Partial rescue of the prophase I defects of Atm-deficient mice by p53 and p21 null alleles (9999)
Carrolee Barlow, Marek Liyanage, Peter B. Moens, Chu-Xia Deng, Thomas Ried, Anthony Wynshaw-Boris
Detecting genetic variation in microarray expression data (2007)
Greenhall, Jennifer A., Zapala, Matthew A., Cáceres, Mario, Libiger, Ondrej, Barlow, Carrolee, Schork, Nicholas J., ...
The use of high-density oligonucleotide arrays to measure the expression levels of thousands of genes in parallel has become commonplace. To take further advantage of the growing body of data, we...
Hovatta, Iiris, Zapala, Matthew A, Broide, Ron S, Schadt, Eric E, Libiger, Ondrej, Schork, Nicholas J, ...
Abstract Background Expression quantitative trait locus (eQTL) mapping is used to find loci that are responsible for the transcriptional activity of a particular gene. In recent eQTL studies,...
Glyoxalase 1 and glutathione reductase 1 regulate anxiety in mice (2005)
Iiris Hovatta, Richard S. Tennant, Robert Helton, Robert A. Marr, Oded Singer, Jeffrey M. Redwine, ...
Mechanisms of aging in senescence-accelerated mice (2005)
Carter, Todd A, Greenhall, Jennifer A, Yoshida, Shigeo, Fuchs, Sebastian, Helton, Robert, Swaroop, Anand, ...
Abstract Background Progressive neurological dysfunction is a key aspect of human aging. Because of underlying differences in the aging of mice and humans, useful mouse models have been difficult to...
Aberrant recombination involving the granzyme locus occurs in Atm-/- T-cell lymphomas (2005)
Winrow, Christopher J., Pankratz, Daniel G., Vibat, Cecile Rose T., Bowen, T.J., Callahan, Marie A., Warren, Amy J., ...
Ataxia telangiectasia (A-T) is an autosomal recessive disease caused by loss of function of the serine/threonine protein kinase ATM (ataxia telangiectasia mutated). A-T patients have a 250–700-fold...
Cancer chemoprevention by the antioxidant tempol acts partially via the p53 tumor suppressor (2005)
Erker, Laura, Schubert, Ralf, Yakushiji, Hiroyuki, Barlow, Carrolee, Larson, Denise, Mitchell, James B., ...
We previously demonstrated that the nitroxide antioxidant tempol (4-hydroxy-2,2,6,6-tetramethylpiperidine-N-oxyl) increased latency to tumorigenesis and doubled (100%) the lifespan of...
Cancer chemoprevention by the antioxidant tempol acts partially via the p53 tumor suppressor (2005)
Erker, Laura, Schubert, Ralf, Yakushiji, Hiroyuki, Barlow, Carrolee, Larson, Denise, Mitchell, James B., ...
We previously demonstrated that the nitroxide antioxidant Tempol (4-hydroxy-2,2,6,6-tetramethylpiperidine-N-oxyl) increased latency to tumorigenesis and doubled (100%) the lifespan of Atm-deficient...
Aberrant recombination involving the granzyme locus occurs in Atm-/-T-Cell Lymphomas (2005)
Winrow, Christopher J., Pankratz, Daniel G., Vibat, Cecile Rose T., Bowen, T. J., Callahan, Marie A., Warren, Amy J., ...
Ataxia Telangiectasia (A-T) is an autosomal recessive disease caused by loss of function of the serine/threonine protein kinase ATM. A-T patients have a 250-700 fold increased risk of developing...
Todd A Carter, Jennifer A Greenhall, Shigeo Yoshida, Sebastian Fuchs, Robert Helton, David J Lockhart, ...
The electronic version of this article is the complete one and can be
Yoshida, Shigeo, Mears, Alan J., Friedman, James S., Carter, Todd, He, Shirley, Oh, Edwin, ...
The rod photoreceptor-specific neural retina leucine zipper protein Nrl is essential for rod differentiation and plays a critical role in regulating gene expression. In the mouse retina, rods account...
Cancer chemoprevention by the antioxidant Tempol in Atm-deficient mice (2004)
Schubert, Ralf, Erker, Laura, Barlow, Carrolee, Yakushiji, Hiroyuki, Larson, Denise, Russo, Angelo, ...
Reactive oxygen species (ROS) are important endogenous etiological agents for DNA damage, and ROS perform critical signaling functions in apoptosis, stress responses and proliferation. The...
Cancer chemoprevention by the antioxidant tempol in Atm-deficient mice (2004)
Schubert, Ralf, Erker, Laura, Barlow, Carrolee, Yakushiji, Hiroyuki, Larson, Denise, Russo, Angelo, ...
Reactive oxygen species (ROS) are important endogenous etiological agents for DNA damage, and ROS perform critical signaling functions in apoptosis, stress responses and proliferation. The...
Yoshida, Shigeo, Mears, Alan J., Friedman, James S., Carter, Todd, He, Shirley, Oh, Edwin, ...
The rod photoreceptor-specific neural retina leucine zipper protein Nrl is essential for rod differentiation and plays a critical role in regulating gene expression. In the mouse retina, rods account...
Yoshida, Shigeo, Mears, Alan J., Friedman, James S., Carter, Todd, He, Shirley, Oh, Edwin, ...
The rod photoreceptor-specific neural retina leucine zipper protein Nrl is essential for rod differentiation and plays a critical role in regulating gene expression. In the mouse retina, rods account...
Cancer chemoprevention by the antioxidant Tempol in Atm-deficient mice (2004)
Schubert, Ralf, Erker, Laura, Barlow, Carrolee, Yakushiji, Hiroyuki, Larson, Denise, Russo, Angelo, ...
Reactive oxygen species (ROS) are important endogenous etiological agents for DNA damage, and ROS perform critical signaling functions in apoptosis, stress responses and proliferation. The...
An inbred 129SvEv GFPCre transgenic mouse that deletes loxP-flanked genes in all tissues (2003)
Scheel, John R., Garrett, Lisa J., Allen, Duane M., Carter, Todd A., Randolph-Moore, Lynne, Gambello, Micheal J., ...
A common method for generating mice with subtle genetic manipulations uses homologous recombination (HR) in embryonic stem (ES) cells to replace a wild‐type gene with a slightly modified one....
Software and methods for oligonucleotide and cDNA array data analysis (2002)
Zapala, Matthew A, Lockhart, Daniel J, Pankratz, Daniel G, Garcia, Anthony J, Barlow, Carrolee, Lockhart, David J
Abstract Two HTML-based programs were developed to analyze and filter gene-expression data: 'Bullfrog' for Affymetrix oligonucleotide arrays and 'Spot' for custom cDNA arrays. The programs provide...
Karabinis, Melissa E., Larson, Denise, Barlow, Carrolee, Wynshaw-Boris, Anthony, Moser, Amy Rapaich
The proteins encoded by BRCA1 and ATM may be important in DNA repair and maintenance of genomic integrity. Women heterozygous for a mutation in BRCA1 have an increased incidence of breast cancer....
Ataxia telangiectasia mutated is essential during adult neurogenesis (2001)
Allen, Duane M., Van Praag, Henriette, Ray, Jasodhara, Weaver, Zoë, Winrow, Christopher J., Carter, Todd A., ...
ATM is a cytoplasmic protein in mouse brain required to prevent lysosomal accumulation. (2000)
Barlow, Carrolee, Ribaut-Barassin, Catherine, Zwingman, Theresa A., Pope, Amber J., Brown, Kevin D., Owens, Jennie W., ...
We previously generated a mouse model with a mutation in the murine Atm gene that recapitulates many aspects of the childhood neurodegenerative disease ataxia-telangiectasia. Atm-deficient (Atm-/-)...
Loss of the ataxia-telangiectasia gene product causes oxidative damage in target organs. (1999)
Barlow, Carrolee, Dennery, Phyllis A., Shigenaga, Mark K., Smith, Mark A., Morrow, Jason D., Roberts, L. Jackson, ...
Ataxia-telangiectasia (A-T) is characterized by a markedly increased sensitivity to ionizing radiation, increased incidence of cancer, and neurodegeneration, especially of the cerebellar Purkinje...
Dantzer, Françoise, Ménissier-de Murcia, Josiane, Barlow, Carrolee, Wynshaw-Boris, Anthony, De Murcia, Gilbert
Poly(ADP-ribose) polymerase (PARP) is a constitutive factor of the DNA damage surveillance network in dividing cells. Based on its capacity to bind to DNA strand breaks, PARP plays a regulatory role...
Abnormal heart rate and body temperature in mice lacking thyroid hormone receptor α1 (1998)
Lilian Wikström, Catarina Johansson, Carmen Saltó, Carrolee Barlow, Angel Campos Barros, Frank Baas, ...
ATM is a cytoplasmic protein in mouse brain required to prevent lysosomal accumulation
Barlow, Carrolee, Ribaut-Barassin, Catherine, Zwingman, Theresa A., Pope, Amber J., Brown, Kevin D., Owens, Jennie W., ...
We previously generated a mouse model with a mutation in the murine Atm gene that recapitulates many aspects of the childhood neurodegenerative disease ataxia-telangiectasia. Atm-deficient...
Petiniot, Lisa K., Weaver, Zoë, Barlow, Carrolee, Shen, Rhuna, Eckhaus, Michael, Steinberg, Seth M., ...
The majority of Atm-deficient mice die of malignant thymic lymphoma by 4–5 mo of age. Cytogenetic abnormalities in these tumors are consistently identified within the Tcr α/δ locus, suggesting...
Loss of the ataxia–telangiectasia gene product causes oxidative damage in target organs
Barlow, Carrolee, Dennery, Phyllis A., Shigenaga, Mark K., Smith, Mark A., Morrow, Jason D., Roberts, L. Jackson, ...
Ataxia–telangiectasia (A-T) is characterized by a markedly increased sensitivity to ionizing radiation, increased incidence of cancer, and neurodegeneration, especially of the cerebellar Purkinje...
Yamanaka, Ryuya, Barlow, Carrolee, Lekstrom-Himes, Julie, Castilla, Lucio H., Liu, Pu P., Eckhaus, Michael, ...
Polymorphonuclear leukocytes are essential for host defense to infectious diseases. CCAAT/enhancer binding protein ɛ (C/EBPɛ) is preferentially expressed in granulocytes and lymphoid cells. Mice...
Regional and strain-specific gene expression mapping in the adult mouse brain
Sandberg, Rickard, Yasuda, Rie, Pankratz, Daniel G., Carter, Todd A., Del Rio, Jo A., Wodicka, Lisa, ...
To determine the genetic causes and molecular mechanisms responsible for neurobehavioral differences in mice, we used highly parallel gene expression profiling to detect genes that are differentially...
Kaneshige, Masahiro, Kaneshige, Kumiko, Zhu, Xu-guang, Dace, Alexandra, Garrett, Lisa, Carter, Todd A., ...
Patients with mutations in the thyroid hormone receptor β (TRβ) gene manifest resistance to thyroid hormone (RTH), resulting in a constellation of variable phenotypic abnormalities. To understand...
Kaneshige, Masahiro, Suzuki, Hideyo, Kaneshige, Kumiko, Cheng, Jun, Wimbrow, Heather, Barlow, Carrolee, ...
Mutations in the thyroid hormone receptor β (TRβ) gene result in resistance to thyroid hormone. However, it is unknown whether mutations in the TRα gene could lead to a similar disease. To address...
Atm Is Dispensable for p53 Apoptosis and Tumor Suppression Triggered by Cell Cycle Dysfunction
Liao, Mai-Jing, Yin, Chaoying, Barlow, Carrolee, Wynshaw-Boris, Anthony, Van Dyke, Terry
Both p53 and ATM are checkpoint regulators with roles in genetic stabilization and cancer susceptibility. ATM appears to function in the same DNA damage checkpoint pathway as p53. However, ATM’s...
RAG-Mediated V(D)J Recombination Is Not Essential for Tumorigenesis in Atm-Deficient Mice
Petiniot, Lisa K., Weaver, Zoë, Vacchio, Melanie, Shen, Rhuna, Wangsa, Danny, Barlow, Carrolee, ...
Atm-deficient mice die of malignant thymic lymphomas characterized by translocations within the Tcrα/δ locus, suggesting that tumorigenesis is secondary to aberrant responses to double-stranded DNA...
Software and methods for oligonucleotide and cDNA array data analysis
Zapala, Matthew A, Lockhart, Daniel J, Pankratz, Daniel G, Garcia, Anthony J, Barlow, Carrolee, Lockhart, David J
Two HTML-based programs were developed to analyze and filter gene-expression data. A background subtraction and normalization program for cDNA arrays was also built that provides an informative...
An inbred 129SvEv GFPCre transgenic mouse that deletes loxP-flanked genes in all tissues
Scheel, John R., Garrett, Lisa J., Allen, Duane M., Carter, Todd A., Randolph-Moore, Lynne, Gambello, Micheal J., ...
A common method for generating mice with subtle genetic manipulations uses homologous recombination (HR) in embryonic stem (ES) cells to replace a wild-type gene with a slightly modified one....
Evidence that mouse brain neuropathy target esterase is a lysophospholipase
Quistad, Gary B., Barlow, Carrolee, Winrow, Christopher J., Sparks, Susan E., Casida, John E.
Neuropathy target esterase (NTE) is inhibited by several organophosphorus (OP) pesticides, chemical warfare agents, lubricants, and plasticizers, leading to OP-induced delayed neuropathy in people...
Elevated gene expression levels distinguish human from non-human primate brains
Cáceres, Mario, Lachuer, Joel, Zapala, Matthew A., Redmond, John C., Kudo, Lili, Geschwind, Daniel H., ...
Little is known about how the human brain differs from that of our closest relatives. To investigate the genetic basis of human specializations in brain organization and cognition, we compared gene...
Adult mouse brain gene expression patterns bear an embryologic imprint
Zapala, Matthew A., Hovatta, Iiris, Ellison, Julie A., Wodicka, Lisa, Del Rio, Jo A., Tennant, Richard, ...
The current model to explain the organization of the mammalian nervous system is based on studies of anatomy, embryology, and evolution. To further investigate the molecular organization of the adult...
Mechanisms of aging in senescence-accelerated mice
Carter, Todd A, Greenhall, Jennifer A, Yoshida, Shigeo, Fuchs, Sebastian, Helton, Robert, Swaroop, Anand, ...
Gene-expression analysis and polymorphism screening to study molecular senescence of the retina and hippocampus in two rare inbred mouse models of accelerated neurological senescence as well as a...
Ataxia telangiectasia mutated is essential during adult neurogenesis
Allen, Duane M., Van Praag, Henriette, Ray, Jasodhara, Weaver, Zoë, Winrow, Christopher J., Carter, Todd A., ...
Ataxia telangiectasia (A-T) is an autosomal recessive disease characterized by normal brain development followed by progressive neurodegeneration. The gene mutated in A-T (ATM) is a serine protein...
ATM is a cytoplasmic protein in mouse brain required to prevent lysosomal accumulation
Barlow, Carrolee, Ribaut-Barassin, Catherine, Zwingman, Theresa A., Pope, Amber J., Brown, Kevin D., Owens, Jennie W., ...
We previously generated a mouse model with a mutation in the murine Atm gene that recapitulates many aspects of the childhood neurodegenerative disease ataxia-telangiectasia. Atm-deficient...
Petiniot, Lisa K., Weaver, Zoë, Barlow, Carrolee, Shen, Rhuna, Eckhaus, Michael, Steinberg, Seth M., ...
The majority of Atm-deficient mice die of malignant thymic lymphoma by 4–5 mo of age. Cytogenetic abnormalities in these tumors are consistently identified within the Tcr α/δ locus, suggesting...
Loss of the ataxia–telangiectasia gene product causes oxidative damage in target organs
Barlow, Carrolee, Dennery, Phyllis A., Shigenaga, Mark K., Smith, Mark A., Morrow, Jason D., Roberts, L. Jackson, ...
Ataxia–telangiectasia (A-T) is characterized by a markedly increased sensitivity to ionizing radiation, increased incidence of cancer, and neurodegeneration, especially of the cerebellar Purkinje...
Yamanaka, Ryuya, Barlow, Carrolee, Lekstrom-Himes, Julie, Castilla, Lucio H., Liu, Pu P., Eckhaus, Michael, ...
Polymorphonuclear leukocytes are essential for host defense to infectious diseases. CCAAT/enhancer binding protein ɛ (C/EBPɛ) is preferentially expressed in granulocytes and lymphoid cells. Mice...
Regional and strain-specific gene expression mapping in the adult mouse brain
Sandberg, Rickard, Yasuda, Rie, Pankratz, Daniel G., Carter, Todd A., Del Rio, Jo A., Wodicka, Lisa, ...
To determine the genetic causes and molecular mechanisms responsible for neurobehavioral differences in mice, we used highly parallel gene expression profiling to detect genes that are differentially...
Kaneshige, Masahiro, Kaneshige, Kumiko, Zhu, Xu-guang, Dace, Alexandra, Garrett, Lisa, Carter, Todd A., ...
Patients with mutations in the thyroid hormone receptor β (TRβ) gene manifest resistance to thyroid hormone (RTH), resulting in a constellation of variable phenotypic abnormalities. To understand...
Kaneshige, Masahiro, Suzuki, Hideyo, Kaneshige, Kumiko, Cheng, Jun, Wimbrow, Heather, Barlow, Carrolee, ...
Mutations in the thyroid hormone receptor β (TRβ) gene result in resistance to thyroid hormone. However, it is unknown whether mutations in the TRα gene could lead to a similar disease. To address...
Atm Is Dispensable for p53 Apoptosis and Tumor Suppression Triggered by Cell Cycle Dysfunction
Liao, Mai-Jing, Yin, Chaoying, Barlow, Carrolee, Wynshaw-Boris, Anthony, Van Dyke, Terry
Both p53 and ATM are checkpoint regulators with roles in genetic stabilization and cancer susceptibility. ATM appears to function in the same DNA damage checkpoint pathway as p53. However, ATM’s...
RAG-Mediated V(D)J Recombination Is Not Essential for Tumorigenesis in Atm-Deficient Mice
Petiniot, Lisa K., Weaver, Zoë, Vacchio, Melanie, Shen, Rhuna, Wangsa, Danny, Barlow, Carrolee, ...
Atm-deficient mice die of malignant thymic lymphomas characterized by translocations within the Tcrα/δ locus, suggesting that tumorigenesis is secondary to aberrant responses to double-stranded DNA...
Software and methods for oligonucleotide and cDNA array data analysis
Zapala, Matthew A, Lockhart, Daniel J, Pankratz, Daniel G, Garcia, Anthony J, Barlow, Carrolee, Lockhart, David J
Two HTML-based programs were developed to analyze and filter gene-expression data. A background subtraction and normalization program for cDNA arrays was also built that provides an informative...
An inbred 129SvEv GFPCre transgenic mouse that deletes loxP-flanked genes in all tissues
Scheel, John R., Garrett, Lisa J., Allen, Duane M., Carter, Todd A., Randolph-Moore, Lynne, Gambello, Micheal J., ...
A common method for generating mice with subtle genetic manipulations uses homologous recombination (HR) in embryonic stem (ES) cells to replace a wild-type gene with a slightly modified one....
Evidence that mouse brain neuropathy target esterase is a lysophospholipase
Quistad, Gary B., Barlow, Carrolee, Winrow, Christopher J., Sparks, Susan E., Casida, John E.
Neuropathy target esterase (NTE) is inhibited by several organophosphorus (OP) pesticides, chemical warfare agents, lubricants, and plasticizers, leading to OP-induced delayed neuropathy in people...
Elevated gene expression levels distinguish human from non-human primate brains
Cáceres, Mario, Lachuer, Joel, Zapala, Matthew A., Redmond, John C., Kudo, Lili, Geschwind, Daniel H., ...
Little is known about how the human brain differs from that of our closest relatives. To investigate the genetic basis of human specializations in brain organization and cognition, we compared gene...
Ataxia telangiectasia mutated is essential during adult neurogenesis
Allen, Duane M., Van Praag, Henriette, Ray, Jasodhara, Weaver, Zoë, Winrow, Christopher J., Carter, Todd A., ...
Ataxia telangiectasia (A-T) is an autosomal recessive disease characterized by normal brain development followed by progressive neurodegeneration. The gene mutated in A-T (ATM) is a serine protein...
Adult mouse brain gene expression patterns bear an embryologic imprint
Zapala, Matthew A., Hovatta, Iiris, Ellison, Julie A., Wodicka, Lisa, Del Rio, Jo A., Tennant, Richard, ...
The current model to explain the organization of the mammalian nervous system is based on studies of anatomy, embryology, and evolution. To further investigate the molecular organization of the adult...
Mechanisms of aging in senescence-accelerated mice
Carter, Todd A, Greenhall, Jennifer A, Yoshida, Shigeo, Fuchs, Sebastian, Helton, Robert, Swaroop, Anand, ...
Gene-expression analysis and polymorphism screening to study molecular senescence of the retina and hippocampus in two rare inbred mouse models of accelerated neurological senescence as well as a...
Hovatta, Iiris, Zapala, Matthew A, Broide, Ron S, Schadt, Eric E, Libiger, Ondrej, Schork, Nicholas J, ...
Gene expression profiles of five brain regions from six inbred mouse strains suggest that many regulatory networks are highly specific to particular brain regions.
Detecting genetic variation in microarray expression data
Greenhall, Jennifer A., Zapala, Matthew A., Cáceres, Mario, Libiger, Ondrej, Barlow, Carrolee, Schork, Nicholas J., ...
The use of high-density oligonucleotide arrays to measure the expression levels of thousands of genes in parallel has become commonplace. To take further advantage of the growing body of data, we...
Immunoglobulin Class Switch Recombination Is Impaired in Atm-deficient Mice
Lumsden, Joanne M., McCarty, Thomas, Petiniot, Lisa K., Shen, Rhuna, Barlow, Carrolee, Wynn, Thomas A., ...
Immunoglobulin class switch recombination (Ig CSR) involves DNA double strand breaks (DSBs) at recombining switch regions and repair of these breaks by nonhomologous end-joining. Because the protein...