Cunningham, S.C., Kamangar, F., Kim, M.P., Hammoud, S., Haque, R., Iacobuzio-Donahue, C.A., ...
Approximately 23,000 new gastric cancer cases and 12,000 associated deaths occur annually in the United States. Intestinal metaplasia and gastric epithelial dysplasia are precursor lesions to gastric...
Yeo, C J, Jaffe, B M, Zinner, M J
Serotonin and substance P of gastrointestinal origin have been measured by radioimmunoassay in the bowel lumen under basal and stimulated conditions. To investigate the possibility that local blood...
Lillemoe, K D, Martin, S A, Cameron, J L, Yeo, C J, Talamini, M A, Kaushal, S, ...
OBJECTIVE: The authors provide the results of follow-up evaluation after combined surgical and radiologic management of 89 patients with major bile duct injuries during laparoscopic cholecystectomy....
Adenocarcinoma of the ampulla of Vater. A 28-year experience.
Talamini, M A, Moesinger, R C, Pitt, H A, Sohn, T A, Hruban, R H, Lillemoe, K D, ...
OBJECTIVE: The aim of this study were to review the experience with adenocarcinoma of the ampulla of Vater at The Johns Hopkins Hospital and to determine what factors influenced the long-term outcome...
Yeo, C J, Abrams, R A, Grochow, L B, Sohn, T A, Ord, S E, Hruban, R H, ...
OBJECTIVE: This study was designed to evaluate prospectively survival after pancreaticoduodenectomy for pancreatic adenocarcinoma, comparing two different postoperative adjuvant chemoradiation...
Yeo, C J, Cameron, J L, Sohn, T A, Lillemoe, K D, Pitt, H A, Talamini, M A, ...
OBJECTIVE: The authors reviewed the pathology, complications, and outcomes in a consecutive group of 650 patients undergoing pancreaticoduodenectomy in the 1990s. SUMMARY BACKGROUND DATA:...
Periampullary adenocarcinoma: analysis of 5-year survivors.
Yeo, C J, Sohn, T A, Cameron, J L, Hruban, R H, Lillemoe, K D, Pitt, H A
OBJECTIVE: This single-institution experience retrospectively reviews the outcomes in a group of patients treated 5 or more years ago by pancreaticoduodenectomy for periampullary adenocarcinoma....
Cystadenomas of the pancreas: is enucleation an adequate operation?
Talamini, M A, Moesinger, R, Yeo, C J, Poulose, B, Hruban, R H, Cameron, J L, ...
OBJECTIVE: The objective was to determine whether surgical enucleation of mucinous cystadenoma of the pancreas is a safe and adequate operation. SUMMARY BACKGROUND DATA: Mucinous cystadenomas of the...
Importance of hospital volume in the overall management of pancreatic cancer.
Sosa, J A, Bowman, H M, Gordon, T A, Bass, E B, Yeo, C J, Lillemoe, K D, ...
OBJECTIVE: To determine whether hospital volume is associated with clinical and economic outcomes for patients with pancreatic cancer who underwent pancreatic resection, palliative bypass, or...
Sohn, T A, Lillemoe, K D, Cameron, J L, Pitt, H A, Huang, J J, Hruban, R H, ...
OBJECTIVE: This single-institution experience retrospectively reviews the outcomes of patients undergoing reexploration for periampullary carcinoma at a high-volume center. SUMMARY BACKGROUND DATA:...
Pancreaticoduodenectomy for cancer of the head of the pancreas. 201 patients.
Yeo, C J, Cameron, J L, Lillemoe, K D, Sitzmann, J V, Hruban, R H, Goodman, S N, ...
OBJECTIVE: This single-institution study examined the outcome after pancreaticoduodenectomy in patients with adenocarcinoma of the head of the pancreas. SUMMARY OF BACKGROUND DATA: In recent years,...
Perihilar cholangiocarcinoma. Postoperative radiotherapy does not improve survival.
Pitt, H A, Nakeeb, A, Abrams, R A, Coleman, J, Piantadosi, S, Yeo, C J, ...
OBJECTIVE: The aims of this analysis were to determine prospectively the effects of surgical resection and radiation therapy on the length and quality of survival as well as late toxicity in patients...
Yeo, C J, Cameron, J L, Maher, M M, Sauter, P K, Zahurak, M L, Talamini, M A, ...
OBJECTIVE: The authors hypothesized that pancreaticogastrostomy is safer than pancreaticojejunostomy after pancreaticoduodenectomy and less likely to be associated with a postoperative pancreatic...
Pancreaticoduodenectomy. Does it have a role in the palliation of pancreatic cancer?
Lillemoe, K D, Cameron, J L, Yeo, C J, Sohn, T A, Nakeeb, A, Sauter, P K, ...
OBJECTIVE: The authors define the role of palliative pancreaticoduodenectomy in patients with pancreatic carcinoma. BACKGROUND: Decreases in perioperative morbidity and mortality and improved...
Cholangiocarcinoma. A spectrum of intrahepatic, perihilar, and distal tumors.
Nakeeb, A, Pitt, H A, Sohn, T A, Coleman, J, Abrams, R A, Piantadosi, S, ...
OBJECTIVE: The objective of this article is to introduce a simple method for classifying cholangiocarcinomas and to apply this system to analyze a large number of patients from a single institution....
Selective cholangiography. Current role in laparoscopic cholecystectomy.
Lillemoe, K D, Yeo, C J, Talamini, M A, Wang, B H, Pitt, H A, Gadacz, T R
The initial 22-month experience with laparoscopic cholecystectomy in 400 patients employing an algorithm of selective cholangiographic evaluation is reported. Preoperative or postoperative endoscopic...
Small bowel origin and calorie dependence of a signal for meal-induced jejunal absorption.
Anthone, G J, Zinner, M J, Yeo, C J
The ingestion of a meal stimulates the absorption of water and electrolytes from the small intestine independent of the cephalic or gastric phases of digestion. This study tested two hypotheses: (1)...
One hundred and forty-five consecutive pancreaticoduodenectomies without mortality.
Cameron, J L, Pitt, H A, Yeo, C J, Lillemoe, K D, Kaufman, H S, Coleman, J
OBJECTIVE: A review of mortality and morbidity for pancreaticoduodenectomy was performed for 145 consecutive patients who underwent the operative procedure between 1988 and 1991. SUMMARY BACKGROUND...
Lillemoe, K D, Cameron, J L, Kaufman, H S, Yeo, C J, Pitt, H A, Sauter, P K
OBJECTIVE: A prospective, randomized, double-blind study was completed comparing intraoperative chemical splanchnicectomy with 50% alcohol versus a placebo injection of saline in patients with...
Yeo, C J, Barry, M K, Sauter, P K, Sostre, S, Lillemoe, K D, Pitt, H A, ...
OBJECTIVE: This study tested the hypothesis that erythromycin, a motilin agonist, reduces the incidence of early DGE after pancreaticoduodenectomy. SUMMARY BACKGROUND DATA: Delayed gastric emptying...
Nitric oxide modulates water and electrolyte transport in the ileum.
Barry, M K, Aloisi, J D, Pickering, S P, Yeo, C J
OBJECTIVE: To test the hypothesis that nitric oxide is a modulator of ileal water and ion transport. SUMMARY BACKGROUND DATA: Nitric oxide is produced in the vascular endothelium and enteric neural...
The effect of carcinoid levels of serotonin and substance P on hemodynamics.
Zinner, M J, Yeo, C J, Jaffe, B M
Serotonin and substance P circulate in high concentrations in patients with the carcinoid syndrome. These studies were performed to evaluate the effects of intravenous infusions of serotonin and...
Yeo, C J, Bastidas, J A, Schmieg, R E, Walfisch, S, Couse, N F, Olson, J L, ...
Chronic pancreatitis is associated with glucose intolerance and resultant pancreatogenic diabetes. Using the canine pancreatic duct-ligated model of pancreatitis, we serially evaluated pancreatic...
Yeo, C J, Jaffe, B M, Zinner, M J
Serotonin and substance P of gastrointestinal origin have been measured by radioimmunoassay in the bowel lumen under basal and stimulated conditions. To investigate the possibility that local blood...
Lillemoe, K D, Martin, S A, Cameron, J L, Yeo, C J, Talamini, M A, Kaushal, S, ...
OBJECTIVE: The authors provide the results of follow-up evaluation after combined surgical and radiologic management of 89 patients with major bile duct injuries during laparoscopic cholecystectomy....
Adenocarcinoma of the ampulla of Vater. A 28-year experience.
Talamini, M A, Moesinger, R C, Pitt, H A, Sohn, T A, Hruban, R H, Lillemoe, K D, ...
OBJECTIVE: The aim of this study were to review the experience with adenocarcinoma of the ampulla of Vater at The Johns Hopkins Hospital and to determine what factors influenced the long-term outcome...
Yeo, C J, Abrams, R A, Grochow, L B, Sohn, T A, Ord, S E, Hruban, R H, ...
OBJECTIVE: This study was designed to evaluate prospectively survival after pancreaticoduodenectomy for pancreatic adenocarcinoma, comparing two different postoperative adjuvant chemoradiation...
Yeo, C J, Cameron, J L, Sohn, T A, Lillemoe, K D, Pitt, H A, Talamini, M A, ...
OBJECTIVE: The authors reviewed the pathology, complications, and outcomes in a consecutive group of 650 patients undergoing pancreaticoduodenectomy in the 1990s. SUMMARY BACKGROUND DATA:...
Periampullary adenocarcinoma: analysis of 5-year survivors.
Yeo, C J, Sohn, T A, Cameron, J L, Hruban, R H, Lillemoe, K D, Pitt, H A
OBJECTIVE: This single-institution experience retrospectively reviews the outcomes in a group of patients treated 5 or more years ago by pancreaticoduodenectomy for periampullary adenocarcinoma....
Cystadenomas of the pancreas: is enucleation an adequate operation?
Talamini, M A, Moesinger, R, Yeo, C J, Poulose, B, Hruban, R H, Cameron, J L, ...
OBJECTIVE: The objective was to determine whether surgical enucleation of mucinous cystadenoma of the pancreas is a safe and adequate operation. SUMMARY BACKGROUND DATA: Mucinous cystadenomas of the...
Importance of hospital volume in the overall management of pancreatic cancer.
Sosa, J A, Bowman, H M, Gordon, T A, Bass, E B, Yeo, C J, Lillemoe, K D, ...
OBJECTIVE: To determine whether hospital volume is associated with clinical and economic outcomes for patients with pancreatic cancer who underwent pancreatic resection, palliative bypass, or...
Sohn, T A, Lillemoe, K D, Cameron, J L, Pitt, H A, Huang, J J, Hruban, R H, ...
OBJECTIVE: This single-institution experience retrospectively reviews the outcomes of patients undergoing reexploration for periampullary carcinoma at a high-volume center. SUMMARY BACKGROUND DATA:...
Pancreaticoduodenectomy for cancer of the head of the pancreas. 201 patients.
Yeo, C J, Cameron, J L, Lillemoe, K D, Sitzmann, J V, Hruban, R H, Goodman, S N, ...
OBJECTIVE: This single-institution study examined the outcome after pancreaticoduodenectomy in patients with adenocarcinoma of the head of the pancreas. SUMMARY OF BACKGROUND DATA: In recent years,...
Perihilar cholangiocarcinoma. Postoperative radiotherapy does not improve survival.
Pitt, H A, Nakeeb, A, Abrams, R A, Coleman, J, Piantadosi, S, Yeo, C J, ...
OBJECTIVE: The aims of this analysis were to determine prospectively the effects of surgical resection and radiation therapy on the length and quality of survival as well as late toxicity in patients...
Yeo, C J, Cameron, J L, Maher, M M, Sauter, P K, Zahurak, M L, Talamini, M A, ...
OBJECTIVE: The authors hypothesized that pancreaticogastrostomy is safer than pancreaticojejunostomy after pancreaticoduodenectomy and less likely to be associated with a postoperative pancreatic...
Pancreaticoduodenectomy. Does it have a role in the palliation of pancreatic cancer?
Lillemoe, K D, Cameron, J L, Yeo, C J, Sohn, T A, Nakeeb, A, Sauter, P K, ...
OBJECTIVE: The authors define the role of palliative pancreaticoduodenectomy in patients with pancreatic carcinoma. BACKGROUND: Decreases in perioperative morbidity and mortality and improved...
Cholangiocarcinoma. A spectrum of intrahepatic, perihilar, and distal tumors.
Nakeeb, A, Pitt, H A, Sohn, T A, Coleman, J, Abrams, R A, Piantadosi, S, ...
OBJECTIVE: The objective of this article is to introduce a simple method for classifying cholangiocarcinomas and to apply this system to analyze a large number of patients from a single institution....
Selective cholangiography. Current role in laparoscopic cholecystectomy.
Lillemoe, K D, Yeo, C J, Talamini, M A, Wang, B H, Pitt, H A, Gadacz, T R
The initial 22-month experience with laparoscopic cholecystectomy in 400 patients employing an algorithm of selective cholangiographic evaluation is reported. Preoperative or postoperative endoscopic...
Small bowel origin and calorie dependence of a signal for meal-induced jejunal absorption.
Anthone, G J, Zinner, M J, Yeo, C J
The ingestion of a meal stimulates the absorption of water and electrolytes from the small intestine independent of the cephalic or gastric phases of digestion. This study tested two hypotheses: (1)...
One hundred and forty-five consecutive pancreaticoduodenectomies without mortality.
Cameron, J L, Pitt, H A, Yeo, C J, Lillemoe, K D, Kaufman, H S, Coleman, J
OBJECTIVE: A review of mortality and morbidity for pancreaticoduodenectomy was performed for 145 consecutive patients who underwent the operative procedure between 1988 and 1991. SUMMARY BACKGROUND...
Lillemoe, K D, Cameron, J L, Kaufman, H S, Yeo, C J, Pitt, H A, Sauter, P K
OBJECTIVE: A prospective, randomized, double-blind study was completed comparing intraoperative chemical splanchnicectomy with 50% alcohol versus a placebo injection of saline in patients with...
Yeo, C J, Barry, M K, Sauter, P K, Sostre, S, Lillemoe, K D, Pitt, H A, ...
OBJECTIVE: This study tested the hypothesis that erythromycin, a motilin agonist, reduces the incidence of early DGE after pancreaticoduodenectomy. SUMMARY BACKGROUND DATA: Delayed gastric emptying...
Nitric oxide modulates water and electrolyte transport in the ileum.
Barry, M K, Aloisi, J D, Pickering, S P, Yeo, C J
OBJECTIVE: To test the hypothesis that nitric oxide is a modulator of ileal water and ion transport. SUMMARY BACKGROUND DATA: Nitric oxide is produced in the vascular endothelium and enteric neural...
The effect of carcinoid levels of serotonin and substance P on hemodynamics.
Zinner, M J, Yeo, C J, Jaffe, B M
Serotonin and substance P circulate in high concentrations in patients with the carcinoid syndrome. These studies were performed to evaluate the effects of intravenous infusions of serotonin and...
Yeo, C J, Bastidas, J A, Schmieg, R E, Walfisch, S, Couse, N F, Olson, J L, ...
Chronic pancreatitis is associated with glucose intolerance and resultant pancreatogenic diabetes. Using the canine pancreatic duct-ligated model of pancreatitis, we serially evaluated pancreatic...
Hruban, R. H., Sturm, P. D., Slebos, R. J., Wilentz, R. E., Musler, A. R., Yeo, C. J., ...
It can be difficult to distinguish benign bile duct proliferations (BDPs) from well-differentiated metastatic peripancreatic adenocarcinomas on histological grounds alone. Most peripancreatic...
Brat, D. J., Hahn, S. A., Griffin, C. A., Yeo, C. J., Kern, S. E., Hruban, R. H.
Molecular genetic alterations are known to be important in human carcinoma, but the structural basis of these changes is largely unknown. To examine the basis of these changes, we compared the...
Goggins, M., Offerhaus, G. J., Hilgers, W., Griffin, C. A., Shekher, M., Tang, D., ...
The clinical and pathological features of carcinomas of the pancreas with DNA replication errors (RER+) have not been characterized. Eighty-two xenografted carcinomas of the pancreas were screened...
p53-independent expression of the cyclin-dependent kinase inhibitor p21 in pancreatic carcinoma.
DiGiuseppe, J. A., Redston, M. S., Yeo, C. J., Kern, S. E., Hruban, R. H.
The p53 tumor suppressor gene is mutated in the majority of pancreatic adenocarcinomas, and several studies have suggested that loss of p53 function may contribute to the aggressive clinical behavior...