Carlos Briones

The dawn of the RNA World: Toward functional complexity through ligation of random RNA oligomers (2009)

Briones, Carlos, Stich, Michael, Manrubia, Susanna C.

A main unsolved problem in the RNA World scenario for the origin of life is how a template-dependent RNA polymerase ribozyme emerged from short RNA oligomers obtained by random polymerization on...

Topology of evolving, mutagenized viral populations: quasispecies expansion, compression, and operation of negative selection (2008)

Ojosnegros, Samuel, Agudo, Rubén, Sierra, Macarena, Briones, Carlos, Sierra, Saleta, ...

Abstract Background The molecular events and evolutionary forces underlying lethal mutagenesis of virus (or virus extinction through an excess of mutations) are not well understood. Here we apply for...

Topology of evolving, mutagenized viral populations: quasispecies expansion, compression, and operation of negative selection (2008)

Ojosnegros, Samuel, Agudo, Rubén, Sierra, Macarena, Briones, Carlos, Sierra, Saleta, ...

Additional files: Additional file 1: Neighbour-joining, maximum likelihood and maximum parsimony analysis of populations RAp35 and RA0p35. Additional file 2: Maximum likelihood phylogenetic analysis...

Label-free detection of DNA hybridization based on hydration-induced tension in nucleic acid films (2008)

Mertens, Johann, Rogero, Celia, Calleja, Montserrat, Ramos, Daniel, Briones, Carlos, ...

The properties of water at the nanoscale are crucial in many areas of biology, but the confinement of water molecules in sub-nanometre channels in biological systems has received relatively little...

Characterization of minority subpopulations in the mutant spectrum of HIV-1 quasispecies by successive specific amplifications (2007)

García-Arriaza, Juan, Domingo, Esteban, Briones, Carlos

12 pages, 3 figures, 3 tables.-- PMID: 17706828 [PubMed].-- ISI Article Identifier: 000251111000007.-- Printed version published Nov 2007.

Collective properties of evolving molecular quasispecies (2007)

Stich, Michael, Briones, Carlos, Manrubia, Susanna C

Abstract Background RNA molecules, through their dual appearance as sequence and structure, represent a suitable model to study evolutionary properties of quasispecies. The essential ingredient in...

Collective properties of evolving molecular quasispecies (2007)

Stich, Michael, Briones, Carlos, Manrubia, Susanna C.

This article is available from: http://www.biomedcentral.com/1471-2148/7/110

Método para la detección de genomas minoritarios en cuasiespecies virales usando microchips de ADN (2007)

Arias, Armando, Briones, Carlos, Domingo, Esteban, Escarmis, Cristina, Gómez, Jordi, Martín, Carmen, ...

Traducción de Patente Europea E01929654 (fecha de solicitud, 27/04/2001).-- Prioridad: ES20000427200001068.-- Titular: Consejo Superior de Investigaciones Científicas (CSIC).

Do peptide nucleic acids form self-assembled monolayers on pyrite surfaces? (2007)

Mateo Martí, Eva, Rogero, Celia, Briones, Carlos, Martín Gago, José Ángel

5 pages, 3 figures, 1 table.-- ISI Article Identifier: 000250414600112.-- Printed version Sep 15, 2007.-- Issue title: ECOSS-24, Proceedings of the 24th European Conference on Surface Science (Paris,...

A DNA biosensor based on peptide nucleic acids on gold surfaces (2007)

Mateo Martí, Eva, Briones, Carlos, Pradier, C. M., Martín Gago, José Ángel

7 pages, 3 figures, 2 tables.-- Available online 25 Sep. 2006.-- Selected Papers from the Ninth World Congress On Biosensors. Toronto, Canada 10 - 12 May 2006.

Modular evolution and increase of functional complexity in replicating RNA molecules (2007)

Manrubia, Susanna C., Briones, Carlos

Copyright © by Cambridge University Press.-- Final full-text version of the paper available at: http://intl.rnajournal.org/cgi/content/abstract/13/1/97

Modular evolution and increase of functional complexity in replicating RNA molecules (2007)

Manrubia, Susanna C., Briones, Carlos

11 pages, 5 figures.-- PMID: 17105993 [PubMed].-- PMCID: PMC1705761.-- ISI Article Identifier: 000243206800011.-- Available online Nov 14, 2006.

Modular evolution and increase of functional complexity in replicating RNA molecules (2007)

Manrubia, Susanna C., Briones, Carlos

At early stages of biochemical evolution, the complexity of replicating molecules was limited by unavoidably high mutation rates. In an RNA world, prior to the appearance of cellular life, an...

Microarray-based identification of antigenic variants of foot-and-mouth disease virus: a bioinformatics quality assessment (2006)

Martín, Verónica, Perales, Celia, Abia, David, Ortíz, Angel R, Domingo, Esteban, Briones, Carlos

Abstract Background The evolution of viral quasispecies can influence viral pathogenesis and the response to antiviral treatments. Mutant clouds in infected organisms represent the first stage in the...

Método y aparato para la detección de sustancias o analitos a partir del análisis de una o varias muestras (2006)

Gómez Elvira, Javier, Parro García, Víctor, Briones, Carlos, Pérez Mercader, Juan, Sebastián Martínez, Eduardo, Rodríguez Manfredi, José Antonio, ...

Referencia OEPM: P200301292.-- Fecha de solicitud: 30/05/2003.-- Titulares: Instituto Nacional de Técnica Aeroespacial “Esteban Terradas”, Sener ingeniería y Sistemas S.A. y Consejo Superior de...

Modular evolution and increase of functional complexity in replicating RNA molecules (2006)

Manrubia, Susanna C., Briones, Carlos

At early stages of biochemical evolution, the complexity of replicating molecules was limited by unavoidably high mutation rates. In an RNA world, prior to the appearance of cellular life, an...

Modular evolution and increase of functional complexity in replicating RNA molecules (2006)

Manrubia, Susanna C., Briones, Carlos

At early stages of biochemical evolution, the complexity of replicating molecules was limited by unavoidably high mutation rates. In an RNA world, prior to the appearance of cellular life, an...

Structural analysis of hepatitis C RNA genome using DNA microarrays (2004)

Martell, María, Briones, Carlos, De Vicente, Aránzazu, Piron, María, Esteban, Juan I., Esteban, Rafael, ...

Many studies have tried to identify specific nucleotide sequences in the quasispecies of hepatitis C virus (HCV) that determine resistance or sensitivity to interferon (IFN) therapy, unfortunately...

Role of a dipeptide insertion between codons 69 and 70 of HIV-1 reverse transcriptase in the mechanism of AZT resistance (2000)

Mas, Antonio, Parera, Mariona, Briones, Carlos, Soriano, Vicente, Martínez, Miguel Angel, Domingo, Esteban, ...

The 3'-azido-3'-deoxythymidine (AZT)-resistant pheno type of a heavily mutated human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) carrying a dipeptide (Ser-Ser) insertion between...

Conformational changes induced in the Saccharomyces cerevisiae GTPase-associated rRNA by ribosomal stalk components and a translocation inhibitor (2000)

Briones, Carlos, Ballesta, Juan P. G.

The yeast ribosomal GTPase associated center is made of parts of the 26S rRNA domains II and VI, and a number of proteins including P0, P1α, P1&bgr;, P2α, P2&bgr; and L12. Mapping of the rRNA...

Conformational changes induced in the Saccharomyces cerevisiae GTPase-associated rRNA by ribosomal stalk components and a translocation inhibitor

Briones, Carlos, Ballesta, Juan P. G.

The yeast ribosomal GTPase associated center is made of parts of the 26S rRNA domains II and VI, and a number of proteins including P0, P1α, P1β, P2α, P2β and L12. Mapping of the rRNA...

Role of a dipeptide insertion between codons 69 and 70 of HIV-1 reverse transcriptase in the mechanism of AZT resistance

Mas, Antonio, Parera, Mariona, Briones, Carlos, Soriano, Vicente, Martínez, Miguel Angel, Domingo, Esteban, ...

The 3′-azido-3′-deoxythymidine (AZT)-resistant pheno type of a heavily mutated human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) carrying a dipeptide (Ser-Ser) insertion...

Structural analysis of hepatitis C RNA genome using DNA microarrays

Martell, María, Briones, Carlos, De Vicente, Aránzazu, Piron, María, Esteban, Juan I., Esteban, Rafael, ...

Many studies have tried to identify specific nucleotide sequences in the quasispecies of hepatitis C virus (HCV) that determine resistance or sensitivity to interferon (IFN) therapy, unfortunately...

Conformational changes induced in the Saccharomyces cerevisiae GTPase-associated rRNA by ribosomal stalk components and a translocation inhibitor

Briones, Carlos, Ballesta, Juan P. G.

The yeast ribosomal GTPase associated center is made of parts of the 26S rRNA domains II and VI, and a number of proteins including P0, P1α, P1β, P2α, P2β and L12. Mapping of the rRNA...

Role of a dipeptide insertion between codons 69 and 70 of HIV-1 reverse transcriptase in the mechanism of AZT resistance

Mas, Antonio, Parera, Mariona, Briones, Carlos, Soriano, Vicente, Martínez, Miguel Angel, Domingo, Esteban, ...

The 3′-azido-3′-deoxythymidine (AZT)-resistant pheno type of a heavily mutated human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) carrying a dipeptide (Ser-Ser) insertion...

Structural analysis of hepatitis C RNA genome using DNA microarrays

Martell, María, Briones, Carlos, De Vicente, Aránzazu, Piron, María, Esteban, Juan I., Esteban, Rafael, ...

Many studies have tried to identify specific nucleotide sequences in the quasispecies of hepatitis C virus (HCV) that determine resistance or sensitivity to interferon (IFN) therapy, unfortunately...

Modular evolution and increase of functional complexity in replicating RNA molecules

Manrubia, Susanna C., Briones, Carlos

At early stages of biochemical evolution, the complexity of replicating molecules was limited by unavoidably high mutation rates. In an RNA world, prior to the appearance of cellular life, an...

The dawn of the RNA World: Toward functional complexity through ligation of random RNA oligomers

Briones, Carlos, Stich, Michael, Manrubia, Susanna C.

A main unsolved problem in the RNA World scenario for the origin of life is how a template-dependent RNA polymerase ribozyme emerged from short RNA oligomers obtained by random polymerization on...