Caroline M. Nievergelt

Genetic analysis of hybridization and introgression between wild mongoose and brown lemurs (2009)

Pastorini, Jennifer, Zaramody, Alphonse, Curtis, Deborah J, Nievergelt, Caroline M, Mundy, Nicholas I

Abstract Background Hybrid zones generally represent areas of secondary contact after speciation. The nature of the interaction between genes of individuals in a hybrid zone is of interest in the...

Circadian polymorphisms associated with affective disorders (2009)

Kripke, Daniel F, Nievergelt, Caroline M, Joo, EJ, Shekhtman, Tatyana, Kelsoe, John R

Abstract Background Clinical symptoms of affective disorders, their response to light treatment, and sensitivity to other circadian interventions indicate that the circadian system has a role in mood...

Delayed sleep phase cases and controls (2008)

Kripke, Daniel F, Rex, Katharine M, Ancoli-Israel, Sonia, Nievergelt, Caroline M, Klimecki, Walt, Kelsoe, John R

Abstract Background Delayed sleep phase disorder (DSPD) is a condition in which patients have difficulty falling asleep before the early morning hours and commonly have trouble awakening before late...

Generalized Analysis of Molecular Variance (2007)

Caroline M. Nievergelt, Ondrej Libiger, Nicholas J. Schork

Many studies in the fields of genetic epidemiology and applied population genetics are predicated on, or require, an assessment of the genetic background diversity of the individuals chosen for...

Generalized Analysis of Molecular Variance (2007)

Caroline M Nievergelt, Ondrej Libiger, Nik J. Schork

Many studies in the fields of genetic epidemiology and applied population genetics are predicated on, or require, an assessment of the genetic background diversity of the individuals chosen for...

Susceptibility and modifier genes in Portuguese transthyretin V30M amyloid polyneuropathy: complexity in a single-gene disease (2005)

Soares, Miguel L., Coelho, Teresa, Sousa, Alda, Batalov, Serge, Conceição, Isabel, Sales-Luís, Maria L., ...

Familial amyloid polyneuropathy type I is an autosomal dominant disorder caused by mutations in the transthyretin (TTR) gene; however, carriers of the same mutation exhibit variability in penetrance...

Large-Scale Integration of Human Genetic and Physical Maps (2004)

Nievergelt, Caroline M., Smith, Douglas W., Kohlenberg, J. Bradley, Schork, Nicholas J.

Genetic maps are used routinely in family-based linkage studies to identify the rough location of genes that influence human traits and diseases. Unlike physical maps, genetic maps are based on the...

Large-Scale Integration of Human Genetic and Physical Maps (2004)

Nievergelt, Caroline M., Smith, Douglas W., Kohlenberg, J. Bradley, Schork, Nicholas J.

Genetic maps are used routinely in family-based linkage studies to identify the rough location of genes that influence human traits and diseases. Unlike physical maps, genetic maps are based on the...

Large-Scale Integration of Human Genetic and Physical Maps

Nievergelt, Caroline M., Smith, Douglas W., Kohlenberg, J. Bradley, Schork, Nicholas J.

Genetic maps are used routinely in family-based linkage studies to identify the rough location of genes that influence human traits and diseases. Unlike physical maps, genetic maps are based on the...

Large-Scale Integration of Human Genetic and Physical Maps

Nievergelt, Caroline M., Smith, Douglas W., Kohlenberg, J. Bradley, Schork, Nicholas J.

Genetic maps are used routinely in family-based linkage studies to identify the rough location of genes that influence human traits and diseases. Unlike physical maps, genetic maps are based on the...

Population Structure, Admixture, and Aging-Related Phenotypes in African American Adults: The Cardiovascular Health Study

Reiner, Alexander P., Ziv, Elad, Lind, Denise L., Nievergelt, Caroline M., Schork, Nicholas J., Cummings, Steven R., ...

U.S. populations are genetically admixed, but surprisingly little empirical data exists documenting the impact of such heterogeneity on type I and type II error in genetic-association studies of...

Generalized Analysis of Molecular Variance

Nievergelt, Caroline M, Libiger, Ondrej, Schork, Nicholas J

Many studies in the fields of genetic epidemiology and applied population genetics are predicated on, or require, an assessment of the genetic background diversity of the individuals chosen for...

Tracing Sub-Structure in the European American Population with PCA-Informative Markers

Paschou, Peristera, Drineas, Petros, Lewis, Jamey, Nievergelt, Caroline M., Nickerson, Deborah A., Smith, Joshua D., ...

Genetic structure in the European American population reflects waves of migration and recent gene flow among different populations. This complex structure can introduce bias in genetic association...