Potential for La Crosse virus segment reassortment in nature (2008)
Reese, Sara M, Blitvich, Bradley J, Blair, Carol D, Geske, Dave, Beaty, Barry J, Black, William C
Abstract The evolutionary success of La Crosse virus (LACV, family Bunyaviridae ) is due to its ability to adapt to changing conditions through intramolecular genetic changes and segment...
Aedes aegyptiuses RNA interference in defense against Sindbis virus infection (2008)
Campbell, Corey L, Keene, Kimberly M, Brackney, Douglas E, Olson, Ken E, Blair, Carol D, Wilusz, Jeffrey, ...
Abstract Background RNA interference (RNAi) is an important anti-viral defense mechanism. The Aedes aegypti genome encodes RNAi component orthologs, however, most populations of this mosquito are...
Beaty, Barry J., Blair, Carol D.
Nucleic acid hybridization techniques have been developed to detect dengue and LaCrosse arbovirus RNA in cells and in cell and tissue suspensions. Probes are comprised of cDNAs of portions of the...
Beaty,Barry J., Blair,Carol D.
Sandwich hybridization techniques have been developed for detection of dengue virus RNA. Capture and detector probe constructs have been prepared in M13 and in vitro transcription plasmids,...
Beaty, Barry J., Blair, Carol D.
Nucleic acid hybridization techniques have been developed for detection of LaCrosse and dengue virus RNA in cells and in mosquitoes. RNA transcript or DNA probes of the respective viruses were...
Molecular Strategies for Interrupting Arthropod-Borne Virus Transmission by Mosquitoes
Blair, Carol D., Adelman, Zachary N., Olson, Ken E.
Arthropod-borne virus (arbovirus) infections cause a number of emerging and resurgent human and veterinary infectious diseases. Traditional means of controlling arbovirus diseases include vaccination...
Adelman, Zach N., Sanchez-Vargas, Irma, Travanty, Emily A., Carlson, Jon O., Beaty, Barry J., Blair, Carol D., ...
Double-stranded RNA (dsRNA) initiates cellular posttranscriptional responses that are collectively called RNA silencing in a number of different organisms, including plants, nematodes, and fruit...
Effect of Sendai Virus Infection on Lipid Metabolism in Chick Embryo Fibroblasts
Blair, Carol D., Brennan, Patrick J.
Lipid metabolism in the “abortive” system, Sendai virus-infected primary chick embryo fibroblasts, was examined by using 32P-orthophosphate, 14C-glucose, and 14C-glycerol as precursors....
Replication of Sendai Virus: II. Steps in Virus Assembly
Blair, Carol D., Robinson, William S.
Chick embryo fibroblast cultures infected with Sendai virus were incubated with 3H-uridine in the presence of actinomycin D beginning at 18 hr after infection. The 35 and 18S virus-specific...
Keene, Kimberly M., Foy, Brian D., Sanchez-Vargas, Irma, Beaty, Barry J., Blair, Carol D., Olson, Ken E.
RNA interference (RNAi) is triggered in eukaryotic organisms by double-stranded RNA (dsRNA), and it destroys any mRNA that has sequence identity with the dsRNA trigger. The RNAi pathway in Anopheles...
Franz, Alexander W. E., Sanchez-Vargas, Irma, Adelman, Zach N., Blair, Carol D., Beaty, Barry J., James, Anthony A., ...
Mosquitoes (Aedes aegypti) were genetically modified to exhibit impaired vector competence for dengue type 2 viruses (DENV-2). We exploited the natural antiviral RNA interference (RNAi) pathway in...
Molecular Strategies for Interrupting Arthropod-Borne Virus Transmission by Mosquitoes
Blair, Carol D., Adelman, Zachary N., Olson, Ken E.
Arthropod-borne virus (arbovirus) infections cause a number of emerging and resurgent human and veterinary infectious diseases. Traditional means of controlling arbovirus diseases include vaccination...
Adelman, Zach N., Sanchez-Vargas, Irma, Travanty, Emily A., Carlson, Jon O., Beaty, Barry J., Blair, Carol D., ...
Double-stranded RNA (dsRNA) initiates cellular posttranscriptional responses that are collectively called RNA silencing in a number of different organisms, including plants, nematodes, and fruit...
Effect of Sendai Virus Infection on Lipid Metabolism in Chick Embryo Fibroblasts
Blair, Carol D., Brennan, Patrick J.
Lipid metabolism in the “abortive” system, Sendai virus-infected primary chick embryo fibroblasts, was examined by using 32P-orthophosphate, 14C-glucose, and 14C-glycerol as precursors....
Replication of Sendai Virus: II. Steps in Virus Assembly
Blair, Carol D., Robinson, William S.
Chick embryo fibroblast cultures infected with Sendai virus were incubated with 3H-uridine in the presence of actinomycin D beginning at 18 hr after infection. The 35 and 18S virus-specific...
Keene, Kimberly M., Foy, Brian D., Sanchez-Vargas, Irma, Beaty, Barry J., Blair, Carol D., Olson, Ken E.
RNA interference (RNAi) is triggered in eukaryotic organisms by double-stranded RNA (dsRNA), and it destroys any mRNA that has sequence identity with the dsRNA trigger. The RNAi pathway in Anopheles...
Franz, Alexander W. E., Sanchez-Vargas, Irma, Adelman, Zach N., Blair, Carol D., Beaty, Barry J., James, Anthony A., ...
Mosquitoes (Aedes aegypti) were genetically modified to exhibit impaired vector competence for dengue type 2 viruses (DENV-2). We exploited the natural antiviral RNA interference (RNAi) pathway in...
Blakqori, Gjon, Delhaye, Sophie, Habjan, Matthias, Blair, Carol D., Sánchez-Vargas, Irma, Olson, Ken E., ...
La Crosse virus (LACV) is a mosquito-transmitted member of the Bunyaviridae family that causes severe encephalitis in children. For the LACV nonstructural protein NSs, previous overexpression studies...
Aedes aegypti uses RNA interference in defense against Sindbis virus infection
Campbell, Corey L, Keene, Kimberly M, Brackney, Douglas E, Olson, Ken E, Blair, Carol D, Wilusz, Jeffrey, ...
Potential for La Crosse virus segment reassortment in nature
Reese, Sara M, Blitvich, Bradley J, Blair, Carol D, Geske, Dave, Beaty, Barry J, Black, William C
The evolutionary success of La Crosse virus (LACV, family Bunyaviridae) is due to its ability to adapt to changing conditions through intramolecular genetic changes and segment reassortment. Vertical...
Sánchez-Vargas, Irma, Scott, Jaclyn C., Poole-Smith, B. Katherine, Franz, Alexander W. E., Barbosa-Solomieu, Valérie, Wilusz, Jeffrey, ...
A number of studies have shown that both innate and adaptive immune defense mechanisms greatly influence the course of human dengue virus (DENV) infections, but little is known about the innate...