Origins of phase contrast in the atomic force microscope in liquids (2009)
Melcher, John, Carrasco, Carolina, Xu, Xianfan, Carrascosa, Jose L, Gomez-Herrero, Julio, Jose De Pablo, Pedro, ...
We study the physical origins of phase contrast in dynamic atomic force microscopy (dAFM) in liquids where low-stiffness microcantilever probes are often used for nanoscale imaging of soft biological...
Palazuelos, Javier, Aguado, Tania, Pazos, M. Ruth, Julien, Boris, Carrasco, Carolina, Resel, Eva, ...
Cannabinoid-derived drugs are promising agents for the development of novel neuroprotective strategies. Activation of neuronal CB1 cannabinoid receptors attenuates excitotoxic glutamatergic...
Xu, Xin, Carrasco, Carolina, Jose De Pablo, Pedro, Gomez-Herrero, Julio, Raman, Arvind
Dynamic atomic force microscopy is widely used for the imaging of soft biological materials in liquid environments; yet very little is known about the peak forces exerted by the oscillating probe...
Bailly, Christian, Chessari, Gianni, Carrasco, Carolina, Joubert, Alexandra, Mann, John, Wilson, W. David, ...
The binding of two symmetric bis‐benzimidazole compounds,...
Tight binding of the antitumor drug ditercalinium to quadruplex DNA (2002)
Carrasco, Carolina, Rosu, Frédéric, Gabelica, Valérie, Houssier, Claude, De Pauw, Edwin, Garbay-Jaureguiberry, Christiane, ...
The structural selectivity of the DNA-binding antitumor drug ditercalinium was investigated by competition dialysis with a series of nineteen different DNA substrates. The 7H-pyridocarbazole dimer...
Carrasco, Carolina, Facompré, Michaël, Chisholm, John D., Van Vranken, David L., Wilson, W. David, Bailly, Christian
The antibiotic AT2433-B1 belongs to a therapeutically important class of antitumor agents. This natural product contains an indolocarbazole aglycone connected to a unique disaccharide consisting of a...
Carrasco, Carolina, Facompré, Michaël, Chisholm, John D., Van Vranken, David L., Wilson, W. David, Bailly, Christian
The antibiotic AT2433-B1 belongs to a therapeutically important class of antitumor agents. This natural product contains an indolocarbazole aglycone connected to a unique disaccharide consisting of a...
Sequence-specific minor groove binding by bis-benzimidazoles: water molecules in ligand recognition
Bailly, Christian, Chessari, Gianni, Carrasco, Carolina, Joubert, Alexandra, Mann, John, Wilson, W. David, ...
The binding of two symmetric bis-benzimidazole compounds, 2,2-bis-[4′-(3″-dimethylamino-1″-propyloxy)phenyl]-5,5-bi-1H-benzimidazole and its piperidinpropylphenyl analog, to the minor groove of...
Carrasco, Carolina, Facompré, Michaël, Chisholm, John D., Van Vranken, David L., Wilson, W. David, Bailly, Christian
The antibiotic AT2433-B1 belongs to a therapeutically important class of antitumor agents. This natural product contains an indolocarbazole aglycone connected to a unique disaccharide consisting of a...
Sequence-specific minor groove binding by bis-benzimidazoles: water molecules in ligand recognition
Bailly, Christian, Chessari, Gianni, Carrasco, Carolina, Joubert, Alexandra, Mann, John, Wilson, W. David, ...
The binding of two symmetric bis-benzimidazole compounds, 2,2-bis-[4′-(3″-dimethylamino-1″-propyloxy)phenyl]-5,5-bi-1H-benzimidazole and its piperidinpropylphenyl analog, to the minor groove of...
Elastic Response, Buckling, and Instability of Microtubules under Radial Indentation
Schaap, Iwan A. T., Carrasco, Carolina, De Pablo, Pedro J., MacKintosh, Frederick C., Schmidt, Christoph F.
We tested the mechanical properties of single microtubules by lateral indentation with the tip of an atomic force microscope. Indentations up to ∼3.6 nm, i.e., 15% of the microtubule diameter,...
Manipulation of the mechanical properties of a virus by protein engineering
Carrasco, Carolina, Castellanos, Milagros, De Pablo, Pedro J., Mateu, Mauricio G.
In a previous study, we showed that the DNA molecule within a spherical virus (the minute virus of mice) plays an architectural role by anisotropically increasing the mechanical stiffness of the...
Xu, Xin, Carrasco, Carolina, De Pablo, Pedro Jose, Gomez-Herrero, Julio, Raman, Arvind
Dynamic atomic force microscopy is widely used for the imaging of soft biological materials in liquid environments; yet very little is known about the peak forces exerted by the oscillating probe...