C. Pasquinelli

Hepatitis B virus (HBV) sequence variation of cytotoxic T lymphocyte epitopes is not common in patients with chronic HBV infection.

Rehermann, B, Pasquinelli, C, Mosier, S M, Chisari, F V

It has been suggested that immune selection pressure exerted by the cytotoxic T lymphocyte (CTL) response could be responsible for viral persistence during chronic hepatitis B virus infection. To...

The hepatitis B virus (HBV) precore protein inhibits HBV replication in transgenic mice.

Guidotti, L G, Matzke, B, Pasquinelli, C, Shoenberger, J M, Rogler, C E, Chisari, F V

In this study, we examined the ability of the hepatitis B virus (HBV) precore, envelope, and X gene products to modulate HBV replication in the livers of transgenic mice that replicate the virus....

Rearrangement of a common cellular DNA domain on chromosome 4 in human primary liver tumors.

Pasquinelli, C, Garreau, F, Bougueleret, L, Cariani, E, Grzeschik, K H, Thiers, V, ...

Hepatitis B virus (HBV) DNA integration has been shown to occur frequently in human hepatocellular carcinomas. We have investigated whether common cellular DNA domains might be rearranged, possibly...

Hepatitis B virus persistence after recovery from acute viral hepatitis.

Michalak, T I, Pasquinelli, C, Guilhot, S, Chisari, F V

Contrary to current opinion, the disappearance of hepatitis B surface antigen (HBsAg) from the serum, the development of anti-HBs antibodies, and normalization of liver function may not reflect...

Cytotoxic T lymphocyte response to hepatitis C virus-derived peptides containing the HLA A2.1 binding motif.

Cerny, A, McHutchison, J G, Pasquinelli, C, Brown, M E, Brothers, M A, Grabscheid, B, ...

The HLA class I-restricted cytotoxic T lymphocyte (CTL) response is a major defense mechanism in viral infections. It has been suggested that the CTL response may contribute to viral clearance and...

Immunological significance of cytotoxic T lymphocyte epitope variants in patients chronically infected by the hepatitis C virus.

Chang, K M, Rehermann, B, McHutchison, J G, Pasquinelli, C, Southwood, S, Sette, A, ...

This study was performed to test the hypothesis that cytotoxic T lymphocyte (CTL) selection of hepatitis C virus (HCV) escape variants plays a role in HCV persistence. The peripheral blood CTL...

Hepatitis B virus (HBV) sequence variation of cytotoxic T lymphocyte epitopes is not common in patients with chronic HBV infection.

Rehermann, B, Pasquinelli, C, Mosier, S M, Chisari, F V

It has been suggested that immune selection pressure exerted by the cytotoxic T lymphocyte (CTL) response could be responsible for viral persistence during chronic hepatitis B virus infection. To...

The hepatitis B virus (HBV) precore protein inhibits HBV replication in transgenic mice.

Guidotti, L G, Matzke, B, Pasquinelli, C, Shoenberger, J M, Rogler, C E, Chisari, F V

In this study, we examined the ability of the hepatitis B virus (HBV) precore, envelope, and X gene products to modulate HBV replication in the livers of transgenic mice that replicate the virus....

Rearrangement of a common cellular DNA domain on chromosome 4 in human primary liver tumors.

Pasquinelli, C, Garreau, F, Bougueleret, L, Cariani, E, Grzeschik, K H, Thiers, V, ...

Hepatitis B virus (HBV) DNA integration has been shown to occur frequently in human hepatocellular carcinomas. We have investigated whether common cellular DNA domains might be rearranged, possibly...

Hepatitis B virus persistence after recovery from acute viral hepatitis.

Michalak, T I, Pasquinelli, C, Guilhot, S, Chisari, F V

Contrary to current opinion, the disappearance of hepatitis B surface antigen (HBsAg) from the serum, the development of anti-HBs antibodies, and normalization of liver function may not reflect...

Cytotoxic T lymphocyte response to hepatitis C virus-derived peptides containing the HLA A2.1 binding motif.

Cerny, A, McHutchison, J G, Pasquinelli, C, Brown, M E, Brothers, M A, Grabscheid, B, ...

The HLA class I-restricted cytotoxic T lymphocyte (CTL) response is a major defense mechanism in viral infections. It has been suggested that the CTL response may contribute to viral clearance and...

Immunological significance of cytotoxic T lymphocyte epitope variants in patients chronically infected by the hepatitis C virus.

Chang, K M, Rehermann, B, McHutchison, J G, Pasquinelli, C, Southwood, S, Sette, A, ...

This study was performed to test the hypothesis that cytotoxic T lymphocyte (CTL) selection of hepatitis C virus (HCV) escape variants plays a role in HCV persistence. The peripheral blood CTL...