Carmen Argmann

The Pro12Ala PPARgamma2 variant determines metabolism at the gene-environment interface. (2009)

Heikkinen, Sami, Argmann, Carmen, Feige, Jérôme N, Koutnikova, Hana, Champy, Marie-France, Dali-Youcef, Nassim, ...

The metabolic impact of the common peroxisome proliferator-activated receptor gamma isoform 2 (PPARgamma2) variant Pro12Ala in human populations has been widely debated. We demonstrate, using a...

Integrating siRNA and protein-protein interaction data to identify an expanded insulin signaling network (2009)

Tu, Zhidong, Argmann, Carmen, Wong, Kenny K., Mitnaul, Lyndon J., Edwards, Stephen, Sach, Iliana C., ...

Insulin resistance is one of the dominant symptoms of type 2 diabetes (T2D). Although the molecular mechanisms leading to this resistance are largely unknown, experimental data support that the...

A gene expression network model of type 2 diabetes links cell cycle regulation in islets with diabetes susceptibility (2008)

Keller, Mark P., Choi, YounJeong, Wang, Ping, Belt Davis, Dawn, Rabaglia, Mary E., Oler, Angie T., ...

Insulin resistance is necessary but not sufficient for the development of type 2 diabetes. Diabetes results when pancreatic beta-cells fail to compensate for insulin resistance by increasing insulin...

Compromised intestinal lipid absorption in mice with a liver-specific deficiency of liver receptor homolog 1. (2007)

Mataki, Chikage, Magnier, Benjamin C, Houten, Sander M, Annicotte, Jean-Sébastien, Argmann, Carmen, Thomas, Charles, ...

Bile acids (BAs) are water-soluble end products from cholesterol metabolism and are essential for efficient absorption of dietary lipids. By using targeted somatic mutagenesis of the nuclear receptor...

Insulin secretion: SIRT4 gets in on the act. (2006)

Argmann, Carmen, Auwerx, Johan

Despite their initial characterization as histone deacetylases controlling transcription, sirtuins also turn out to be critical regulators of metabolism. In this issue of Cell, Haigis et al. (2006)...

Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha. (2006)

Lagouge, Marie, Argmann, Carmen, Gerhart-Hines, Zachary, Meziane, Hamid, Lerin, Carles, Daussin, Frederic, ...

Diminished mitochondrial oxidative phosphorylation and aerobic capacity are associated with reduced longevity. We tested whether resveratrol (RSV), which is known to extend lifespan, impacts...

Compromised Intestinal Lipid Absorption in Mice with a Liver-Specific Deficiency of Liver Receptor Homolog 1▿

Mataki, Chikage, Magnier, Benjamin C., Houten, Sander M., Annicotte, Jean-Sébastien, Argmann, Carmen, Thomas, Charles, ...

Bile acids (BAs) are water-soluble end products from cholesterol metabolism and are essential for efficient absorption of dietary lipids. By using targeted somatic mutagenesis of the nuclear receptor...

A gene expression network model of type 2 diabetes links cell cycle regulation in islets with diabetes susceptibility

Keller, Mark P., Choi, YounJeong, Wang, Ping, Belt Davis, Dawn, Rabaglia, Mary E., Oler, Angie T., ...

Insulin resistance is necessary but not sufficient for the development of type 2 diabetes. Diabetes results when pancreatic beta-cells fail to compensate for insulin resistance by increasing insulin...