Derudder, Emmanuel, Cadera, Emily J., Val, J. Christoph, Wang, Jing, Fox, Casey J., Zha, Shan, ...
By genetically ablating I kappa B kinase (IKK)-mediated activation of the transcription factor NF-kappa B in the B cell lineage and by analyzing a mouse mutant in which immunoglobulin...
Pogacic, Vanda, Bendit, Marina, Chappuis, Richard, Nawijn, Martijn C, Duyster, Justus, ...
Previous studies have shown that activation of the signal transducer and activator of transcription 5 (STAT5) plays an essential role in leukemogenesis mediated through constitutive activated protein...
The serine/threonine kinase Pim-2 is a transcriptionally regulated apoptotic inhibitor (2003)
Fox, Casey J., Hammerman, Peter S., Cinalli, Ryan M., Master, Stephen R., Chodosh, Lewis A., Thompson, Craig B.
Growth factor withdrawal results in the termination of factor-dependent transcription. One transcript that declines rapidly following growth factor deprivation of hematopoietic cells is the...
The serine/threonine kinase Pim-2 is a transcriptionally regulated apoptotic inhibitor (2003)
Fox, Casey J., Hammerman, Peter S., Cinalli, Ryan M., Master, Stephen R., Chodosh, Lewis A., Thompson, Craig B.
Growth factor withdrawal results in the termination of factor-dependent transcription. One transcript that declines rapidly following growth factor deprivation of hematopoietic cells is the...
Growth Factors Can Influence Cell Growth and Survival through Effects on Glucose Metabolism
Vander Heiden, Matthew G., Plas, David R., Rathmell, Jeffrey C., Fox, Casey J., Harris, Marian H., Thompson, Craig B.
Cells from multicellular organisms are dependent upon exogenous signals for survival, growth, and proliferation. The relationship among these three processes was examined using an interleukin-3...
Bcl-XL affects Ca2+ homeostasis by altering expression of inositol 1,4,5-trisphosphate receptors
Li, Chi, Fox, Casey J., Master, Stephen R., Bindokas, Vytautas P., Chodosh, Lewis A., Thompson, Craig B.
An oligonucleotide-based microarray analysis of 9,500 genes and expressed sequence tags (ESTs) demonstrated that the type 1 inositol 1,4,5-trisphosphate receptor (IP3R) was significantly...
The serine/threonine kinase Pim-2 is a transcriptionally regulated apoptotic inhibitor
Fox, Casey J., Hammerman, Peter S., Cinalli, Ryan M., Master, Stephen R., Chodosh, Lewis A., Thompson, Craig B.
Growth factor withdrawal results in the termination of factor-dependent transcription. One transcript that declines rapidly following growth factor deprivation of hematopoietic cells is the...
Rathmell, Jeffrey C., Fox, Casey J., Plas, David R., Hammerman, Peter S., Cinalli, Ryan M., Thompson, Craig B.
The serine/threonine kinase Akt is a component of many receptor signal transduction pathways and can prevent cell death following growth factor withdrawal. Here, we show that Akt inhibition of cell...
Fox, Casey J., Paterson, Andrew D., Mortin-Toth, Steven M., Danska, Jayne S.
Insulin-dependent diabetes mellitus (IDDM) is a polygenic disease caused by progressive autoimmune infiltration (insulitis) of the pancreatic islets of Langerhan, culminating in the destruction of...
Growth Factors Can Influence Cell Growth and Survival through Effects on Glucose Metabolism
Vander Heiden, Matthew G., Plas, David R., Rathmell, Jeffrey C., Fox, Casey J., Harris, Marian H., Thompson, Craig B.
Cells from multicellular organisms are dependent upon exogenous signals for survival, growth, and proliferation. The relationship among these three processes was examined using an interleukin-3...
Bcl-XL affects Ca2+ homeostasis by altering expression of inositol 1,4,5-trisphosphate receptors
Li, Chi, Fox, Casey J., Master, Stephen R., Bindokas, Vytautas P., Chodosh, Lewis A., Thompson, Craig B.
An oligonucleotide-based microarray analysis of 9,500 genes and expressed sequence tags (ESTs) demonstrated that the type 1 inositol 1,4,5-trisphosphate receptor (IP3R) was significantly...
The serine/threonine kinase Pim-2 is a transcriptionally regulated apoptotic inhibitor
Fox, Casey J., Hammerman, Peter S., Cinalli, Ryan M., Master, Stephen R., Chodosh, Lewis A., Thompson, Craig B.
Growth factor withdrawal results in the termination of factor-dependent transcription. One transcript that declines rapidly following growth factor deprivation of hematopoietic cells is the...
Rathmell, Jeffrey C., Fox, Casey J., Plas, David R., Hammerman, Peter S., Cinalli, Ryan M., Thompson, Craig B.
The serine/threonine kinase Akt is a component of many receptor signal transduction pathways and can prevent cell death following growth factor withdrawal. Here, we show that Akt inhibition of cell...
Fox, Casey J., Paterson, Andrew D., Mortin-Toth, Steven M., Danska, Jayne S.
Insulin-dependent diabetes mellitus (IDDM) is a polygenic disease caused by progressive autoimmune infiltration (insulitis) of the pancreatic islets of Langerhan, culminating in the destruction of...
Pim and Akt oncogenes are independent regulators of hematopoietic cell growth and survival
Hammerman, Peter S., Fox, Casey J., Birnbaum, Morris J., Thompson, Craig B.
The Akt kinases promote hematopoietic cell growth and accumulation through phosphorylation of apoptotic effectors and stimulation of mTOR-dependent translation. In Akt-transformed leukemic cells,...
The Pim kinases control rapamycin-resistant T cell survival and activation
Fox, Casey J., Hammerman, Peter S., Thompson, Craig B.
Although Pim-1 or Pim-2 can contribute to lymphoid transformation when overexpressed, the physiologic role of these kinases in the immune response is uncertain. We now report that T cells from...
Multiple signaling pathways promote B lymphocyte stimulator–dependent B-cell growth and survival
Woodland, Robert T., Fox, Casey J., Schmidt, Madelyn R., Hammerman, Peter S., Opferman, Joseph T., Korsmeyer, Stanley J., ...
We investigated the mechanism by which B lymphocyte stimulator (BLyS)/BAFF, a tumor necrosis factor superfamily ligand, promotes B-cell survival and resistance to atrophy. BLyS stimulation activates...