The geometric mean bactericidal...
Efficacy of Caspofungin against Aspergillus flavus, Aspergillus terreus, and Aspergillus nidulans▿
Bowman, J. C., Abruzzo, G. K., Flattery, A. M., Gill, C. J., Hickey, E. J., Hsu, M. J., ...
The echinocandin caspofungin is a potent inhibitor of the activity of 1,3-β-d-glucan synthase from Aspergillus flavus, Aspergillus terreus, and Aspergillus nidulans. In murine models of disseminated...