Synthetic partial agonists reveal key steps in IP3 receptor activation (2009)
Rossi, A. M., Riley, Andrew M, Tovey, S. C., Rahman, T., Dellis, O., Taylor, E. J. A., ...
Inositol 1,4,5-trisphosphate receptors (IP(3)Rs) are ubiquitous intracellular Ca2+ channels. IP3 binding to the IP3-binding core (IBC) near the N terminus initiates conformational changes that lead...
Activation of IP3 receptors by synthetic bisphosphate ligands (2009)
Sureshan, K. M., Riley, Andrew M, Rossi, A. M., Tovey, S. C., Dedos, S. G., Taylor, C. W., ...
Ca2+ release by D-myo-inositol 1,4,5-trisphosphate receptors (IP(3)Rs) is widely considered to require the vicinal 4,5-bisphosphate motif of IP3, with P-5 and P-4 engaging the alpha and beta domains...
Rapid functional assays of recombinant IP 3 receptors (2005)
Laude, A. J., Tovey, S. C., Dedos, S. G., Potter, B. V. L., Lummis, S. C. R., Taylor, C. W.
Parnell, J., Osinski, G. R., Lee, P., Cockell, C. S., Taylor, C. W.
Hopanoid biomarkers have been traced from bedrock to ice in the Haughton Impact Structure, suggesting that they represent a promising strategy in the search for life in ice deposits on Mars and other...
Kidd, J.F., Pilkington, M.F., Schell, M.J., Fogarty, K.E., Skepper, J.N, Taylor, C.W., ...
This paper arose out of studies on the calcium signaling characteristics of secretory epithelial cells. Through extensive prior work, including much of my own work, we probably know more about...
Kidd, J. F., Pilkington, M. F., Schell, M. J., Fogarty, K. E., Skepper, J. N., Taylor, C. W., ...
We have characterized the effects of the antimitotic drug paclitaxel (Taxol(TM)) on the Ca2+ signaling cascade of terminally differentiated mouse pancreatic acinar cells. Using single cell...
Kidd, J. F., Pilkington, M. F., Schell, M. J., Fogarty, K. E., Skepper, J. N., Taylor, C. W., ...
We have characterized the effects of the antimitotic drug paclitaxel (Taxol(TM)) on the Ca2+ signaling cascade of terminally differentiated mouse pancreatic acinar cells. Using single cell...
Determinants of adenophostin A binding to inositol trisphosphate receptors (2002)
Morris, S. A., Nerou, E. P., Riley, A. M., Potter, B. V. L., Taylor, C. W.
Calcium signalling: IP3 rises again ... and again (2001)
Recent results indicate that 'regulators of G-protein signalling' may contribute to the generation of receptor-specific patterns of cytosolic Ca2+ oscillations by associating with specific receptors,...
Calcium signalling: IP3 rises again ... and again (2001)
Recent results indicate that 'regulators of G-protein signalling' may contribute to the generation of receptor-specific patterns of cytosolic Ca2+ oscillations by associating with specific receptors,...
Riley, A. M., Correa, V., Mahon, M. F., Taylor, C. W., Potter, B. V. L.
The high affinity of adenophostin A for 1D-myo-inositol 1,4,5-trisphosphate [Ins(1,4,5)P-3] receptors may be related to an alteration in the position of its 2'-phosphate group relative to the...
Structural determinants of adenophostin A activity at inositol trisphosphate receptors (2001)
Correa, V., Riley, A. M., Shuto, S., Horne, G., Nerou, E. P., Marwood, R. D., ...
Morris, S A, Török, K, Taylor, C W
InsP(3) binding to type-1, but not type-3, InsP(3) receptors is inhibited by calmodulin in a Ca(2+)-independent fashion [Cardy and Taylor (1998) Biochem. J. 334, 447-455], and Ca(2+) mobilization by...
Taylor,C. W., Travers,R. M. W., Karlin,L.
Supplement 1 to AD-B951 462.
1. Spontaneous Ca2+ release from the inositol 1,4,5-trisphosphate (InsP3)-sensitive stores in permeabilized hepatocytes was monitored using Fluo-3 to measure the free [Ca2+] of the medium bathing the...
Spontaneous calcium release from inositol trisphosphate-sensitive calcium stores (1991)
Inositol 1,4,5-trisphosphate (InsP3) functions as a second messenger to mobilize Ca2+ from intracellular reservoirs. The release mechanism displays all-or-none characteristics, that may account for...
Yeoman, L C, Jordan, J J, Busch, R K, Taylor, C W, Savage, H E, Busch, H
Antibodies to chromatin proteins of Novikoff hepatoma cells formed precipitin bands in the double-diffusion immunoprecipitation assay with chromatin proteins of Novikoff hepatoma, Walker 256...
Combettes, L, Cheek, T R, Taylor, C W
The quantal behaviour of inositol trisphosphate (InsP3) receptors allows rapid graded release of Ca2+ from intracellular stores, but the mechanisms are unknown. In Ca2+-depleted stores loaded with...
The histology and cytology of changes in the epithelium of the cervix uteri
Govan, A. D. T., Haines, R. M., Langley, F. A., Taylor, C. W., Woodcock, A. S.
Abnormalities of the cervical epithelium are set out in two main groups: bland lesions which are regarded as unrelated to malignancy, and malign lesions which are considered as potential precursors...
Heparin and other polyanions uncouple alpha 1-adrenoceptors from G-proteins.
Several polyanionic compounds antagonize the interaction between receptors and the G-proteins that regulate adenylate cyclase or K+ channels, possibly by binding to a basic stretch of the receptor...
An explanation of the complex effects of hormones on intracellular Ca2+ requires that the intracellular actions of Ins(1,4,5)P3 and the relationships between intracellular Ca2+ stores are fully...
Liver inositol, 1,4,5-trisphosphate-binding sites are the Ca2(+)-mobilizing receptors.
Ins(1,4,5)P3 is the intracellular messenger that in many cells mediates the effects of Ca2(+)-mobilizing receptors on intracellular Ca2+ stores. An Ins(1,4,5)P3 receptor from cerebellum has been...
Caffeine has been much used to examine the possibility that ryanodine receptors similar to those found in skeletal and cardiac muscle may be more widely distributed and perhaps contribute to...
Luminal Ca2+ increases the affinity of inositol 1,4,5-trisphosphate for its receptor.
Luminal Ca2+ has been proposed to regulate the sensitivity of intracellular Ca2+ stores to InsP3 and perhaps thereby to contribute to the mechanisms responsible for regenerative intracellular Ca2+...
Submaximal concentrations of inositol 1,4,5-trisphosphate (InsP3) rapidly release only a fraction of the InsP3-sensitive intracellular Ca2+ stores, despite the ability of further increases in InsP3...
Molecular target sizes of inositol 1,4,5-trisphosphate receptors in liver and cerebellum.
Nunn, D L, Potter, B V, Taylor, C W
Ins(1,4,5)P3 is the intracellular messenger that mediates the effects of many cell-surface receptors on intracellular Ca2+ stores. Although radioligand-binding studies have identified high-affinity...
Cytosolic Ca2+ biphasically regulates Ins(1,4,5)P3-stimulated Ca2+ mobilization in liver [Marshall and Taylor (1993) J. Biol. Chem. 268, 13214-13220]. We have investigated the mechanisms underlying...
Taylor, C W, Berridge, M J, Cooke, A M, Potter, B V
D-Ins(1,4,5)P3 is now recognized as an intracellular messenger that mediates the actions of many cell-surface receptors on intracellular Ca2+ pools, but its complex and rapid metabolism in intact...
Merritt, J E, Taylor, C W, Rubin, R P, Putney, J W
The initial response of many cells to 'Ca2+-mobilizing' agonists is phospholipase C-mediated hydrolysis of phosphatidylinositol bisphosphate to inositol trisphosphate (IP3) and diacylglycerol. It has...
Effects of Ca2+ on phosphoinositide breakdown in exocrine pancreas.
Taylor, C W, Merritt, J E, Putney, J W, Rubin, R P
Recent studies have established that inositol 1,4,5-trisphosphate [I(1,4,5)P3] provides the link between receptor-regulated polyphosphoinositide hydrolysis and mobilization of intracellular Ca2+....
Isomers of inositol trisphosphate in exocrine pancreas.
Merritt, J E, Taylor, C W, Rubin, R P, Putney, J W
In rat pancreatic acinar cells, the Ca2+-mobilizing receptor-agonist, caerulein, at both maximal and submaximal concentrations, stimulated a rapid, transient, increase in [3H]inositol...
Taylor, C W, Blakeley, D M, Corps, A N, Berridge, M J, Brown, K D
We have compared the effects of pretreatment of Swiss 3T3 cell with pertussis toxin on the stimulation of DNA synthesis and phosphoinositide hydrolysis in response to a wide variety of mitogens. The...
Size of the inositol 1,4,5-trisphosphate-sensitive calcium pool in guinea-pig hepatocytes.
Permeabilized hepatocytes accumulated 45Ca2+ into a non-mitochondrial pool when provided with ATP. 45Ca2+ efflux from this pool was revealed by removal of ATP with glucose and hexokinase or by...
Broad, L M, Powis, D A, Taylor, C W
Differentiation of BC3H1 cells leads to expression of a variety of proteins characteristic of smooth muscle and to changes in the behaviour of intracellular Ca2+ stores. Treatment of both...
Marchant, J S, Chang, Y T, Chung, S K, Irvine, R F, Taylor, C W
Ins(2,4,5)P3, a metabolically stable analogue of Ins(1,4,5)P3, is widely used in analyses of Ca2+ signalling pathways, but its utility depends upon it faithfully mimicking the effects of the natural...
The kinetics of Ins(1,4,5)P3 (InsP3)-stimulated Ca2+ release from intracellular stores are unusual in that submaximal concentrations of InsP3 rapidly release only a fraction of the InsP3-sensitive...
Differential regulation of types-1 and -3 inositol trisphosphate receptors by cytosolic Ca2+.
Cardy, T J, Traynor, D, Taylor, C W
Biphasic regulation of inositol trisphosphate (IP3)-stimulated Ca2+ mobilization by cytosolic Ca2+ is believed to contribute to regenerative intracellular Ca2+ signals. Since cells typically express...
Nucleolar protein p120 contains an arginine-rich domain that binds to ribosomal RNA.
Gustafson, W C, Taylor, C W, Valdez, B C, Henning, D, Phippard, A, Ren, Y, ...
Human proliferation-associated protein p120 has previously been shown to localize to the nucleolus, and several functional domains of p120 have been elucidated. By using a nitrocellulose filter...
Luminal Ca2+ regulates passive Ca2+ efflux from the intracellular stores of hepatocytes.
Ca2+ uptake into the intracellular stores of permeabilized hepatocytes was entirely dependent on ATP and substantially inhibited by either ionomycin or thapsigargin, although both were required for...
A novel role for calmodulin: Ca2+-independent inhibition of type-1 inositol trisphosphate receptors.
Calmodulin inhibits both inositol 1,4,5-trisphosphate (IP3) binding to, and IP3-evoked Ca2+ release by, cerebellar IP3 receptors [Patel, Morris, Adkins, O'Beirne and Taylor (1997) Proc. Natl. Acad....
Extracellular heavy-metal ions stimulate Ca2+ mobilization in hepatocytes.
Populations of hepatocytes in primary culture were loaded with fura 2 and the effects of extracellular heavy-metal ions were examined under conditions that allowed changes in fura 2 fluorescence...
Broad, L M, Cannon, T R, Short, A D, Taylor, C W
In A7r5 cells with empty intracellular Ca(2+) stores in which the cytosolic free Ca(2+) concentration ([Ca(2+)](i)) had been increased by capacitative Ca(2+) entry, stimulation of receptors linked to...
Swatton, J E, Morris, S A, Cardy, T J, Taylor, C W
There are three subtypes of mammalian Ins(1,4,5)P(3) (InsP(3)) receptor, each of which forms an intracellular Ca(2+) channel. Biphasic regulation of InsP(3) receptors by cytosolic Ca(2+) is well...
Adkins, C E, Morris, S A, De Smedt, H, Sienaert, I, Török, K, Taylor, C W
InsP(3) binding to type-1, but not type-3, InsP(3) receptors is inhibited by calmodulin in a Ca(2+)-independent fashion [Cardy and Taylor (1998) Biochem. J. 334, 447-455], and Ca(2+) mobilization by...
Short, A D, Winston, G P, Taylor, C W
In cells expressing different receptors linked to Ins(1,4,5)P(3) formation, maximal stimulation of any one of them often releases all the Ins(1,4,5)P(3)-sensitive Ca(2+) stores, suggesting that...
Rapid activation and partial inactivation of inositol trisphosphate receptors by adenophostin A.
Adkins, C E, Wissing, F, Potter, B V, Taylor, C W
Adenophostin A, the most potent known agonist of inositol 1,4, 5-trisphosphate (InsP(3)) receptors, stimulated (45)Ca(2+) release from the intracellular stores of permeabilized hepatocytes. The...
Selective recognition of inositol phosphates by subtypes of the inositol trisphosphate receptor.
Nerou, E P, Riley, A M, Potter, B V, Taylor, C W
Synthetic analogues of inositol trisphosphate (IP(3)), all of which included structures equivalent to the 4,5-bisphosphate of (1,4,5)IP(3), were used to probe the recognition properties of rat...
Functional properties of Drosophila inositol trisphosphate receptors.
Swatton, J E, Morris, S A, Wissing, F, Taylor, C W
The functional properties of the only inositol trisphosphate (IP(3)) receptor subtype expressed in Drosophila were examined in permeabilized S2 cells. The IP(3) receptors of S2 cells bound...
Endogenous heavy metal ions perturb fura-2 measurements of basal and hormone-evoked Ca2+ signals.
Snitsarev, V A, McNulty, T J, Taylor, C W
Using the membrane-permeant chelator of heavy metal ions, N,N,N',N'-tetrakis(2-pyridylmethyl)ethylene diamine (TPEN), we demonstrate that in pancreatic acinar cells, hepatocytes, and a variety of...
Quantal Ca2+ mobilization stimulated by inositol 1,4,5-trisphosphate in permeabilized hepatocytes.
Oldershaw, K A, Nunn, D L, Taylor, C W
In several cell types, including hepatocytes, submaximal concentrations of Ins(1,4,5)P3 stimulate an initial rapid mobilization of intracellular Ca2+ stores that is followed by either no further Ca2+...
1. Arg8-vasopressin (AVP)-regulated Ca2+ transport were investigated in fura-2-loaded A7r5 cells using both single cell and population measurements. 2. AVP evokes an initial concentration-dependent...
Madge, L, Marshall, I C, Taylor, C W
1. In calf pulmonary artery endothelial (CPAE) cells loaded with fura-2, the effects of ATP on Ca2+ entry were mediated entirely by the ability of P2U purinoceptors to stimulate InsP3 formation,...
Missiaen, L, Taylor, C W, Berridge, M J
1. Spontaneous Ca2+ release from the inositol 1,4,5-trisphosphate (InsP3)-sensitive stores in permeabilized hepatocytes was monitored using Fluo-3 to measure the free [Ca2+] of the medium bathing the...
Bootman, M D, Berridge, M J, Taylor, C W
1. Histamine-stimulated mobilization of intracellular Ca2+ stores was monitored in intact and permeabilized populations of HeLa cells using both the fluorescent Ca2+ indicator Fura-2 and 45Ca2+...
Yeoman, L C, Jordan, J J, Busch, R K, Taylor, C W, Savage, H E, Busch, H
Antibodies to chromatin proteins of Novikoff hepatoma cells formed precipitin bands in the double-diffusion immunoprecipitation assay with chromatin proteins of Novikoff hepatoma, Walker 256...
Combettes, L, Cheek, T R, Taylor, C W
The quantal behaviour of inositol trisphosphate (InsP3) receptors allows rapid graded release of Ca2+ from intracellular stores, but the mechanisms are unknown. In Ca2+-depleted stores loaded with...
The histology and cytology of changes in the epithelium of the cervix uteri
Govan, A. D. T., Haines, R. M., Langley, F. A., Taylor, C. W., Woodcock, A. S.
Abnormalities of the cervical epithelium are set out in two main groups: bland lesions which are regarded as unrelated to malignancy, and malign lesions which are considered as potential precursors...
Heparin and other polyanions uncouple alpha 1-adrenoceptors from G-proteins.
Several polyanionic compounds antagonize the interaction between receptors and the G-proteins that regulate adenylate cyclase or K+ channels, possibly by binding to a basic stretch of the receptor...
An explanation of the complex effects of hormones on intracellular Ca2+ requires that the intracellular actions of Ins(1,4,5)P3 and the relationships between intracellular Ca2+ stores are fully...
Liver inositol, 1,4,5-trisphosphate-binding sites are the Ca2(+)-mobilizing receptors.
Ins(1,4,5)P3 is the intracellular messenger that in many cells mediates the effects of Ca2(+)-mobilizing receptors on intracellular Ca2+ stores. An Ins(1,4,5)P3 receptor from cerebellum has been...
Caffeine has been much used to examine the possibility that ryanodine receptors similar to those found in skeletal and cardiac muscle may be more widely distributed and perhaps contribute to...
Luminal Ca2+ increases the affinity of inositol 1,4,5-trisphosphate for its receptor.
Luminal Ca2+ has been proposed to regulate the sensitivity of intracellular Ca2+ stores to InsP3 and perhaps thereby to contribute to the mechanisms responsible for regenerative intracellular Ca2+...
Submaximal concentrations of inositol 1,4,5-trisphosphate (InsP3) rapidly release only a fraction of the InsP3-sensitive intracellular Ca2+ stores, despite the ability of further increases in InsP3...
Molecular target sizes of inositol 1,4,5-trisphosphate receptors in liver and cerebellum.
Nunn, D L, Potter, B V, Taylor, C W
Ins(1,4,5)P3 is the intracellular messenger that mediates the effects of many cell-surface receptors on intracellular Ca2+ stores. Although radioligand-binding studies have identified high-affinity...
Cytosolic Ca2+ biphasically regulates Ins(1,4,5)P3-stimulated Ca2+ mobilization in liver [Marshall and Taylor (1993) J. Biol. Chem. 268, 13214-13220]. We have investigated the mechanisms underlying...
Taylor, C W, Berridge, M J, Cooke, A M, Potter, B V
D-Ins(1,4,5)P3 is now recognized as an intracellular messenger that mediates the actions of many cell-surface receptors on intracellular Ca2+ pools, but its complex and rapid metabolism in intact...
Merritt, J E, Taylor, C W, Rubin, R P, Putney, J W
The initial response of many cells to 'Ca2+-mobilizing' agonists is phospholipase C-mediated hydrolysis of phosphatidylinositol bisphosphate to inositol trisphosphate (IP3) and diacylglycerol. It has...
Effects of Ca2+ on phosphoinositide breakdown in exocrine pancreas.
Taylor, C W, Merritt, J E, Putney, J W, Rubin, R P
Recent studies have established that inositol 1,4,5-trisphosphate [I(1,4,5)P3] provides the link between receptor-regulated polyphosphoinositide hydrolysis and mobilization of intracellular Ca2+....
Isomers of inositol trisphosphate in exocrine pancreas.
Merritt, J E, Taylor, C W, Rubin, R P, Putney, J W
In rat pancreatic acinar cells, the Ca2+-mobilizing receptor-agonist, caerulein, at both maximal and submaximal concentrations, stimulated a rapid, transient, increase in [3H]inositol...
Taylor, C W, Blakeley, D M, Corps, A N, Berridge, M J, Brown, K D
We have compared the effects of pretreatment of Swiss 3T3 cell with pertussis toxin on the stimulation of DNA synthesis and phosphoinositide hydrolysis in response to a wide variety of mitogens. The...
Quantal Ca2+ mobilization stimulated by inositol 1,4,5-trisphosphate in permeabilized hepatocytes.
Oldershaw, K A, Nunn, D L, Taylor, C W
In several cell types, including hepatocytes, submaximal concentrations of Ins(1,4,5)P3 stimulate an initial rapid mobilization of intracellular Ca2+ stores that is followed by either no further Ca2+...
Size of the inositol 1,4,5-trisphosphate-sensitive calcium pool in guinea-pig hepatocytes.
Permeabilized hepatocytes accumulated 45Ca2+ into a non-mitochondrial pool when provided with ATP. 45Ca2+ efflux from this pool was revealed by removal of ATP with glucose and hexokinase or by...
1. Arg8-vasopressin (AVP)-regulated Ca2+ transport were investigated in fura-2-loaded A7r5 cells using both single cell and population measurements. 2. AVP evokes an initial concentration-dependent...
Madge, L, Marshall, I C, Taylor, C W
1. In calf pulmonary artery endothelial (CPAE) cells loaded with fura-2, the effects of ATP on Ca2+ entry were mediated entirely by the ability of P2U purinoceptors to stimulate InsP3 formation,...
Missiaen, L, Taylor, C W, Berridge, M J
1. Spontaneous Ca2+ release from the inositol 1,4,5-trisphosphate (InsP3)-sensitive stores in permeabilized hepatocytes was monitored using Fluo-3 to measure the free [Ca2+] of the medium bathing the...
Bootman, M D, Berridge, M J, Taylor, C W
1. Histamine-stimulated mobilization of intracellular Ca2+ stores was monitored in intact and permeabilized populations of HeLa cells using both the fluorescent Ca2+ indicator Fura-2 and 45Ca2+...
Broad, L M, Powis, D A, Taylor, C W
Differentiation of BC3H1 cells leads to expression of a variety of proteins characteristic of smooth muscle and to changes in the behaviour of intracellular Ca2+ stores. Treatment of both...
Marchant, J S, Chang, Y T, Chung, S K, Irvine, R F, Taylor, C W
Ins(2,4,5)P3, a metabolically stable analogue of Ins(1,4,5)P3, is widely used in analyses of Ca2+ signalling pathways, but its utility depends upon it faithfully mimicking the effects of the natural...
The kinetics of Ins(1,4,5)P3 (InsP3)-stimulated Ca2+ release from intracellular stores are unusual in that submaximal concentrations of InsP3 rapidly release only a fraction of the InsP3-sensitive...
Differential regulation of types-1 and -3 inositol trisphosphate receptors by cytosolic Ca2+.
Cardy, T J, Traynor, D, Taylor, C W
Biphasic regulation of inositol trisphosphate (IP3)-stimulated Ca2+ mobilization by cytosolic Ca2+ is believed to contribute to regenerative intracellular Ca2+ signals. Since cells typically express...
Nucleolar protein p120 contains an arginine-rich domain that binds to ribosomal RNA.
Gustafson, W C, Taylor, C W, Valdez, B C, Henning, D, Phippard, A, Ren, Y, ...
Human proliferation-associated protein p120 has previously been shown to localize to the nucleolus, and several functional domains of p120 have been elucidated. By using a nitrocellulose filter...
Luminal Ca2+ regulates passive Ca2+ efflux from the intracellular stores of hepatocytes.
Ca2+ uptake into the intracellular stores of permeabilized hepatocytes was entirely dependent on ATP and substantially inhibited by either ionomycin or thapsigargin, although both were required for...
A novel role for calmodulin: Ca2+-independent inhibition of type-1 inositol trisphosphate receptors.
Calmodulin inhibits both inositol 1,4,5-trisphosphate (IP3) binding to, and IP3-evoked Ca2+ release by, cerebellar IP3 receptors [Patel, Morris, Adkins, O'Beirne and Taylor (1997) Proc. Natl. Acad....
Extracellular heavy-metal ions stimulate Ca2+ mobilization in hepatocytes.
Populations of hepatocytes in primary culture were loaded with fura 2 and the effects of extracellular heavy-metal ions were examined under conditions that allowed changes in fura 2 fluorescence...
Broad, L M, Cannon, T R, Short, A D, Taylor, C W
In A7r5 cells with empty intracellular Ca(2+) stores in which the cytosolic free Ca(2+) concentration ([Ca(2+)](i)) had been increased by capacitative Ca(2+) entry, stimulation of receptors linked to...
Swatton, J E, Morris, S A, Cardy, T J, Taylor, C W
There are three subtypes of mammalian Ins(1,4,5)P(3) (InsP(3)) receptor, each of which forms an intracellular Ca(2+) channel. Biphasic regulation of InsP(3) receptors by cytosolic Ca(2+) is well...
Adkins, C E, Morris, S A, De Smedt, H, Sienaert, I, Török, K, Taylor, C W
InsP(3) binding to type-1, but not type-3, InsP(3) receptors is inhibited by calmodulin in a Ca(2+)-independent fashion [Cardy and Taylor (1998) Biochem. J. 334, 447-455], and Ca(2+) mobilization by...
Short, A D, Winston, G P, Taylor, C W
In cells expressing different receptors linked to Ins(1,4,5)P(3) formation, maximal stimulation of any one of them often releases all the Ins(1,4,5)P(3)-sensitive Ca(2+) stores, suggesting that...
Rapid activation and partial inactivation of inositol trisphosphate receptors by adenophostin A.
Adkins, C E, Wissing, F, Potter, B V, Taylor, C W
Adenophostin A, the most potent known agonist of inositol 1,4, 5-trisphosphate (InsP(3)) receptors, stimulated (45)Ca(2+) release from the intracellular stores of permeabilized hepatocytes. The...
Selective recognition of inositol phosphates by subtypes of the inositol trisphosphate receptor.
Nerou, E P, Riley, A M, Potter, B V, Taylor, C W
Synthetic analogues of inositol trisphosphate (IP(3)), all of which included structures equivalent to the 4,5-bisphosphate of (1,4,5)IP(3), were used to probe the recognition properties of rat...
Functional properties of Drosophila inositol trisphosphate receptors.
Swatton, J E, Morris, S A, Wissing, F, Taylor, C W
The functional properties of the only inositol trisphosphate (IP(3)) receptor subtype expressed in Drosophila were examined in permeabilized S2 cells. The IP(3) receptors of S2 cells bound...
Endogenous heavy metal ions perturb fura-2 measurements of basal and hormone-evoked Ca2+ signals.
Snitsarev, V A, McNulty, T J, Taylor, C W
Using the membrane-permeant chelator of heavy metal ions, N,N,N',N'-tetrakis(2-pyridylmethyl)ethylene diamine (TPEN), we demonstrate that in pancreatic acinar cells, hepatocytes, and a variety of...
Taylor, C. W., Dalton, W. S., Parrish, P. R., Gleason, M. C., Bellamy, W. T., Thompson, F. H., ...
We selected two drug resistant variants of the MCF7 human breast cancer cell line by chronic in vitro exposure to doxorubicin (MCF7/D40 cell line) and mitoxantrone (MCF7/Mitox cell line),...