A global benchmark study using affinity-based biosensors (2009)
Rich, Rebecca L., Papalia, Giuseppe A., Flynn, Peter J., Furneisen, Jamie, Quinn, John, Klein, Joshua S., ...
To explore the variability in biosensor studies, 150 participants from 20 countries were given the same protein samples and asked to determine kinetic rate constants for the interaction. We chose a...
RNA loop-loop complexes are motifs that regulate biological functions in both prokaryotic and eukaryotic organisms. In E. coli, RNAI, an antisense RNA encoded by the ColE1 plasmid, regulates the...
RNA loop-loop complexes are motifs that regulate biological functions in both prokaryotic and eukaryotic organisms. In E. coli, RNAI, an antisense RNA encoded by the ColE1 plasmid, regulates the...
RNA loop-loop complexes are motifs that regulate biological functions in both prokaryotic and eukaryotic organisms. In E. coli, RNAI, an antisense RNA encoded by the ColE1 plasmid, regulates the...
Lebars, Isabelle, Legrand, Pierre, Aimé, Ahissan, Pinaud, Noël, Fribourg, Sébastien, Di Primo, Carmelo
In HIV-1, trans-activation of transcription of the viral genome is regulated by an imperfect hairpin, the trans-activating responsive (TAR) RNA element, located at the 5' untranslated end of all...
Lebars, Isabelle, Legrand, Pierre, Aimé, Ahissan, Pinaud, Noël, Fribourg, Sébastien, Di Primo, Carmelo
In HIV-1, trans-activation of transcription of the viral genome is regulated by an imperfect hairpin, the trans-activating responsive (TAR) RNA element, located at the 5' untranslated end of all...
Lebars, Isabelle, Legrand, Pierre, Aimé, Ahissan, Pinaud, Noël, Fribourg, Sébastien, Di Primo, Carmelo
In HIV-1, trans-activation of transcription of the viral genome is regulated by an imperfect hairpin, the trans-activating responsive (TAR) RNA element, located at the 5' untranslated end of all...
Lebars, Isabelle, Richard, Tristan, Di Primo, Carmelo, Toulmé, Jean-Jacques
The trans-activating responsive (TAR) RNA element located in the 5′ untranslated region of the HIV-1 genome is a 57-nt imperfect stem-loop essential for the viral replication. TAR regulates...
LNA/DNA chimeric oligomers mimic RNA aptamers targeted to the TAR RNA element of HIV-1 (2004)
Darfeuille, Fabien, Hansen, Jens Bo, Orum, Henrik, Di Primo, Carmelo, Toulmé, Jean-Jacques
Beaurain, François, Di Primo, Carmelo, Toulmé, Jean Jacques, Laguerre, Michel
A RNA aptamer (R06) raised against the trans‐ activation responsive (TAR) element of HIV‐1 was previously shown to generate a loop–loop complex whose stability is strongly dependent on...
Darfeuille, Fabien, Arzumanov, Andrey, Gryaznov, Sergei, Gait, Michael J., Di Primo, Carmelo, Toulmé, Jean-Jacques
A hairpin RNA aptamer has been identified by in vitro selection against the transactivation-responsive element (TAR) of HIV-1. A nuclease-resistant N3′ → P5′ phosphoramidate isosequential...
Beaurain, François, Di Primo, Carmelo, Toulmé, Jean Jacques, Laguerre, Michel
A RNA aptamer (R06) raised against the trans- activation responsive (TAR) element of HIV-1 was previously shown to generate a loop–loop complex whose stability is strongly dependent on the selected...
LNA/DNA chimeric oligomers mimic RNA aptamers targeted to the TAR RNA element of HIV-1
Darfeuille, Fabien, Bo Hansen, Jens, Orum, Henrik, Di Primo, Carmelo, Toulmé, Jean-Jacques
One of the major limitations of the use of phosphodiester oligonucleotides in cells is their rapid degradation by nucleases. To date, several chemical modifications have been employed to overcome...
Darfeuille, Fabien, Arzumanov, Andrey, Gryaznov, Sergei, Gait, Michael J., Di Primo, Carmelo, Toulmé, Jean-Jacques
A hairpin RNA aptamer has been identified by in vitro selection against the transactivation-responsive element (TAR) of HIV-1. A nuclease-resistant N3′ → P5′ phosphoramidate isosequential...
Beaurain, François, Di Primo, Carmelo, Toulmé, Jean Jacques, Laguerre, Michel
A RNA aptamer (R06) raised against the trans- activation responsive (TAR) element of HIV-1 was previously shown to generate a loop–loop complex whose stability is strongly dependent on the selected...
LNA/DNA chimeric oligomers mimic RNA aptamers targeted to the TAR RNA element of HIV-1
Darfeuille, Fabien, Bo Hansen, Jens, Orum, Henrik, Di Primo, Carmelo, Toulmé, Jean-Jacques
One of the major limitations of the use of phosphodiester oligonucleotides in cells is their rapid degradation by nucleases. To date, several chemical modifications have been employed to overcome...
Lebars, Isabelle, Richard, Tristan, Di Primo, Carmelo, Toulmé, Jean-Jacques
The trans-activating responsive (TAR) RNA element located in the 5′ untranslated region of the HIV-1 genome is a 57-nt imperfect stem-loop essential for the viral replication. TAR regulates...
Van Melckebeke, Hélène, Devany, Matthew, Di Primo, Carmelo, Beaurain, François, Toulmé, Jean-Jacques, Bryce, David L., ...
Transactivation-response element (TAR) is a stable stem–loop structure of HIV RNA, which plays a crucial role during the life cycle of the virus. The apical loop of TAR acts as a binding site for...
Lebars, Isabelle, Legrand, Pierre, Aimé, Ahissan, Pinaud, Noël, Fribourg, Sébastien, Di Primo, Carmelo
In HIV-1, trans-activation of transcription of the viral genome is regulated by an imperfect hairpin, the trans-activating responsive (TAR) RNA element, located at the 5′ untranslated end of all...