C. R. Butlin

Clinical outcomes in a randomized controlled study comparing azathioprine and prednisolone versus prednisolone alone in the treatment of severe leprosy type 1 reactions in Nepal (2004)

Marlowe, S.N.S., Hawksworth, R.A., Butlin, C.R., Nicholls, P, Lockwood, D.N.J.

The ILEP nerve function impairment and reaction research programme (INFIR 2) was a group of clinical trials conducted to identify second-line treatments for severe leprosy type 1 reactions (T1R)....

A 35-kilodalton protein is a major target of the human immune response to Mycobacterium leprae.

Triccas, J A, Roche, P W, Winter, N, Feng, C G, Butlin, C R, Britton, W J

The control of leprosy will be facilitated by the identification of major Mycobacterium leprae-specific antigens which mirror the immune response to the organism across the leprosy spectrum. We have...

A 35-kilodalton protein is a major target of the human immune response to Mycobacterium leprae.

Triccas, J A, Roche, P W, Winter, N, Feng, C G, Butlin, C R, Britton, W J

The control of leprosy will be facilitated by the identification of major Mycobacterium leprae-specific antigens which mirror the immune response to the organism across the leprosy spectrum. We have...

Use of a whole blood assay to evaluate in vitro T cell responses to new leprosy skin test antigens in leprosy patients and healthy subjects

Weir, R E, Brennan, P J, Butlin, C R, Dockrell, H M

Development of an immunological tool to detect infection with Mycobacterium leprae would greatly benefit leprosy control programmes, as demonstrated by the contribution of the tuberculin test to...

High levels of inflammatory cytokines are associated with poor clinical response to steroid treatment and recurrent episodes of type 1 reactions in leprosy

MANANDHAR, R, SHRESTHA, N, BUTLIN, C R, ROCHE, P W

Levels of leprosy antigen-induced interferon-gamma (IFN-γ), tumour necrosis factor alpha (TNF-α) and interleukin-10 (IL-10) were measured in 96 leprosy patients with type 1 reactions (T1R) before,...

Impairment of vasomotor reflexes in the fingertips of leprosy patients.

Beck, J S, Abbot, N C, Samson, P D, Butlin, C R, Grange, J M, Cree, I A, ...

A method is described for eliciting fingertip vasomotor reflexes by inspiratory gasp and contralateral hand cold challenge. The results of the two tests are reproducible on replicate testing and,...