Lin, Xiukun, Parsels, Leslie A., Voeller, Donna M., Allegra, Carmen J., Maley, Gladys F., Maley, Frank, ...
Thymidylate synthase (TS) functions as an RNA-binding protein by interacting with two different sequences on its own mRNA. One site is located in the 5′-upstream region of human TS mRNA while the...
Voeller, Donna M., Changchien, Li-ming, Maley, Gladys F., Maley, Frank, Takechi, Teiji, Turner, Ross E., ...
Previous studies have shown that human TS mRNA translation Is controlled by a negative autoregulatory mechanism. In this study, an RNA electrophoretic gel mobility shift assay confirmed a direct...
Yee, Lorrin K., Allegra, Carmen J., Steinberg, Seth M., Grem, Jean L.
Background: We previously reported that recombinant interferon α-2a (IFN α-2a) therapy was associated with a dose-dependent decrease in fluorouracil (5-FU) clearance. Purpose: In this study, we...
Toxicity of Levamisole and 5-Fluorouracil in Human Colon Carcinoma Cells (1989)
Grem, Jean L, Allegra, Carmen J.
The combination of 5-fluorouracil (5-FU) with the immunomodulator levamisole (Lev) has been clinically tested in patients with metastatic colorectal carcinoma and as adjuvant therapy following...
Park, Jae-Gahb, Collins, Jerry M., Gazdar, Adi F., Allegra, Carmen J., Steinberg, Seth M., Greene, Raymond F., ...
Reduced folates have been shown to increase the cytotoxicity of 5-fluorouracil (5-FU) by stabilizing the 5-fluoro-2′-deoxyuridine-5′-monophosphate-thymidylate synthase complex, thus increasing...
Niklinski, Jacek, Claassen, Gisela, Meyers, Cheryl, Gregory, Mark A., Allegra, Carmen J., Kaye, Frederic J., ...
Somatic mutations at Thr-58 of c-Myc have been detected in Burkitt's lymphoma (BL) tumors and have been shown to affect the transforming potential of the Myc oncoprotein. In addition, the N-terminal...
Lin, Xiukun, Parsels, Leslie A., Voeller, Donna M., Allegra, Carmen J., Maley, Gladys F., Maley, Frank, ...
Thymidylate synthase (TS) functions as an RNA-binding protein by interacting with two different sequences on its own mRNA. One site is located in the 5′-upstream region of human TS mRNA while the...
Thymidylate Synthase Protein and p53 mRNA Form an In Vivo Ribonucleoprotein Complex
Chu, Edward, Copur, Sitki M., Ju, Jingfang, Chen, Tian-men, Khleif, Samir, Voeller, Donna M., ...
A thymidylate synthase (TS)-ribonucleoprotein (RNP) complex composed of TS protein and the mRNA of the tumor suppressor gene p53 was isolated from cultured human colon cancer cells. RNA gel shift...
Niklinski, Jacek, Claassen, Gisela, Meyers, Cheryl, Gregory, Mark A., Allegra, Carmen J., Kaye, Frederic J., ...
Somatic mutations at Thr-58 of c-Myc have been detected in Burkitt's lymphoma (BL) tumors and have been shown to affect the transforming potential of the Myc oncoprotein. In addition, the N-terminal...
Lin, Xiukun, Parsels, Leslie A., Voeller, Donna M., Allegra, Carmen J., Maley, Gladys F., Maley, Frank, ...
Thymidylate synthase (TS) functions as an RNA-binding protein by interacting with two different sequences on its own mRNA. One site is located in the 5′-upstream region of human TS mRNA while the...
Thymidylate Synthase Protein and p53 mRNA Form an In Vivo Ribonucleoprotein Complex
Chu, Edward, Copur, Sitki M., Ju, Jingfang, Chen, Tian-men, Khleif, Samir, Voeller, Donna M., ...
A thymidylate synthase (TS)-ribonucleoprotein (RNP) complex composed of TS protein and the mRNA of the tumor suppressor gene p53 was isolated from cultured human colon cancer cells. RNA gel shift...