Identification of two Ikaros-like transcription factors in lamprey (2002)
Mayer, W. E., O'Huigin, C., Tichy, H., Terzic, J., Saraga-Babic, M.
The jawless Agnatha (lampreys and hagfishes) represent the phylogenetically oldest order of vertebrates that are believed to lack the adaptive immune system of jawed vertebrates. In order to search...
Kuroda, N., Figueroa, F., O'hUigin, C., Klein, J.
In the zebrafish, Danio rerio, and other teleosts, the class I and class II loci of the major histocompatibility complex (Mhc) reside on different chromosomes. To shed light on the events that might...
New ß chain-encoding Mhc class II genes in the carp. (1993)
Ohno, H., O'Huigin, C., Vincek, V., Stet, R.J.M., Figueroa, F., Klein, J.
Grahovac, B, Mayer, WE, Vincek, V, Figueroa, F, O'hUigin, C, Tichy, H, ...
Molecular genetics of speciation and human origins.
Ayala, F J, Escalante, A, O'Huigin, C, Klein, J
The major histocompatibility complex (MHC) plays a cardinal role in the defense of vertebrates against parasites and other pathogens. In some genes there are extensive and ancient polymorphisms that...
Intensity of natural selection at the major histocompatibility complex loci.
Satta, Y, O'hUigin, C, Takahata, N, Klein, J
Long persistence of allelic lineages, prevalence of nonsynonymous over synonymous substitutions in the peptide-binding region (PBR), and deviation from neutrality of the expected gene identity...
The synonymous substitution rate of the major histocompatibility complex loci in primates.
Satta, Y, O'hUigin, C, Takahata, N, Klein, J
Because the divergence of many allelic lineages at the major histocompatibility complex (MHC) loci predates species divergence, standard methods of calculating synonymous substitution rates are not...
Resolution of the HLA-DRB6 puzzle: a case of grafting a de novo-generated exon on an existing gene.
Mayer, W E, O'hUigin, C, Klein, J
HLA-DRB6, one of the human major histocompatibility complex genes, lacks exon 1, which normally codes for the leader and the first four amino acid residues of the mature protein. Because it also...
Major histocompatibility complex class II genes of zebrafish.
Ono, H, Klein, D, Vincek, V, Figueroa, F, O'hUigin, C, Tichy, H, ...
Twenty cDNA clones derived from beta-chain-encoding class II genes of the zebrafish (Brachydanio rerio) major histocompatibility complex (MHC) have been sequenced. They fall into three groups...
Li, W H, Gouy, M, Sharp, P M, O'hUigin, C, Yang, Y W
Phylogenetic analysis of DNA sequences from primates, rodents, lagomorphs, artiodactyls, carnivores, and birds strongly suggests that the order Rodentia is an outgroup to the other four mammalian...
Dating the Primigenial C4-Cyp21 Duplication in Primates
Horiuchi, Y., Kawaguchi, H., Figueroa, F., O'hUigin, C., Klein, J.
C4 and CYP21 are two adjacent, but functionally unrelated genes residing in the middle of the mammalian major histocompatibility complex (Mhc). The C4 gene codes for the fourth component of the...
Origin of gene overlap: the case of TCP1 and ACAT2.
Shintani, S, O'hUigin, C, Toyosawa, S, Michalová, V, Klein, J
The human acetyl-CoA acetyltransferase 2 gene, ACAT2, codes for a thiolase, an enzyme involved in lipid metabolism. The human T-complex protein 1 gene, TCP1, encodes a molecular chaperone of the...
The implications of intergenic polymorphism for major histocompatibility complex evolution.
O'hUigin, C, Satta, Y, Hausmann, A, Dawkins, R L, Klein, J
A systematic survey of six intergenic regions flanking the human HLA-B locus in eight haplotypes reveals the regions to be up to 20 times more polymorphic than the reported average degree of human...
Evolutionary origin of mutations in the primate cytochrome P450c21 gene.
Kawaguchi, H, O'hUigin, C, Klein, J
The CYP21 gene codes for the enzyme cytochrome P450c21 (21-hydroxylase), which is critically involved in the synthesis of glucocorticoids and mineralocorticoids. Standard human haplotypes contain two...
Molecular genetics of speciation and human origins.
Ayala, F J, Escalante, A, O'Huigin, C, Klein, J
The major histocompatibility complex (MHC) plays a cardinal role in the defense of vertebrates against parasites and other pathogens. In some genes there are extensive and ancient polymorphisms that...
Intensity of natural selection at the major histocompatibility complex loci.
Satta, Y, O'hUigin, C, Takahata, N, Klein, J
Long persistence of allelic lineages, prevalence of nonsynonymous over synonymous substitutions in the peptide-binding region (PBR), and deviation from neutrality of the expected gene identity...
The synonymous substitution rate of the major histocompatibility complex loci in primates.
Satta, Y, O'hUigin, C, Takahata, N, Klein, J
Because the divergence of many allelic lineages at the major histocompatibility complex (MHC) loci predates species divergence, standard methods of calculating synonymous substitution rates are not...
Resolution of the HLA-DRB6 puzzle: a case of grafting a de novo-generated exon on an existing gene.
Mayer, W E, O'hUigin, C, Klein, J
HLA-DRB6, one of the human major histocompatibility complex genes, lacks exon 1, which normally codes for the leader and the first four amino acid residues of the mature protein. Because it also...
Major histocompatibility complex class II genes of zebrafish.
Ono, H, Klein, D, Vincek, V, Figueroa, F, O'hUigin, C, Tichy, H, ...
Twenty cDNA clones derived from beta-chain-encoding class II genes of the zebrafish (Brachydanio rerio) major histocompatibility complex (MHC) have been sequenced. They fall into three groups...
Li, W H, Gouy, M, Sharp, P M, O'hUigin, C, Yang, Y W
Phylogenetic analysis of DNA sequences from primates, rodents, lagomorphs, artiodactyls, carnivores, and birds strongly suggests that the order Rodentia is an outgroup to the other four mammalian...
Dating the Primigenial C4-Cyp21 Duplication in Primates
Horiuchi, Y., Kawaguchi, H., Figueroa, F., O'hUigin, C., Klein, J.
C4 and CYP21 are two adjacent, but functionally unrelated genes residing in the middle of the mammalian major histocompatibility complex (Mhc). The C4 gene codes for the fourth component of the...
Origin of gene overlap: the case of TCP1 and ACAT2.
Shintani, S, O'hUigin, C, Toyosawa, S, Michalová, V, Klein, J
The human acetyl-CoA acetyltransferase 2 gene, ACAT2, codes for a thiolase, an enzyme involved in lipid metabolism. The human T-complex protein 1 gene, TCP1, encodes a molecular chaperone of the...
The implications of intergenic polymorphism for major histocompatibility complex evolution.
O'hUigin, C, Satta, Y, Hausmann, A, Dawkins, R L, Klein, J
A systematic survey of six intergenic regions flanking the human HLA-B locus in eight haplotypes reveals the regions to be up to 20 times more polymorphic than the reported average degree of human...
Evolutionary origin of mutations in the primate cytochrome P450c21 gene.
Kawaguchi, H, O'hUigin, C, Klein, J
The CYP21 gene codes for the enzyme cytochrome P450c21 (21-hydroxylase), which is critically involved in the synthesis of glucocorticoids and mineralocorticoids. Standard human haplotypes contain two...
How large was the founding population of Darwin's finches?
Vincek, V., O'Huigin, C., Satta, Y., Takahata, Y., Boag, P. T., Grant, P. R., ...
A key assumption of many allopatric speciation models is that evolution in peripheral or isolated populations is facilitated by drastic reductions in population size. Population bottlenecks are...