Scientific Commons: C. Rinaldo

Enhancement of natural killer cell activity in human immunodeficiency virus-infected subjects by in vitro treatment with biologic response modifier OK-432.

Huang, X L, Fan, Z, Murayama, T, Rinaldo, C

A decrease in natural killer (NK) cell function has been related to the progression of human immunodeficiency virus (HIV) infection. In the present study, we assessed the ability of a...

Selective decrease in human immunodeficiency virus type 1 (HIV-1)-induced alpha interferon production by peripheral blood mononuclear cells during HIV-1 infection.

Ferbas, J, Navratil, J, Logar, A, Rinaldo, C

We previously reported that human immunodeficiency virus type 1 (HIV-1), herpes simplex virus (HSV), and Sendai virus induce higher levels of alpha interferon (IFN-alpha) in blood dendritic cells...

Long-term serologic follow-up of hepatitis C virus-seropositive homosexual men.

Ndimbie, O K, Nedjar, S, Kingsley, L, Riddle, P, Rinaldo, C

Hepatitis C virus (HCV) infection may go undiagnosed and continue to present a source of community-acquired or transfusion-associated infection because of shortcomings in sensitivity, specificity,...

Detection of human immunodeficiency virus type 1-specific memory cytotoxic T lymphocytes in freshly donated and frozen-thawed peripheral blood mononuclear cells.

Huang, X L, Fan, Z, Liebmann, J, Rinaldo, C

Loss of anti-human immunodeficiency virus type 1 (HIV-1) memory cytotoxic T-lymphocyte (CTLm) responses is associated with disease progression in HIV-1 infection. In this study, nonspecific...

A semiquantitative assay for CD8+ T-cell-mediated suppression of human immunodeficiency virus type 1 infection.

Chen, Y, Rinaldo, C, Gupta, P

A reproducible, semiquantitative assay was developed to measure the level of the anti-human immunodeficiency virus type 1 (anti-HIV-1) suppressive activity of CD8+ T cells. The assay had a wide...

High levels of anti-human immunodeficiency virus type 1 (HIV-1) memory cytotoxic T-lymphocyte activity and low viral load are associated with lack of disease in HIV-1-infected long-term nonprogressors.

Rinaldo, C, Huang, X L, Fan, Z F, Ding, M, Beltz, L, Logar, A, ...

Lack of disease in long-term nonprogressors with human immunodeficiency virus type 1 (HIV-1) infection was strongly associated with very low copy numbers of HIV-1 DNA and RNA in peripheral blood...

Quantitation of human immunodeficiency virus type 1 DNA and RNA by a novel internally controlled PCR assay.

Gupta, P, Ding, M, Cottrill, M, Rinaldo, C, Kingsley, L, Wolinsky, S, ...

A novel internally controlled PCR (ICPCR) assay was developed to accurately quantitate human immunodeficiency virus type 1 (HIV-1) DNA and RNA in peripheral blood mononuclear cells and plasma. The...

Cell-to-cell transmission of human immunodeficiency virus type 1 in the presence of azidothymidine and neutralizing antibody.

Gupta, P, Balachandran, R, Ho, M, Enrico, A, Rinaldo, C

Very few peripheral blood lymphocytes of seropositive individuals are presumably actively infected with human immunodeficiency virus type 1 (HIV-1). During coculture of lymphocytes of a seropositive...

Diagnosis of cytomegalovirus infections by shell vial assay and conventional cell culture during antiviral prophylaxis.

Mañez, R, St George, K, Linden, P, Martin, M, Kusne, S, Grossi, P, ...

A total of 3,552 specimens for conventional cytomegalovirus (CMV) culture and shell vial assay for CMV immediate-early antigen were obtained during a prospective randomized trial for prophylaxis of...

Use of cryopreserved normal peripheral blood lymphocytes for isolation of human immunodeficiency virus from seropositive men.

Balachandran, R, Thampatty, P, Rinaldo, C, Gupta, P

The possibility was investigated of using frozen stocks of phytohemagglutinin (PHA)-stimulated normal human peripheral blood lymphocytes (PBL) in cocultivation with human immunodeficiency virus...

Association of human immunodeficiency virus (HIV) p24 antigenemia with decrease in CD4+ lymphocytes and onset of acquired immunodeficiency syndrome during the early phase of HIV infection.

Rinaldo, C, Kingsley, L, Neumann, J, Reed, D, Gupta, P, Lyter, D

Human immunodeficiency virus (HIV) p24 antigenemia was assessed in a longitudinal study of 52 homosexual men who developed serum antibody to HIV. Antibody seroconversion to HIV as defined by a...

Detection of human immunodeficiency virus by reverse transcriptase assay, antigen capture assay, and radioimmunoassay.

Gupta, P, Balachandran, R, Grovit, K, Webster, D, Rinaldo, C

The reverse transcriptase assay, antigen capture assay, and radioimmunoassay were compared for the detection of human immunodeficiency virus (HIV) in culture fluids of virus-infected lymphocytes. The...

Prospective multicenter study on isolation of human immunodeficiency virus type 1 from homosexual men after seroconversion.

Gupta, P, Farzadegan, H, Imagawa, D, Lee, M, Kingsley, L, Zhou, S, ...

A prospective multicenter study was undertaken to isolate human immunodeficiency virus type 1 (HIV-1) from 45 homosexual men for a period of 30 months after seroconversion. Efficiency of HIV-1...

Heterozygosity for a defective gene for CC chemokine receptor 5 is not the sole determinant for the immunologic and virologic phenotype of HIV-infected long-term nonprogressors.

Cohen, O J, Vaccarezza, M, Lam, G K, Baird, B F, Wildt, K, Murphy, P M, ...

HIV-1-infected long-term nonprogressors are a heterogeneous group of individuals with regard to immunologic and virologic markers of HIV-1 disease. CC chemokine receptor 5 (CCR5) has recently been...