A View Extension to an Object-Oriented Type System (2008)
Many languages provide support for describing composite and other user-defined types which in turn depend upon built-in types. A built-in or primitive type is typically composed of a data structure,...
Moorman, A.V., Richards, S.M., Hancock, J.P., Mitchell, C.D., Vora, A.J., Harrison, C.J., ...
Although both MRD and karyotype are powerful determinants of outcome in childhood ALL, few studies have examined the kinetics of MRD clearance by cytogenetics. In ALL2003, patients are stratified by...
Jalali, G.R., An, Q., Konn, Z.J., Worley, H., Wright, S.L., Harrison, C.J., ...
We describe four cases of childhood B-cell progenitor acute lymphoblastic leukaemia (BCP-ALL) and one of T-cell (T-ALL) with unexpected numbers of interphase signals for ETV6 with an ETV6-RUNX1...
Russell, L.J., Akasaka, T., Majid, A., Sugimoto, K.J., Karran, E.L., Nagel, I., ...
Translocations involving the immunoglobulin heavy chain locus (IGH@) at chromosome band 14q32 are common in mature B-cell neoplasms, but are rare in B-cell precursor acute lymphoblastic leukemia...
Forestier, E., Izraeli, S., Beverloo, B., Haas, O., Pession, A., Michalova, K., ...
Children with Down syndrome (DS) have a markedly increased risk of acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML). To identify chromosomal changes cooperating with +21 that may...
Stable asymptomatic myeloma and MGUS in the presence of T(4;14) (2007)
Ross, M., Chiecchio, L., Protheroe, R.K.M., Dagrada, G.P., Stockley, D.M., Nightingale, M., ...
Stable asymptomatic myeloma and MGUS in the presence of T(4;14) (2007)
Ross, M., Chiecchio, L., Protheroe, R.K.M., Dagrada, G.P., Stockley, D.M., Nightingale, M., ...
Stable asymptomatic myeloma and MGUS in the presence of T(4;14) (2007)
Ross, F.M., Chiecchio, L., Protheroe, R.K.M., Dagrada, G.P., Stockley, D.M., Nightingale, M., ...
Cytogenetic classification of T lineage acute lymphoblastic leukaemia (2007)
Harrison, C.J., Barber, K., Broadfield, Z., Stewart, A., Wright, S., Martineau, M., ...
A de novo (1;2;3;15;18) chromosome rearrangement with six nonreciprocal translocations (2007)
Rivera, H., Dominguez, M.G., Crolla, J.A., Harrison, C.J., Jalali, G.R.
A de novo complex chromosome rearrangement (CCR) found in a phenotypically abnormal boy was characterized by G-bands, FISH with subtelomere probes, and M-FISH. The G-banding analysis revealed...
Akasaka, T., Balasas, T., Russell, L.J., Sugimoto, K., Majid, A., Walewska, R., ...
CCAAT enhancer-binding protein (CEBP) transcription factors play pivotal roles in proliferation and differentiation, including suppression of myeloid leukemogenesis. Mutations of CEBPA are found in a...
Hasle, H., Alonzo, T.A., Auvrignon, A., Behar, C., Chang, M., Creutzig, U., ...
Monosomy 7 (-7) and deletion 7q [del(7q)] are rare in childhood acute myeloid leukemia (AML). We retrospectively collected data on 258 children with AML or refractory anemia with excess blasts in...
Moorman, A.V., Richards, S.M., Robinson, H.M., Strefford, J.C., Gibson, B.E.S., Kinsey, S.E., ...
Patients with acute lymphoblastic leukemia (ALL) and an intrachromosomal amplification of chromosome 21 (iAMP21) comprise a novel and distinct biological subgroup. We prospectively screened 1630...
Strefford, J.C., Worley, H., Barber, K., Wright, S., Stewart, A.R.M., Robinson, H.M., ...
Chromosomal abnormalities are important for the classification and risk stratification of patients with acute lymphoblastic leukemia (ALL). However, approximately 30% of childhood and 50% of adult...
Outcome of treatment in children with hypodiploid acute lymphoblastic leukemia (2007)
Nachman, J.B., Heerema, N.A., Sather, H., Camitta, B., Forestier, E., Harrison, C.J., ...
One-hundred thirty-nine patients with acute lymphoblastic leukemia (ALL) and hypodiploldly (fewer than 45 chromosomes) were collected from 10 different national ALL study groups and single...
Russell, L.J., Akasaka, T., Balasas, T., Chaprio, E., Bernard, O., Siebert, R., ...
Chromosomal translocations lead to oncogene activation in a significant number of haematological malignancies. Those involving the immunoglobulin heavy chain locus, IGH, at chromosome band 14q32 are...
Disruption of PAX5 in patients with acute lymphoblastic leukaemia and dicentric chromosomes (2007)
An, Q., Wright, S.L., Konn, Z.J., Moorman, A.V., Harrison, C.J., Strefford, J.C.
A de novo (1;2;3;15;18) chromosome rearrangement with six non reciprocal translocations (2007)
Rivera, H., Dominguez, M.G., Crolla, J.A., Harrison, C.J., Jalali, G.R.
A de novo (1;2;3;15;18) chromosome rearrangement with six nonreciprocal translocations: A de novo complex chromosome rearrangement (CCR) found in a phenotypically abnormal boy was characterized by...
Chiecchio, L., Protheroe, R.K.M., Ibrahim, A.H., Cheung, K.L., Rudduck, C., Dagrada, G.P., ...
In myeloma, the prognostic impact of different strategies used to detect chromosome 13 deletion (Delta13) remains controversial. To address this, we compared conventional cytogenetics and interphase...
Chapiro, E., Russell, L., Radford-Weiss, I., Bastard, C., Lessard, M., Struski, S., ...
Subtle variation in the expression or function of a small group of transcription factors can drive leukemogenesis. The CEBPA protein is known to regulate the balance between cell proliferation and...
PAX5-ETV6 fusion in acute lymphoblastic leukaemia does not define the dic(9;12) (2006)
Broadfield, Z., Martineau, M., Moorman, A.V., Wright, S.L., Bown, N., Harrison, C.J.
Ross, F.M., Ibrahim, A.H., Vilain-Holmes, A., Winfield, M.O., Chiecchio, L., Protheroe, R.K., ...
A simple high throughput micro-fluorescence in situ hybridisation technique (FISH) was used to detect chromosome 13 deletions (delta13), immunoglobulin heavy chain (IgH) rearrangements,...
Damberger, F. F., Pelton, J. G., Harrison, C. J., Nelson, H. C., Wemmer, D. E.
The solution structure of the 92-residue DNA-binding domain of the heat shock transcription factor from Kluyveromyces lactis has been determined using multidimensional NMR methods. Three-dimensional...
The fragile X: a scanning electron microscope study.
Harrison, C J, Jack, E M, Allen, T D, Harris, R
Scanning electron microscopy (SEM) has been used to study the fragile X chromosome. The fragile site appears as an isochromatid gap in the majority of cases, confirming light microscope (LM)...
Investigation of human chromosome polymorphisms by scanning electron microscopy.
Harrison, C J, Jack, E M, Allen, T D, Harris, R
Human chromosome polymorphisms were investigated by scanning electron microscopy (SEM). Centromeric heterochromatin was of a constricted morphology. The extent of the C banded region was demarcated...
Waiting times and patient satisfaction in the accident and emergency department.
Booth, A J, Harrison, C J, Gardener, G J, Gray, A J
A survey of the waiting times and patients' opinions of these times was undertaken in a busy district general hospital A&E department. The various components of the overall waiting time are analysed...
Postnatal encephaloclastic porencephaly--a new lesion?
Cross, J H, Harrison, C J, Preston, P R, Rushton, D I, Newell, S J, Morgan, M E, ...
A previously unrecognised and distinctive pattern of severe brain injury in extreme preterm neonates was observed recently. Fifteen neonates of birth weight 600-1270 g and gestation of 24-32 weeks...
Harrison, C. J., Connell, J. R., Allen, T. D., Ockey, C. H.
The relationship between ageing and transformation has been investigated by a serial study of the changes in cell-surface morphology as normal and carcinogen-treated cells progressed in culture. A...