Cross-correlated chemical shift modulation: A signature of slow internal motions in proteins (2001)
Frueh, Dominique, Tolman, Joel R., Bodenhausen, Geoffrey, Zwahlen, Catherine
A novel NMR expt. allows one to characterize slow motion in macromols. The method exploits the fact that motions, such as rotation about dihedral angles, induce correlated fluctuations of the...
Vincent, Sebastien J. F., Zwahlen, Catherine, Post, Carol Beth, Burgner, John W., Bodenhausen, Geoffrey
The conformation of NAD bound to dogfish lactate dehydrogenase (LDH) was reinvestigated by using an NMR expt. that allows one to exploit NOEs to det. internuclear distances between pairs of protons,...
Isolation of selected exchange processes in nuclear magnetic resonance (1996)
Zwahlen, Catherine, Vincent, Sebastien J. F., Schwager, Martina, Bodenhausen, Geoffrey
It is possible to inhibit the transfer of magnetization in a system with several exchanging sites in dynamic equil., as in a mixt. of cis- and trans-ZrCl4L2 with excess free ligand L (L = (CH3O)3PO)....
Vincent, Sebastien J. F., Zwahlen, Catherine, Bolton, Philip H., Logan, Timothy M., Bodenhausen, Geoffrey
A variant of two-dimensional nuclear Overhauser effect spectroscopy (NOESY) is described which allows one to observe cross-relaxation pathways between protons that have heteronuclear scalar couplings...
Suppression of spin diffusion in selected frequency bands of nuclear Overhauser spectra (1996)
Vincent, Sebastien J. F., Zwahlen, Catherine, Bodenhausen, Geoffrey
A variant of 2-dimensional nuclear Overhauser effect spectroscopy (NOESY) is described that yields information about cross-relaxation rates between pairs of spins, while the migration of...
Vincent, Sebastien J. F., Zwahlen, Catherine, Bodenhausen, Geoffrey
The anal. of 2-dimensional NOESY spectra can be misleading if spin diffusion effects are not properly taken into account. An approach consisting in suppressing spin diffusion by selective inversion...
Vincent, Sebastien J. F., Zwahlen, Catherine, Bodenhausen, Geoffrey
Passive spin filters are combined with pure in-phase correlation spectroscopy (PICSY) to obtain SIS-(p,q)-PICSY expts., where p and q are the nos. of passive spins that are simultaneously or...
Zwahlen, Catherine, Vincent, Sebastien J. F., Di Bari, Lorenzo, Levitt, Malcolm H., Bodenhausen, Geoffrey
In high-resoln. NMR, the transfer of longitudinal magnetization from one spin to another (A -> X) under the effect of cross relaxation NOE is often complicated by spin-diffusion pathways through...
Vincent, Sebastien J. F., Zwahlen, Catherine, Bodenhausen, Geoffrey
A method was developed for measuring the rise and fall curves corresponding to selected peaks in NOESY spectrum. When applied to a std. two-dimensional NOESY spectrum, this technique gives result the...
Huber, Peter, Zwahlen, Catherine, Vincent, Sebastien J. F., Bodenhausen, Geoffrey
The authors describe how the value of a nuclear spin coupling const. JAX can be detd. very accurately by comparing 2 complementary 2-dimensional multiplets obtained with selective correlation NMR...
Selective magnetic resonance correlation spectroscopy with in-phase multiplets (1993)
Vincent, Sebastien J. F., Zwahlen, Catherine, Bodenhausen, Geoffrey
New 2-dimensional NMR correlation methods are presented which allow one to obtain selected high-resoln. multiplets where all signals have pos. pure absorption peak shapes. The multiplets do not...
Vincent, Sebastien J. F., Zwahlen, Catherine, Bodenhausen, Geoffrey
It is shown how selective high resoln. 2-dimensional NMR spectra can be obtained which feature multiplets where all peaks have the same pos. sign and pure absorption lineshapes. [on SciFinder (R)]
Zwahlen, Catherine, Vincent, Sebastien J. F., Bodenhausen, Geoffrey
A SPLIT-COSY (SPLIT = sepn. of patterns by lifting of the imbroglio of transfer) technique is proposed for the sepn. of overlapping multiplets in the signal-rich region of a COSY spectra. This...
Vincent, Sébastien J. F., Zwahlen, Catherine, Post, Carol Beth, Burgner, John W., Bodenhausen, Geoffrey
We have reinvestigated the conformation of NAD+ bound to dogfish lactate dehydrogenase (LDH) by using an NMR experiment that allows one to exploit nuclear Overhauser effects to determine internuclear...
Li, Shun-Cheng, Songyang, Zhou, Vincent, Sébastien J. F., Zwahlen, Catherine, Wiley, Sandra, Cantley, Lewis, ...
The phosphotyrosine-binding (PTB) domain is a recently identified protein module that has been characterized as binding to phosphopeptides containing an NPXpY motif (X = any amino acid). We describe...
Butty, Anne-Christine, Perrinjaquet, Nathalie, Petit, Audrey, Jaquenoud, Malika, Segall, Jeffrey E., Hofmann, Kay, ...
In Saccharomyces cerevisiae, activation of Cdc42 by its guanine-nucleotide exchange factor Cdc24 triggers polarization of the actin cytoskeleton at bud emergence and in response to mating pheromones....
Multiple modes of peptide recognition by the PTB domain of the cell fate determinant Numb
Zwahlen, Catherine, Li, Shun-Cheng, Kay, Lewis E., Pawson, Tony, Forman-Kay, Julie D.
The phosphotyrosine-binding (PTB) domain of the cell fate determinant Numb is involved in the formation of multiple protein complexes in vivo and can bind a diverse array of peptide sequences in...
Vincent, Sébastien J. F., Zwahlen, Catherine, Post, Carol Beth, Burgner, John W., Bodenhausen, Geoffrey
We have reinvestigated the conformation of NAD+ bound to dogfish lactate dehydrogenase (LDH) by using an NMR experiment that allows one to exploit nuclear Overhauser effects to determine internuclear...
Li, Shun-Cheng, Songyang, Zhou, Vincent, Sébastien J. F., Zwahlen, Catherine, Wiley, Sandra, Cantley, Lewis, ...
The phosphotyrosine-binding (PTB) domain is a recently identified protein module that has been characterized as binding to phosphopeptides containing an NPXpY motif (X = any amino acid). We describe...
Butty, Anne-Christine, Perrinjaquet, Nathalie, Petit, Audrey, Jaquenoud, Malika, Segall, Jeffrey E., Hofmann, Kay, ...
In Saccharomyces cerevisiae, activation of Cdc42 by its guanine-nucleotide exchange factor Cdc24 triggers polarization of the actin cytoskeleton at bud emergence and in response to mating pheromones....
Multiple modes of peptide recognition by the PTB domain of the cell fate determinant Numb
Zwahlen, Catherine, Li, Shun-Cheng, Kay, Lewis E., Pawson, Tony, Forman-Kay, Julie D.
The phosphotyrosine-binding (PTB) domain of the cell fate determinant Numb is involved in the formation of multiple protein complexes in vivo and can bind a diverse array of peptide sequences in...