C. P. Rhoads

SURVIVAL OF THE VIRUS OF POLIOMYELITIS FOR EIGHT YEARS IN GLYCEROL

Rhoads, C. P.

1. An instance of successful inoculation of poliomyelitis virus after preservation for 8 years in 50 per cent glycerol is reported. 2. The virulence of the material injected remained essentially...

INTRADERMAL VERSUS SUBCUTANEOUS IMMUNIZATION OF MONKEYS AGAINST POLIOMYELITIS

Stewart, F. W., Rhoads, C. P.

1. The introduction of considerable amounts of living, active poliomyelitis virus into the skin and subcutaneous tissue of monkeys protects the animals against intracerebral inoculations of similar...

THE EFFECT OF CATAPHORESIS ON POLIOMYELITIS VIRUS

Olitsky, P. K., Rhoads, C. P., Long, P. H.

1. Under ordinary conditions of hydrogen ion concentration the virus of poliomyelitis, as such, or associated with particles in fine suspension, migrates in an electrical field to the anode. It...

INTRADERMAL IMMUNIZATION OF MONKEYS WITH ONE SET OF INJECTIONS OF POLIOMYELITIS VIRUS

Rhoads, C. P.

1. By means of a single large dose of poliomyelitis virus, distributed at a number of intradermal sites, active immunity has been produced in Macacus rhesus monkeys, as shown by skin neutralization...

SURVIVAL AND MULTIPLICATION OF THE VIRUS OF POLIOMYELITIS IN VITRO

Long, P. H., Olitsky, P. K., Rhoads, C. P.

The study here reported concerns attempts at bacteriological cultivations with fragments of brain or cord, or with Berkefeld V filtrates of the nervous tissues, from seven monkeys successfully...

IMMUNIZATION AGAINST VACCINIA BY NON-INFECTIVE MIXTURES OF VIRUS AND IMMUNE SERUM

Rhoads, C. P.

1. Vaccine virus and specific immune serum mixed in such proportions as to produce no lesion when inoculated intradermally induce immunity when instilled into the nasal cavities of rabbits. 2. The...

EXPERIMENTAL STUDY OF A HORSE ANTIPOLIOMYELITIC SERUM

Rhoads, C. P.

Through the kindness of Dr. W. H. Park we have been enabled to study a horse antipoliomyelitic serum. This preparation has been supplied us in three forms: citrated blood plasma, serum, and globulin...

REINFORCEMENT OF CONVALESCENT ANTIPOLIOMYELITIC SERUM IN THE MONKEY

Rhoads, C. P.

A comparison has been made of the neutralizing value of pooled convalescent monkey serum for the filtered virus of poliomyelitis, before and after a series of reinforcement injections of the same...

IMMUNITY FOLLOWING THE INJECTION OF MONKEYS WITH MIXTURES OF POLIOMYELITIS VIRUS AND CONVALESCENT HUMAN SERUM

Rhoads, C. P.

1. Experiments are reported on the use of poliomyelitis virus neutralized by specific antiserum as an agent to induce active immunity against the experimental disease in monkeys. 2. The results...

IMMUNIZATION WITH MIXTURES OF POLIOMYELITIS VIRUS AND ALUMINUM HYDROXIDE

Rhoads, C. P.

Preliminary experiments are presented which indicate that poliomyelitis virus can be inactivated by a certain preparation of aluminum hydroxide. This effect is seen at neutrality and at a pH of 5.5,...

THE PATHOLOGY OF EXPERIMENTAL DERMAL PNEUMOCOCCUS INFECTION IN THE RABBIT

Rhoads, C. P., Goodner, Kenneth

1. The pathology of the experimental dermal pneumococcic infection in the rabbit is described in detail and the findings are compared with the histological alterations seen in the human pneumonic...

REACTIONS OF RABBITS TO INTRACUTANEOUS INJECTIONS OF PNEUMOCOCCI AND THEIR PRODUCTS : VII. THE RELATION OF HYPERSENSITIVENESS TO LESIONS IN THE LUNGS OF RABBITS INFECTED WITH PNEUMOCOCCI

Julianelle, L. A., Rhoads, C. P.

1. The intratracheal injection of egg albumin or pneumococcus protein induces an inflammatory reaction in the lungs of rabbits previously inoculated with the respective antigen. 2. A similar reaction...

THE PRODUCTION IN DOGS OF CHRONIC BLACK TONGUE WITH ANEMIA

Rhoads, C. P., Miller, D. K.

1. By the feeding of a particular diet, apparently lacking a substance closely associated with vitamin B2 G, a chronic disease may be produced irregularly in dogs. 2. The disease is characterized by...

THE VITAMIN B1 AND B2 G CONTENT OF LIVER EXTRACT AND BREWERS' YEAST CONCENTRATE

Miller, D. K., Rhoads, C. P.

1. Liver extract powder, No. 343 Lilly, and the same material prepared for parenteral use, when administered daily by mouth in amounts derived from 2.5 gm. of fresh whole liver, to rats weighing from...

THE EFFECT OF HEMOGLOBIN INJECTIONS ON ERYTHROPOIESIS AND ERYTHROCYTE SIZE IN RABBITS RENDERED ANEMIC BY BLEEDING

Miller, D. K., Rhoads, C. P.

1. An anemia characterized by increased size of the red blood cells and a high color index was produced in rabbits by repeated bleeding and by the subcutaneous injection of stroma-free hemoglobin...

THE ASSOCIATION OF BARTONELLA BODIES WITH INDUCED ANEMIA IN THE DOG

Rhoads, C. P., Miller, D. K.

On feeding to splenectomized dogs a diet producing black tongue, severe anemia developed associated with the presence of small bodies in or on the erythrocytes. The bodies were morphologically...

THE EXPERIMENTAL PRODUCTION IN DOGS OF ACUTE STOMATITIS, ASSOCIATED WITH LEUCOPENIA AND A MATURATION DEFECT OF THE MYELOID ELEMENTS OF THE BONE MARROW

Miller, D. K., Rhoads, C. P.

An ulcerative stomatitis associated with leucopenia and granulopenia can be induced in dogs by means of a diet causing black tongue. The decrease of circulating leucocytes is due to a suppression of...

THE INCREASED SUSCEPTIBILITY TO HEMOLYSIS BY INDOL IN DOGS FED DEFICIENT DIETS

Rhoads, C. P., Barker, W. Halsey, Miller, D. K.

1. Indol is more hemolytic in the presence of a deficiency complex than when a normal diet is fed. 2. The hemolytic effect can be abolished by supplementing the deficient diet with liver extract...

THE HEMOLYTIC EFFECT OF INDOL IN DOGS FED NORMAL DIETS

Rhoads, C. P., Barker, W. Halsey

Indol is mildly hemolytic when fed to dogs taking normal diets.

INDUCED SUSCEPTIBILITY OF THE BLOOD TO INDOL

Rhoads, C. P., Miller, D. K.

1. Indol, orally administered, causes anemia when certain deficient diets are fed. 2. The same amount of indol causes no considerable hematologic disturbance when normal diets are fed. 3. The anemia...

THE EFFECT OF DIET ON THE SUSCEPTIBILITY OF THE CANINE HEMATOPOIETIC FUNCTION TO DAMAGE BY AMIDOPYRINE

Miller, D. K., Rhoads, C. P.

1. By feeding dogs a black tongue diet and at the same time administering amidopyrine, acute stomatitis and anemia may be produced. 2. Both stomatitis and anemia occur some time before they could be...

HEPATIC VITAMIN A IN THE RAT AS AFFECTED BY THE ADMINISTRATION OF DIBENZANTHRACENE

Abels, Jules C., Gorham, Alice T., Eberlin, Shirley L., Halter, Robert, Rhoads, C. P.

1. The decreased concentrations of vitamin A in the livers of rats given dibenzanthracene probably are due to a particular effect of the carcinogen on the ability of the liver to store the vitamin...

HEPATIC DYSFUNCTION IN DOGS FED DIETS CAUSATIVE OF BLACK TONGUE

Rhoads, C. P., Miller, D. K.

1. The feeding to dogs of a diet lacking the vitamin B2 (G) complex results in a lowered capacity of the liver to excrete intravenously injected bilirubin. 2. Normal function can be partly restored...

THE ABSENCE FROM THE URINE OF PERNICIOUS ANEMIA PATIENTS OF A MOSQUITO GROWTH FACTOR PRESENT IN NORMAL URINE

Trager, W., Miller, D. K., Rhoads, C. P.

Extracts prepared from the urine of normal persons or patients with aplastic anemia or leukemia contain a substance, possibly flavine or a flavine compound, which under suitable conditions of test...