Direct inhibition of caspase 3 is dispensable for the anti-apoptotic activity of XIAP
Silke, John, Ekert, Paul G., Day, Catherine L., Hawkins, Christine J., Baca, Manuel, Chew, Joanne, ...
XIAP is a mammalian inhibitor of apoptosis protein (IAP). To determine residues within the second baculoviral IAP repeat (BIR2) required for inhibition of caspase 3, we screened a library of BIR2...
The structure of Bcl-w reveals a role for the C-terminal residues in modulating biological activity
Hinds, Mark G., Lackmann, Martin, Skea, Gretchen L., Harrison, Penny J., Huang, David C.S., Day, Catherine L.
Pro-survival Bcl-2-related proteins, critical regulators of apoptosis, contain a hydrophobic groove targeted for binding by the BH3 domain of the pro-apoptotic BH3-only proteins. The solution...
Localization of dynein light chains 1 and 2 and their pro-apoptotic ligands.
Day, Catherine L, Puthalakath, Hamsa, Skea, Gretchen, Strasser, Andreas, Barsukov, Igor, Lian, Lu-Yun, ...
The dynein and myosin V motor complexes are multi-protein structures that function to transport molecules and organelles within the cell. DLC (dynein light-chain) proteins, found as components of...
Silke, John, Kratina, Tobias, Chu, Diep, Ekert, Paul G., Day, Catherine L., Pakusch, Miha, ...
Inhibitor of apoptosis (IAP) proteins, which bind to caspases via their baculoviral IAP repeat domains, also bear RING domains that enable them to promote ubiquitylation of themselves and other...
Direct inhibition of caspase 3 is dispensable for the anti-apoptotic activity of XIAP
Silke, John, Ekert, Paul G., Day, Catherine L., Hawkins, Christine J., Baca, Manuel, Chew, Joanne, ...
XIAP is a mammalian inhibitor of apoptosis protein (IAP). To determine residues within the second baculoviral IAP repeat (BIR2) required for inhibition of caspase 3, we screened a library of BIR2...
The structure of Bcl-w reveals a role for the C-terminal residues in modulating biological activity
Hinds, Mark G., Lackmann, Martin, Skea, Gretchen L., Harrison, Penny J., Huang, David C.S., Day, Catherine L.
Pro-survival Bcl-2-related proteins, critical regulators of apoptosis, contain a hydrophobic groove targeted for binding by the BH3 domain of the pro-apoptotic BH3-only proteins. The solution...
Localization of dynein light chains 1 and 2 and their pro-apoptotic ligands.
Day, Catherine L, Puthalakath, Hamsa, Skea, Gretchen, Strasser, Andreas, Barsukov, Igor, Lian, Lu-Yun, ...
The dynein and myosin V motor complexes are multi-protein structures that function to transport molecules and organelles within the cell. DLC (dynein light-chain) proteins, found as components of...
Silke, John, Kratina, Tobias, Chu, Diep, Ekert, Paul G., Day, Catherine L., Pakusch, Miha, ...
Inhibitor of apoptosis (IAP) proteins, which bind to caspases via their baculoviral IAP repeat domains, also bear RING domains that enable them to promote ubiquitylation of themselves and other...
Structural insights into the degradation of Mcl-1 induced by BH3 domains
Czabotar, Peter E., Lee, Erinna F., Van Delft, Mark F., Day, Catherine L., Smith, Brian J., Huang, David C. S., ...
Apoptosis is held in check by prosurvival proteins of the Bcl-2 family. The distantly related BH3-only proteins bind to and antagonize them, thereby promoting apoptosis. Whereas binding of the...
Wilson-Annan, Julie, O'Reilly, Lorraine A., Crawford, Simon A., Hausmann, George, Beaumont, Jennifer G., Parma, Loes P., ...
Prosurvival Bcl-2–like proteins, like Bcl-w, are thought to function on organelles such as the mitochondrion and to be targeted to them by their hydrophobic COOH-terminal domain. We unexpectedly...
Silke, John, Hawkins, Christine J., Ekert, Paul G., Chew, Joanne, Day, Catherine L., Pakusch, Miha, ...
The X-linked mammalian inhibitor of apoptosis protein (XIAP) has been shown to bind several partners. These partners include caspase 3, caspase 9, DIABLO/Smac, HtrA2/Omi, TAB1, the bone morphogenetic...