Ackerman, S L, Minden, A G, Yeung, C Y
The murine adenosine deaminase gene has a structurally archetypal TATAA-box-deficient G+C-rich promoter. The three Sp1 binding sites of the promoter are neither necessary nor sufficient for promoter...
Ackerman, S L, Minden, A G, Williams, G T, Bobonis, C, Yeung, C Y
The murine adenosine deaminase (ADA) gene has a (G + C)-rich promoter that can support diverse tissue-specific gene expression. By using deletion and mutation analyses, we have identified a...
Prospective study of community-acquired rotavirus infection.
Zheng, B J, Lo, S K, Tam, J S, Lo, M, Yeung, C Y, Ng, M H
We determined titers of group A rotavirus common antibodies and neutralizing antibodies against serotypes 1 to 4 of prototype human rotavirus (HRV) in cord blood and serum specimens obtained from 38...
Distinct populations of rotaviruses circulating among neonates and older infants.
Tam, J S, Zheng, B J, Lo, S K, Yeung, C Y, Lo, M, Ng, M H
We obtained three stool specimens from each of 371 neonates. Two specimens were obtained between days 1 and 3 after birth, while they were in the hospital, and one specimen was obtained between days...
Molecular epidemiology of human rotavirus infection in children in Hong Kong.
Tam, J S, Kum, W W, Lam, B, Yeung, C Y, Ng, M H
Rotavirus was identified in 256 (28.5%) of 899 hospitalized children with diarrhea during a 12-month period in Hong Kong. Fourteen electropherotypes were identified, and the appearance of each...
Escherichia coli associated with childhood diarrheas.
Yam, W C, Lung, M L, Yeung, C Y, Tam, J S, Ng, M H
We studied 2,246 episodes of childhood diarrhea over a 2-year period in a general hospital serving a population of about one million on the island of Hong Kong. Rotavirus (24%) and nontyphoid...
Selection and amplification of heterologous genes encoding adenosine deaminase in mammalian cells.
Kaufman, R J, Murtha, P, Ingolia, D E, Yeung, C Y, Kellems, R E
We demonstrate that an adenosine deaminase (ADA) cDNA gene can function as a dominant selectable and amplifiable marker for gene transfer experiments in mammalian cells. Cells that incorporate the...
Ingolia, D E, Al-Ubaidi, M R, Yeung, C Y, Bigo, H A, Wright, D, Kellems, R E
A genomic library was prepared with DNA from a genetically enriched mouse cell line in which amplified copies of the adenosine deaminase (ADA) gene account for over 5% of the genome. Overlapping...
Yoder, S S, Robberson, B L, Leys, E J, Hook, A G, Al-Ubaidi, M, Yeung, C Y, ...
Infection of human cells by adenovirus results in multiple alterations of host gene expression. To examine the effects of viral infection on the expression of a single gene, a line of human cells was...
Ackerman, S L, Minden, A G, Yeung, C Y
The murine adenosine deaminase gene has a structurally archetypal TATAA-box-deficient G+C-rich promoter. The three Sp1 binding sites of the promoter are neither necessary nor sufficient for promoter...
Ackerman, S L, Minden, A G, Williams, G T, Bobonis, C, Yeung, C Y
The murine adenosine deaminase (ADA) gene has a (G + C)-rich promoter that can support diverse tissue-specific gene expression. By using deletion and mutation analyses, we have identified a...
Prospective study of community-acquired rotavirus infection.
Zheng, B J, Lo, S K, Tam, J S, Lo, M, Yeung, C Y, Ng, M H
We determined titers of group A rotavirus common antibodies and neutralizing antibodies against serotypes 1 to 4 of prototype human rotavirus (HRV) in cord blood and serum specimens obtained from 38...
Distinct populations of rotaviruses circulating among neonates and older infants.
Tam, J S, Zheng, B J, Lo, S K, Yeung, C Y, Lo, M, Ng, M H
We obtained three stool specimens from each of 371 neonates. Two specimens were obtained between days 1 and 3 after birth, while they were in the hospital, and one specimen was obtained between days...
Molecular epidemiology of human rotavirus infection in children in Hong Kong.
Tam, J S, Kum, W W, Lam, B, Yeung, C Y, Ng, M H
Rotavirus was identified in 256 (28.5%) of 899 hospitalized children with diarrhea during a 12-month period in Hong Kong. Fourteen electropherotypes were identified, and the appearance of each...
Escherichia coli associated with childhood diarrheas.
Yam, W C, Lung, M L, Yeung, C Y, Tam, J S, Ng, M H
We studied 2,246 episodes of childhood diarrhea over a 2-year period in a general hospital serving a population of about one million on the island of Hong Kong. Rotavirus (24%) and nontyphoid...
Selection and amplification of heterologous genes encoding adenosine deaminase in mammalian cells.
Kaufman, R J, Murtha, P, Ingolia, D E, Yeung, C Y, Kellems, R E
We demonstrate that an adenosine deaminase (ADA) cDNA gene can function as a dominant selectable and amplifiable marker for gene transfer experiments in mammalian cells. Cells that incorporate the...
Ingolia, D E, Al-Ubaidi, M R, Yeung, C Y, Bigo, H A, Wright, D, Kellems, R E
A genomic library was prepared with DNA from a genetically enriched mouse cell line in which amplified copies of the adenosine deaminase (ADA) gene account for over 5% of the genome. Overlapping...
Yoder, S S, Robberson, B L, Leys, E J, Hook, A G, Al-Ubaidi, M, Yeung, C Y, ...
Infection of human cells by adenovirus results in multiple alterations of host gene expression. To examine the effects of viral infection on the expression of a single gene, a line of human cells was...
Leung, M P, Mok, C K, Lau, K C, Lo, R, Yeung, C Y
The application of cross sectional echocardiography and pulsed Doppler ultrasound to the management of symptomatic neonates with suspected congenital heart disease was studied in 96 consecutive...
Percentile ranges for serum IgG subclass concentrations in healthy Chinese children.
Lau, Y L, Jones, B M, Ng, K W, Yeung, C Y
In order to establish normal reference ranges of serum immunoglobulin G subclasses for different age groups in Chinese, we measured the four IgG subclasses by radial immunodiffusion using polyclonal...
Massive pulmonary hemorrhage in neonatal infection.
Of 35 newborn infants who died from an infection 19 had postmortem evidence of massive pulmonary hemorrhage. All but 1 of the 19 had evidence of antimortem formation of intravascular fibrin clots in...
Intrathecal antibiotic therapy for neonatal meningitis.
Twenty infants with neonatal meningitis were treated with systemic and lumbar intrathecal antibiotics upon initial diagnosis. Failure to sterilize the CSF in 2-3 days was associated with evidence of...
Effect of indomethacin on binding of bilirubin to albumin.
Lam, B C, Wong, H N, Yeung, C Y
The effect of indomethacin on the binding of bilirubin to protein was studied in vitro by the horseradish peroxidase oxidation method. Plasma indomethacin concentrations ranging from 1500...
Blood Sugar Changes in Neonatal Hyperbilirubinaemia and Phenobarbitone Therapy
A controlled study was carried out to show the effect of bilirubinaemia and phenobarbitone therapy on the blood sugar metabolism in newborn infants. In the control infants, a significant inverse...
Gastric Aspirate Findings in Neonatal Pneumonia
Yeung, C. Y., Tam, Anita S. Y.
A study on the gastric aspirate findings in infants with features of neonatal pneumonia and in healthy controls is presented. Definite pneumonia was associated with thickly mucoid gastric fluid...
Severe neonatal pertussis treated by salbutamol.
Two neonates with severe culture proven pertussis were successfully treated with salbutamol 0.5 mg three times daily. There was a demonstrable decrease in the total number of coughing spasms, their...
Abnormal radial artery in Down's syndrome.
Lo, R N, Leung, M P, Lau, K C, Yeung, C Y
Abnormal arterial patterns in the forearm were discovered in 12 of 77 patients (16%) with Down's syndrome. Eight patients had an enlarged anterior interosseous artery, the distal portion of which was...
Left ventricular function in beta thalassaemia major.
Lau, K C, Li, A M, Hui, P W, Yeung, C Y
The left ventricular dimension and posterior wall dynamics were studied by computer assisted analysis of M mode echocardiography in 25 normal children (group 1) and 32 transfusion dependent children...
Wong, C K, Ho, A W Y, Tong, P C Y, Yeung, C Y, Kong, A P S, Lun, S W M, ...
Cytokine-induced inflammation is involved in the pathogenesis of type 2 diabetes mellitus (DM). We investigated plasma concentrations and ex vivo production of cytokines and chemokines, and...