Cluster analysis of protein array results via similarity of Gene Ontology annotation (2006)
Wolting, Cheryl, McGlade, C Jane, Tritchler, David
Abstract Background With the advent of high-throughput proteomic experiments such as arrays of purified proteins comes the need to analyse sets of proteins as an ensemble, as opposed to the...
Cheryl Wolting, C Jane Mcglade, David Tritchler, Open Access
This is an Open Access article distributed under the terms of the Creative Commons Attribution License
Woods, Stacy A., McGlade, C. Jane, Guha, Abhijit
Malignant astrocytomas are characterized by extensive vascularization attributed to increased expression of the angiogenic cytokine vascular endothelial growth factor (VEGF). VEGF is elevated in...
Nie, Jing, McGill, Melanie A., Dermer, Matt, Dho, Sascha E., Wolting, Cheryl D., McGlade, C.Jane
LNX is a RING finger and PDZ domain containing protein that interacts with the cell fate determinant Numb. To investigate the function of LNX, we tested its RING finger domain for ubiquitin ligase...
Loreto, Michael P., Berry, Donna M., McGlade, C. Jane
Adaptor proteins assemble multiprotein signaling complexes, enabling the transduction of intracellular signals. While many adaptor proteins positively regulate signaling in this manner, a subgroup of...
Gads/Grb2-Mediated Association with LAT Is Critical for the Inhibitory Function of Gab2 in T Cells
Yamasaki, Sho, Nishida, Keigo, Sakuma, Machie, Berry, Donna, McGlade, C. Jane, Hirano, Toshio, ...
A docking protein, Gab2, is recruited to the vicinity of the TCR complex and inhibits downstream signaling by interaction with negative regulators. However, the molecular mechanisms of this...
Calderwood, David A., Fujioka, Yosuke, De Pereda, Jose M., García-Alvarez, Begoña, Nakamoto, Tetsuya, Margolis, Ben, ...
The cytoplasmic domains (tails) of heterodimeric integrin adhesion receptors mediate integrins' biological functions by binding to cytoplasmic proteins. Most integrin β tails contain one or two...
Smith, Christian A., Dho, Sascha E., Donaldson, Julie, Tepass, Ulrich, McGlade, C. Jane
The adaptor protein Numb is necessary for the cell fate specification of progenitor cells in the Drosophila nervous system. Numb is evolutionarily conserved and previous studies have provided...
Simoncic, Paul D., Bourdeau, Annie, Lee-Loy, Ailsa, Rohrschneider, Larry R., Tremblay, Michel L., Stanley, E. Richard, ...
Mice null for the T-cell protein tyrosine phosphatase (Tcptp−/−) die shortly after birth due to complications arising from the development of a systemic inflammatory disease. It was originally...
Dho, Sascha E., Trejo, JoAnn, Siderovski, David P., McGlade, C. Jane
The cell fate determinant Numb is a membrane-associated adaptor protein involved in both development and intracellular vesicular trafficking. It has a phosphotyrosine-binding (PTB) domain and...
Nie, Jing, McGill, Melanie A., Dermer, Matt, Dho, Sascha E., Wolting, Cheryl D., McGlade, C.Jane
LNX is a RING finger and PDZ domain containing protein that interacts with the cell fate determinant Numb. To investigate the function of LNX, we tested its RING finger domain for ubiquitin ligase...
Loreto, Michael P., Berry, Donna M., McGlade, C. Jane
Adaptor proteins assemble multiprotein signaling complexes, enabling the transduction of intracellular signals. While many adaptor proteins positively regulate signaling in this manner, a subgroup of...
Gads/Grb2-Mediated Association with LAT Is Critical for the Inhibitory Function of Gab2 in T Cells
Yamasaki, Sho, Nishida, Keigo, Sakuma, Machie, Berry, Donna, McGlade, C. Jane, Hirano, Toshio, ...
A docking protein, Gab2, is recruited to the vicinity of the TCR complex and inhibits downstream signaling by interaction with negative regulators. However, the molecular mechanisms of this...
Calderwood, David A., Fujioka, Yosuke, De Pereda, Jose M., García-Alvarez, Begoña, Nakamoto, Tetsuya, Margolis, Ben, ...
The cytoplasmic domains (tails) of heterodimeric integrin adhesion receptors mediate integrins' biological functions by binding to cytoplasmic proteins. Most integrin β tails contain one or two...
Smith, Christian A., Dho, Sascha E., Donaldson, Julie, Tepass, Ulrich, McGlade, C. Jane
The adaptor protein Numb is necessary for the cell fate specification of progenitor cells in the Drosophila nervous system. Numb is evolutionarily conserved and previous studies have provided...
Simoncic, Paul D., Bourdeau, Annie, Lee-Loy, Ailsa, Rohrschneider, Larry R., Tremblay, Michel L., Stanley, E. Richard, ...
Mice null for the T-cell protein tyrosine phosphatase (Tcptp−/−) die shortly after birth due to complications arising from the development of a systemic inflammatory disease. It was originally...
Dho, Sascha E., Trejo, JoAnn, Siderovski, David P., McGlade, C. Jane
The cell fate determinant Numb is a membrane-associated adaptor protein involved in both development and intracellular vesicular trafficking. It has a phosphotyrosine-binding (PTB) domain and...
Woods, Stacy A., McGlade, C. Jane, Guha, Abhijit
Malignant astrocytomas are characterized by extensive vascularization attributed to increased expression of the angiogenic cytokine vascular endothelial growth factor (VEGF). VEGF is elevated in...
Smith, Christian A, Lau, Kimberly M, Rahmani, Zohra, Dho, Sascha E, Brothers, Greg, She, Ye Min, ...
In Drosophila, the partition defective (Par) complex containing Par3, Par6 and atypical protein kinase C (aPKC) directs the polarized distribution and unequal segregation of the cell fate determinant...
Seet, Bruce T, Berry, Donna M, Maltzman, Jonathan S, Shabason, Jacob, Raina, Monica, Koretzky, Gary A, ...
The relationship between the binding affinity and specificity of modular interaction domains is potentially important in determining biological signaling responses. In signaling from the T-cell...
The SH3–SAM Adaptor HACS1 is Up-regulated in B Cell Activation Signaling Cascades
Zhu, Yuan Xiao, Benn, Sally, Li, Zhi Hua, Wei, Ellen, Masih-Khan, Esther, Trieu, Young, ...
HACS1 is a Src homology 3 and sterile alpha motif domain–containing adaptor that is preferentially expressed in normal hematopoietic tissues and malignancies including myeloid leukemia, lymphoma,...
T cell receptor ligation induces the formation of dynamically regulated signaling assemblies
Bunnell, Stephen C., Hong, David I., Kardon, Julia R., Yamazaki, Tetsuo, McGlade, C. Jane, Barr, Valarie A., ...
Tcell antigen receptor (TCR) ligation initiates tyrosine kinase activation, signaling complex assembly, and immune synapse formation. Here, we studied the kinetics and mechanics of signaling complex...