Scientific Commons: C. Walz

Comparison of mutated ABL1 and JAK2 as oncogenes and drug targets in myeloproliferative disorders (2008)

Walz, C., Cross, N.C., Van Etten, R.A., Reiter, A.

Constitutively activated mutants of the non-receptor tyrosine kinases (TK) ABL1 (Abelson murine leukemia viral (v-abl) homolog (1) protein) and JAK2 (JAnus Kinase 2 or Just Another Kinase 2) play a...

The severity of FIP1L1-PDGFRA-positive chronic eosinophilic leukaemia is associated with polymorphic variation at the IL5RA locus (2007)

Burgstaller, S., Kreil, S., Waghorn, K., Metzgeroth, G., Preudhomme, C., Zoi, K., ...

We have investigated the hypothesis that constitutional genetic variation in IL-5 signalling may be associated with the development or severity of FIP1L1-PDGFRA-positive chronic eosinophilic...

Recurrent finding of the FIP1L1-PDGFRA fusion gene in eosinophilia-associated acute myeloid leukemia and lymphoblastic T-cell lymphoma (2007)

Metzgeroth, G., Walz, C., Score, J., Siebert, R., Schnittger, S., Haferlach, C., ...

The FIP1L1-PDGFRA fusion gene has been described in patients with eosinophilia-associated myeloproliferative disorders (Eos-MPD). Here, we report on seven FIP1L1-PDGFRA-positive patients who...

Low-dose imatinib mesylate leads to rapid induction of major molecular responses and achievement of complete molecular remission in FIP1L1-PDGFRA-positive chronic eosinophilic leukemia (2007)

Jovanovic, J.V., Score, J., Waghorn, K., Cilloni, D., Gottardi, E., Metzgeroth, G., ...

The FIP1L1-PDGFRA fusion gene is a recurrent molecular lesion in eosinophilia-associated myeloproliferative disorders, predicting a favorable response to imatinib mesylate. To investigate its...

Bidirectional Trafficking of Prostaglandin E2 Receptors Involved in Long-Term Potentiation in Visual Cortex (2006)

Jan D. Huizinga, D. E. Reed, I. Berezin, Diana T. Valdez, ...

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Sensitive detection of FIP1L1-PDGFRA fusion transcripts by real-time quantitative RT-PCR (RQ-PCR) reveals achievement of molecular remission in chronic eosinophilic leukemia treated with low-dose imatinib therapy (2005)

Jovanovic, J., Reiter, A., Cilloni, D., Gottardi, E., Score, J., Popp, H., ...

The FIP1L1-PDGFRA fusion gene generated by a cryptic interstitial deletion at 4q12 is a recurrent molecular lesion in idiopathic hypereosinophilic syndrome (HES), that forms a basis for diagnosis of...

The t(8;17)(p11;q23) in the 8p11 myeloproliferative syndrome fuses MYO18A to FGFR1 (2005)

Walz, C., Chase, A., Schoch, C., Weisser, A., Schlegel, F., Hochhaus, A., ...

The 8p11 myeloproliferative syndrome (EMS) also known as stem cell leukemia-lymphoma syndrome (SCLL) is associated with translocations that disrupt FGFR1. The resultant fusion proteins are...

The t(8;17)(p11;q23) in the 8p11 myeloproliferative syndrome fuses MYO18A to FGFR1 (2005)

Walz, C., Chase, A., Schoch, C., Weisser, A., Schlegel, F., Hochhaus, A., ...

The 8p11 myeloproliferative syndrome (EMS) also known as stem cell leukemia-lymphoma syndrome (SCLL) is associated with translocations that disrupt FGFR1. The resultant fusion proteins are...

Oral sessions. Sensitive detection of FIP1L1-PDGFRA fusion transcripts by real-time quantitative RT-PCR (RQ-PCR) reveals achievement of molecular remission in chronic eosinophilic leukemia treated with low-dose imatinib therapy (2005)

Jovanovic, J., Reiter, A., Cilloni, D., Gottardi, E., Score, J., Popp, H., ...

The FIP1L1-PDGFRA fusion gene generated by a cryptic interstitial deletion at 4q12 is a recurrent molecular lesion in idiopathic hypereosinophilic syndrome (HES), that forms a basis for diagnosis of...

Laser cladding and primer application as a one-step process (2004)

Stiles, E., Walz, C., Beyer, E.

Steel plates used in shipbuilding are generally protected from corrosion by painting. However, when the plates are welded or cut, any paint near the process is vaporized, and has to be reapplied. In...

Proteomics of curcurbit phloem exudate reveals a network of defence proteins (2004)

Walz, C., Giavalisco, P., Schad, M., Juenger, M., Klose, J., Kehr, J.

Many different proteins can be separated from the sap of mature sieve tubes of different plant species. To date, only a limited number of those have been identified and functionally characterised....

Xylem sap protein composition is conserved among different plant species (2004)

Buhtz, A., Kolasa, A., Arlt, K., Walz, C., Kehr, J.

Xylem sap from broccoli (Brassica oleracea L. cv. Calabrais), rape (Brassica napus L. cv. Drakkar), pumpkin (Cucurbita maxima Duch. cv. gelber Zentner) and cucumber (Cucumis sativus L. cv. Hoffmanns...

Genomic anatomy of the specific reciprocal translocation t(15;17) in acute promyelocytic leukemia (2003)

Reiter, A., Saussele, S., Grimwade, D., Wiemels, J. L., Segal, M. R., Lafage-Pochitaloff, M., ...

The genomic breakpoints in the t(15;17)(q22;q21), associated with acute promyelocytic leukemia (APL), are known to occur within three different PML breakpoint cluster regions (bcr) on chromosome 15...

A simple, chisel assisted mechanical microdissection system for harvesting homogenous plant tissue suitable for the analysis of nucleic acids and proteins. (2003)

Brandt, S., Walz, C., Schad, M., Pavlovic, N., Kehr, J.

Laser application for automotive powertrain components (2003)

Beyer, E., Brenner, B., Nowotny, S., Walz, C.

Mechanisms underlying loss of reciprocal fusion gene expression in acute promyelocytic leukaemia: evidence for deletions on der(17) and complex rearrangements yielding novel fusion gene transcripts (2003)

Walz, C., Grimwade, D., Saussele, S., Weisser, A., Lafage-Pochitaloff, M., Hochhaus, A., ...

Mitoxantrone induces DNA topoisomerase II cleavage at translocation breakpoint hotspot in PML gene in acute promyelocytic leukemia (2003)

Mistry, A.R., Felix, C.A., Whitmarsh, R., Mason, A., Reiter, A., Cassinat, B., ...

Evidence for the presence and activity of a complete antioxidant defence system in mature sieve tubes. (2002)

Walz, C., Juenger, M., Schad, M., Kehr, J.

New innovations in diode laser cladding (2002)

Groth, A., Walz, C., Nägeler, S.

The Fraunhofer Center for Surface and Laser Processing developed a new cladding process, utilizing a 3kW direct diode laser and a coaxial powder-fedding nozzle. Porosity free and near crack free...

Automation of remote maintenance by an industrial robot mounted on a gantry crane. (1989)

Benner, J., Till, W., Walz, C.

Proc.of the 3rd Topical Meeting on Robotics and Remote Systems, Charleston, S.C., March 13-16, 1989

Modification of some biological properties of HeLa cells containing adeno-associated virus DNA integrated into chromosome 17.

Walz, C, Schlehofer, J R

Parvoviruses are known to interfere with cellular transformation and carcinogenesis. Since infecting adeno-associated virus (AAV) frequently integrates its DNA into the cellular genome, we analyzed...

Adeno-associated virus sensitizes HeLa cell tumors to gamma rays.

Walz, C, Schlehofer, J R, Flentje, M, Rudat, V, Zur Hausen, H

Infection with the helper virus-dependent human parvovirus adeno-associated virus (AAV) is known to interfere with cellular transformation in vitro and oncogenesis in vivo. Here we report on...