Kim, IH, Nishi, K, Tsai, HJ, Bradford, T, Koda, Y, Watanabe, T, ...
The soluble epoxide hydrolase (sEH) plays an important role in the metabolism of endogenous chemical mediators involved in blood pressure regulation and vascular inflammation....
Prevention of hypertension in DOCA-salt rats by an inhibitor of soluble epoxide hydrolase (2007)
Loch, D, Hoey, A, Morisseau, C, Hammock, BO, Brown, L
Cyclooxygenase and lipoxygenase metabolism of arachidonic acid produces compounds important in cardiovascular control. Further, arachidonic acid can be metabolised by cytochrome p450 to produce...
Prevention of hypertension in DOCA-salt rats by an inhibitor of soluble epoxide hydrolase (2007)
Loch, D, Hoey, A, Morisseau, C, Hammock, BO, Brown, L
Cyclooxygenase and lipoxygenase metabolism of arachidonic acid produces compounds important in cardiovascular control. Further, arachidonic acid can be metabolised by cytochrome p450 to produce...
Fisslthaler, B, Suzuki, M, ...
TRPV4 is a broadly expressed Ca2+-permeable cation channel in the vanilloid subfamily of transient receptor potential channels. TRPV4 gates in response to a large variety of stimuli, including cell...
Stok, J E, Goloshchapov, A, Song, C, Wheelock, C E, Derbel, MBH, Morisseau, C, ...
Carboxylesterases are enzymes that catalyze the hydrolysis of ester and amide moieties. These enzymes have an active site that is composed of a nucleophile (Set), a base (His), and an acid (Glu) that...
Stok, J E, Huang, H Z, Jones, P D, Wheelock, C E, Morisseau, C, Hammock, B D
Carboxylesterases are enzymes that catalyze the hydrolysis of a wide range of ester-containing endogenous and xenobiotic compounds. Although the use of pyrethroids is increasing, the specific enzymes...
Chiappe, C, Leandri, E, Lucchesi, S, Pieraccini, D, Hammock, B D, Morisseau, C
Soluble epoxide hydrolase (sEH) was shown to catalyze hydrolysis of epoxides using the ionic liquids (ILs) [bmim][PF6], [bmim][N(Tf)(2)], and [bmim][BF4] (where bmim = 1-butyl-3-methylimidazolium,...
Differential induction of hepatic drug-metabolizing enzymes by fenvaleric acid in male rats (1999)
Morisseau, C, Derbel, M, Lane, TR, Stoutamire, D, Hammock, BD
Dans un réseau lacunaire constitué d'un petit nombre de capteurs dans une pupille de grande dimension, des lobes latéraux importants sont le prix de la résolution élevée. L'élimination des...
Evaluation of fish models of soluble epoxide hydrolase inhibition.
Newman, J W, Denton, D L, Morisseau, C, Koger, C S, Wheelock, C E, Hinton, D E, ...
Substituted ureas and carbamates are mechanistic inhibitors of the soluble epoxide hydrolase (sEH). We screened a set of chemicals containing these functionalities in larval fathead minnow (Pimphales...
Evaluation of fish models of soluble epoxide hydrolase inhibition.
Newman, J W, Denton, D L, Morisseau, C, Koger, C S, Wheelock, C E, Hinton, D E, ...
Substituted ureas and carbamates are mechanistic inhibitors of the soluble epoxide hydrolase (sEH). We screened a set of chemicals containing these functionalities in larval fathead minnow (Pimphales...