The beta catenin/TCF4 complex imposes a crypt progenitor phenotype on colorectal cancer cells (2002)
Wetering, M. Van De, Sancho, E., Verweij, C., Lau, W. De, Oving, I., Hurlstone, A., ...
Wetering, M. Van De, Sancho, E., Verweij, C., Lau, W. De, Oving, I., Hurlstone, A., ...
The transactivation of TCF target genes induced by Wnt pathway mutations constitutes the primary transforming event in colorectal cancer (CRC). We show that disruption of β-catenin/TCF-4 activity in...
Kloppenburg, M, Brinkman, B M, Miltenburg, A M, Daha, M R, Breedveld, F C, ...
Minocycline is a tetracycline derivative that has beneficial effects in noninfectious forms of arthritis and dermatitis. To investigate whether this effect may be attributed to interference with...
Rood, M, Keijsers, V, Van Der Linden, M W, Tong, T, Borggreve, S, Verweij, C, ...
OBJECTIVE—To investigate the association of interleukin 10 (IL10) promoter polymorphisms and neuropsychiatric manifestations of systemic lupus erythematosus (SLE). METHODS—IL10 haplotypes of...
Activation of the STAT1 pathway in rheumatoid arthritis
Kasperkovitz, P, Verbeet, N, Smeets, T, Kraan, M, ...
Background: Expression of signal transducer and activator of transcription 1 (STAT1), the mediator of interferon (IFN) signalling, is raised in synovial tissue (ST) from patients with rheumatoid...
Characterization of complement C6 deficiency in a PVG/c rat strain
TIMMERMAN, J J, MUIZERT, Y, VERWEIJ, C, DISCIPIO, R G, ...
Complement C6 plays an important role in the effector phase of complement-mediated cell lysis. Recently, a PVG/c rat strain deficient in haemolytic C6 activity was discovered. In the present study we...